Questions and answers about AstraZeneca — Canada’s newest COVID-19 vaccine - Toronto Star | Canada News Media
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Questions and answers about AstraZeneca — Canada’s newest COVID-19 vaccine – Toronto Star

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Canada has a new COVID-19 vaccine at its disposal — one that relies on different technology than the other two doses that have been approved for use in this country.

The federal regulator announced Friday it has authorized the vaccine created in a collaboration between AstraZeneca and Oxford University. At the same time, the regulator also approved the version made by the Serum Institute of India, known by the name Covishield.

The federal government has already procured 20 million doses of the vaccine, and now says it has procured an additional two million doses from India, with the first shipment to arrive within weeks.

The AstraZeneca/Oxford vaccine has had a more winding journey to authorization than the previous two vaccines, with the European regulator at one point saying there wasn’t enough evidence to show it was effective in seniors. South African officials have also raised questions about its usefulness against the variant that emerged in their country.

But the approval of this shot is significant, experts say, because of the edge it has in terms of the speed at which it can be manufactured and the ease with which it can be shipped around the country.

“The transportability is really important — it offers more options, and more flexible vaccination planning at a health unit level,” Dr. Lynora Saxinger, an infectious diseases specialist at the University of Alberta, said in an email.

Federal officials also reiterated Friday that it will be just one weapon in their public health arsenal.

“The idea is to have a suite of vaccines that are available,” said Dr. Supriya Sharma, a senior medical adviser with Health Canada. “I think Canada is hungry for vaccines; we’re putting more on the buffet table to be used.”

The regulator made its decision based on four human trials — conducted in the United Kingdom, Brazil and South Africa; and the federal department said the two-shot regimen has an efficacy of 62.1 per cent. It added there have been no deaths or life-threatening events related to the vaccine.

“Based on the available data, the vaccine at the indicated dose was considered safe and well-tolerated,” Health Canada said in its decision.

Here’s what we know about the new dose.

How is it given?

Like the two vaccines currently on the market, the AstraZeneca/Oxford vaccine is a two-dose regimen, given between four and 12 weeks apart.

The vaccine dose is 0.5mL of a colourless to slightly brown solution that is injected intramuscularly, normally into the arm.

Who can take it?

People 18 and up.

Who should not take it?

Anyone allergic to the ingredients in the vaccine, anyone who had an allergic reaction to the first dose, or anyone with COVID-19 symptoms. For other questions, ask your doctor.

Does it work in older people?

The trials included relatively few older adults, leading the European regulator to conclude there wasn’t enough information to definitely conclude the vaccine worked in seniors, but that protection was expected.

Health Canada said there is “limited information” from clinical trials on the efficacy of the vaccine in those over the age of 65.

However, they also say that “emerging real world evidence” from countries where the vaccine is being used suggests “a potential benefit and no safety concerns.”

How is it different from the Pfizer and Moderna vaccines Canada has previously approved?

AstraZeneca’s vaccine uses a different technique than the two vaccines developed by Moderna and Pfizer, which relied on new mRNA technology.

Its approach is called a viral vector, which uses a virus normally found in chimpanzees to sneak the DNA for a coronavirus spike protein into your body, which then teaches your immune system how to fight off a future potential infection from the actual coronavirus.

Doses are expected to be cheaper and can be stored in a normal fridge, which would be a win for poorer countries.

“It’s more nimble,” as Saxinger puts it.

“It’s fairly inexpensive and easy to mass produce and store, comparatively, so you can get it to remote places much more easily, and it can possibly be given in doctors’ offices, as just usual refrigeration is needed.”

How well does it work?

According to Health Canada, getting two full doses of vaccine is between 62.1 and 59.5 per cent effective.

Isn’t 62.1 per cent a little low?

While this isn’t quite as high as Moderna and Pfizer, experts say it’s still higher than the 50 per cent efficacy rate vaccine makers were aiming far, and isn’t far off from the usual efficacy rate of the annual flu vaccine.

“(If) you look back, for example, just to last year, the effectiveness of the flu vaccine against the most common strain was about 64 per cent; across the next common strain it was about 54 per cent,” Sharma said. “These vaccines do have a use.”

In addition, this vaccine has also proven to be effective in reducing serious illness and death.

Saxinger cautioned people not to get hung up on efficacy numbers here: “A few months ago, people would’ve been clamouring for a 70 per cent effective vaccine,” she said.

“It’s important for everyone to realize that protection from severe disease is excellent for all of the vaccines so far.”

Why did it take so long to get approved?

While both Pfizer and Moderna got the green light not long after submitting their final trial results, AstraZeneca has been in limbo for weeks.

Observers point to some confusion about the efficacy of this vaccine early on, based on a dosing error during testing that saw some volunteers get a half dose for their first shot.

Back in November, AstraZeneca said its vaccine was about 72 per cent effective overall, but ranging from as low as 62 per cent to as high as 90 per cent.

In a news release, the company revealed it had mistakenly tried out two different doses in one of its trials — and that had led to two different results.

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While two full doses was about 62 per cent effective, the mistaken half dose appeared to raise that number to 90 per cent, but only in a small sample, and researchers aren’t sure why.

As a result, the regulator’s job was “a bit more complicated” this time around, Sharma told reporters in January.

Given the need to make sure the data was clear, Saxinger called the delay here “appropriate.”

In the end, Health Canada followed in the footsteps of regulators in the European Union and Britain by authorizing two full doses, because that’s the regimen tested on more people to date.

What about the variants?

Earlier this month, South Africa halted the rollout of this vaccine because of concerns it would be less effective against B. 1.351, the virus variant now dominant there.

A relatively small trial of 2,000 people suggested the vaccine offered “minimal protection” against mild and moderate cases, though research continues and experts haven’t ruled out the vaccine’s effectiveness against serious cases.

Right now, there are relatively few cases of the variant in Canada, but experts say this will have to be watched.

However, the vaccine seems to be just fine when faced with B. 117, the variant that emerged in the U.K. AstraZeneca has been a major pillar of vaccination efforts there.

The World Health Organization is still recommending the use of AstraZeneca’s vaccine, even in countries where variants emerged as dominant.

What about transmission?

All of the vaccines were designed to do one, big thing — stop someone exposed to the coronavirus from getting the illness we now know as COVID-19.

But in order to achieve herd immunity, the vaccines will need to do something else — stop a person exposed to the coronavirus from giving it to others.

Determining how good these vaccines are at stopping transmission takes time, so for many doses, this was a question we just couldn’t answer yet.

However there’s some possible good news on that front for AstraZeneca. Research done by British researchers — which still needs to be peer-reviewed, or vetted by other scientists — suggests that vaccinated people may be less infectious.

The study didn’t look at transmission directly (for example, it didn’t test the family members of those who had been vaccinated) but it took nasal swabs from study participants and found that the rate of positive PCR results fell by half after two doses.

What are the side effects?

According to the United Kingdom, where the shot is already in use, very common side effects include tenderness, pain or bruising at the injection site, as well fatigue, headache or joint pain.

It’s also common to experience a fever or flu-like symptoms.

More uncommon symptoms include feeling dizzy, decreased appetite, abdominal pain and enlarged lymph nodes.

According to Health Canada, the most commonly reported adverse infections were tenderness (75.3 per cent) and pain (54.2 per cent) at the injection site, fatigue (62.3 per cent), headache (57.5 per cent) and myalgia, or muscle pain (48.6 per cent).

Most reactions were mild or moderate.

How is it transported?

According to the company, the vaccine can be stored, transported and handled at “normal refrigerated conditions,” meaning between two and eight degrees Celsius for at least six months.

It can be given in “existing health-care settings.”

This will make it easier to transport that the existing vaccines, both of which are transported frozen, or in the case of Pfizer, in ultra cold temperatures, according to Health Canada.

With files from Alex Ballingall

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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

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Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

___

Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Pediatric group says doctors should regularly screen kids for reading difficulties

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The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

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