The risk to young, healthy participants, the argument goes, is small to start with and offset by the potentially massive benefit to society
Health
Support grows for deliberately exposing vaccine trial subjects to COVID-19, with Oxford team leading the way – Sarnia Observer
It began as a proposal on the fringes of science: deliberately exposing people to COVID-19 to speed up development of vaccines, even though there’s no sure-fire treatment for the potentially lethal bug.
But the controversial idea of so-called challenge trials to test coronavirus shots seems to be picking up steam, with one huge endorsement pushing the concept ahead in recent days.
Scientists at Oxford University, which published promising early results of its would-be vaccine Monday, say they’re actively planning a challenge study.
The Oxford team is working with an unusual grass-roots group, 1DaySooner, that has recruited more than 32,000 volunteers from around the world willing to risk getting COVID-19 by taking part in such a trial.
And the group said Monday it is in talks with other vaccine developers, too, not yet ready to go public with their intentions.
Last week, the organization released an open letter signed by several Nobel laureates and other academic experts promoting the concept, as a separate survey of residents of Canada and other countries found wide support for it.
“Challenge trials are no longer a thought experiment; they may soon become a reality,” Abie Rohrig, a 1DaySooner spokesman, said Monday. “Support is growing from many scientific fields.”
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Underlying the movement is the widespread belief that the world will not be free of the virus — and the economic devastation wrought by it — until people can be immunized against SARS-COV-2, the virus that causes COVID-19.
The hope is that challenge trials will get vaccines on the market sooner, as conventional Phase 3 studies depend on subjects being exposed to a germ in everyday life and seeing if they are infected. That can take months or longer.
The risk to young, healthy participants, the argument goes, is small to start with and offset by the potentially massive benefit to society.
Critics respond that the danger is unacceptable because, unlike challenge trials conducted in the past, COVID-19 can kill and there is no life-saving “rescue therapy.” Researchers preparing one of the first human trials of a vaccine in Canada have rejected the idea.
Adrian Hill, head of Oxford’s Jenner Institute, told The Guardian last week that his team developing a COVID-19 shot hopes to begin a challenge trial by the end of the year, in parallel with conventional Phase 3 studies.
Challenge trials are no longer a thought experiment
Using healthy people in their 20s as subjects, “everybody would agree that the risk is extremely low,” Hill told the British newspaper. “It’s so low that it’s very difficult to measure.”
The Oxford vaccine candidate, being developed with pharmaceutical giant AstraZeneca, is one of the furthest advanced in the world. And on Monday, the journal Lancet published results of a combined Phase 1 and 2 trial involving 1,073 people that found it to be safe and to generate an immune response.
Whether it actually prevents infection from the COVID-19 virus is still unknown, and what the Phase 3 or challenge trial would seek to find out.
A vaccine developed by China’s CanSino, which the Canadian government is now helping test, also published results of a 500-person trial showing general safety and a less-promising immune response.
Rohrig said 1DaySooner is in touch with other vaccine developers about conducting their own challenge trials, but they’re “not at a point where they can make a similar announcement.”
Meanwhile, the group is collaborating with the Oxford team in preparing the “challenge doses” — the live coronavirus to which participants will be exposed. That involves finding facilities where the exposure can occur safely, he said.
Ethicist Nir Eyal, who published the first peer-reviewed journal paper advocating COVID-19 challenge trials with colleagues at Rutgers University, said he too has heard from other scientists in the field.
“Some vaccine production teams have been in touch and expressed keen interest (in challenge trials),” he said. “That sometimes included people who publicly expressed no interest.”
Eyal said the concept can satisfy all the basic requirements of ethical research, such as informing subjects of the risk, limiting that danger and providing a commensurate benefit to society.
Rohrig cited recent French research that found the risk of death for COVID-19-infected people between ages 20 and 29 is about one in 14,000, and that includes those with underlying conditions. The risk of dying from donating a kidney — something society considers acceptable — is about one in 3,300. The 1DaySooner spokesman donated a kidney himself last year.
But Francoise Baylis, a bioethicist at Dalhousie University, is among those less than keen on the idea. She has advised the Canadian Centre for Vaccinology at Dalhousie that is readying Canadian trials of the CanSino vaccine.
She said challenge trials can only be ethically justified if there is no alternative with a similar risk-benefit equation. The Dalhousie group is planning to use “adaptive” trial designs, which enable studies to be modified as they move along in response to findings, and which they believe can be just as speedy.
“If you can achieve the same benefit — faster route to a safe and effective vaccine — with less risk to research participants, there is an ethical obligation to take (that) path,” said Baylis.
• Email: tblackwell@postmedia.com | Twitter: tomblackwellNP
Health
What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season
Give the gift of great skin this holiday season Skinstitut Holiday Gift Kits take the stress out of gifting Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group. In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis. “These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season. There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes. Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent. Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59. In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.
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Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca. |
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Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca. |
Health
Here is how to prepare your online accounts for when you die
LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?
It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.
Here’s how you can prepare your digital life for your survivors:
Apple
The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.
For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.
You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.
Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.
Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.
When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.
You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.
There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.
Facebook and Instagram
Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.
When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.
The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.
You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.
TikTok
The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.
Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.
X
It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.
Passwords
Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?
Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.
But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.
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Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.
Health
Pediatric group says doctors should regularly screen kids for reading difficulties
The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.
New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.
The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.
Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.
Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.
“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.
“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”
McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.
But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.
The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.
He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.
“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.
“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.
McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”
McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.
He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.
“Early identification of reading difficulty can truly change the trajectory of a child’s life.”
This report by The Canadian Press was first published Oct. 23, 2024.
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