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Secrets of ‘SuperAgers’ with superior memories into their 80s

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Despite volunteering and working out at the gym several days each week, socializing frequently with friends and family, reading all manner of books and doing daily crossword puzzles, 85-year-old Carol Siegler is restless.

 

85-year-old Carol Seigler is a SuperAger

 



 

“I’m bored. I feel like a Corvette being used as a grocery cart,” said Siegler, who lives in the Chicago suburb of Palatine.

Siegler is a cognitive “SuperAger,” possessing a brain as sharp as people 20 to 30 years younger. She is part of an elite group enrolled in the Northwestern SuperAging Research Program, which has been studying the elderly with superior memories for 14 years. The program is part of the Mesulam Center for Cognitive Neurology and Alzheimer’s Disease at Northwestern University Feinberg School of Medicine in Chicago.

“I’ve auditioned twice for ‘Jeopardy!’ and did well enough on it to be invited to the live auditions. Then Covid hit,” said Siegler.

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“Who knows how well I would have done,” she added with a chuckle. “What I have told my children and anybody else who asked me: ‘I may know an awful lot about Beethoven and Liszt, but I know very little about Beyoncé and Lizzo.'”

What is a SuperAger?

To be a SuperAger, a term coined by the Northwestern researchers, a person must be over 80 and undergo extensive cognitive testing. Acceptance in the study only occurs if the person’s memory is as good or better than cognitively normal people in their 50s and 60s.

 

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“SuperAgers are required to have outstanding episodic memory — the ability to recall everyday events and past personal experiences — but then SuperAgers just need to have at least average performance on the other cognitive tests,” said cognitive neuroscientist Emily Rogalski, a professor of psychiatry and behavioral sciences at Feinberg School of Medicine.

Only about 10% of people who apply to the program meet those criteria, said Rogalski, who developed the SuperAger project.

“It’s important to point out when we compare the SuperAgers to the average agers, they have similar levels of IQ, so the differences we’re seeing are not just due to intelligence,” she said.

Carol Seigler

 

SuperAger Carol Seigler is shown with her grandchildren (from left): Alex Siegler, 23; Elizabeth Siegler, 27; Carol Siegler, 85; Megan Boyle, 18; Conor Boyle, 17; Jacob Siegler, 29.

 



 

Once accepted, colorful 3D scans are taken of the brain and cognitive testing and brain scans are repeated every year or so. Analysis of the data over the years have yielded fascinating results.

Bigger, tau-free neurons

Most people’s brains shrink as they grow older. In SuperAgers, however, studies have shown the cortex, responsible for thinking, decision-making and memory, remains much thicker and shrinks more slowly than those of people in their 50s and 60s.

 

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A SuperAger’s brain, usually donated to the research program by participants after death, also has bigger, healthier cells in the entorhinal cortex. It’s “one of the first areas of the brain to get ‘hit’ by Alzheimer’s disease,” said Tamar Gefen, an assistant professor of psychiatry and behavioral sciences at Northwestern, in an email.

The entorhinal cortex has direct connections to another key memory center, the hippocampus, and “is essential for memory and learning,” said Gefen, the lead author of a November study comparing the brains of deceased SuperAgers with those of older and younger cognitively normal people and people diagnosed with early Alzheimer’s.

Carol Seigler

 

Carol Seigler learned to read at a young age.

 



 

SuperAger brains had three times fewer tau tangles, or abnormal formations of protein within nerve cells, than the brains of cognitively healthy controls, the study also found. Tau tangles are a hallmark sign of Alzheimer’s and other dementias.

“We believe that larger neurons in the entorhinal cortex suggest that they are more ‘structurally sound’ and can perhaps withstand neurofibrillary tau tangle formation,” Gefen said.

Gefen also found the brains of SuperAgers had many more von economo neurons, a rare type of brain cell, which so far has been found in humans, great apes, elephants, whales, dolphins and songbirds. The corkscrew-like von economo neurons are thought to allow rapid communication across the brain. Another theory is that the neurons give humans and great apes an intuitive advantage in social situations.

The von economo neurons were found in the anterior cingulate cortex, which forms a collar in the front of the brain linking the cognitive, reasoning side with the emotional, feeling side. The anterior cingulate is thought to be important for regulating emotions and paying attention — another key to good memory.

Taken together, these discoveries appear to point to a genetic link to becoming a SuperAger, Gefen said. However, she added: “The only way to confirm whether SuperAgers are born with larger entorhinal neurons would be to measure these neurons from birth until death. That obviously isn’t possible.”

Can environment play a role?

SuperAgers share similar traits, said Rogalski, who is also the associate director of the Mesulam Center for Cognitive Neurology and Alzheimer Disease at Feinberg. These folks stay active physically. They tend to be positive. They challenge their brain every day, reading or learning something new — many continue to work into their 80s. SuperAgers are also social butterflies, surrounded by family and friends, and can often be found volunteering in the community.

 

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“When we compare SuperAgers to normal agers we see that they tend to endorse more positive relations with others,” Rogalski said.

“This social connectedness may be a feature of SuperAgers that distinguishes them from those who are still doing well but who are what we would call an average or normal ager,” she said.

Looking back at her life, Carol Siegler recognizes many SuperAger traits. As a young child during the Great Depression, she taught herself to spell and play piano. She learned to read Hebrew at her grandfather’s knee, poring over his weekly Yiddish newspaper.

“I have a great memory. I’ve always had it,” Siegler said. “I was always the kid that you could say, ‘Hey, what’s Sofia’s phone number?’ and I would just know it off the top of my head.”

She graduated from high school at 16 and immediately went to college. Siegler got her pilot’s license at age 23 and later started a family business in her basement that grew to have 100 employees. At 82, she won the American Crossword Puzzle Tournament for her age group, which she said she entered “as a gag.”

After seeing an advertisement for the SuperAger program on television, Siegler thought it too sounded like fun. Being chosen as a SuperAger was a thrill, Siegler said, but she is aware she was born lucky.

“Somebody with the same abilities or talents as a SuperAger who lived in a place where there was very little way to express them, might never know that he or she had them,” she said. “And that is a true shame.”

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We all experience stress. How we handle it is key to our health, say experts – CBC.ca

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The Dose24:36What’s the connection between stress and my health and well-being?

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It could be a morning traffic jam. A deadline at work. A conflict with a family member. Taking care of kids and aging parents. 

Stressful situations are all around us, and experts say how we manage stress is key to preventing it from causing long-term health problems — both physical and mental. 

Short-term stress doesn’t have to be negative, but research shows that ongoing stress wears away at the body’s systems and can lead to an increased risk of heart attack, stroke, Type 2 Diabetes, and mental health challenges.

“It’s like walking around with a ten or fifteen-pound weight continually on your back and not being able to shed that weight,” psychologist Dr. Zindel Segal told Dr. Brian Goldman, host of CBC’s The Dose

There are techniques and strategies to decrease that stressful load, however, and lessen the impact of stress on the body and the mind. 

Is stress good or bad? 

Stress means that we are unable to use our personal or social resources to meet the demands being placed on us, said Dr. Eli Puterman, a health psychologist and associate professor in the school of kinesiology at UBC. 

But not all stress is bad stress, said Puterman. 

“It sometimes can motivate you to also move in the direction of, ‘Let’s change our goals,'” he said. 

From an evolutionary perspective, our bodies are engineered to handle stress, said Segal, a distinguished professor of psychology and mood disorders at the University of Toronto Scarborough. 

But after the stress response, we need a period of rest and recovery, which allows the body to recoup the resources that were used up during the stressful situation. 

Chronic stress is when we’re unable to step out of the situation and take advantage of our own natural capacity to restore, said Segal. 

It’s a system that is “stuck in the fifth gear without the ability to downshift,” he said. 

Connecting with your senses

The first step to managing stress is recognizing it, said Segal, and that means tuning into our bodies. 

“Are you noticing that maybe your heart is racing, or that your palms are sweating, or that your temple and forehead are pounding?” he said. 

Grounding techniques can anchor us in the present moment and help pull us away from intrusive thoughts or feelings to take a broader view of the situation, said Segal. 

Deep breathing and meditation can both help you tune into your senses during stressful moments. (Maggie MacPherson/CBC)

“One of the things that we lose the ability to connect with is the sensory world,” he said, which is why so many techniques for managing stress are about reconnecting with your senses. 

“Sensations are a way of actually helping us step out of thinking, to ground ourselves.” 

A breath of fresh air 

Doing yoga, meditating, exercising and deep breathing can all help ground us in our bodies and change our perspectives on stress, said Segal. 

However, stress can cause barriers to being physically active, said Puterman, so he prefers to think about moving our bodies as opposed to exercising. 

“Getting outside and going for some walks for 10, 15 minutes per day can help us start having those moments where we’re taking care of our bodies,” he said. 

LISTEN | Try this guided exercise in box breathing with Dr. Zindel Segal: 

The Dose1:50A guided exercise in box breathing

One simple exercise Segal recommends is a technique called box breathing. Here’s how to try it: 

  • Sit in a chair and notice the sensations of sitting: the feet pressing down into the floor, the hands folded in the lap or on the thighs. 
  • Breathe in for four beats (visualize the left side of the box). 
  • Hold for four beats (visualize the top of the box).
  • Breathe out for four beats (visualize the right side of the box). 
  • Hold for four beats (visualize the bottom of the box). 
  • Repeat as many times as you like. 

What stress does to the body 

It may be easy to understand how stress can take an emotional and mental toll, but research also shows that stress can have an impact on our physical health — including an increased risk of heart attack or stroke. 

“In the short term, it rapidly increases your blood pressure, which can potentially result in a tear in the plaque that is in your arteries and then subsequently cause a heart attack or a stroke,” said Dr. Hassan Mir, a cardiologist at the Ottawa Heart Institute. 

When we’re feeling stress, it activates our sympathetic nervous system, the part of our nervous system that carries signals related to our fight-or-flight response. 

That can cause an increase in our blood pressure and heart rate, said Mir. 

Another reaction to acute stress is a condition called takotsubo cardiomyopathy, or a weakened heart muscle, he said.

“When you’re really stressed, you can have this release of adrenaline in your body,” Mir said. 

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Mir has seen people who come into the hospital because their partner had a cardiac arrest, and then they suddenly get rushed to the ER because it looks like they’re having a heart attack. 

“You go and look inside and the coronary arteries look completely fine, but their heart muscle looks like it’s completely weakened,” Mir said. 

If you’re frequently activating your sympathetic nervous system due to stress, that can cause other issues in the body, said Puterman. 

“If you’re starting to shift your baseline of the functioning of your physiology, you’re now entering the state where now you have too much cortisol that’s then activating too much glucose release,” he said. 

Too much glucose released into the body can cause people to enter a pre-diabetes state, said Puterman. 

How much stress is too much?  

A little bit of stress could help us handle more stressful events in the future, a theory called the inoculation hypothesis, said Puterman. 

“Some stress on a daily basis or in life actually inoculates you to future exposures to stressors,” he said. 

But there are some telltale signs that the stress you’re experiencing is causing harmful effects, said Puterman. They include: 

  • Not sleeping well.
  • Not getting as much exercise as usual.
  • Consuming more alcohol or drugs.
  • Withdrawing from others socially.
  • Getting into more arguments with family or friends.

The trick is finding that sweet spot, said Segal, between having enough stress and too much. 

“We don’t want to tip over into a point where the stress that we’re facing is overwhelming,” Segal said. 

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Medical officer encourages measles vaccinations as global cases rise – SteinbachOnline.com

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As cases of measles are increasing in parts of Canada and around the world, Manitobans are reminded that staying up to date on their vaccinations is one of the most important ways to prevent and reduce the risk of measles and other serious illnesses. 

Measles is very contagious, says Dr. Mahmoud Khodaveisi, Medical Officer of Health for Southern Health-Santé Sud. 

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The most recognized symptom of measles is a red, blotchy rash, which often begins on the face and spreads down the body. Other common symptoms include fever, runny nose, cough, drowsiness, irritability and red eyes. Measles is a serious illness, especially for young children, and can result in lung and brain infections and other conditions that lead to serious complications or death. 

Although there have been no recent confirmed cases of measles in our province since 2019, there is increasing concern as the number of cases are rising in Canada and around the world. 

Dr. Khodaveisi says that before the vaccine was available, measles was a significant cause of childhood illness, and as a result, people born before 1970 are considered immune to measles as they were likely exposed growing up. 

As part of Manitoba’s routine immunization schedule, children can receive two doses of a vaccine that protects against measles, first at 12 months and again between the ages of four and six. Together, these doses provide 97 per cent protection against measles. 

The province reports that the most recent data available shows that about 80 per cent of children in Manitoba have received one dose of the vaccine that protects against measles by age two. Nearly 75 per cent of children have received two doses of the vaccine by age seven and this rate increases to over 88 per cent by the age of 17. 

The province has sent information out about measles to health-care providers. 

Measles is a reportable disease, meaning public health must be informed about cases by laboratories and health-care providers. Once a case is reported, public health will launch an investigation. This includes identifying close contacts, offering vaccination where appropriate and notifying the public of relevant exposures if needed. 

Manitoba’s immunization registry was established in 1988, so records for anyone who has received immunizations since then should be contained in the registry. 

If you are not sure if you or your children have been vaccinated, immunization records can be requested online at https://forms.gov.mb.ca/immunization-update-request/. Alternatively, you can contact your local public health office or contact your health-care provider.

-With files from Corny Rempel. 

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Measles in Toronto: 2nd case confirmed

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A second lab-confirmed case of measles has been identified in Toronto.

The city’s public health agency said that an infant who recently returned from travel has contracted the disease. The child is recovering at home.

The first Toronto case was identified on Feb. 16.

Toronto Public Health is warning that anyone who attended the Agincourt Public Library between 1 p.m. and 5:30 p.m. on March 11 may have been exposed. Individuals should monitor for symptoms until April 1 and double check that their vaccinations are up to date.

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Symptoms of measles include red rashes, fever, cough, runny nose, red eyes and fatigue. Individuals can also get unusual white spots in their mouth.

The number of measles infections in Ontario so far this year has already surpassed the total number of cases reported in 2023.

As of March 13, Public Health Ontario had confirmed at least eight cases of measles across the province. Cases have been identified in Peel Region, Hamilton, Brant County and Windsor-Essex County.

Of those infections, six were related to travel and two had an unknown source of exposure.

In 2023, there were seven cases of measles confirmed in Ontario.

Canada-wide data is less detailed, with the Public Health Agency of Canada reporting 17 cases of measles as of March 2, along with one case of congenital rubella syndrome.

 

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