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Pfizer-BioNTech vaccine appears effective against mutation in new coronavirus variants, study suggests – CBC.ca

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Pfizer Inc. and BioNTech’s COVID-19 vaccine appeared to work against a key mutation in the highly transmissible new variants of the coronavirus discovered in Britain and South Africa, according to a laboratory study conducted by the U.S. drugmaker.

The study by Pfizer and scientists from the University of Texas Medical Branch, which has not yet been peer-reviewed, indicated the vaccine was effective in neutralizing virus with the so-called N501Y mutation of the spike protein.

The mutation could be responsible for greater transmissibility and there had been concern it could also make the virus escape antibody neutralization elicited by the vaccine, said Phil Dormitzer, one of Pfizer’s top viral vaccine scientists.

The first results of tests on the variants offer a glimmer of hope while more studies are carried out as Britain and other countries try to tame the more infectious variants that authorities believe are driving a surge in infections that could overwhelm health-care systems.

The Pfizer-BioNTech study was conducted on blood taken from people who had been given the vaccine. Its findings are limited because it does not look at the full set of mutations found in either of the new variants of the rapidly spreading virus.

Dormitzer said it was encouraging that the vaccine appears effective against the mutation, as well as 15 other mutations the company has previously tested against.

“So we’ve now tested 16 different mutations, and none of them have really had any significant impact. That’s the good news,” he said. “That doesn’t mean that the 17th won’t.”

Dormitzer said another mutation found in the South African variant, called the E484K mutation, was also concerning.

The researchers plan to run similar tests to establish whether the vaccine is effective against other mutations found in the British and South African variants and hope to have more data within weeks.

The variants are said by scientists to be more transmissible than previously dominant ones, but they are not thought to cause more serious illness.

Scientists said the results of the study would help calm concerns that people will not be protected by vaccines being given to millions of people around the world in the fight against the pandemic, which has killed more than 1.8 million people and roiled economies.

But they cautioned that more clinical tests and data are still needed to come to a definitive conclusion.

“This is good news, mainly because it is not bad news,” said Stephen Evans, professor of pharmacoepidemiology at the London School of Hygiene & Tropical Medicine.

“So, yes this is good news, but it does not yet give us total confidence that the Pfizer (or other) vaccines will definitely give protection.”

AstraZeneca, Moderna, CureVac testing against variants

AstraZeneca, Moderna and CureVac are also testing whether their shots work against the fast-spreading variants. They have said they expect them to be effective, but the timing of those studies is not known.

A senior British lawmaker expressed concerns in an interview on Friday that COVID-19 vaccines might not work properly against the South African variant. He was not responding to questions about Friday’s data.

The Pfizer-BioNTech vaccine and the one from Moderna Inc., which use synthetic messenger RNA technology, can be quickly tweaked to address new mutations of a virus if necessary. Scientists have suggested the changes could be made in as little as six weeks.

The variant is not the first of the pandemic to emerge and Eleanor Riley, professor of immunology and infectious disease at the University of Edinburgh, said these types of studies will be needed as they appear.

“It may be necessary to tweak the vaccine over time,” she said.

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Ontario reports 3,422 new cases of COVID-19, 69 additional deaths – 680 News

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Ontario is reporting 3,422 new cases of COVID-19 on Sunday with another 69 people having died as a result of the virus.

It’s the third day out of the last four that the provincial case count has surpassed 3,000.

More than half of the new deaths, 36, are attributed to long-term care settings. The total number of people in the province who have died as a result of COVID-19 now sits at 5,409. More than 400 people have passed away since last Sunday from the virus.

Toronto reported 1,035 new cases of the virus – the first time in a week that the number of new cases has topped 1,000. Peel Region reported 585 new infections, while York Region reported 246 additional cases.

Provincial health officials conducted 60,183 tests in the last 24 hours, the first time in three days provincial labs failed to complete more than 70,000 tests. That leaves the backlog of tests to be processed at just over 30,000.

Hospitalizations sit at more than 1,500, however, as is the case on the weekend a number of hospitals have not provided data to provincial officials. There are 395 COVID-19 patients in the ICU with 293 currently on a ventilator.

Ontario administered just over 11,000 doses of the COVID-19 vaccine on Saturday, bringing the provincial total to over 200,000.

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Potential COVID exposure on two flights – HalifaxToday.ca

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NEWS RELEASE
NOVA SCOTIA HEALTH
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Nova Scotia Health Public Health is advising of potential exposure to COVID-19 on two flights from Toronto to Halifax. In addition to media releases, all potential exposure notifications are listed here: http://www.nshealth.ca/covid-exposures.

Anyone who was on the following flights in the specified rows and seats is asked to continue to self-isolate and immediately visit https://covid-self-assessment.novascotia.ca/en to book a COVID-19 test, regardless of whether or not they have COVID-19 symptoms. You can also call 811 if you don’t have online access or if you have other symptoms that concern you.

  • Air Canada flight 604 travelling on Jan. 5 from Toronto (8:00 a.m.) to Halifax (11:00 a.m.). Passengers in rows 22-28 seats C, D, E and F are asked to continue to self-isolate and immediately visit https://covid-self-assessment.novascotia.ca/en to book a COVID-19 test, regardless of whether or not they have COVID-19 symptoms. All other passengers on this flight should continue to self-isolate as required and monitor for signs and symptoms of COVID-19. It is anticipated that anyone exposed to the virus on this flight on the named date may develop symptoms up to, and including, Jan. 19.
  • Swoop flight 408 travelling on Jan. 8 from Toronto (5:30 p.m.) to Halifax (8:30 p.m.). Passengers in rows 16-22 seats A, B, C and D are asked to continue to self-isolate and immediately visit https://covid-self-assessment.novascotia.ca/en to book a COVID-19 test, regardless of whether or not they have COVID-19 symptoms. All other passengers on this flight should continue to self-isolate as required and monitor for signs and symptoms of COVID-19. It is anticipated that anyone exposed to the virus on this flight on the named date may develop symptoms up to, and including, Jan. 22.

Please remember:

Do not go directly to a COVID-19 assessment centre without being directed to do so. Please book an appointment online and do not go to a pop-up rapid testing location.

Currently, anyone who traveled outside Nova Scotia, PEI or Newfoundland and Labrador is expected to self-isolate alone for 14 days after arriving. If a person returning from non-essential travel outside Nova Scotia, PEI or Newfoundland and Labrador is unable to isolate alone, then everyone in the home where they are self-isolating will have to self-isolate as well.

When Nova Scotia Health Public Health makes a public notification it is not in any way a reflection on the behaviour or activities of those named in the notification.

All Nova Scotians are advised to continue monitoring for COVID-19 symptoms and are urged to follow Public Health guidelines on how to access care. Up to date information about COVID-19 is available at novascotia.ca/coronavirus

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Ontario wants everyone vaccinated by early August, general says – CBC.ca

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Ontario wants to have everyone vaccinated by late July or early August, the head of its vaccine distribution plan told CBC News Sunday.

The updated timeline came as the province saw 3,422 new COVID-19 cases and 69 more deaths, with Toronto alone recording more than 1,000 new infections.

Retired general Rick Hillier said while accomplishing the summer goal hinges on Ontario getting a steady supply of vaccine, there’s a plan to get them in arms.

“When they come, we’re going to be able to use them all,” Hillier told the CBC’s Rosemary Barton.

“I’d love to see the province of Ontario done by the end of July or early August with all those who want to have a vaccine and who are eligible to receive it. But until we get the vaccine allocation, until we know what’s coming, we just can’t do it.”

WATCH | Hillier’s full interview on Rosemary Barton Live:

Retired general told CBC’s Rosemary Barton Live he wants to see everyone who wants a vaccine get one by late July or early August. 7:52

Ontario has distributed the most COVID-19 vaccines of any province, but has administered only 72 per cent of the doses it has received. You can get the latest details by using the CBC News vaccine tracker

For now, a provincewide stay-at-home order remains in place as Ontario tries to limit the spread of the virus.

GTA continues to see bulk of province’s new cases

Toronto reported 1,035 new COVID-19 cases on Sunday, marking another day that the province’s biggest city also had the most infections.

In addition to Toronto’s cases, there were 585 new cases in Peel, 254 in Windsor-Essex, 246 in York and 186 in the Niagara area. The new cases drive the seven-day average, a key figure that reduces noise in the data, to 3,143 new cases per day.

A further 69 more people with the illness died, bringing the province’s official death toll to 5,409.

At least 1,570 people are in hospital, and there are now 293 patients on ventilators. Just over 3,078 cases were marked resolved.

There were 60,183 tests completed, and the province’s positivity rate is now 5.2 per cent.

Ford, Tory touring future mass vaccination site

Ontario has now administered 200,097 doses of COVID-19 vaccine, and remains in the first phase of its rollout plan.

Premier Doug Ford and Toronto Mayor John Tory toured the city’s first mass vaccination site, located at the Metro Toronto Convention Centre, on Sunday. 

Mass vaccinations haven’t started yet (long-term care and health-care settings are being prioritized) but the Toronto facility is set to serve as a blueprint for what could be coming to other locations in the coming months. The city provided these details about the mass vaccination site, which it’s calling a “proof-of-concept clinic”:

  • Opens Monday, but not to the general public.
  • Will start with 250 vaccinations per day.
  • Will use the Moderna vaccine.

Tory said he hopes the test site will provide some hope during the grey winter months.

“Vaccination is soon to come and we’re just working away at being ready to do that,” Tory said.

Paramedics transport a patient to Mt. Sinai Hospital, in Toronto. There are 1,570 hospitalized COVID-19 patients as of Sunday. (Evan Mitsui/CBC)

Ford said the province will be ready when it’s time to ramp up vaccinations in April, May and June. 

“Our goal is to get as many needles in people’s arms as possible,” he said.

The two leaders didn’t take questions from reporters. 

When will you get a COVID-19 vaccine? Here’s a look at how the province is prioritizing its rollout plan

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