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Moderna enters clinical trials for its mRNA-based flu vaccine – Engadget

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Moderna has injected its mRNA-derived vaccine for the seasonal flu into a human volunteer for the first time as part of a Phase 1/2 clinical study, the company announced on Wednesday. 

This is a very early test for the new vaccine technology, geared primarily towards building a baseline understanding of the treatment’s “safety, reactogenicity and immunogenicity,” according to a Moderna release. mRNA-1010, as the vaccine has been dubbed, is designed to be effective against the four most common strains of the virus including, A H1N1, H3N2, influenza B Yamagata and influenza B Victoria. 

According to the World Health Organization, these strains cause between 3 and 5 million severe cases of flu every year, resulting in as many as 650,000 flu-related respiratory deaths annually. In the US alone, roughly 8 percent of the population comes down with the flu every winter. The company hopes this vaccine will prove more potent than the current 40 to 60 percent efficacy rate of conventional flu vaccines.  

“We are pleased to have begun this Phase 1/2 study of mRNA-1010, our first mRNA seasonal flu vaccine candidate to enter the clinic. We expect that our seasonal influenza vaccine candidates will be an important component of our future combination respiratory vaccines,” Moderna CEO Stéphane Bancel said. “Respiratory combination vaccines are an important pillar of our overall mRNA vaccine strategy. We believe that the advantages of mRNA vaccines include the ability to combine different antigens to protect against multiple viruses and the ability to rapidly respond to the evolution of respiratory viruses, such as influenza, SARS-CoV-2 and RSV. Our vision is to develop an mRNA combination vaccine so that people can get one shot each fall for high efficacy protection against the most problematic respiratory viruses.”

This vaccine has been generated using the same genomic techniques the company utilized to develop its COVID-19 treatment in 2020. The technique works by exploiting the human body’s own cells to reproduce snippets of viral DNA to instigate an immune response and prime the body against future infection. Since this method doesn’t require the entire virus (either weakened or dead) but rather just a birt of its genetic code, mRNA vaccines could be applied to any number of deadly modern diseases including malaria, TB — even cancer.  

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Peel Region reports its first confirmed case of monkeypox – CP24 Toronto's Breaking News

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Peel Region has its first confirmed case of monkeypox.

According to Peel Public Health, the person infected is an adult male in his 30s who lives in Mississauga.

The heath unit said the risk to the public remains low.

Monkeypox, which comes from the same virus family as smallpox, spreads though close contact with an infected individual. Most transmission happens through close contact with the skin lesions of monkeypox, but the virus can also be spread by large droplets or by sharing contaminated items.

To reduce risk of infection, people are advised to be cautious when engaging in intimate activities with others. Vaccination is available for high-risk contacts of cases and for those deemed at high risk of exposure to monkeypox.

Symptoms can include fever, headache, fatigue, swollen lymph nodes, and a rash/lesions, which could appear on the face or genitals and then spread to other areas.

Anyone who develops these symptoms should contact their healthcare provider and avoid close contact with others until they have improved and rash/lesions have healed.

While most people recover on their own without treatment, those who have been in close contact with someone who has tested positive for monkeypox should self-monitor for symptoms, and contact PPH to see if they are eligible for vaccination.

The Mississauga case is at least the 34th confirmed case of the disease in Ontario, with dozens more under investigation.

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Monkeypox case count rises to more than 3400 globally, WHO says – The Globe and Mail

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More than 3,400 confirmed monkeypox cases and one death were reported to the World Health Organization as of last Wednesday, with a majority of them from Europe, the agency said in an update on Monday.

WHO said that since June 17, 1,310 new cases were reported to the agency, with eight new countries reporting monkeypox cases.

Monkeypox is not yet a global health emergency, WHO ruled last week, although WHO Director-General Tedros Adhanom Ghebreyesus said he was deeply concerned about the outbreak.

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Sudbury news: Northern agencies highlight national HIV testing day | CTV News – CTV News Northern Ontario

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Monday was national HIV testing day. Officials say this year’s theme surrounds how getting tested is an act of self-care.

From clinics to self-testing kits, groups in the north say there are many options to get tested and everyone should use whichever way works best for them.

Just more than a year ago, Reseau Access Network in Sudbury teamed with Ready to Know and Get a Kit, groups that provide HIV self-testing kits at a pickup location.

Officials said it has been a huge success.

“We get a consistent number throughout each month and I can’t really divulge those figures, unfortunately, but as part of the overall study I can tell you the pickup of self-tests is a fraction of the amount of tests being ordered,” said Angel Riess, of Reseau Access Network.

“There’s actually a lot of tests being shipped to homes directly but I can confirm that they have been active and there’s a significant number of people who have chosen to engage in both programs.”

Elsewhere, the Aids Committee of North Bay and Area held a point-of-care testing clinic to mark the day.

“It’s an opportunity for us to remind everyone that getting tested is essential. If you don’t know you have HIV, you can’t take the steps to try to mitigate the possibility of spread,” said executive director Stacey Mayhall.

In addition to stopping the spread, knowing whether you are positive sooner rather than later can allow for a better quality of life.

“HIV is not a death sentence that it used to be,” said Riess.

“There have been advances in testing and medication and people can live long, healthy lives living with HIV.”

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