Health
Oxford COVID-19 vaccine developer won’t guarantee 2020 roll-out
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The University of Oxford’s possible COVID-19 vaccine could be rolled out by the end of the year but there is no certainty, the lead developer of the vaccine said on Tuesday.
The experimental vaccine, which has been licensed to AstraZeneca, produced an immune response in early-stage clinical trials, data showed on Monday, preserving hopes it could be in use by the end of 2020.
“The end of the year target for getting vaccine roll-out, it’s a possibility but there’s absolutely no certainty about that because we need three things to happen,” Sarah Gilbert told BBC Radio.
She said it needed to be shown to work in late-stage trials, there needed to be large quantities manufactured, and regulators had to agree quickly to license it for emergency use before large numbers of people could be vaccinated.
England’s Chief Medical Officer Chris Whitty and his deputy Jonathan Van-Tam took differing views on the potential timeline.
“The chance of us getting a vaccine before Christmas that actually is highly effective are, in my view, very low,” Whitty told lawmakers.
Van-Tam, however, said he was “cautiously optimistic that we will have some vaccine this side of Christmas.”
Sitting somewhere in the middle, health minister Matt Hancock told a parliamentary committee that despite being an “optimist in life” for what he called the best case scenario in getting a vaccine for Christmas, he could not “promise to play Santa”.
The Oxford scientists had eyed a million doses of the potential vaccine to be produced by September.
Although the deal with AstraZeneca has provided manufacturing capacity to do that, the lower prevalence of the novel coronavirus in Britain has complicated the process of proving its efficacy.
Late-stage trials crucial for providing data are under way in Brazil and South Africa and are due to start in the United States also.
There are no approved vaccines yet for COVID-19, but the World Health Organization has said AstraZeneca’s shot is one of the leading candidates.
Source: – The Globe and Mail
Health
RCMP warn about benzodiazepine-laced fentanyl tied to overdose in Alberta – Edmonton Journal
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Grande Prairie RCMP issued a warning Friday after it was revealed fentanyl linked to a deadly overdose was mixed with a chemical that doesn’t respond to naloxone treatment.
The drugs were initially seized on Feb. 28 after a fatal overdose, and this week, Health Canada reported back to Mounties that the fentanyl had been mixed with Bromazolam, which is a benzodiazepine.
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Mounties say this is the first recorded instance of Bromazolam in Alberta. The drug has previously been linked to nine fatal overdoses in New Brunswick in 2022.
The pills seized in Alberta were oval-shaped and stamped with “20” and “SS,” though Mounties say it can come in other forms.
Naloxone treatment, given in many cases of opioid toxicity, is not effective in reversing the effects of Bromazalam, Mounties said, and therefore, any fentanyl mixed with the benzodiazepine “would see a reduced effectiveness of naloxone, requiring the use of additional doses and may still result in a fatality.”
From January to November of last year, there were 1,706 opioid-related deaths in Alberta, and 57 linked to benzodiazepine, up from 1,375 and 43, respectively, in 2022.
Mounties say officers responded to about 1,100 opioid-related calls for service, last year with a third of those proving fatal. RCMP officers also used naloxone 67 times while in the field, a jump of nearly a third over the previous year.
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Health
CFIA continues surveillance for HPAI in cattle, while sticking with original name for disease – RealAgriculture
The Canada Food Inspection Agency will continue to refer to highly pathogenic avian influenza in cattle as HPAI in cattle, and not refer to it as bovine influenza A virus (BIAV), as suggested by the American Association of Bovine Practitioners earlier this month.
Dr. Martin Appelt, senior director for the Canadian Food Inspection Agency, in the interview below, says at this time Canada will stick with “HPAI in cattle” when referencing the disease that’s been confirmed in dairy cattle in multiple states in the U.S.
The CFIA’s naming policy is consistent with the agency’s U.S. counterparts’, as the U.S. Animal and Plant Health Inspection Service has also said it will continue referring to it as HPAI or H5N1.
Appelt explains how the CFIA is learning from the U.S. experience to-date, and how it is working with veterinarians across Canada to stay vigilant for signs of the disease in dairy and beef cattle.
As of April 19, there has not been a confirmed case of HPAI in cattle in Canada. Appelt says it’s too soon to say if an eventual positive case will significantly restrict animal movement, as is the case with positive poultry cases.
This is a major concern for the cattle industry, as beef cattle especially move north and south across the U.S. border by the thousands. Appelt says that CFIA will address an infection in each species differently in conjunction with how the disease is spread and the threat to neighbouring farms or livestock.
Currently, provincial dairy organizations have advised producers to postpone any non-essential tours of dairy barns, as a precaution, in addition to other biosecurity measures to reduce the risk of cattle contracting HPAI.
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Health
Toronto reports 2 more measles cases. Use our tool to check the spread in Canada – Toronto Star
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Canada has seen a concerning rise in measles cases in the first months of 2024.
By the third week of March, the country had already recorded more than three times the number of cases as all of last year. Canada had just 12 cases of measles in 2023, up from three in 2022.
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