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Omicron variant better at evading protection: study – CTV News

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The new Omicron variant may have a greater ability than other strains of the virus to escape immune protection from antibodies produced by previous COVID-19 infection, and potentially vaccines.

That’s according to a new, peer-reviewed study published on Saturday in the journal Emerging Microbes & Infection.

The Omicron variant has caused global panic prompting many countries, including Canada, to impose more stringent travel rules.

Experts say the Omicron variant is unusual because it has a high number of mutations in two key areas of the virus’ spike protein.

Dozens of cases of the variant have been detected across Canada.

The researchers said their study showed test tube samples of the Omicron variant “exceeded” all other COVID-19 variants in its ability to evade the protection gained from previous infection or vaccination.

Youchun Wang, senior research fellow from the National Institutes for Food and Drug Control in China, said the research supports recent findings in South Africa that suggest Omicron finds it “easy to evade immunity.”

“We found the large number of mutations of the Omicron variant did cause significant changes of neutralization sensitivity against people who had already had COVID,” Wang said in a press release.

“However, the average ED50 (protection level) against Omicron is still higher than the baseline, which indicated there is still some protection effect can be observed,” Wang continued.

Wang, the vice chairman of the Medical Microbiology and Immunology of the Chinese Medical Association, cautioned that because antibody protection from either vaccination or previous infection decreases over a period of six months, the variant “may be able to escape immunity even better.”

The study suggests that while a third dose of a COVID-19 vaccine “can significantly boost immunity,” the protection it provides from Omicron “may be compromised.”

“In addition, it needs to be re-evaluated whether the therapeutic monoclonal antibodies can still be effective against the Omicron variant,” the study reads.

“More laboratory and the real-world studies are needed to understand whether Omicron can escape from the vaccine elicited immunity to cause more severe disease and death.”

In order to conduct the study, researchers looked at 28 serum samples from patients who were recovering from the original COVID-19 strain, known as SARS-CoV-2.

These were tested against test-tube or in-vitro samples of Omicron and other strains deemed “variants of concern” by the World Health Organization, including Alpha, Beta, Gamma and Delta.

Researchers also tested samples of variants of interest Lambda and Mu.

Wang said the study “verifies the enhanced immune escape” of the Omicron variant, “which sounds the alarm to the world and has important implications for the public health planning and the development of matching strategies.”

However, the team of researchers say more research is needed to better understand the variant, and said real-world studies, not just in-vitro, must be conducted.

The authors said research to determine whether the Omicron variant can “escape from the vaccine elicited immunity to cause more severe disease and death,” must also be conducted.

“It needs to be re-evaluated whether the antibodies can still be effective against the Omicron variant,” the authors wrote in the paper.

“The exact impact to human protection may be influenced by more factors such as the infectivity of Omicron variant relative to other variants to human populations and the viral fitness of Omicron once the humans are infected,” the study reads.

The authors call for “more population studies,” saying research into the level of immune protection and symptoms among people infected with Omicron are needed “to fully establish the global impact of Omicron to the control of [the] COVID-19 pandemic.” 

VACCINE DATA SO FAR

Meanwhile on Saturday, researchers in Israel said they found a three-shot course of the Pfizer/BioNTech COVID-19 vaccine provided significant protection against the Omicron variant.

The study released Saturday, was conducted by the Sheba Medical Center and the Health Ministry’s Central Virology Laboratory.

Researchers compared the blood of 20 people who had received two vaccine doses five to six months earlier to 20 individuals who received a booster a month before.

The study found people who received the second dose five or six months ago did “not have neutralization ability against Omicron.”

“They do have some against the Delta (strain,)” Gili Regev-Yochay, director of the Infectious Diseases Unit at Sheba told reporters.

“The good news is that with the booster dose it increases about a hundredfold,” she said. “There is a significant protection of the booster dose. It is lower than the neutralization ability against the Delta, about four times lower.”

What’s more, on Wednesday, Pfizer released preliminary data that suggests two doses may not be protective enough to prevent an Omicron COVID-19 infection.

However, the company said that a booster dose increased by 25-fold an individual’s level of antibodies against the Omicron variant.

Pfizer’s findings are preliminary though, meaning they have not yet been peer-reviewed.

With files from CTV News’ Nicole Bogart and Reuters 

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Virginia Democrats advance efforts to protect abortion, voting rights, marriage equality

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RICHMOND, Va. (AP) — Democrats who control both chambers of the Virginia legislature are hoping to make good on promises made on the campaign trail, including becoming the first Southern state to expand constitutional protections for abortion access.

The House Privileges and Elections Committee advanced three proposed constitutional amendments Wednesday, including a measure to protect reproductive rights. Its members also discussed measures to repeal a now-defunct state constitutional ban on same-sex marriage and ways to revise Virginia’s process to restore voting rights for people who served time for felony crimes.

“This meeting was an important next step considering the moment in history we find ourselves in,” Democratic Del. Cia Price, the committee chair, said during a news conference. “We have urgent threats to our freedoms that could impact constituents in all of the districts we serve.”

The at-times raucous meeting will pave the way for the House and Senate to take up the resolutions early next year after lawmakers tabled the measures last January. Democrats previously said the move was standard practice, given that amendments are typically introduced in odd-numbered years. But Republican Minority Leader Todd Gilbert said Wednesday the committee should not have delved into the amendments before next year’s legislative session. He said the resolutions, particularly the abortion amendment, need further vetting.

“No one who is still serving remembers it being done in this way ever,” Gilbert said after the meeting. “Certainly not for something this important. This is as big and weighty an issue as it gets.”

The Democrats’ legislative lineup comes after Republican Governor Glenn Youngkin, to the dismay of voting-rights advocates, rolled back a process to restore people’s civil rights after they completed sentences for felonies. Virginia is the only state that permanently bans anyone convicted of a felony from voting unless a governor restores their rights.

“This amendment creates a process that is bounded by transparent rules and criteria that will apply to everybody — it’s not left to the discretion of a single individual,” Del. Elizabeth Bennett-Parker, the patron of the voting rights resolution, which passed along party lines, said at the news conference.

Though Democrats have sparred with the governor over their legislative agenda, constitutional amendments put forth by lawmakers do not require his signature, allowing the Democrat-led House and Senate to bypass Youngkin’s blessing.

Instead, the General Assembly must pass proposed amendments twice in at least two years, with a legislative election sandwiched between each statehouse session. After that, the public can vote by referendum on the issues. The cumbersome process will likely hinge upon the success of all three amendments on Democrats’ ability to preserve their edge in the House and Senate, where they hold razor-thin majorities.

It’s not the first time lawmakers have attempted to champion the three amendments. Republicans in a House subcommittee killed a constitutional amendment to restore voting rights in 2022, a year after the measure passed in a Democrat-led House. The same subcommittee also struck down legislation supporting a constitutional amendment to repeal an amendment from 2006 banning marriage equality.

On Wednesday, a bipartisan group of lawmakers voted 16-5 in favor of legislation protecting same-sex marriage, with four Republicans supporting the resolution.

“To say the least, voters enacted this (amendment) in 2006, and we have had 100,000 voters a year become of voting age since then,” said Del. Mark Sickles, who sponsored the amendment as one of the first openly gay men serving in the General Assembly. “Many people have changed their opinions of this as the years have passed.”

A constitutional amendment protecting abortion previously passed the Senate in 2023 but died in a Republican-led House. On Wednesday, the amendment passed on party lines.

If successful, the resolution proposed by House Majority Leader Charniele Herring would be part of a growing trend of reproductive rights-related ballot questions given to voters. Since 2022, 18 questions have gone before voters across the U.S., and they have sided with abortion rights advocates 14 times.

The voters have approved constitutional amendments ensuring the right to abortion until fetal viability in nine states: Arizona, California, Colorado, Maryland, Michigan, Missouri, Montana, Ohio and Vermont. Voters also passed a right-to-abortion measure in Nevada in 2024, but it must be passed again in 2026 to be added to the state constitution.

As lawmakers debated the measure, roughly 18 members spoke. Mercedes Perkins, at 38 weeks pregnant, described the importance of women making decisions about their own bodies. Rhea Simon, another Virginia resident, anecdotally described how reproductive health care shaped her life.

Then all at once, more than 50 people lined up to speak against the abortion amendment.

“Let’s do the compassionate thing and care for mothers and all unborn children,” resident Sheila Furey said.

The audience gave a collective “Amen,” followed by a round of applause.

___

Associated Press writer Geoff Mulvihill in Cherry Hill, New Jersey, contributed to this report.

___

Olivia Diaz is a corps member for The Associated Press/Report for America Statehouse News Initiative.

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Vancouver Canucks winger Joshua set for season debut after cancer treatment

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Vancouver Canucks winger Dakota Joshua is set to make his season debut Thursday after missing time for cancer treatment.

Head coach Rick Tocchet says Joshua will slot into the lineup Thursday when Vancouver (8-3-3) hosts the New York Islanders.

The 28-year-old from Dearborn, Mich., was diagnosed with testicular cancer this summer and underwent surgery in early September.

He spoke earlier this month about his recovery, saying it had been “very hard to go through” and that he was thankful for support from his friends, family, teammates and fans.

“That was a scary time but I am very thankful and just happy to be in this position still and be able to go out there and play,,” Joshua said following Thursday’s morning skate.

The cancer diagnosis followed a career season where Joshua contributed 18 goals and 14 assists across 63 regular-season games, then added four goals and four assists in the playoffs.

Now, he’s ready to focus on contributing again.

“I expect to be good, I don’t expect a grace period. I’ve been putting the work in so I expect to come out there and make an impact as soon as possible,” he said.

“I don’t know if it’s going to be perfect right from the get-go, but it’s about putting your best foot forward and working your way to a point of perfection.”

The six-foot-three, 206-pound Joshua signed a four-year, US$13-million contract extension at the end of June.

This report by The Canadian Press was first published Nov. 14, 2024.

The Canadian Press. All rights reserved.

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Trump chooses anti-vaccine activist Robert F. Kennedy Jr. as health secretary

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NEW YORK (AP) — President-elect Donald Trump says he will nominate anti-vaccine activist Robert F. Kennedy Jr. to lead the Department of Health and Human Services, putting him in charge of a massive agency that oversees everything from drug, vaccine and food safety to medical research and the social safety net programs Medicare and Medicaid.

“For too long, Americans have been crushed by the industrial food complex and drug companies who have engaged in deception, misinformation, and disinformation when it comes to Public Health,” Trump said in a post on his Truth Social site announcing the appointment. Kennedy, he said, would “Make America Great and Healthy Again!”

Kennedy, a former Democrat who ran as an independent in this year’s presidential race, abandoned his bid after striking a deal to give Trump his endorsement with a promise to have a role in health policy in the administration.

He and Trump have since become good friends, with Kennedy frequently receiving loud applause at Trump’s rallies.

The expected appointment was first reported by Politico Thursday.

A longtime vaccine skeptic, Kennedy is an attorney who has built a loyal following over several decades of people who admire his lawsuits against major pesticide and pharmaceutical companies. He has pushed for tighter regulations around the ingredients in foods.

With the Trump campaign, he worked to shore up support among young mothers in particular, with his message of making food healthier in the U.S., promising to model regulations imposed in Europe. In a nod to Trump’s original campaign slogan, he named the effort “Make America Healthy Again.”

It remains unclear how that will square with Trump’s history of deregulation of big industries, including food. Trump pushed for fewer inspections of the meat industry, for example.

Kennedy’s stance on vaccines has also made him a controversial figure among Democrats and some Republicans, raising question about his ability to get confirmed, even in a GOP-controlled Senate. Kennedy has espoused misinformation around the safety of vaccines, including pushing a totally discredited theory that childhood vaccines cause autism.

He also has said he would recommend removing fluoride from drinking water. The addition of the material has been cited as leading to improved dental health.

HHS has more than 80,000 employees across the country. It houses the Food and Drug Administration, the Centers for Disease Control and Prevention, the Medicare and Medicaid programs and the National Institutes of Health.

Kennedy’s anti-vaccine nonprofit group, Children’s Health Defense, currently has a lawsuit pending against a number of news organizations, among them The Associated Press, accusing them of violating antitrust laws by taking action to identify misinformation, including about COVID-19 and COVID-19 vaccines. Kennedy took leave from the group when he announced his run for president but is listed as one of its attorneys in the lawsuit.

__ Seitz reported from Washington.

The Canadian Press. All rights reserved.

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