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Monkeypox Outbreak: Monitoring, Diagnosis, and Treatment – Medscape

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This transcript has been edited for clarity.

Hello. I’m Paul Auwaerter with Medscape Infectious Diseases, speaking from the Johns Hopkins University School of Medicine.

Monkeypox joins the legion of occasional emerging infectious diseases that, as an infectious diseases consultant, we have to become at least familiar with, even if we’ve never seen it personally, and consider it when the occasion arises.

Monkeypox is a member of the orthopoxvirus family, which is the same as smallpox. It is generally a milder infection that causes very similar diseases, which I’ve never seen clinically, with the exception of one laboratory-acquired case of generalized vaccinia in a lab worker many years ago that we diagnosed by electron microscopy.

The current situation with monkeypox has certainly been in the news following an outbreak that, as of late May, has at least 260 cases in 19 countries, including many European countries, Argentina, and Australia, and also here in the United States, with at least 6 states reporting infections, including California, New York, Massachusetts, and Florida.

Monkeypox is something that we’ve seen before in the US. In 2003, there was an outbreak of 71 suspected or confirmed cases that were traced to the importation of Gambian giant rats, squirrels, or dormice that had spread to prairie dogs that were subsequently sold as pets. In all, 18 people were hospitalized, but there were no deaths, certainly suggesting a milder illness and that a higher mortality is seen with smallpox.

We don’t know much about monkeypox. Although it can reside in monkeys and be transmitted by that pathway, the thought is it probably has a reservoir more frequently seen in rodents. Acquisition to humans could be from handling infected animals or transmission through skin or mucous membranes, but it is mostly thought to be large droplet–related, because this is a large DNA virus and probably not prone to aerosolization.

The current outbreak here, in 2022, isn’t exactly clear, but there have been descriptions in Europe that certain social networks — such as, for example, men who have sex with men — may be contributing to the spread. Therefore, it needs to be considered also in the spectrum of, perhaps, a sexually transmitted disease (STD) when we’re evaluating patients.

From acquisition to acquiring symptoms can range from 5 to 21 days, with a 1- to 2-week average. The initial infection is, indeed, just a viral-like prodrome: sometimes a sore throat or lesions, with a rash that typically begins 1-3 days later, initially a viral-type exanthema that’s not specific. Flat or macular to papular lesions subsequently become nodular, umbilicated, or pustulovesicular before crusting. They classically occur on the face and then spread elsewhere to the body, with involvement of the palms and soles, which certainly makes it different from other things that might be on your differential, such as chickenpox. You may have some lymphadenitis as well.

The differential diagnosis, of course, comes up with primary infection with varicella, but other pox infections — cowpox, or smallpox if there’s a bioterror event — maybe should be considered if you’re thinking of measles or sexually transmitted infections (STIs), such as syphilis, herpes simplex virus (HSV), or chancroid.

How to diagnose it is, unfortunately, not straightforward. Neither a commercial laboratory nor your health system laboratory will be able to make the diagnosis, so you need to contact your local or state health department. There are links below this video for the CDC’s monkeypox site, where there is specimen collection information for obtaining direct skin lesion material for PCR analysis that can help confirm.

Generally, the skin is where you see most of this infection. Occasionally, if it’s severe, in patients with elevated fever or more than 100 lesions, especially in children, it can be quite awful and include pneumonitis. You may need to also consider proctitis if there is sexual transmission.

In terms of treatment, there are no approved treatments and most have been lifted from smallpox. There are now two FDA-approved oral drugs that seem to have broad in vitro poxvirus activity, including tecovirimat, which is FDA approved for smallpox in adults and children, and brincidofovir, a variant of cidofovir, which also can be used in people as young as the neonatal age range.

Other modalities could include a vaccinia immunoglobulin, hoping that there’s cross-reactivity. In terms of prevention, there is the smallpox vaccine available on limited supply, and also a modified vaccinia that has fewer side effects than typical vaccinia virus that goes by the trade name Jynneos. It’s available in very limited supply, but if you have a case with potential contacts, it might be considered, or it may be considered as adjuvant therapy for someone who’s infected.

There’s nothing well known or described. There’s a handful of case reports and a nice study out of the UK summarizing experience with monkeypox and some of these newer treatments, but it is uncertain whether they had an impact on outcomes or quicker resolution of illness, given the limited number of data points.

These are all things that I think will continue to evolve. Certainly, it sounds like this is the largest outbreak of monkeypox to date and it bears watching. Many have opined that they don’t think this will become significant from a public health standpoint, but it certainly bears watching and consideration by infectious disease consultants when evaluating certain patient types.

Thanks so much for listening. I hope this is helpful. Please see the background information if you need more. Thank you.

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Older patients, non-English speakers more likely to be harmed in hospital: report

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Patients who are older, don’t speak English, and don’t have a high school education are more likely to experience harm during a hospital stay in Canada, according to new research.

The Canadian Institute for Health Information measured preventableharmful events from 2023 to 2024, such as bed sores and medication errors,experienced by patients who received acute care in hospital.

The research published Thursday shows patients who don’t speak English or French are 30 per cent more likely to experience harm. Patients without a high school education are 20 per cent more likely to endure harm compared to those with higher education levels.

The report also found that patients 85 and older are five times more likely to experience harm during a hospital stay compared to those under 20.

“The goal of this report is to get folks thinking about equity as being a key dimension of the patient safety effort within a hospital,” says Dana Riley, an author of the report and a program lead on CIHI’s population health team.

When a health-care provider and a patient don’t speak the same language, that can result in the administration of a wrong test or procedure, research shows. Similarly, Riley says a lower level of education is associated with a lower level of health literacy, which can result in increased vulnerability to communication errors.

“It’s fairly costly to the patient and it’s costly to the system,” says Riley, noting the average hospital stay for a patient who experiences harm is four times more expensive than the cost of a hospital stay without a harmful event – $42,558 compared to $9,072.

“I think there are a variety of different reasons why we might start to think about patient safety, think about equity, as key interconnected dimensions of health-care quality,” says Riley.

The analysis doesn’t include data on racialized patients because Riley says pan-Canadian data was not available for their research. Data from Quebec and some mental health patients was also excluded due to differences in data collection.

Efforts to reduce patient injuries at one Ontario hospital network appears to have resulted in less harm. Patient falls at Mackenzie Health causing injury are down 40 per cent, pressure injuries have decreased 51 per cent, and central line-associated bloodstream infections, such as IV therapy, have been reduced 34 per cent.

The hospital created a “zero harm” plan in 2019 to reduce errors after a hospital survey revealed low safety scores. They integrated principles used in aviation and nuclear industries, which prioritize safety in complex high-risk environments.

“The premise is first driven by a cultural shift where people feel comfortable actually calling out these events,” says Mackenzie Health President and Chief Executive Officer Altaf Stationwala.

They introduced harm reduction training and daily meetings to discuss risks in the hospital. Mackenzie partnered with virtual interpreters that speak 240 languages and understand medical jargon. Geriatric care nurses serve the nearly 70 per cent of patients over the age of 75, and staff are encouraged to communicate as frequently as possible, and in plain language, says Stationwala.

“What we do in health care is we take control away from patients and families, and what we know is we need to empower patients and families and that ultimately results in better health care.”

This report by The Canadian Press was first published Oct. 17, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

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Alberta to launch new primary care agency by next month in health overhaul

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CALGARY – Alberta’s health minister says a new agency responsible for primary health care should be up and running by next month.

Adriana LaGrange says Primary Care Alberta will work to improve Albertans’ access to primary care providers like family doctors or nurse practitioners, create new models of primary care and increase access to after-hours care through virtual means.

Her announcement comes as the provincial government continues to divide Alberta Health Services into four new agencies.

LaGrange says Alberta Health Services hasn’t been able to focus on primary health care, and has been missing system oversight.

The Alberta government’s dismantling of the health agency is expected to include two more organizations responsible for hospital care and continuing care.

Another new agency, Recovery Alberta, recently took over the mental health and addictions portfolio of Alberta Health Services.

This report by The Canadian Press was first published Oct. 15, 2024.

The Canadian Press. All rights reserved.

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Experts urge streamlined, more compassionate miscarriage care in Canada

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Rana Van Tuyl was about 12 weeks pregnant when she got devastating news at her ultrasound appointment in December 2020.

Her fetus’s heartbeat had stopped.

“We were both shattered,” says Van Tuyl, who lives in Nanaimo, B.C., with her partner. Her doctor said she could surgically or medically pass the pregnancy and she chose the medical option, a combination of two drugs taken at home.

“That was the last I heard from our maternity physician, with no further followup,” she says.

But complications followed. She bled for a month and required a surgical procedure to remove pregnancy tissue her body had retained.

Looking back, Van Tuyl says she wishes she had followup care and mental health support as the couple grieved.

Her story is not an anomaly. Miscarriages affect one in five pregnancies in Canada, yet there is often a disconnect between the medical view of early pregnancy loss as something that is easily managed and the reality of the patients’ own traumatizing experiences, according to a paper published Tuesday in the Canadian Medical Association Journal.

An accompanying editorial says it’s time to invest in early pregnancy assessment clinics that can provide proper care during and after a miscarriage, which can have devastating effects.

The editorial and a review of medical literature on early pregnancy loss say patients seeking help in emergency departments often receive “suboptimal” care. Non-critical miscarriage cases drop to the bottom of the triage list, resulting in longer wait times that make patients feel like they are “wasting” health-care providers’ time. Many of those patients are discharged without a followup plan, the editorial says.

But not all miscarriages need to be treated in the emergency room, says Dr. Modupe Tunde-Byass, one of the authors of the literature review and an obstetrician/gynecologist at Toronto’s North York General Hospital.

She says patients should be referred to early pregnancy assessment clinics, which provide compassionate care that accounts for the psychological impact of pregnancy loss – including grief, guilt, anxiety and post-traumatic stress.

But while North York General Hospital and a patchwork of other health-care providers in the country have clinics dedicated to miscarriage care, Tunde-Byass says that’s not widely adopted – and it should be.

She’s been thinking about this gap in the Canadian health-care system for a long time, ever since her medical training almost four decades ago in the United Kingdom, where she says early pregnancy assessment centres are common.

“One of the things that we did at North York was to have a clinic to provide care for our patients, and also to try to bridge that gap,” says Tunde-Byass.

Provincial agency Health Quality Ontario acknowledged in 2019 the need for these services in a list of ways to better manage early pregnancy complications and loss.

“Five years on, little if any progress has been made toward achieving this goal,” Dr. Catherine Varner, an emergency physician, wrote in the CMAJ editorial. “Early pregnancy assessment services remain a pipe dream for many, especially in rural Canada.”

The quality standard released in Ontario did, however, prompt a registered nurse to apply for funding to open an early pregnancy assessment clinic at St. Joseph’s Healthcare Hamilton in 2021.

Jessica Desjardins says that after taking patient referrals from the hospital’s emergency room, the team quickly realized that they would need a bigger space and more people to provide care. The clinic now operates five days a week.

“We’ve been often hearing from our patients that early pregnancy loss and experiencing early pregnancy complications is a really confusing, overwhelming, isolating time for them, and (it) often felt really difficult to know where to go for care and where to get comprehensive, well-rounded care,” she says.

At the Hamilton clinic, Desjardins says patients are brought into a quiet area to talk and make decisions with providers – “not only (from) a physical perspective, but also keeping in mind the psychosocial piece that comes along with loss and the grief that’s a piece of that.”

Ashley Hilliard says attending an early pregnancy assessment clinic at The Ottawa Hospital was the “best case scenario” after the worst case scenario.

In 2020, she was about eight weeks pregnant when her fetus died and she hemorrhaged after taking medication to pass the pregnancy at home.

Shortly after Hilliard was rushed to the emergency room, she was assigned an OB-GYN at an early pregnancy assessment clinic who directed and monitored her care, calling her with blood test results and sending her for ultrasounds when bleeding and cramping persisted.

“That was super helpful to have somebody to go through just that, somebody who does this all the time,” says Hilliard.

“It was really validating.”

This report by The Canadian Press was first published Oct. 15, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

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