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Renowned scientist Frank Plummer has died

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The former scientific director of Canada’s National Microbiology Laboratory in Winnipeg who had experimental brain surgery to battle alcoholism has died.

Dr. Frank Plummer, a world-renowned microbiologist and infectious-disease expert, was 67.

“He was a scientific maverick,” Theresa Tam, Canada’s chief public health officer, tweeted on Tuesday.

Plummer was a mentor, she said, who helped set up and make the national laboratory in Winnipeg a world-class institution.

Plummer was at the helm of the lab during the SARS, influenza and H1N1 epidemics, as well as during the development of an Ebola vaccine.

Prior to his time at the lab, Plummer’s research shaped public health policy around the world.

 

He built a world-class research operation in Kenya, where he observed a particular group of women who had a natural immunity to HIV-1.

That discovery provided important information for HIV vaccine and drug development.

“He was admired and regarded highly by academics and researchers around the world, and his legacy of seeking to develop an HIV vaccine remains one of the landmarks of infectious disease prevention,” University of Manitoba president David Barnard said in a statement.

“His contributions have had a cumulative global impact on saving the lives of tens of thousands of people for decades and also improving the lives of HIV positive people around the world,” added Digvir Jayas, the university’s vice-president of research.

‘He was a proud Winnipegger and a proud Canadian’

Plummer was named an Officer of the Order of Canada in 2006 and a member of the Order of Manitoba three years later.

He received numerous prestigious awards throughout his career, including the Flavelle Medal from the Royal Society of Canada in 2018 for his contributions to biological science.

Plummer had recently shared his own battle with alcoholism.

In an article he wrote for Toronto’s Sunnybrook Health Sciences Centre, Plummer explained how he began to drink scotch to “to celebrate, relax and deal with stress, anxiety, disappointment and grief.”

After decades of drinking, attempts at quitting and a liver transplant, Plummer decided to get experimental treatment using deep brain stimulation in 2018.

“Having committed my career to medical science and human health I saw this study as one more way to make a contribution – this time, literally using my brain!” Plummer wrote.

Keith Fowke, head of medical microbiology and infectious diseases at the University of Manitoba, was a grad student under Plummer’s tutelage when they made the major discovery in Kenya. They later became close friends and colleagues.

Fowke said as a scientist or a research participant, Plummer always wanted to help people.

“He was always focused on truth and knowledge and making the world a better place,” Fowke said.

Fowke described his friend as warm and kind. He called Plummer a loving father and husband who enjoyed having his friends over for dinner.

“He wanted everyone to know he was a proud Winnipegger and a proud Canadian, and that all of us can make important globally significant contributions.”

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InnovationRx: Stretching Monkeypox Vaccine Doses; Plus, Omicron Subvariant Boosters – Forbes

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InnovationRx is your weekly digest of healthcare news. To get it in your inbox, subscribe here.

As the U.S. continues to face a rise in monkeypox cases (nearly 9,500 cases as of Tuesday), the FDA has OKed a new dosing strategy to stretch vaccine supplies. Bavarian Nordic’s Jynneos vaccine was originally approved by the FDA for a full dose to be administered subcutaneously, meaning underneath the skin into the fat of the arm. On Tuesday, the FDA issued an emergency use authorization that allows health workers to inject one-fifth of a normal dose intradermally, meaning into the skin.

But experts tell Forbes that this new method poses challenges for the vaccine rollout: there is limited data supporting the strategy and most healthcare workers have experience giving intradermal injections. This method could also produce more side effects, like swelling and itching at the injection site, compared to the standard dose, according to Dr. Jay Varma, a professor at Weill Cornell Medicine. Though Varma also said he thinks the new approach is the best one “given the vaccine supply shortage.”


Facebook Gave Nebraska Cops A Teen’s DMs So They Could Prosecute Her For Having An Abortion

A Nebraska teenager is facing criminal charges alleging she aborted a fetus in violation of state law, after authorities obtained her Facebook messages using a search warrant. This marks one of the first instances of a person’s Facebook activity being used to incriminate her in a state where abortion access is restricted — a scenario that has remained largely hypothetical in the weeks following the US Supreme Court’s decision to overturn Roe v. Wade.

Read more here.


Deals Of The Week

Funding Extension: Biofourmis, a startup developing digital therapeutics and artificial intelligence to remotely monitor patients, has raised a $20 million Series D extension led by Intel Capital. SCAN group president and CEO Sachin Jain and former Tenet Healthcare chairman and CEO Trevor Fetter are also joining the company’s board. Biofourmis was valued at $1.3 billion following its $300 million funding round in April.

Sickle Cell: Pfizer is acquiring Global Blood Therapeutics in a deal valued at $5.4 billion, as the pharma giant acquires its sickle cell disease portfolio. Pfizer estimates its approved treatment Oxbryta and pipeline of drugs in development “could achieve combined worldwide peak sales of more than $3 billion,” according to a press release.

Health Outcomes: HCA Healthcare is partnering with Johnson & Johnson on a pilot program to address early-stage lung cancer detection among the Black community. The two companies will also work together on health equity training for nurses and research using digital technology to improve outcomes for heart disease.

Diabetes: Abbott is partnering with WeightWatchers on a program for patients with diabetes that pairs Abbott’s FreeStyle Libre continuous glucose monitor with WeightWatchers’ diabetes management app that focuses on nutrition and meal planning.

Alzheimer’s Collaboration: Drug discovery firm Cerevance announced Tuesday that it has signed a multi-year contract with Merck to identify novel drug targets for Alzheimer’s disease. The deal calls for Cerevance to get $25 million upfront, and if all goes well with drug development, could be worth up to $1.1 billion in milestone payments in addition to royalties.


Noteworthy

A new study suggests over half of infectious diseases could be worsened by climate change, as warming temperatures, droughts, wildfires and other weather phenomena that displace people make it easier for pathogens to spread.

Cigna reported nearly $1.6 billion in quarterly profits due to continued growth in health plan membership and the company’s Evernorth health services business.

Parents in Georgia can claim embryos with detectable heartbeats as dependents on their state tax returns following the overturn of Roe v. Wade.

Medicare advantage company Alignment Healthcare’s losses are narrowing as its enrollment rises, per latest earnings report.

Meet Danielle Carnival, the scientist coordinating President Joe Biden’s new cancer moonshot.

Coronavirus Updates

Pfizer and BioNTech have completed clinical trials for vaccines that include specific protection against the original omicron variant. Now the two companies have begun testing for vaccines specific to the BA.4 and BA.5 Omicron subvariants, which are the fastest spreading variants of Covid-19 in the United States. Manufacturing for the new vaccines has already begun, and could be rolled out as early as October pending regulatory approvals. That’s good news as we approach the fall and winter, which have been the times of year where Covid spread is at its highest. Competitor Moderna has also begun testing an omicron specific booster, but the FDA has not yet authorized any Omicron-specific vaccines.


Newly Discovered Monkey Antibodies Could Hold Key To Vaccine Against All Coronavirus Strains

Researchers have identified monkey antibodies that are effective against numerous Covid variants and other coronaviruses, a discovery that could help scientists develop better vaccines and prepare for future pandemics as pharma firms race to update their shots.

Read more here.

Other Coronavirus News

New research presented earlier this month suggests that the loss of smell during a Covid infection is associated with long-term cognitive impairment.

A recently published study finds that wind instruments, especially brass instruments like trumpets and trombones, are most likely to spread respiratory particles and therefore diseases like Covid.

Americans’ outlook of the Covid-19 pandemic has become increasingly pessimistic in recent months, a new Gallup poll found, with a growing share believing things are getting worse instead of better.

A very small retrospective study found that among patients hospitalized for Covid-19, those who admitted to being chronic cannabis users were less likely to be admitted to the ICU, but the authors of the study urged caution and more definitive research before drawing conclusions.

Across Forbes

The Cloud 100

How Much Has Trump Made From Mar-A-Lago, His Palm Beach Estate Under Siege?

Google Calls On Apple To Fix Hated Green Bubbles On iMessage

What Else We are Reading

As billionaires race to fund anti-aging projects, a much-discussed trial goes overlooked (STAT)

Covid Sewage Surveillance Labs Join the Hunt for Monkeypox (Kaiser Health News)

Long-COVID treatments: why the world is still waiting (Nature)

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Polio largely vanished thanks to vaccines. So why is it now back in more countries? – CBC News

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Polio, a potentially disabling virus that’s long been forgotten in many parts of the world, is now circulating in parts of the U.S. and U.K., on the heels of an outbreak in Israel — prompting health officials to launch vaccination campaigns to ensure the public is protected.

Even in Canada, a country free of polio for the last two decades, medical experts say it’s a wake-up call that the virus still poses a threat to anyone who remains unvaccinated, given polio’s ability to spread through global travel networks and wastewater systems.

On Wednesday, British health authorities announced they will offer a polio booster dose to children aged one to nine in London, after finding evidence the virus has been spreading in multiple regions of the capital. Britain’s Health Security Agency said polio virus samples were found in sewage water from eight boroughs of London, but there were no confirmed infections.

Still, the agency’s analysis showed transmission has likely “gone beyond a close network of a few individuals.”

“We know the areas in London where the poliovirus is being transmitted have some of the lowest vaccination rates,” said Dr. Vanessa Saliba, a consultant epidemiologist at the U.K. Health Security Agency. 

WATCH | Hundreds could be infected with polio in New York state, officials say:

100s could be infected with polio in New York, health officials say

1 day ago

Duration 2:19

A health official in New York State says hundreds of people could be infected with the polio virus.

The agency said it was working closely with health authorities in the U.S. and Israel, as well as the World Health Organization, to investigate the links between polio viruses detected in those two countries. 

In July, Israel announced a recent outbreak of polio infections appeared to be under control, after multiple people became infected, including a Jerusalem girl who was paralyzed and now requires rehabilitation, according to the Jerusalem Post.

More recently, in the state of New York, one unvaccinated young adult suffered paralysis after a polio infection in Rockland County — an area known for low vaccination rates — which marked the first case reported in the U.S. in nearly a decade. 

Vaccination campaigns are now underway as samples of the virus were also detected in the wastewater of both Rockland and another county, just north of New York City. Officials also say hundreds more people may already be infected.

“The scope may be even much larger than we can even fathom or imagine,” said New York-based immunologist Dr. Purvi Parikh.

“Because vaccines have become the victim of their own success, we don’t see it — so we may not even realize what the spread of polio is, because for the majority of us who are vaccinated, it doesn’t really [affect] us.”

Outbreaks do still happen in certain countries

Before mass vaccination campaigns largely wiped out polio from circulation in higher-income countries like Canada between the 1950s and early 1990s, the virus was known for sparking outbreaks and striking children, causing paralysis or death in some cases.

Even now, war, poverty, and social unrest make it difficult to achieve eradication in many countries around the world. Outbreaks remain common in Afghanistan, Pakistan, and parts of Africa.

Parikh said polio cases aren’t entirely a surprise in any community where vaccination rates are lower, either due to anti-vaccine sentiments or disruptions to routine immunizations during the COVID-19 pandemic.

“Now the concern is, some of these infectious diseases that we haven’t seen in nearly decades may actually come back and pose to be a problem,” she said.

Part of the challenge in wiping polio out around the world actually comes from the vaccination approach used in certain regions. While higher-income countries now use an inactivated poliovirus vaccine given as a traditional shot, others rely on a weakened poliovirus that’s easy to administer by mouth.

Both types of vaccines helped curb global transmission and, crucially, neither one is capable of giving someone a case of symptomatic polio.

Colourized electron micrograph of the poliovirus, taken in 1975. (U.S. Centers for Disease Control and Prevention)

However, since the oral version winds up in the stomach, it’s eventually flushed out of the body into wastewater systems — where, over time, the virus can evolve back into a form that’s able to cause disease.

“So if you have a shedding of that particular virus and transmission of that in a community, it can cause a polio outbreak,” said Dr. Isaac Bogoch, an infectious diseases specialist with the University Health Network in Toronto.

“And in fact, if you look at many parts of the world, there have been small outbreaks of vaccine-derived polio.”

‘Polio is only a plane trip away’

Lab testing conducted on the case in New York, for instance, linked the virus samples to transmission from someone who’d received the oral vaccine, which hasn’t been used in the U.S. since 2000. “This suggests that the virus may have originated in a location outside of the U.S. where [the oral vaccine] is administered,” officials said.

In London, out of more than 100 polio samples identified in sewage, most were vaccine-like virus, according to the UK Health Security Agency, while others had enough mutations to be more like “wild” polio that can cause serious health impacts.

Global travel between countries with high rates of polio transmission and regions with lagging vaccination rates could pose a problem going forward, said Wes Hazlitt, a Winnipeg polio survivor, advocate, and president of the Post-Polio Network in Manitoba.

“Polio,” he added, “is only a plane trip away.”

Another challenge in tackling outbreaks stems from this virus’s ability to spread undetected, experts say, with most people unaware they’re even infected — leaving countries vulnerable to slow-growing outbreaks before any patients show up with major disease and paralysis.

“Most people will have no symptoms or mild symptoms, but about one in 200 or so will have significant symptoms,” Bogoch said.

WATCH | 1953, the year polio last stalked Canada: 

A history of polio in Canada

29 years ago

Duration 23:24

A look back 40 years later at the year 1953, when polio last stalked Canada. Aired on CBC’s Prime Time News on Dec. 7, 1993.

Under-vaccinated communities remain at risk

So when it comes to experiencing a future polio outbreak, how at risk is Canada? That all depends on vaccination rates both now and in the future, multiple medical experts said.

“If you start not vaccinating the kids from the primary series — like the measles, mumps, rubella, diphtheria, tetanus, pertussis, polio — then you risk those diseases coming back,” warned Dr. Anna Banerji, a pediatrician and infectious disease specialist in Toronto.

A vast majority of the Canadian public has been vaccinated against polio, and while immunization rates among children ebb and flow, the latest available federal data from 2017 shows roughly 90 per cent of toddlers had all three required polio shots. 

But that coverage isn’t uniform across the country. Polio vaccination rates were below 90 per cent in British Columbia and Manitoba, and close to just 80 per cent in Nunavut, while uptake in specific communities can vary and may have been disrupted by COVID-19 school closures.

Polio wards were lined not only with beds but with iron lungs, large metal ventilators that helped patients to breathe during the worst of the infection. Some survivors never regained lung function and spent the rest of their lives in the devices. (U.S. Food and Drug Administration)

“We do have our issues in Canada, with under-vaccinated communities for a variety of reasons, and a lot of this predates COVID-19,” said Bogoch, adding many public health teams across the country did offer immunization programs throughout the pandemic to get children caught up.

While pockets of the population could remain vulnerable to polio infection, Fatima Tokhmafshan, a researcher and geneticist at the Research Institute of the McGill University Health Centre, said most Canadians shouldn’t be overly concerned.

“If you see something circulating, it’s good to be on your guard, but not panicking,” she said. 

“So it’s important to keep an eye out. And reach out to your network, to your friends, your family — make sure everybody’s vaccinated.”

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Quebec rejects plea to send army to northern region facing health worker shortage

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MONTREAL — Quebec’s Health Department has rejected a request from officials in the northern region of Nunavik to have Armed Forces members brought in to help ease a shortage of health-care workers.

Kathleen Poulin, a spokeswoman for Nunavik Regional Board of Health, said Wednesday that labour shortages in the health sector are hitting Nunavik particularly hard due to the region’s “remoteness and its specific characteristics.”

“In some of the smaller villages that have only two to four nurses, the briefest absence can require a complete reorganization of activities in order to maintain services,” Poulin said in a statement.

“Considering the sizes of the communities, a handful of (additional) health-care workers can make a big difference in the level of services offered to the population.”

The health board, Poulin said, has been asking Quebec in recent weeks to supply medical workers. That included a request that Ottawa send Armed Forces members who can provide health care after some of Nunavik’s 14 Indigenous communities were forced over the summer to limit their services to emergencies only.

Health Minister Christian Dubé told reporters on Wednesday he would “soon” travel to the region to assess the situation, adding that Quebec has a “contingency plan” to handle the crisis.

“We have five or six paramedics already on their way, and doctors from other provinces that offered to help,” Dubé said.

The department, however, opted to seek the Canadian Red Cross’s help in Nunavik rather than the army, Dubé said, as the organization “helped a lot during the pandemic.” The department said the request for Armed Forces support was received Aug. 2.

“It’s a question of who’s the best and most appropriate group to complete our staff,” Dubé said. “The situation is already better than what it was.”

But Charlie Lapointe-Robert, a nurse who works in Inukjuak at the Inuulitsivik Health Centre, said Dubé’s statement is misleading. She said rather than being able to offer proper care to the community, health-care workers are forced to tell residents to “be careful.”

“We’re the ones who are supposed to take care of them,” Lapointe-Robert said in an interview on Wednesday, adding that her health centre still doesn’t know when to expect help from the government.

“We are accumulating delays, blood tests that need to be done, children’s vaccinations, followups, cancer prevention that isn’t done .… The situation is not better than it was. We are heading toward a greater crisis.”

The labour shortage in Nunavik’s health sector is not new — and neither are the requests for government action, Lapointe-Robert said.

The nurse, who’s currently on vacation in Montreal, said she doesn’t understand why it took so long to create a contingency plan as it is now a matter of days before the community could be left with no nurses on duty.

“We are on a tightrope, there is a risk of error and incredible tragedy,” she said, adding that normally up to six nurses are working in Inukjuak.

Poulin said a labour shortage affecting the entire province has left nursing agencies unable to meet the demand.

“Summer means vacation for many. It is necessary for the workers to take some time off, mostly after two years of COVID-19. Again, just a few people more or less make a big difference.”

The union representing nurses in the northern region, the Syndicat nordique des infirmières et infirmiers de la Baie d’Hudson, said it has been warning the government about the situation since last year.

“We are in a G7 country and I believe that the Inuit communities of Hudson Bay have a right to quality health care,” union president Cyril Gabreau said on social media. “Actions could have been taken yesterday to avoid tomorrow’s catastrophe.”

This report by The Canadian Press was first published on Aug. 10, 2022.

This story was produced with the financial assistance of the Meta and Canadian Press News Fellowship.

 

Virginie Ann, The Canadian Press

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