U.K. study shows cervical cancer is preventable with HPV vaccine, experts say - CBC.ca | Canada News Media
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U.K. study shows cervical cancer is preventable with HPV vaccine, experts say – CBC.ca

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A vaccine for human papillomavirus (HPV) can almost entirely prevent cervical cancer and precancers if given to girls early enough, a U.K. study published in the Lancet on Wednesday evening suggests.  

Researchers from King’s College London found an 87 per cent relative reduction in cervical cancer among women who had received the Cervarix HPV vaccine when they were 12 or 13, compared to the expected rate among unvaccinated women.  

There was a 62 per cent reduction among those who had received their shots between the ages 14 and 16, and a 34 per cent reduction among women who were immunized when they were 16 to 18 years old.

The peer-reviewed study also showed significant reductions in non-invasive cervical carcinoma (CIN3) — a type of cervical precancer — ranging from a 39 per cent reduction in women who had received the HPV vaccine between age 16 to 18, to a 97 per cent reduction for those immunized at age 12 or 13. 

“Our findings should greatly reassure those still hesitant about the benefits of HPV vaccination,” the study authors said.

“We have shown that HPV vaccination with high coverage in 12-13 year old girls has almost eliminated cervical cancer and cervical precancer up to age 25 (the extent of the observed data).”

This undated image provided by Merck in October 2018 shows a vial and packaging for the Gardasil 9 vaccine. Gardisil and Gardisil 9 are more commonly used in Canada. (Merck/The Associated Press)

For this observational study, the researchers examined data from a population-based cancer registry. They looked at cervical cancer and precancer assessments conducted between Jan. 1, 2006 and June 30, 2019 in women between 20- and 64-years old.

All the women lived in the U.K., which began its school-based HPV immunization program in 2008. The older generations represented in the data would not have had access to HPV vaccination.   

The researchers estimated that between 2006 and 2019 there had been approximately 448 fewer than expected cervical cancers and 17,235 fewer than expected cases of the CIN3 precancer among those in the vaccinated cohorts. 

‘Very exciting study’

Cervarix protects against two strains of HPV associated with cervical cancer (Type 16 and Type 18). The Gardisil and Gardisil 9 vaccines are more commonly used in Canada, which started its school-based HPV vaccination program in 2007.

But the study’s results are relevant in this country too, said Dr. Amanda Selk, an obstetrician-gynecologist at Mount Sinai Hospital in Toronto. She was not involved in the British research. 

“It’s a very exciting study, because it’s the first study that’s actually shown the HPV vaccine can prevent cervix cancer. All previous studies have shown that the vaccine can prevent the precancers,” said Selk, who is also president of the Society of Canadian Colposcopists. (Colposcopists examine the cervix.) 

The results aren’t a surprise, she said, but the study provides additional proof of the vaccine’s importance — and may help convince parents who have been hesitant to have their children vaccinated. 

“Many of us assumed it prevented cancers, but there were non-believers who wanted to see the cancer data. So here it is. Now we have it,” she said. 

According to the Canadian Cancer Society, more than 1,400 people in Canada are expected to be diagnosed with cervical cancer in 2021 and about 380 will die from it. Both the society and the World Health Organization say nearly all cervical cancers are preventable, and have called for increased uptake of the HPV vaccine. 

Dr. Allan Covens, head of gynecologic oncology at Sunnybrook Health Sciences Centre in Toronto, said the British study is “significant” for Canada.   

“Both countries have adopted mass vaccination for young women,” Covens, who also was not involved in the U.K. study, said.

“So we can expect to see similar results in reduction in not only cervical cancer, but also precancerous changes [in cervical cells].” 

Dr. Amanda Selk, an obstetrician-gynecologist in Toronto and president of the Society of Canadian Colposcopists, says the research offers firm evidence that the HPV vaccine prevents cervical cancer. (Women’s College Hospital)

The goal, Covens said, is to vaccinate young people before they become sexually active and are exposed to HPV. In addition, the younger someone is, the more robust their immune response to the vaccine is expected to be. 

“We have the ability to prevent cervical cancer. Cervical cancer is related to a viral infection, and we can mitigate and prevent it with simple vaccination,” Covens said. 

“It’s a safe vaccine and we’ve proven that it does exactly what it has been claimed to do,” Covens said.  

Continued followup needed

The U.K. researchers acknowledged some limitations in their study, including the fact that since the HPV immunization program only started 13 years ago, the vaccinated population is still young and therefore would be less likely to be diagnosed with cervical cancer anyway. 

Because cervical cancer is rare in young women, more followup as they grow older is needed, they said.  

However, Type 16 and Type 18 HPV are found in up to 92 per cent of “women diagnosed with cervical cancer before the age of 30,” the authors said in a news release. 

Despite the limitation, the study results are still significant, both Covens and Selk said. 

In fact, the benefits could be even greater than the results suggest, they said, because the researchers only looked at outcomes for those who had received the Cervarix vaccine.  

Gardisil also protects against HPV Types 16 and 18, and two types that cause genital warts. Gardisil 9 also protects against five additional HPV strains that can cause cervical cancer.

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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

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Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

___

Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Pediatric group says doctors should regularly screen kids for reading difficulties

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The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

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