Spreading version of Omicron resists all but one drug; T cell defense vs Omicron deficient in some | Canada News Media
Connect with us

Health

Spreading version of Omicron resists all but one drug; T cell defense vs Omicron deficient in some

Published

 on

The following is a summary of some recent studies on COVID-19. They include research that warrants further study to corroborate the findings and that has yet to be certified by peer review.

Spreading version of Omicron resists all but one new drug

Until Friday, just one COVID-19 antibody drug has been effective against the Omicron variant – sotrovimab from Vir Biotechnology and GSK – and that drug is unlikely to do as well against at least one new version of the variant spreading globally, new research suggests.

An antibody drug approved on Friday by the U.S. Food and Drug Administration does show promise when tested against “sublineages,” or subvariants, of Omicron, the research found.

The World Health Organization is monitoring several Omicron subvariants. Data posted on Wednesday on bioRxiv ahead of peer review showed that the rapidly spreading BA.2 subvariant “exhibited marked resistance” to sotrovimab in lab experiments, researchers said. Britain-based GSK announced on Thursday, without formally releasing any data, that its drug does retain the ability to neutralize BA.2 in a test tube. David Ho of Columbia University, senior author of the bioRxiv report, said his research “also showed that sotrovimab still has activity against BA.2, consistent with their statement. But its activity is down substantially, 27-fold as stated in our preprint.” In repeat experiments, the drop was even more pronounced, he said of testing done after the paper was submitted.

The drug approved on Friday – bebtelovimab, from Eli Lilly, remained potent in neutralizing all Omicron subvariants, Ho’s team said.

Two antibody drugs from AstraZeneca – cilgavimab and tixagevimab – did remain effective against BA.2, but they are only approved for preventing COVID-19 in certain circumstances, not for treating it.

 

Second-line Omicron immune defense deficient in some people

T cells, a key component of the body’s immune defenses, may not work well against the Omicron variant in some people, according to new research.

T cells learn to recognize germs either during natural infection or after vaccination. When invading organisms slip past antibodies, T cells launch an attack to prevent severe illness. Researchers studying 76 volunteers found that most individuals’ T cells continued to defend against Omicron even when their antibodies did not, regardless of the source of the antibodies, including from booster shots. But about 20% of people had more than a 50% reduction in their T cell response to Omicron, compared to responses to earlier variants, the researchers reported in Cell. This “surprising” finding might be due to genetic differences, said Dr. Gaurav Gaiha of the Ragon Institute of MGH, MIT and Harvard.

What the decrease in T cell recognition of Omicron means is unclear, “but it is possible that these individuals will have reduced protection against severe disease,” Gaiha said. It could also mean SARS-CoV-2 “can evolve to escape even T cells, so we have to continue work on vaccines that may be resistant to future variants, and keep taking sensible precautions like mask-wearing and testing,” added Gaiha, who noted that vaccine boosters “dramatically increased the T cell response to Omicron by 20 times.”

 

New or persistent health problems follow COVID-19 in seniors

Older adults infected with SARS-CoV-2 before vaccines were available were at higher-than-average risk for needing medical care for a persistent or new problem in the months afterward, according to a report published on Wednesday in The BMJ.

Researchers studied nearly 133,000 Americans over age 65 who had coronavirus infections in 2020 and a roughly equal number of closely matched uninfected individuals. Nearly one-in-three COVID-19 patients sought medical attention at least three weeks after diagnosis for a new or persistent condition, an 11% higher rate than researchers saw in the comparison group. The COVID-19 patients were at increased risk for respiratory failure (an additional 7.6 cases per 100 people), fatigue (an extra 5.7 per 100 people), high blood pressure (an extra 4.4 per 100 people), and mental health diagnoses (an extra 2.5 per 100 people), the researchers found. When the COVID patients were compared to people previously infected with other respiratory viruses, like flu, only new problems with respiratory failure, dementia, and fatigue were more common after COVID-19.

Although hospitalized patients were at higher risk for new or persistent problems, “the larger population… who did not require admission to hospital for COVID-19 were still at risk,” the researchers said.

 

For a graphic on vaccines in development: https://graphics.reuters.com/HEALTH-CORONAVIRUS/VACCINE-TRACKER/xegpbqnlovq/

 

(Reporting by Nancy Lapid; Editing by Bill Berkrot and Grant McCool)

Health

Canada to donate up to 200,000 vaccine doses to combat mpox outbreaks in Africa

Published

 on

 

The Canadian government says it will donate up to 200,000 vaccine doses to fight the mpox outbreak in Congo and other African countries.

It says the donated doses of Imvamune will come from Canada’s existing supply and will not affect the country’s preparedness for mpox cases in this country.

Minister of Health Mark Holland says the donation “will help to protect those in the most affected regions of Africa and will help prevent further spread of the virus.”

Dr. Madhukar Pai, Canada research chair in epidemiology and global health, says although the donation is welcome, it is a very small portion of the estimated 10 million vaccine doses needed to control the outbreak.

Vaccine donations from wealthier countries have only recently started arriving in Africa, almost a month after the World Health Organization declared the mpox outbreak a public health emergency of international concern.

A few days after the declaration in August, Global Affairs Canada announced a contribution of $1 million for mpox surveillance, diagnostic tools, research and community awareness in Africa.

On Thursday, the Africa Centres for Disease Control and Prevention said mpox is still on the rise and that testing rates are “insufficient” across the continent.

Jason Kindrachuk, Canada research chair in emerging viruses at the University of Manitoba, said donating vaccines, in addition to supporting surveillance and diagnostic tests, is “massively important.”

But Kindrachuk, who has worked on the ground in Congo during the epidemic, also said that the international response to the mpox outbreak is “better late than never (but) better never late.”

“It would have been fantastic for us globally to not be in this position by having provided doses a much, much longer time prior than when we are,” he said, noting that the outbreak of clade I mpox in Congo started in early 2023.

Clade II mpox, endemic in regions of West Africa, came to the world’s attention even earlier — in 2022 — as that strain of virus spread to other countries, including Canada.

Two doses are recommended for mpox vaccination, so the donation may only benefit 100,000 people, Pai said.

Pai questioned whether Canada is contributing enough, as the federal government hasn’t said what percentage of its mpox vaccine stockpile it is donating.

“Small donations are simply not going to help end this crisis. We need to show greater solidarity and support,” he said in an email.

“That is the biggest lesson from the COVID-19 pandemic — our collective safety is tied with that of other nations.”

This report by The Canadian Press was first published Sept. 13, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

Source link

Continue Reading

Health

How many Nova Scotians are on the doctor wait-list? Number hit 160,000 in June

Published

 on

 

HALIFAX – The Nova Scotia government says it could be months before it reveals how many people are on the wait-list for a family doctor.

The head of the province’s health authority told reporters Wednesday that the government won’t release updated data until the 160,000 people who were on the wait-list in June are contacted to verify whether they still need primary care.

Karen Oldfield said Nova Scotia Health is working on validating the primary care wait-list data before posting new numbers, and that work may take a matter of months. The most recent public wait-list figures are from June 1, when 160,234 people, or about 16 per cent of the population, were on it.

“It’s going to take time to make 160,000 calls,” Oldfield said. “We are not talking weeks, we are talking months.”

The interim CEO and president of Nova Scotia Health said people on the list are being asked where they live, whether they still need a family doctor, and to give an update on their health.

A spokesperson with the province’s Health Department says the government and its health authority are “working hard” to turn the wait-list registry into a useful tool, adding that the data will be shared once it is validated.

Nova Scotia’s NDP are calling on Premier Tim Houston to immediately release statistics on how many people are looking for a family doctor. On Tuesday, the NDP introduced a bill that would require the health minister to make the number public every month.

“It is unacceptable for the list to be more than three months out of date,” NDP Leader Claudia Chender said Tuesday.

Chender said releasing this data regularly is vital so Nova Scotians can track the government’s progress on its main 2021 campaign promise: fixing health care.

The number of people in need of a family doctor has more than doubled between the 2021 summer election campaign and June 2024. Since September 2021 about 300 doctors have been added to the provincial health system, the Health Department said.

“We’ll know if Tim Houston is keeping his 2021 election promise to fix health care when Nova Scotians are attached to primary care,” Chender said.

This report by The Canadian Press was first published Sept. 11, 2024.

The Canadian Press. All rights reserved.

Source link

Continue Reading

Health

Newfoundland and Labrador monitoring rise in whooping cough cases: medical officer

Published

 on

 

ST. JOHN’S, N.L. – Newfoundland and Labrador‘s chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.

Dr. Janice Fitzgerald says that so far this year, the province has recorded 230 confirmed cases of the vaccine-preventable respiratory tract infection, also known as pertussis.

Late last month, Quebec reported more than 11,000 cases during the same time period, while Ontario counted 470 cases, well above the five-year average of 98. In Quebec, the majority of patients are between the ages of 10 and 14.

Meanwhile, New Brunswick has declared a whooping cough outbreak across the province. A total of 141 cases were reported by last month, exceeding the five-year average of 34.

The disease can lead to severe complications among vulnerable populations including infants, who are at the highest risk of suffering from complications like pneumonia and seizures. Symptoms may start with a runny nose, mild fever and cough, then progress to severe coughing accompanied by a distinctive “whooping” sound during inhalation.

“The public, especially pregnant people and those in close contact with infants, are encouraged to be aware of symptoms related to pertussis and to ensure vaccinations are up to date,” Newfoundland and Labrador’s Health Department said in a statement.

Whooping cough can be treated with antibiotics, but vaccination is the most effective way to control the spread of the disease. As a result, the province has expanded immunization efforts this school year. While booster doses are already offered in Grade 9, the vaccine is now being offered to Grade 8 students as well.

Public health officials say whooping cough is a cyclical disease that increases every two to five or six years.

Meanwhile, New Brunswick’s acting chief medical officer of health expects the current case count to get worse before tapering off.

A rise in whooping cough cases has also been reported in the United States and elsewhere. The Pan American Health Organization issued an alert in July encouraging countries to ramp up their surveillance and vaccination coverage.

This report by The Canadian Press was first published Sept. 10, 2024.

The Canadian Press. All rights reserved.

Source link

Continue Reading

Trending

Exit mobile version