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One-hour British DnaNudge COVID-19 test is accurate, study finds

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LONDON (Reuters) – A British COVID-19 test known as DnaNudge that gives results in just over an hour and which requires no laboratory was accurate in almost all cases, an academic review in the Lancet has found.

 

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Faster testing could allow more people to return to work or permit testing on entry to hospital, thus slowing a second spike in coronavirus infections.

The new test, based on the design of a DNA test developed by a professor at Imperial College London, received approval for clinical use by the Medicines and Healthcare Products Regulatory Agency (MHRA) at the end of April after successful trials.

In a study in The Lancet Microbe, the test was found to have an average sensitivity – the ability to correctly identify those with COVID-19 – of 94.4% and a specificity – correctly identifying those without the disease – of 100%.

“These results suggest that the CovidNudge test, which can be performed at a patient’s bedside without the need to handle any sample material, has comparable accuracy to standard laboratory testing,” Professor Graham Cooke, lead author of the study from the Department of Infectious Disease at Imperial College London, said.

The Lancet paper described the test, which requires one nostril swab, as “a sensitive, specific, and rapid point of care test for the presence of SARS-CoV-2 without laboratory handling or sample pre-processing”.

Health Secretary Matt Hancock told LBC radio that Britain was rolling out the tests across hospitals.

“The critical thing in terms of usefulness is that the machine doesn’t need to be in a lab – it is about the size of a shoebox – therefore you can put one, say, in an A&E (accident and emergency) department and they can know whether people coming in have got the coronavirus or not,” Hancock said.

Hancock said the machines could also be deployed at other locations such as schools.

Each box can run one test at a time so could process about 16 tests per day, said a spokeswoman for the company that produces the tests.

For the text of the Lancet paper: here

Reporting by Guy Faulconbridge; editing by Kate Holton and Gareth Jones

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RCMP warn about benzodiazepine-laced fentanyl tied to overdose in Alberta – Edmonton Journal

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Grande Prairie RCMP issued a warning Friday after it was revealed fentanyl linked to a deadly overdose was mixed with a chemical that doesn’t respond to naloxone treatment.

The drugs were initially seized on Feb. 28 after a fatal overdose, and this week, Health Canada reported back to Mounties that the fentanyl had been mixed with Bromazolam, which is a benzodiazepine.

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Mounties say this is the first recorded instance of Bromazolam in Alberta. The drug has previously been linked to nine fatal overdoses in New Brunswick in 2022.

The pills seized in Alberta were oval-shaped and stamped with “20” and “SS,” though Mounties say it can come in other forms.

Naloxone treatment, given in many cases of opioid toxicity, is not effective in reversing the effects of Bromazalam, Mounties said, and therefore, any fentanyl mixed with the benzodiazepine “would see a reduced effectiveness of naloxone, requiring the use of additional doses and may still result in a fatality.”

Photo of benzodiazepine-laced fentanyl seized earlier this year by Grande Prairie RCMP after a fatal overdose. edm

From January to November of last year, there were 1,706 opioid-related deaths in Alberta, and 57 linked to benzodiazepine, up from 1,375 and 43, respectively, in 2022.

Mounties say officers responded to about 1,100 opioid-related calls for service, last year with a third of those proving fatal. RCMP officers also used naloxone 67 times while in the field, a jump of nearly a third over the previous year.

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CFIA continues surveillance for HPAI in cattle, while sticking with original name for disease – RealAgriculture

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The Canada Food Inspection Agency will continue to refer to highly pathogenic avian influenza in cattle as HPAI in cattle, and not refer to it as bovine influenza A virus (BIAV), as suggested by the American Association of Bovine Practitioners earlier this month.

Dr. Martin Appelt, senior director for the Canadian Food Inspection Agency, in the interview below, says at this time Canada will stick with “HPAI in cattle” when referencing the disease that’s been confirmed in dairy cattle in multiple states in the U.S.

The CFIA’s naming policy is consistent with the agency’s U.S. counterparts’, as the U.S. Animal and Plant Health Inspection Service has also said it will continue referring to it as HPAI or H5N1.

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Appelt explains how the CFIA is learning from the U.S. experience to-date, and how it is working with veterinarians across Canada to stay vigilant for signs of the disease in dairy and beef cattle.

As of April 19, there has not been a confirmed case of HPAI in cattle in Canada. Appelt says it’s too soon to say if an eventual positive case will significantly restrict animal movement, as is the case with positive poultry cases.

This is a major concern for the cattle industry, as beef cattle especially move north and south across the U.S. border by the thousands. Appelt says that CFIA will address an infection in each species differently in conjunction with how the disease is spread and the threat to neighbouring farms or livestock.

Currently, provincial dairy organizations have advised producers to postpone any non-essential tours of dairy barns, as a precaution, in addition to other biosecurity measures to reduce the risk of cattle contracting HPAI.

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Toronto reports 2 more measles cases. Use our tool to check the spread in Canada – Toronto Star

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Canada has seen a concerning rise in measles cases in the first months of 2024.

By the third week of March, the country had already recorded more than three times the number of cases as all of last year. Canada had just 12 cases of measles in 2023, up from three in 2022.

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