Popular dietary supplement may offer new treatment option for aggressive cancers | Canada News Media
Connect with us

Health

Popular dietary supplement may offer new treatment option for aggressive cancers

Published

 on

A new study by researchers at UBC’s Faculty of Medicine and McGill University has revealed that the popular dietary supplement alanine may offer an effective treatment option for people diagnosed with several types of aggressive cancer.

The findings, published in Nature Communications, show alanine’s potential as a treatment for cancers characterized by a dual loss of the SMARCA4 and SMARCA2 genes. These SMARCA4/2-deficient cancers include small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) — a rare and lethal tumour that occurs predominantly in women in their mid-twenties — as well as other malignancies, including a subset of lung cancers.

Currently, there are few effective treatments for these forms of cancer, which are often highly resistant to conventional chemotherapies and have very poor outcomes.

Dr. Yemin Wang
(Credit: BC Cancer)

“Through an unbiased genome-wide screen, our teams identified the key metabolic change that enables the development of the aggressive SMARCA4/2-deficient cancers,” said Dr. Yemin Wang, an adjunct professor in UBC’s department of laboratory medicine and staff scientist at the BC Cancer, and co-lead author of the study. “This finding not only helps us better understand the biology of these cancers, but also provided multiple potential treatment strategies, alone or in combination with chemotherapy or immunotherapy, for clinical validation.”

Alanine is an amino acid commonly found in meat and poultry, fish, eggs and dairy products, as well as some protein-rich plant foods. It is also available in powder form as a dietary supplement sold by health food retailers. It has been known to boost the body’s immune system and is popular within the body-building community.

The study shows that alanine can kill SMARCA4/2-deficient cancers cells by interrupting the metabolic pathways they depend on.

“This finding not only helps us better understand the biology of these cancers, but also provided multiple potential treatment strategies.”
Dr. Yemin Wang

Dr. David Huntsman (Credit: BC Cancer)

The findings build on work by study co-author Dr. David Huntsman, a professor in the departments of pathology and laboratory medicine and obstetrics and gynaecology at UBC, and the co-founder and director of OVCARE, B.C.’s multidisciplinary gynecologic cancer research team. Dr. Huntsman and his team previously discovered the key role that the SMARCA4 and SMARCA2 genes play in cancers like SCCOHT.

“This is a tremendous example of how studying a distinctive rare cancer, in this case small cell hypercalcemic ovarian cancers, can lead to insights that could impact other more common cancers,” said Dr. Huntsman. “Most chemotherapies target all dividing cells, not just cancer cells, which is why side effects can be so difficult for patients. We were surprised and are excited by how specific this metabolic vulnerability is and its promise for a treatment approach that could be both more effective and less toxic.”

Dr. Sidong Huang
(Credit: McGill University)

The study was a multi-year collaboration led by researchers at UBC and McGill University. Having established alanine’s efficacy in the lab, the researchers now hope to take the findings into clinical trials.

“The next important stage is to have proper clinical testing to be conclusive, to say whether or not this is actually effective,” said Dr. Sidong Huang, an associate professor at McGill University and the Rosalind and Morris Goodman Cancer Institute, and co-lead author of the report. “Even though it is very safe for most people, if you have an underlying condition such as a metabolism disease, it might not be safe to take this. We just want to be sure patients can tolerate high-dose alanine. It’s important to talk to your doctor.”

The study was funded by the Canadian Institutes of Health Research, Terry Fox Research Institute, Canadian Cancer Society, the BC Cancer Foundation, the VGH & UBC Hospital Foundation and a number of other funding partners.

This story is adapted from an article originally published by McGill University.

 

Source link

Continue Reading

Health

Canada to donate up to 200,000 vaccine doses to combat mpox outbreaks in Africa

Published

 on

 

The Canadian government says it will donate up to 200,000 vaccine doses to fight the mpox outbreak in Congo and other African countries.

It says the donated doses of Imvamune will come from Canada’s existing supply and will not affect the country’s preparedness for mpox cases in this country.

Minister of Health Mark Holland says the donation “will help to protect those in the most affected regions of Africa and will help prevent further spread of the virus.”

Dr. Madhukar Pai, Canada research chair in epidemiology and global health, says although the donation is welcome, it is a very small portion of the estimated 10 million vaccine doses needed to control the outbreak.

Vaccine donations from wealthier countries have only recently started arriving in Africa, almost a month after the World Health Organization declared the mpox outbreak a public health emergency of international concern.

A few days after the declaration in August, Global Affairs Canada announced a contribution of $1 million for mpox surveillance, diagnostic tools, research and community awareness in Africa.

On Thursday, the Africa Centres for Disease Control and Prevention said mpox is still on the rise and that testing rates are “insufficient” across the continent.

Jason Kindrachuk, Canada research chair in emerging viruses at the University of Manitoba, said donating vaccines, in addition to supporting surveillance and diagnostic tests, is “massively important.”

But Kindrachuk, who has worked on the ground in Congo during the epidemic, also said that the international response to the mpox outbreak is “better late than never (but) better never late.”

“It would have been fantastic for us globally to not be in this position by having provided doses a much, much longer time prior than when we are,” he said, noting that the outbreak of clade I mpox in Congo started in early 2023.

Clade II mpox, endemic in regions of West Africa, came to the world’s attention even earlier — in 2022 — as that strain of virus spread to other countries, including Canada.

Two doses are recommended for mpox vaccination, so the donation may only benefit 100,000 people, Pai said.

Pai questioned whether Canada is contributing enough, as the federal government hasn’t said what percentage of its mpox vaccine stockpile it is donating.

“Small donations are simply not going to help end this crisis. We need to show greater solidarity and support,” he said in an email.

“That is the biggest lesson from the COVID-19 pandemic — our collective safety is tied with that of other nations.”

This report by The Canadian Press was first published Sept. 13, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

Source link

Continue Reading

Health

How many Nova Scotians are on the doctor wait-list? Number hit 160,000 in June

Published

 on

 

HALIFAX – The Nova Scotia government says it could be months before it reveals how many people are on the wait-list for a family doctor.

The head of the province’s health authority told reporters Wednesday that the government won’t release updated data until the 160,000 people who were on the wait-list in June are contacted to verify whether they still need primary care.

Karen Oldfield said Nova Scotia Health is working on validating the primary care wait-list data before posting new numbers, and that work may take a matter of months. The most recent public wait-list figures are from June 1, when 160,234 people, or about 16 per cent of the population, were on it.

“It’s going to take time to make 160,000 calls,” Oldfield said. “We are not talking weeks, we are talking months.”

The interim CEO and president of Nova Scotia Health said people on the list are being asked where they live, whether they still need a family doctor, and to give an update on their health.

A spokesperson with the province’s Health Department says the government and its health authority are “working hard” to turn the wait-list registry into a useful tool, adding that the data will be shared once it is validated.

Nova Scotia’s NDP are calling on Premier Tim Houston to immediately release statistics on how many people are looking for a family doctor. On Tuesday, the NDP introduced a bill that would require the health minister to make the number public every month.

“It is unacceptable for the list to be more than three months out of date,” NDP Leader Claudia Chender said Tuesday.

Chender said releasing this data regularly is vital so Nova Scotians can track the government’s progress on its main 2021 campaign promise: fixing health care.

The number of people in need of a family doctor has more than doubled between the 2021 summer election campaign and June 2024. Since September 2021 about 300 doctors have been added to the provincial health system, the Health Department said.

“We’ll know if Tim Houston is keeping his 2021 election promise to fix health care when Nova Scotians are attached to primary care,” Chender said.

This report by The Canadian Press was first published Sept. 11, 2024.

The Canadian Press. All rights reserved.

Source link

Continue Reading

Health

Newfoundland and Labrador monitoring rise in whooping cough cases: medical officer

Published

 on

 

ST. JOHN’S, N.L. – Newfoundland and Labrador‘s chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.

Dr. Janice Fitzgerald says that so far this year, the province has recorded 230 confirmed cases of the vaccine-preventable respiratory tract infection, also known as pertussis.

Late last month, Quebec reported more than 11,000 cases during the same time period, while Ontario counted 470 cases, well above the five-year average of 98. In Quebec, the majority of patients are between the ages of 10 and 14.

Meanwhile, New Brunswick has declared a whooping cough outbreak across the province. A total of 141 cases were reported by last month, exceeding the five-year average of 34.

The disease can lead to severe complications among vulnerable populations including infants, who are at the highest risk of suffering from complications like pneumonia and seizures. Symptoms may start with a runny nose, mild fever and cough, then progress to severe coughing accompanied by a distinctive “whooping” sound during inhalation.

“The public, especially pregnant people and those in close contact with infants, are encouraged to be aware of symptoms related to pertussis and to ensure vaccinations are up to date,” Newfoundland and Labrador’s Health Department said in a statement.

Whooping cough can be treated with antibiotics, but vaccination is the most effective way to control the spread of the disease. As a result, the province has expanded immunization efforts this school year. While booster doses are already offered in Grade 9, the vaccine is now being offered to Grade 8 students as well.

Public health officials say whooping cough is a cyclical disease that increases every two to five or six years.

Meanwhile, New Brunswick’s acting chief medical officer of health expects the current case count to get worse before tapering off.

A rise in whooping cough cases has also been reported in the United States and elsewhere. The Pan American Health Organization issued an alert in July encouraging countries to ramp up their surveillance and vaccination coverage.

This report by The Canadian Press was first published Sept. 10, 2024.

The Canadian Press. All rights reserved.

Source link

Continue Reading

Trending

Exit mobile version