Health
Risk of dangerous blood clots linked to moderate COVID-19; high-dose blood thinner can prevent clots
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The following is a summary of some recent studies on COVID-19. They include research that warrants further study to corroborate the findings and that have yet to be certified by peer review.
Dangerous blood clot can occur in moderate COVID-19
A European study has found an elevated risk of a life-threatening blood clot called venous thromboembolism(VTE) in covid-19 patients who were not critically ill. The blood clot risk had previously been associated with severe COVID-19. The researchers tracked 2,292 patients who came to hospital emergency rooms with mild or moderate COVID-19 but without VTE. Four weeks later, VTE had developed in roughly 1 of every 200 mildly ill patients who had not been hospitalized and nearly 5 of every 200 moderately ill patients overall, the researchers reported on Friday in Thrombosis Research https://bit.ly/3v4YHUO. They conclude that doctors caring for mildly and moderately ill COVID-19 patients need to be aware of these risks, “especially in patients with moderate COVID-19 requiring hospitalization.”
High-dose blood thinners prevent clots in moderate COVID-19
In hospitalized, moderately ill COVID-19 patients who have high levels of the d-dimer protein in their blood – indicating a higher-than-average risk for dangerous blood clots – treatment with high doses of the blood thinner low-molecular weight heparin (LMWH) significantly reduced the odds of clot formation and death, according to data from a clinical trial. The incidence of venous thromboembolism (VTE) or death was 28.7% in the high-dose group, compared to 41.9% in patients getting a standard dose. After accounting for patients’ various risk factors, that was a 32% reduction in risk with high-dose heparin, the researchers said on Monday in a report published in JAMA Internal Medicine https://bit.ly/3lsXPWB. The researchers said they launched the trial “because we saw patients getting blood clots and dying in front of us while on standard doses of preventative heparin,” said study leader Dr. Alex Spyropoulos of the Feinstein Institutes for Medical Research in New York. “We were able to prove … that d-dimer levels more than four times the upper limit of normal are able to predict a very high-risk group of hospitalized COVID-19 patients – and giving therapeutic doses of heparin in these patients works,” Spyropoulos said. “This is practice changing now.”
Click for a Reuters graphic https://tmsnrt.rs/3c7R3Bl on vaccines in development.
(Reporting by Nancy Lapid and Megan Brooks; Editing by Bill Berkrot)
Health
RCMP warn about benzodiazepine-laced fentanyl tied to overdose in Alberta – Edmonton Journal
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Grande Prairie RCMP issued a warning Friday after it was revealed fentanyl linked to a deadly overdose was mixed with a chemical that doesn’t respond to naloxone treatment.
The drugs were initially seized on Feb. 28 after a fatal overdose, and this week, Health Canada reported back to Mounties that the fentanyl had been mixed with Bromazolam, which is a benzodiazepine.
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Mounties say this is the first recorded instance of Bromazolam in Alberta. The drug has previously been linked to nine fatal overdoses in New Brunswick in 2022.
The pills seized in Alberta were oval-shaped and stamped with “20” and “SS,” though Mounties say it can come in other forms.
Naloxone treatment, given in many cases of opioid toxicity, is not effective in reversing the effects of Bromazalam, Mounties said, and therefore, any fentanyl mixed with the benzodiazepine “would see a reduced effectiveness of naloxone, requiring the use of additional doses and may still result in a fatality.”
From January to November of last year, there were 1,706 opioid-related deaths in Alberta, and 57 linked to benzodiazepine, up from 1,375 and 43, respectively, in 2022.
Mounties say officers responded to about 1,100 opioid-related calls for service, last year with a third of those proving fatal. RCMP officers also used naloxone 67 times while in the field, a jump of nearly a third over the previous year.
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Health
CFIA continues surveillance for HPAI in cattle, while sticking with original name for disease – RealAgriculture
The Canada Food Inspection Agency will continue to refer to highly pathogenic avian influenza in cattle as HPAI in cattle, and not refer to it as bovine influenza A virus (BIAV), as suggested by the American Association of Bovine Practitioners earlier this month.
Dr. Martin Appelt, senior director for the Canadian Food Inspection Agency, in the interview below, says at this time Canada will stick with “HPAI in cattle” when referencing the disease that’s been confirmed in dairy cattle in multiple states in the U.S.
The CFIA’s naming policy is consistent with the agency’s U.S. counterparts’, as the U.S. Animal and Plant Health Inspection Service has also said it will continue referring to it as HPAI or H5N1.
Appelt explains how the CFIA is learning from the U.S. experience to-date, and how it is working with veterinarians across Canada to stay vigilant for signs of the disease in dairy and beef cattle.
As of April 19, there has not been a confirmed case of HPAI in cattle in Canada. Appelt says it’s too soon to say if an eventual positive case will significantly restrict animal movement, as is the case with positive poultry cases.
This is a major concern for the cattle industry, as beef cattle especially move north and south across the U.S. border by the thousands. Appelt says that CFIA will address an infection in each species differently in conjunction with how the disease is spread and the threat to neighbouring farms or livestock.
Currently, provincial dairy organizations have advised producers to postpone any non-essential tours of dairy barns, as a precaution, in addition to other biosecurity measures to reduce the risk of cattle contracting HPAI.
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Health
Toronto reports 2 more measles cases. Use our tool to check the spread in Canada – Toronto Star
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Canada has seen a concerning rise in measles cases in the first months of 2024.
By the third week of March, the country had already recorded more than three times the number of cases as all of last year. Canada had just 12 cases of measles in 2023, up from three in 2022.
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