Health
Organ decay halted, cell function restored in pigs after death -study – CTV News


Researchers have found that decay of tissues after death can be halted and cell functions restored based on early experiments in pigs that may eventually help increase the number of transplantable human organs.
Sixty minutes after stopping the heart in the anesthetized animals, Yale researchers were able to restart the circulation using a specialized machine and a synthetic fluid carrying oxygen and other components that promote cellular health and suppress inflammation.
Six hours later, treatment with the so-called OrganEx technology had reduced or corrected some of the damage, such as organ swelling and collapse of blood vessels, that typically results from lack of oxygen when cardiac arrest halts blood flow.
The results show that when the heart stops, the body is “not as dead as we previously assumed,” Zvonimir Vrselja of Yale University said at a press briefing. “We were able to show that we can persuade cells not to die.”
Genetic analysis of the tissues suggested that molecular and cellular repair processes had begun once circulation had been restored, the researchers reported on Wednesday in the journal Nature.
Compared to the traditional means of restoring circulation – extracorporeal membrane oxygenation (ECMO) – OrganEx “preserved tissue integrity, decreased cell death and restored selected molecular and cellular processes across multiple vital organs,” the researchers wrote.
During the entire experiment, the pigs had no evidence of electrical activity in the brain, the researchers said.
They hope OrganEx will eventually enable increased use of organs retrieved after withdrawal of life support in donors with severe, irreversible brain injuries by preventing the damage that ensues when blood stops circulating. Currently, these organs do worse after transplant than those procured from brain-dead donors who remain on life-support.
That could be years away, however.
The pig study result “stops far short of saying that any organs were restored to the level of function” necessary to support life, said Stephen Latham of Yale’s Interdisciplinary Center for Bioethics.
Theoretically, the technology could someday be used to restore life in someone who has just died. “In order to do that, there’s a great deal more experimentation that would be required,” Latham said. “And you’d have to think about what is the state to which a human being would be restored.”
Use in organ transplantation is a much closer, more realistic goal, Latham said. Any use of OrganEx as a medical therapy “is going to be a long ways away.”
Reporting by Nancy Lapid; editing by Caroline Humer and Bill Berkrot
Health
Respiratory Outbreak Over: Jasper Place – Thunder Bay District Health Unit


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March 27, 2023 – The Thunder Bay District Health Unit (TBDHU) and The City of Thunder Bay – Jasper Place confirm that the respiratory outbreak at Jasper Place, located at 1200 Jasper Drive, has been declared over. All outbreak restrictions have been lifted.
TBDHU recommends the public refrain from visiting hospitals, long-term care facilities and other high risk settings when feeling unwell to avoid spreading infections to those most vulnerable and at higher risk of severe outcomes.
The Health Unit reminds the public that they can prevent getting and spreading infections by:
- Staying at home when sick. Wearing a well-fitted mask in indoor spaces, especially when around vulnerable people or when recovering from illness.
- Keeping up-to-date with influenza and COVID-19 vaccinations.
- Washing hands often, for at least 20 seconds with soap and warm water, or by using an alcohol-based hand sanitizer.
- Covering coughs/sneezes with the upper sleeve if no tissue is available.
- Being familiar with the Ontario screening tool, to self-assess and know what to do next.
For more information on current outbreaks, please visit the following link: https://www.tbdhu.com/outbreaks.
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For more information – TBDHU Media: news@tbdhu.com
News Type
News Releases
Health Topics
COVID-19
Diseases & Infections





Health
COVID cold and flu assessment centre to close Friday

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It’s the end of an era of the pandemic.
The COVID Cold and Flu Care Clinic at 400 Southgate Dr. is closing at the end of the week.
The location will take patients until the end of day Friday.
Guelph General Hospital said in a news release the closure is because of the steady few months of low volumes and stable COVID hospital admissions.
“The COVID, Cold, Flu Care Clinic played a significant role in meeting the needs of the community during the pandemic by providing community residents a much-needed alternative to the emergency department and primary care,” Guelph General Hospital president and CEO Marianne Walker said in a release.
“As care transitions back to community providers, I’d like to thank the over 100 team members from Guelph General Hospital, Guelph Family Health Team and other partner organizations for their valuable service during some very difficult times.”
The clinic opened in September 2020, after moving over from the Victoria Road Recreation Centre. The clinic also used to operate on Delhi Street.
The Southgate Drive location expanded last December to include treatment for cold and flu symptoms.
Anyone looking for COVID-19, cold and flu treatment are now asked to go to family doctors, walk-in clinics, pharmacies and clinics led by Guelph Family Health Team physicians and nurse practitioners.
Severe COVID cases should still go to the emergency department.
Wellington-Dufferin-Guelph Public Health said it will still offer COVID-19 and flu shots at its Chancellors Way building.
The hospital does caution that COVID-19 is still prevalent in the community, and to continue taking precautions if you’re not feeling well.





Health
Whooping cough on the rise in southern Ontario


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Several public health units in southwestern Ontario say they’ve seen a spike in cases of whooping cough and are urging residents to get vaccinated against the respiratory illness that can be particularly severe in young children.
Southwestern Public Health – which serves Oxford County, Elgin County and St. Thomas, Ont. – said it recorded 82 cases of whooping cough from January 2022 to the end of this February.
“This was 40 per cent of the provincial total from that time period,” Dr. Ninh Tran, medical officer of health for Southwestern Public Health, said in an interview.
“It’s a significant increase … that is certainly striking.”
Previous years have seen annual caseloads in the single digits, Tran said.
Whooping cough, or pertussis, can see a person’s cough intensify to the point where a “whooping” sound is heard when they try to catch their breath, Tran said.
Lower rates of immunization against whooping cough could be a factor in the rise in cases, he said.
“In our region, we have relatively lower rates of immunization compared to others,” Tran said.
“We’ve had a few cases that were hospitalized. That’s why we just really need folks to get up-to-date on their immunization.”
Huron Perth Public Health, which serves Stratford, Wingham, Listowel and Clinton, said it has confirmed at least 21 cases of whooping cough so far this year. In 2022, there were only three cases.
“The illness can be serious for infants younger than 12 months of age who are not vaccinated, or who have not received all doses of the pertussis vaccine,” Dr. Miriam Klassen, the medical officer of health for Huron Perth, wrote in a statement.
“Young children have the highest risk for severe complications, such as hospitalization and death, if they get sick.”
Klassen said the COVID-19 pandemic might have put residents of southern Ontario behind on routine immunizations, and urged residents to catch up on their vaccines.
The Windsor-Essex County Health Unit said there had been “a recent dramatic rise” in whooping cough cases in its region. It said last week that it counted 18 cases since November 2022.
“Cases have predominately been clustered in the Leamington and Kingsville communities, and exclusively in children who are unvaccinated or partially vaccinated,” it wrote in a statement, urging residents to get vaccinated.
The health unit noted that the cough brought on by pertussis can be so severe that it can cause vomiting. If left untreated in infants, young children and the elderly, it “can lead to complications such as pneumonia, dehydration, brain damage, hospitalization and death.”
Wellington-Dufferin-Guelph Public Health said it recorded 12 cases over the fall and winter, which is “higher than normal for the region.”
“Many individuals may be behind in their vaccinations because they were unable to get them due to COVID-19,” it wrote in a statement. “Now is the time to get fully vaccinated as we engage in more community activities.”
This report by The Canadian Press was first published March 27, 2023.





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