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Pandemic may affect infants’ brain development; coronavirus can trigger kidney scarring

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The following is a summary of some recent studies on COVID-19. They include research that warrants further study to corroborate the findings and that has yet to be certified by peer review.

Pandemic may be affecting infants’ brains

Coronavirus infection during pregnancy does not appear to affect infants’ brain function, but the pandemic itself may be having an impact, a study published on Tuesday in JAMA Pediatrics suggests.

Researchers in New York City tracked 255 full-term infants born during the pandemic, including 114 whose mothers had COVID-19 during pregnancy. When the babies were six months old, the researchers saw “absolutely no effect of maternal infection with SARS-CoV-2” on neurodevelopment, said Dr. Dani Dumitriu of Columbia University and New York State Psychiatric Institute. But overall, compared with 62 infants born before the pandemic, the babies born during the health crisis had slightly lower scores on tasks involving large muscles, tasks requiring small muscle movements, and personal interactions. The findings do not necessarily mean these infants will suffer long-term consequences, Dumitriu said. Assessments at six months are poor predictors of long-term outcomes, she added.

If additional research confirms that birth during the pandemic negatively impacts neurodevelopment, she said, “because this is such an early time point there are lots of opportunities to intervene and get these babies onto the right developmental trajectory.”

Coronavirus can trigger kidney scarring

The coronavirus can directly damage the kidneys by initiating a cascade of molecular events that leads to scarring, new laboratory research found. The resulting scar tissue could have long-term impacts on survivors’ kidney function, according to a report published in Cell Stem Cell.

The researchers exposed tiny replicas of kidneys to the SARS-CoV-2 virus in test tubes. They found the virus could infect multiple types of kidney cells and trigger “a molecular switch” that starts the scarring process. The findings suggest that high rates of kidney function decline seen in a separate study of more than 90,000 COVID-19 survivors might be due to scarring of the kidney by the virus, the researchers said.

Jitske Jansen of Radboud University Medical Center in The Netherlands said in a statement that her team had found another “piece of the puzzle showing the deleterious effects the virus can have in the body.”

Lower COVID-19 risks seen after weight-loss surgery

Weight-loss surgery may reduce the risk of severe COVID-19 even if the infected person is still obese after losing weight, according to a report in JAMA Surgery.

Researchers studied 20,212 obese adults, including 5,053 who had undergone bariatric surgery before the pandemic and lost a substantial amount of weight. On average, the people in the surgery group, while still technically obese, weighed about 44 pounds (20 kg) less than study participants who had not undergone the surgery. Although the two groups had similar rates of SARS-CoV-2 infection at about 9%, infected patients with prior weight-loss surgery had a 49% lower risk of hospitalization, a 63% lower risk of need for supplemental oxygen, and a 60% lower risk of becoming critically ill or dying compared to the non-surgery group. Obesity is well known to be a risk factor for poor COVID-19 outcomes, but as the study was not a randomized trial it cannot prove weight-loss surgery caused the better outcomes. Still, the authors said, patients who underwent weight-loss surgery were likely healthier when they became infected.

The results “support the reversibility of the health consequences of obesity” for patients with COVID-19, coauthor Dr. Steven Nissen of the Cleveland Clinic said in a statement. “This study suggests that an emphasis on weight loss as a public health strategy can improve outcomes during the COVID-19 pandemic… That is a very important finding considering that 40% of Americans have obesity. ”

Click for a Reuters graphic https://tmsnrt.rs/3c7R3Bl on vaccines in development.

 

(Reporting by Nancy Lapid and Megan Brooks; Editing by Bill Berkrot)

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Canada to donate up to 200,000 vaccine doses to combat mpox outbreaks in Africa

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The Canadian government says it will donate up to 200,000 vaccine doses to fight the mpox outbreak in Congo and other African countries.

It says the donated doses of Imvamune will come from Canada’s existing supply and will not affect the country’s preparedness for mpox cases in this country.

Minister of Health Mark Holland says the donation “will help to protect those in the most affected regions of Africa and will help prevent further spread of the virus.”

Dr. Madhukar Pai, Canada research chair in epidemiology and global health, says although the donation is welcome, it is a very small portion of the estimated 10 million vaccine doses needed to control the outbreak.

Vaccine donations from wealthier countries have only recently started arriving in Africa, almost a month after the World Health Organization declared the mpox outbreak a public health emergency of international concern.

A few days after the declaration in August, Global Affairs Canada announced a contribution of $1 million for mpox surveillance, diagnostic tools, research and community awareness in Africa.

On Thursday, the Africa Centres for Disease Control and Prevention said mpox is still on the rise and that testing rates are “insufficient” across the continent.

Jason Kindrachuk, Canada research chair in emerging viruses at the University of Manitoba, said donating vaccines, in addition to supporting surveillance and diagnostic tests, is “massively important.”

But Kindrachuk, who has worked on the ground in Congo during the epidemic, also said that the international response to the mpox outbreak is “better late than never (but) better never late.”

“It would have been fantastic for us globally to not be in this position by having provided doses a much, much longer time prior than when we are,” he said, noting that the outbreak of clade I mpox in Congo started in early 2023.

Clade II mpox, endemic in regions of West Africa, came to the world’s attention even earlier — in 2022 — as that strain of virus spread to other countries, including Canada.

Two doses are recommended for mpox vaccination, so the donation may only benefit 100,000 people, Pai said.

Pai questioned whether Canada is contributing enough, as the federal government hasn’t said what percentage of its mpox vaccine stockpile it is donating.

“Small donations are simply not going to help end this crisis. We need to show greater solidarity and support,” he said in an email.

“That is the biggest lesson from the COVID-19 pandemic — our collective safety is tied with that of other nations.”

This report by The Canadian Press was first published Sept. 13, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

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How many Nova Scotians are on the doctor wait-list? Number hit 160,000 in June

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HALIFAX – The Nova Scotia government says it could be months before it reveals how many people are on the wait-list for a family doctor.

The head of the province’s health authority told reporters Wednesday that the government won’t release updated data until the 160,000 people who were on the wait-list in June are contacted to verify whether they still need primary care.

Karen Oldfield said Nova Scotia Health is working on validating the primary care wait-list data before posting new numbers, and that work may take a matter of months. The most recent public wait-list figures are from June 1, when 160,234 people, or about 16 per cent of the population, were on it.

“It’s going to take time to make 160,000 calls,” Oldfield said. “We are not talking weeks, we are talking months.”

The interim CEO and president of Nova Scotia Health said people on the list are being asked where they live, whether they still need a family doctor, and to give an update on their health.

A spokesperson with the province’s Health Department says the government and its health authority are “working hard” to turn the wait-list registry into a useful tool, adding that the data will be shared once it is validated.

Nova Scotia’s NDP are calling on Premier Tim Houston to immediately release statistics on how many people are looking for a family doctor. On Tuesday, the NDP introduced a bill that would require the health minister to make the number public every month.

“It is unacceptable for the list to be more than three months out of date,” NDP Leader Claudia Chender said Tuesday.

Chender said releasing this data regularly is vital so Nova Scotians can track the government’s progress on its main 2021 campaign promise: fixing health care.

The number of people in need of a family doctor has more than doubled between the 2021 summer election campaign and June 2024. Since September 2021 about 300 doctors have been added to the provincial health system, the Health Department said.

“We’ll know if Tim Houston is keeping his 2021 election promise to fix health care when Nova Scotians are attached to primary care,” Chender said.

This report by The Canadian Press was first published Sept. 11, 2024.

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Newfoundland and Labrador monitoring rise in whooping cough cases: medical officer

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ST. JOHN’S, N.L. – Newfoundland and Labrador‘s chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.

Dr. Janice Fitzgerald says that so far this year, the province has recorded 230 confirmed cases of the vaccine-preventable respiratory tract infection, also known as pertussis.

Late last month, Quebec reported more than 11,000 cases during the same time period, while Ontario counted 470 cases, well above the five-year average of 98. In Quebec, the majority of patients are between the ages of 10 and 14.

Meanwhile, New Brunswick has declared a whooping cough outbreak across the province. A total of 141 cases were reported by last month, exceeding the five-year average of 34.

The disease can lead to severe complications among vulnerable populations including infants, who are at the highest risk of suffering from complications like pneumonia and seizures. Symptoms may start with a runny nose, mild fever and cough, then progress to severe coughing accompanied by a distinctive “whooping” sound during inhalation.

“The public, especially pregnant people and those in close contact with infants, are encouraged to be aware of symptoms related to pertussis and to ensure vaccinations are up to date,” Newfoundland and Labrador’s Health Department said in a statement.

Whooping cough can be treated with antibiotics, but vaccination is the most effective way to control the spread of the disease. As a result, the province has expanded immunization efforts this school year. While booster doses are already offered in Grade 9, the vaccine is now being offered to Grade 8 students as well.

Public health officials say whooping cough is a cyclical disease that increases every two to five or six years.

Meanwhile, New Brunswick’s acting chief medical officer of health expects the current case count to get worse before tapering off.

A rise in whooping cough cases has also been reported in the United States and elsewhere. The Pan American Health Organization issued an alert in July encouraging countries to ramp up their surveillance and vaccination coverage.

This report by The Canadian Press was first published Sept. 10, 2024.

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