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No Link Between COVID-19 Vaccination During Pregnancy and Higher Risk of Preterm Birth or Stillbirth – Technology Networks

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Vaccination against COVID-19 during pregnancy is not associated with a higher risk of preterm birth, small for gestational age at birth, or stillbirth, concludes a new population based retrospective cohort study led by the CHEO Research Institute and the University of Ottawa’s Faculty of Medicine.

These findings, published recently in The BMJnorth_eastexternal link, can help inform evidence based decision making about the risks and benefits of COVID-19 vaccination during pregnancy.

“Our study found no evidence of increased risk of preterm birth, very preterm birth, small-for gestational-age at birth, or still birth following COVID-19 vaccination during pregnancy. The results of this study provide further evidence for care providers and pregnant people about the safety of COVID-19 vaccination during pregnancy,” said lead author Dr. Deshayne Fell, Scientist at the CHEO Research Institute and Associate Professor in the University of Ottawa’s Faculty of Medicine.

SARS-CoV-2 infection during pregnancy has been associated with higher risks of complications, including admission to hospital and death for pregnant individuals, as well as preterm birth and stillbirth. COVID-19 vaccination during pregnancy has been shown to be effective against COVID-19 in pregnant individuals as well as their newborns, but evidence about pregnancy outcomes after COVID-19 vaccination during pregnancy from large studies is limited.

In a project supported by the Public Health Agency of Canada through the Vaccine Surveillance Reference Group and the COVID-19 Immunity Task Force, researchers set out to assess the risk of preterm birth, small for gestational age at birth, and stillbirth after COVID-19 vaccination during pregnancy.

They used the BORN Ontario birth registry, the provincial birth registry based out of CHEO, to identify all liveborn and stillborn infants with a gestational age of at least 20 weeks or birth weight of at least 500g in Ontario, Canada between May 1 and Dec. 31, 2021. This information was then linked to the COVaxON, the province’s COVID-19 immunization database.

A wide range of potentially influential factors were taken into account, including the mother’s age at delivery, pre-pregnancy body mass index, reported smoking or substance use during pregnancy, pre-existing health conditions, number of previous live births and stillbirths, area of residence and income.

Of 85,162 births, 43,099 occurred in individuals who received one dose or more of a COVID-19 vaccine during pregnancy – 42, 979 (99.7%) received an mRNA vaccine, mainly Pfizer-BioNTech or Moderna. (See Figure 1)

The study found that vaccination during pregnancy was not associated with any increased risk of overall preterm birth (6.5% among vaccinated v 6.9% among unvaccinated), spontaneous preterm birth (3.7% v 4.4%), or very preterm birth (0.59% v 0.89%). No increase was found in risk of small for gestational age at birth (9.1% v 9.2%) or stillbirth (0.25% v 0.44%).

Findings were similar irrespective of what stage (trimester) of pregnancy vaccination was given, number of doses received during pregnancy, or which mRNA vaccine product was received. There are still some important unanswered questions in need of future research, such as assessing COVID-19 vaccination before pregnancy or around the time of conception and assessment of non-mRNA vaccines used during pregnancy.

Researchers noted “Future studies to assess similar outcomes after immunisation with nonmRNA COVID-19 vaccine types during pregnancy should be a research priority.”

Reference: Fell DB, Dimanlig-Cruz S, Regan AK, et al. Risk of preterm birth, small for gestational age at birth, and stillbirth after covid-19 vaccination during pregnancy: population based retrospective cohort study. BMJ. 2022;378:e071416. doi: 10.1136/bmj-2022-071416

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

 

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How many Nova Scotians are on the doctor wait-list? Number hit 160,000 in June

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HALIFAX – The Nova Scotia government says it could be months before it reveals how many people are on the wait-list for a family doctor.

The head of the province’s health authority told reporters Wednesday that the government won’t release updated data until the 160,000 people who were on the wait-list in June are contacted to verify whether they still need primary care.

Karen Oldfield said Nova Scotia Health is working on validating the primary care wait-list data before posting new numbers, and that work may take a matter of months. The most recent public wait-list figures are from June 1, when 160,234 people, or about 16 per cent of the population, were on it.

“It’s going to take time to make 160,000 calls,” Oldfield said. “We are not talking weeks, we are talking months.”

The interim CEO and president of Nova Scotia Health said people on the list are being asked where they live, whether they still need a family doctor, and to give an update on their health.

A spokesperson with the province’s Health Department says the government and its health authority are “working hard” to turn the wait-list registry into a useful tool, adding that the data will be shared once it is validated.

Nova Scotia’s NDP are calling on Premier Tim Houston to immediately release statistics on how many people are looking for a family doctor. On Tuesday, the NDP introduced a bill that would require the health minister to make the number public every month.

“It is unacceptable for the list to be more than three months out of date,” NDP Leader Claudia Chender said Tuesday.

Chender said releasing this data regularly is vital so Nova Scotians can track the government’s progress on its main 2021 campaign promise: fixing health care.

The number of people in need of a family doctor has more than doubled between the 2021 summer election campaign and June 2024. Since September 2021 about 300 doctors have been added to the provincial health system, the Health Department said.

“We’ll know if Tim Houston is keeping his 2021 election promise to fix health care when Nova Scotians are attached to primary care,” Chender said.

This report by The Canadian Press was first published Sept. 11, 2024.

The Canadian Press. All rights reserved.

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Newfoundland and Labrador monitoring rise in whooping cough cases: medical officer

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ST. JOHN’S, N.L. – Newfoundland and Labrador‘s chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.

Dr. Janice Fitzgerald says that so far this year, the province has recorded 230 confirmed cases of the vaccine-preventable respiratory tract infection, also known as pertussis.

Late last month, Quebec reported more than 11,000 cases during the same time period, while Ontario counted 470 cases, well above the five-year average of 98. In Quebec, the majority of patients are between the ages of 10 and 14.

Meanwhile, New Brunswick has declared a whooping cough outbreak across the province. A total of 141 cases were reported by last month, exceeding the five-year average of 34.

The disease can lead to severe complications among vulnerable populations including infants, who are at the highest risk of suffering from complications like pneumonia and seizures. Symptoms may start with a runny nose, mild fever and cough, then progress to severe coughing accompanied by a distinctive “whooping” sound during inhalation.

“The public, especially pregnant people and those in close contact with infants, are encouraged to be aware of symptoms related to pertussis and to ensure vaccinations are up to date,” Newfoundland and Labrador’s Health Department said in a statement.

Whooping cough can be treated with antibiotics, but vaccination is the most effective way to control the spread of the disease. As a result, the province has expanded immunization efforts this school year. While booster doses are already offered in Grade 9, the vaccine is now being offered to Grade 8 students as well.

Public health officials say whooping cough is a cyclical disease that increases every two to five or six years.

Meanwhile, New Brunswick’s acting chief medical officer of health expects the current case count to get worse before tapering off.

A rise in whooping cough cases has also been reported in the United States and elsewhere. The Pan American Health Organization issued an alert in July encouraging countries to ramp up their surveillance and vaccination coverage.

This report by The Canadian Press was first published Sept. 10, 2024.

The Canadian Press. All rights reserved.

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