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Ontario man’s cross-Canada cycling trip helps researchers understand how exercise impacts Parkinson’s disease

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After he was diagnosed with Parkinson’s disease, Steve Iseman set out on an 8,000-kilometre trip across Canada to raise money and awareness about the disorder.

But what he experienced when it came to his symptoms during that trip piqued the interest of researchers at the University of Guelph.

Iseman, 57, who lives in Toronto, said the diagnosis a decade ago was “devastating news and frankly, it changed everything.”

Parkinson’s is a neurodegenerative disease that can impact a person’s ability to move and speak. For Iseman, it causes muscle stiffness and brain fog. There is no cure and Parkinson Canada says more than 100,000 Canadians live with the disease.

Iseman said he tried to hide the diagnosis from his friends for about five years before he decided to be open about having Parkinson’s and what it was doing to him.

He worked to stay active because he found physical activity helped alleviate his symptoms.

“I came to recognize the benefits of cycling as a way to treat the symptoms of Parkinson’s disease.”

That led to his decision to do an 85-day cross-country trip, called Spinning Wheels Tour, to raise awareness about the disease.

“Specifically, we were trying to engage with other people who had Parkinson’s, three out of four of which are in hiding or otherwise disconnected from the Parkinson’s community, and sort of draw them in,” he said.

“I was trying to get our voices together.”

Unique research opportunity

At the same time Iseman was starting his cross-country tour in 2022, Philip Millar, a University of Guelph human health and nutritional science associate professor and researcher, was doing an exercise clinical trial that was funded by Parkinson Canada.

“We thought it was a really unique opportunity to be able to test him before and after such a really large kind of dose of exercise.”

The study into Iseman’s trip across Canada and the benefits he saw have been published in the journal Physiological Reports.

Philip Millar is an associate professor who researches cardiovascular physiology at the University of Guelph. (University of Guelph)

Millar said he was aware Iseman was already taking part in regular exercise and was physically fit, doing an average of about 300 minutes per week of cycling, “more than double what the average recommended guideline is.”

“We were unsure of how much more benefits he might see.”

It was thought that, given his physical abilities, Millar wouldn’t see any additional benefit from the cycling trip across Canada.

“That’s not really what we saw at all,” Millar said.

“We saw across almost all of our parameters, he got fitter, some of his motor symptoms decreased, he got stronger.”

Millar said while the really high-volume, high-intensity workout Iseman was doing “isn’t practical for recommending to patients … it is encouraging that it will tell us that there really isn’t an upper bounds to the benefits.”

Exercise is good, more is even be better

Iseman said he definitely felt the benefits on the bike ride — so much so that one day, he tried to go without taking any of his medications.

“It wasn’t great — the symptoms were still there — but it was a testament to the fact that it crossed my mind,” he said.

Millar said they tested Iseman using different scales and ratings, and noted:

  • On the Unified Parkinson Disease Rating Scale Part III, his motor score decreased 44 per cent, from 46 to 26.
  • Iseman’s ability to generate power through knee extensions increased 12 per cent over the trip.
  • His score on a standard test to measure Parkinson’s fatigue, the PFS‐16, decreased 32 per cent, from a 3.4 to 2.3.

Millar said the big takeaway isn’t that people with Parkinson’s should work their way up to being able to cycle across Canada.

Steven Iseman performs a cycling test in the Human Health and Performance Lab at the University of Guelph. (University of Guelph)

Instead, he said, the message is that exercise is good and more is even be better.

“We would have expected that [Iseman] would have already gained a lot of those benefits because he was already doing 300 minutes a week of exercise. So, you know, some might argue that there isn’t going to be room for anymore modification,” Millar said.

“After the trip, when we compare his aerobic fitness to healthy age and sex-matched controls, he was about 150 per cent of normal. So you know, here’s someone that has had Parkinson’s for, at the time, about eight years, and his fitness level is running 150 per cent of what the average Canadian for his age and sex is.”

Iseman’s story ‘an inspiration’

While it’s a review of the experience of one person, Karen Lee, president and CEO of Parkinson Canada, said Iseman’s story is “an inspiration and demonstrates the resilience of the Parkinson’s community.”

The Parkinson Canada National Research Program has invested $31 million in projects since 1981, including Millar’s work, and Lee said in an emailed statement that Iseman’s experience has been proven through other research.

“We have seen time and time again that exercise has positive benefits for people with Parkinson’s,” Lee said.

“The most important takeaway from this research is that it helps equip people with Parkinson’s with information to make informed decisions about the best approaches to manage the disease.”

Iseman kept a blog of his travels across the country and posted photos from the Spinning Wheels Tour to Facebook. (Spinning Wheels Tour/Facebook)

The research on the exercise trials Millar was working on in 2022 when Iseman was doing his ride across Canada are set to be published later this year.

As for Iseman, he has plans to go to northern Norway for a cycling event that “I can’t resist.”

Then, the Spinning Wheels Tour is coming back this summer. They plan to start this time from the Arctic Ocean, where there are “surprisingly few roads,” Iseman said.

“It’s going to be done as a relay and I’m only going to be doing a bit of it,” he said. “If all goes according to plan, we’ll start at the Arctic Ocean and come south.”

 

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Health Canada approves updated Moderna COVID-19 vaccine

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TORONTO – Health Canada has authorized Moderna’s updated COVID-19 vaccine that protects against currently circulating variants of the virus.

The mRNA vaccine, called Spikevax, has been reformulated to target the KP.2 subvariant of Omicron.

It will replace the previous version of the vaccine that was released a year ago, which targeted the XBB.1.5 subvariant of Omicron.

Health Canada recently asked provinces and territories to get rid of their older COVID-19 vaccines to ensure the most current vaccine will be used during this fall’s respiratory virus season.

Health Canada is also reviewing two other updated COVID-19 vaccines but has not yet authorized them.

They are Pfizer’s Comirnaty, which is also an mRNA vaccine, as well as Novavax’s protein-based vaccine.

This report by The Canadian Press was first published Sept. 17, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

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These people say they got listeria after drinking recalled plant-based milks

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TORONTO – Sanniah Jabeen holds a sonogram of the unborn baby she lost after contracting listeria last December. Beneath, it says “love at first sight.”

Jabeen says she believes she and her baby were poisoned by a listeria outbreak linked to some plant-based milks and wants answers. An investigation continues into the recall declared July 8 of several Silk and Great Value plant-based beverages.

“I don’t even have the words. I’m still processing that,” Jabeen says of her loss. She was 18 weeks pregnant when she went into preterm labour.

The first infection linked to the recall was traced back to August 2023. One year later on Aug. 12, 2024, the Public Health Agency of Canada said three people had died and 20 were infected.

The number of cases is likely much higher, says Lawrence Goodridge, Canada Research Chair in foodborne pathogen dynamics at the University of Guelph: “For every person known, generally speaking, there’s typically 20 to 25 or maybe 30 people that are unknown.”

The case count has remained unchanged over the last month, but the Public Health Agency of Canada says it won’t declare the outbreak over until early October because of listeria’s 70-day incubation period and the reporting delays that accompany it.

Danone Canada’s head of communications said in an email Wednesday that the company is still investigating the “root cause” of the outbreak, which has been linked to a production line at a Pickering, Ont., packaging facility.

Pregnant people, adults over 60, and those with weakened immune systems are most at risk of becoming sick with severe listeriosis. If the infection spreads to an unborn baby, Health Canada says it can cause miscarriage, stillbirth, premature birth or life-threatening illness in a newborn.

The Canadian Press spoke to 10 people, from the parents of a toddler to an 89-year-old senior, who say they became sick with listeria after drinking from cartons of plant-based milk stamped with the recalled product code. Here’s a look at some of their experiences.

Sanniah Jabeen, 32, Toronto

Jabeen says she regularly drank Silk oat and almond milk in smoothies while pregnant, and began vomiting seven times a day and shivering at night in December 2023. She had “the worst headache of (her) life” when she went to the emergency room on Dec. 15.

“I just wasn’t functioning like a normal human being,” Jabeen says.

Told she was dehydrated, Jabeen was given fluids and a blood test and sent home. Four days later, she returned to hospital.

“They told me that since you’re 18 weeks, there’s nothing you can do to save your baby,” says Jabeen, who moved to Toronto from Pakistan five years ago.

Jabeen later learned she had listeriosis and an autopsy revealed her baby was infected, too.

“It broke my heart to read that report because I was just imagining my baby drinking poisoned amniotic fluid inside of me. The womb is a place where your baby is supposed to be the safest,” Jabeen said.

Jabeen’s case is likely not included in PHAC’s count. Jabeen says she was called by Health Canada and asked what dairy and fresh produce she ate – foods more commonly associated with listeria – but not asked about plant-based beverages.

She’s pregnant again, and is due in several months. At first, she was scared to eat, not knowing what caused the infection during her last pregnancy.

“Ever since I learned about the almond, oat milk situation, I’ve been feeling a bit better knowing that it wasn’t something that I did. It was something else that caused it. It wasn’t my fault,” Jabeen said.

She’s since joined a proposed class action lawsuit launched by LPC Avocates against the manufacturers and sellers of Silk and Great Value plant-based beverages. The lawsuit has not yet been certified by a judge.

Natalie Grant and her seven year-old daughter, Bowmanville, Ont.

Natalie Grant says she was in a hospital waiting room when she saw a television news report about the recall. She wondered if the dark chocolate almond milk her daughter drank daily was contaminated.

She had brought the girl to hospital because she was vomiting every half hour, constantly on the toilet with diarrhea, and had severe pain in her abdomen.

“I’m definitely thinking that this is a pretty solid chance that she’s got listeria at this point because I knew she had all the symptoms,” Grant says of seeing the news report.

Once her daughter could hold fluids, they went home and Grant cross-checked the recalled product code – 7825 – with the one on her carton. They matched.

“I called the emerg and I said I’m pretty confident she’s been exposed,” Grant said. She was told to return to the hospital if her daughter’s symptoms worsened. An hour and a half later, her fever spiked, the vomiting returned, her face flushed and her energy plummeted.

Grant says they were sent to a hospital in Ajax, Ont. and stayed two weeks while her daughter received antibiotics four times a day until she was discharged July 23.

“Knowing that my little one was just so affected and how it affected us as a family alone, there’s a bitterness left behind,” Grant said. She’s also joined the proposed class action.

Thelma Feldman, 89, Toronto

Thelma Feldman says she regularly taught yoga to friends in her condo building before getting sickened by listeria on July 2. Now, she has a walker and her body aches. She has headaches and digestive problems.

“I’m kind of depressed,” she says.

“It’s caused me a lot of physical and emotional pain.”

Much of the early days of her illness are a blur. She knows she boarded an ambulance with profuse diarrhea on July 2 and spent five days at North York General Hospital. Afterwards, she remembers Health Canada officials entering her apartment and removing Silk almond milk from her fridge, and volunteers from a community organization giving her sponge baths.

“At my age, 89, I’m not a kid anymore and healing takes longer,” Feldman says.

“I don’t even feel like being with people. I just sit at home.”

Jasmine Jiles and three-year-old Max, Kahnawake Mohawk Territory, Que.

Jasmine Jiles says her three-year-old son Max came down with flu-like symptoms and cradled his ears in what she interpreted as a sign of pain, like the one pounding in her own head, around early July.

When Jiles heard about the recall soon after, she called Danone Canada, the plant-based milk manufacturer, to find out if their Silk coconut milk was in the contaminated batch. It was, she says.

“My son is very small, he’s very young, so I asked what we do in terms of overall monitoring and she said someone from the company would get in touch within 24 to 48 hours,” Jiles says from a First Nations reserve near Montreal.

“I never got a call back. I never got an email”

At home, her son’s fever broke after three days, but gas pains stuck with him, she says. It took a couple weeks for him to get back to normal.

“In hindsight, I should have taken him (to the hospital) but we just tried to see if we could nurse him at home because wait times are pretty extreme,” Jiles says, “and I don’t have child care at the moment.”

Joseph Desmond, 50, Sydney, N.S.

Joseph Desmond says he suffered a seizure and fell off his sofa on July 9. He went to the emergency room, where they ran an electroencephalogram (EEG) test, and then returned home. Within hours, he had a second seizure and went back to hospital.

His third seizure happened the next morning while walking to the nurse’s station.

In severe cases of listeriosis, bacteria can spread to the central nervous system and cause seizures, according to Health Canada.

“The last two months have really been a nightmare,” says Desmond, who has joined the proposed lawsuit.

When he returned home from the hospital, his daughter took a carton of Silk dark chocolate almond milk out of the fridge and asked if he had heard about the recall. By that point, Desmond says he was on his second two-litre carton after finishing the first in June.

“It was pretty scary. Terrifying. I honestly thought I was going to die.”

Cheryl McCombe, 63, Haliburton, Ont.

The morning after suffering a second episode of vomiting, feverish sweats and diarrhea in the middle of the night in early July, Cheryl McCombe scrolled through the news on her phone and came across the recall.

A few years earlier, McCombe says she started drinking plant-based milks because it seemed like a healthier choice to splash in her morning coffee. On June 30, she bought two cartons of Silk cashew almond milk.

“It was on the (recall) list. I thought, ‘Oh my God, I got listeria,’” McCombe says. She called her doctor’s office and visited an urgent care clinic hoping to get tested and confirm her suspicion, but she says, “I was basically shut down at the door.”

Public Health Ontario does not recommend listeria testing for infected individuals with mild symptoms unless they are at risk of developing severe illness, such as people who are immunocompromised, elderly, pregnant or newborn.

“No wonder they couldn’t connect the dots,” she adds, referencing that it took close to a year for public health officials to find the source of the outbreak.

“I am a woman in my 60s and sometimes these signs are of, you know, when you’re vomiting and things like that, it can be a sign in women of a bigger issue,” McCombe says. She was seeking confirmation that wasn’t the case.

Disappointed, with her stomach still feeling off, she says she decided to boost her gut health with probiotics. After a couple weeks she started to feel like herself.

But since then, McCombe says, “I’m back on Kawartha Dairy cream in my coffee.”

This report by The Canadian Press was first published Sept. 16, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

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B.C. mayors seek ‘immediate action’ from federal government on mental health crisis

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VANCOUVER – Mayors and other leaders from several British Columbia communities say the provincial and federal governments need to take “immediate action” to tackle mental health and public safety issues that have reached crisis levels.

Vancouver Mayor Ken Sim says it’s become “abundantly clear” that mental health and addiction issues and public safety have caused crises that are “gripping” Vancouver, and he and other politicians, First Nations leaders and law enforcement officials are pleading for federal and provincial help.

In a letter to Prime Minister Justin Trudeau and Premier David Eby, mayors say there are “three critical fronts” that require action including “mandatory care” for people with severe mental health and addiction issues.

The letter says senior governments also need to bring in “meaningful bail reform” for repeat offenders, and the federal government must improve policing at Metro Vancouver ports to stop illicit drugs from coming in and stolen vehicles from being exported.

Sim says the “current system” has failed British Columbians, and the number of people dealing with severe mental health and addiction issues due to lack of proper care has “reached a critical point.”

Vancouver Police Chief Adam Palmer says repeat violent offenders are too often released on bail due to a “revolving door of justice,” and a new approach is needed to deal with mentally ill people who “pose a serious and immediate danger to themselves and others.”

This report by The Canadian Press was first published Sept. 16, 2024

The Canadian Press. All rights reserved.

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