The findings, published Wednesday in the peer-reviewed scientific journal Nature, suggest some people formed unusual antibodies after receiving an adenoviral vector vaccine, and those antibodies could stick to certain blood platelet components, triggering clot formation.
COVID-19 vaccines from Oxford-AstraZeneca and Johnson & Johnson, which both use adenoviral vector technology, are associated with rare cases of vaccine-induced immune thrombotic thrombocytopenia or VITT, a clotting disorder characterized by low blood platelets.
“We do not know why these rare antibodies form in the first place, and we do not know why they cause blood clots in unusual places, but we do know the specific target of the VITT antibody,” McMaster researchers said in the study.
Nova Scotia announces 1st case of rare blood clot linked to AstraZeneca COVID-19 vaccine
Ishac Nazy, the principal investigator and corresponding author, said some people formed VITT antibodies after being vaccinated with the adenoviral vaccines. Those unusual antibodies then bound to a platelet protein in the blood called platelet factor 4 (PF4) “in a very unique and specific orientation.”
The antibodies cluster PF4 proteins together to form immune complexes, which bind and activate platelets and leads to “a self-perpetuating vicious cycle of clotting events,” Nazy said in a release.
The research team used a molecular mapping technique to study the interaction between the VITT antibodies and the PF4 protein, finding the precise location on the PF4 where the VITT antibodies bound.
The study also compared blood samples from five VITT patients to 10 with a similar clotting condition known as heparin-induced thrombocytopenia, or HIT, and found patterns of platelet activation that were distinct from the HIT patient samples. That indicates the tests used to diagnose HIT aren’t suitable to diagnose VITT, the study said.
The study also found that VITT antibodies could bind “very tightly to PF4, more tightly than HIT antibodies.”
Nazy, who’s also the scientific director of the McMaster Platelet Immunology Laboratory, says he hopes the findings can make it easier to diagnose and treat VITT, as well as make vaccines safer.
Ontario confirms 1st rare blood clot death linked to AstraZeneca COVID-19 vaccine
John Kelton, co-investigator of the study and co-medical director of the McMaster Platelet Immunology Laboratory, said the next step is to “develop a rapid diagnostic and accurate test to diagnose VITT.” The researchers say current rapid tests are time-consuming and prone to false-negative results.
“Our major interest is now to move upstream from how the clots happen to preventing them from occurring,” he said in a release.
VITT was found to occur in one in 60,000 AstraZeneca recipients in Canada.
Canada’s National Advisory Committee on Immunization recommended last month that provinces stop administering the AstraZeneca vaccine in most cases, adding that it preferred those who received first doses of AstraZeneca get an mRNA vaccine from either Pfizer-BioNTech or Moderna to complete their two-dose series.
In June, the estimated rate of developing VITT after a second dose was one in 600,000.
© 2021 The Canadian Press
Chatelaine Is Now Available On Apple News+ – Chatelaine
Current and back issues of Chatelaine and all SJC Media titles are available on this premium, all-you-can-read app
If you love magazines, you should get to know Apple News+. Think of it as a digital journalism buffet, an all-access pass to all your favourite magazine and newspaper titles for a subscription of $12.99 a month for the whole family.
What is Apple News+?
If you have an Apple device, you’re likely familiar with Apple News, a news aggregator app designed for the Apple ecosystem, accessible on iPhone, iPad or Mac. While it offers many articles for free—particularly breaking, trending and local news—Apple News also carries paywalled content that requires an Apple News+ subscription to access. Remember Texture? Apple acquired it in 2018 and evolved it into News+, giving readers access to an unprecedented volume of magazine issues, including back issues from 2018 on. Dubbed the “Netflix of magazines,” Apple News+ offers unlimited access to more than 300 magazines, newspapers and publications for a subscription fee of $12.99 per month after a free one-month trial. The subscription can be shared among a family of up to six people with the Family Sharing feature.
What are the benefits of reading Chatelaine on Apple News+?
Apple News+ reflects the ongoing evolution of digital magazines and the enduring value of consuming content in the packaged issue format, created to provide an immersive, premium-content experience. The Apple News+ platform makes a strong case for consuming magazine issues digitally, with proprietary formatting and ease-of-use features like a simple, ubiquitous table of contents that takes you right to a story, the ability to share and save individual stories, and thumb-scrolling design—no zooming necessary (though font settings are provided if you need it). Titles can also be downloaded to read offline—perfect for disconnected plane rides or mobile data savers. Issues usually drop on Apple News+ first (before print subscribers and newsstand) and sometimes include exclusive “live covers,” where video, animations and other interactive elements level up the reading experience.
How can I find Chatelaine on Apple News+?
Open the Apple News app on your Apple device. Hit the search tool, search for Chatelaine and then hit the plus sign on the right to add it to your library. A pop-up will let you opt in to notifications so you’ll be in the know when new stories or issues are published.
To access the landing page for Chatelaine, go to the Following tab at the bottom and navigate to your title. There you’ll see the latest news and stories from the brand, the past few issues as well as the topics we cover. You can also activate Family Sharing via the Following tab.
Continue to add other titles to your News+ library via the search or Following screens; all titles you’ve selected will automatically download when a new issue is ready. Hit the three dots at the bottom of the cover image to download the issue or browse back issues. Happy reading!
'Update Immediately': Govt Issues Vulnerability Warning for iPhones, iPads – The Quint
This vulnerability exists in IOMobileFrameBuffer of Apple iOS and iPadOS due to memory corruption issues with inadequate memory handling. “A remote attacker with kernel privileges can exploit this vulnerability using a maliciously crafted application,” the agency explained.
Not updating to the latest software versions may allow attackers to gain elevated privileges on a targeted system.
Apple had also warned users that this issue may have been actively exploited.
Meanwhile, the new iOS 14.7.1 also fixes an issue where iPhone models with Touch ID cannot unlock a paired Apple Watch using the ‘Unlock with iPhone’ feature.
(With input from The Times of India)
PS5 Firmware Update Will Improve Create Mode Functionality – Push Square
This PlayStation 5 firmware update that’s currently in beta testing sure has a lot of enhancements to look forward to. As well as allowing us to upgrade SSD storage, making improvements to the operating system, and displaying Trophy lists the way God intended, PS5’s Create functionality is set to receive some nice quality of life updates too.
The firmware’s extensive patch notes have been typed out in full, and they list some relatively small but notable improvements to Create mode. Firstly, when you take screenshots, you’ll be able to disable the on-screen confirmation notification that appears in the top right. This will stop it from appearing in later captures if you’re taking multiple at once.
When you’re recording a video, an on-screen timer remains at the bottom of the screen. With this update, the timer will disappear after three seconds and will reappear when needed, which is nice. If you want to save recent gameplay, Sony is adding more video length options. Next up, when you’re editing screenshots before sharing them, the number of fonts for adding text has been expanded.
Finally, the update will include more options for enabling or disabling certain audio from video clips or when broadcasting. You’ll be able to toggle your personal mic audio and party audio on or off, depending on what you want.
Again, nothing monumental here, but certainly some nice improvements for when you’re creating and sharing screens and videos. Will you be making use of these new improvements? Share your thoughts in the comments below.
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