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U of G receives $230,000 for COVID-19 vaccine research – GuelphToday

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The following article was provided by University of Guelph News Services.

University of Guelph researchers have received $230,000 to develop potential COVID-19 vaccines under the province’s Ontario Together investment to advance research to combat the pandemic.

Pathobiology professor Byram Bridle said he believes the team’s vaccine platform – adapted from U of G research into vaccines as cancer therapies — will be a leading candidate among the roughly 120 Canadian projects currently racing to develop an effective vaccine against the pandemic virus.

“We have been focused on cancer for years, but this collaboration shows the flexibility of the technology we have at Guelph,” he said. “We can rapidly apply cancer technology and move it over to infectious disease.”

The team received a one-year, $230,000 grant this week in COVID-19 rapid research funding from the Ontario government to test four vaccines already developed in university labs. Nearly a dozen researchers are involved, including Bridle and co-principal investigators Sarah Wootton and Leo Susta, also faculty members in the Department of Pathobiology.

All three researchers’ labs have been approved for critical research status, allowing them to conduct studies while observing pandemic safety protocols.

Following immunological and safety testing at U of G, the researchers expect to share their top two vaccine candidates in about eight months with collaborators led by Darwyn Kobasa, head of respiratory virus pathogenesis and therapeutics at the National Microbiology Laboratory (NML) in Winnipeg, for efficacy testing.

Bridle said he hopes to see a viable vaccine based on the technology ready for Health Canada approval in 2021.

Their vaccines target a protein found on the surface of the coronavirus. After ferrying the protein into mice using a common adenovirus and an avian virus that normally infects chickens, they will measure immune responses in two ways.

They plan to look for levels of specific antibodies that recognize the protein and prevent the virus from entering lung cells. For any virus that does get past the body’s defences, they will also monitor production of T cells that normally fight off infection.

Out of four potential vaccines, they plan to send the top two candidates to the NML for further testing. The team will work with Health Canada to ensure “fast tracking” for any potential vaccine to be released to the public.

Bridle said Canadian researchers are working on an estimated 120 vaccines for the coronavirus. He said he’s confident the U of G approach will be among the top candidates.

The technology uses a proven testing platform of viruses already used to develop cancer vaccines. By using live vectors to deliver the vaccine directly into cells, he said, the approach ensures an appropriate immune response. Other approaches using a killed virus may be developed more quickly, he said, but many of those vaccines will fail to trigger the body’s proper immune response.

Bridle, Wootton and Susta have collaborated on using viruses in cancer therapy, including one of the viruses that they are now testing for a possible coronavirus vaccine.

He said that unlike other “one-off” approaches to developing a COVID-19 vaccine, the team’s platforms can be adapted to develop vaccines for future versions of a coronavirus. That means future vaccines might be made more quickly and cheaply, giving Canada a foundation for subsequent vaccine development.

“With these vaccine vectors, we designed them to be ‘plug and play.’ You can put any gene into the vectors within two weeks. It could be a target protein in a cancer cell, but it could just as easily be a protein on a virus.”

“I would like to congratulate Byram Bridle and the whole team at the University of Guelph on receiving this project approval through the COVID-19 Rapid Research Fund,” said Kitchener-Conestoga MPP Mike Harris. “The Ontario government is committed to supporting our world-class researchers and institutions in their fight against the current global pandemic.”

Malcolm Campbell, vice-president (research), said, “This very foresighted, incredibly smart support from our provincial government is outstanding.”

By combining three U of G research teams, he said, the project “will in turn power discoveries and fuel innovations aimed at creating a vaccine against SARS-CoV-2, the virus underpinning the COVID-19 pandemic. In doing so, our government’s intelligent investment will ensure that this University of Guelph research will address the challenges of this pandemic, as well as any coronavirus diseases that may emerge in the future.”

Overall, the province has committed $20 million through its COVID-19 Rapid Research Fund – part of the Ontario Together fund — for research to help combat the pandemic.

The team has also received support from the Department of Pathobiology, the Ontario Veterinary College and the University’s COVID-19 Research Development and Catalyst Fund.

Noting that the team brings together experts in viral immunology, virology and pathology, Bridle said the group responded rapidly to the provincial government’s call for research proposals. “We have a strong history of working on developing cancer vaccines. As soon as the call came out for COVID-19 vaccines, we realized we have potential vaccination strategies.”

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Canada to donate up to 200,000 vaccine doses to combat mpox outbreaks in Africa

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The Canadian government says it will donate up to 200,000 vaccine doses to fight the mpox outbreak in Congo and other African countries.

It says the donated doses of Imvamune will come from Canada’s existing supply and will not affect the country’s preparedness for mpox cases in this country.

Minister of Health Mark Holland says the donation “will help to protect those in the most affected regions of Africa and will help prevent further spread of the virus.”

Dr. Madhukar Pai, Canada research chair in epidemiology and global health, says although the donation is welcome, it is a very small portion of the estimated 10 million vaccine doses needed to control the outbreak.

Vaccine donations from wealthier countries have only recently started arriving in Africa, almost a month after the World Health Organization declared the mpox outbreak a public health emergency of international concern.

A few days after the declaration in August, Global Affairs Canada announced a contribution of $1 million for mpox surveillance, diagnostic tools, research and community awareness in Africa.

On Thursday, the Africa Centres for Disease Control and Prevention said mpox is still on the rise and that testing rates are “insufficient” across the continent.

Jason Kindrachuk, Canada research chair in emerging viruses at the University of Manitoba, said donating vaccines, in addition to supporting surveillance and diagnostic tests, is “massively important.”

But Kindrachuk, who has worked on the ground in Congo during the epidemic, also said that the international response to the mpox outbreak is “better late than never (but) better never late.”

“It would have been fantastic for us globally to not be in this position by having provided doses a much, much longer time prior than when we are,” he said, noting that the outbreak of clade I mpox in Congo started in early 2023.

Clade II mpox, endemic in regions of West Africa, came to the world’s attention even earlier — in 2022 — as that strain of virus spread to other countries, including Canada.

Two doses are recommended for mpox vaccination, so the donation may only benefit 100,000 people, Pai said.

Pai questioned whether Canada is contributing enough, as the federal government hasn’t said what percentage of its mpox vaccine stockpile it is donating.

“Small donations are simply not going to help end this crisis. We need to show greater solidarity and support,” he said in an email.

“That is the biggest lesson from the COVID-19 pandemic — our collective safety is tied with that of other nations.”

This report by The Canadian Press was first published Sept. 13, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

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How many Nova Scotians are on the doctor wait-list? Number hit 160,000 in June

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HALIFAX – The Nova Scotia government says it could be months before it reveals how many people are on the wait-list for a family doctor.

The head of the province’s health authority told reporters Wednesday that the government won’t release updated data until the 160,000 people who were on the wait-list in June are contacted to verify whether they still need primary care.

Karen Oldfield said Nova Scotia Health is working on validating the primary care wait-list data before posting new numbers, and that work may take a matter of months. The most recent public wait-list figures are from June 1, when 160,234 people, or about 16 per cent of the population, were on it.

“It’s going to take time to make 160,000 calls,” Oldfield said. “We are not talking weeks, we are talking months.”

The interim CEO and president of Nova Scotia Health said people on the list are being asked where they live, whether they still need a family doctor, and to give an update on their health.

A spokesperson with the province’s Health Department says the government and its health authority are “working hard” to turn the wait-list registry into a useful tool, adding that the data will be shared once it is validated.

Nova Scotia’s NDP are calling on Premier Tim Houston to immediately release statistics on how many people are looking for a family doctor. On Tuesday, the NDP introduced a bill that would require the health minister to make the number public every month.

“It is unacceptable for the list to be more than three months out of date,” NDP Leader Claudia Chender said Tuesday.

Chender said releasing this data regularly is vital so Nova Scotians can track the government’s progress on its main 2021 campaign promise: fixing health care.

The number of people in need of a family doctor has more than doubled between the 2021 summer election campaign and June 2024. Since September 2021 about 300 doctors have been added to the provincial health system, the Health Department said.

“We’ll know if Tim Houston is keeping his 2021 election promise to fix health care when Nova Scotians are attached to primary care,” Chender said.

This report by The Canadian Press was first published Sept. 11, 2024.

The Canadian Press. All rights reserved.

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Newfoundland and Labrador monitoring rise in whooping cough cases: medical officer

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ST. JOHN’S, N.L. – Newfoundland and Labrador‘s chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.

Dr. Janice Fitzgerald says that so far this year, the province has recorded 230 confirmed cases of the vaccine-preventable respiratory tract infection, also known as pertussis.

Late last month, Quebec reported more than 11,000 cases during the same time period, while Ontario counted 470 cases, well above the five-year average of 98. In Quebec, the majority of patients are between the ages of 10 and 14.

Meanwhile, New Brunswick has declared a whooping cough outbreak across the province. A total of 141 cases were reported by last month, exceeding the five-year average of 34.

The disease can lead to severe complications among vulnerable populations including infants, who are at the highest risk of suffering from complications like pneumonia and seizures. Symptoms may start with a runny nose, mild fever and cough, then progress to severe coughing accompanied by a distinctive “whooping” sound during inhalation.

“The public, especially pregnant people and those in close contact with infants, are encouraged to be aware of symptoms related to pertussis and to ensure vaccinations are up to date,” Newfoundland and Labrador’s Health Department said in a statement.

Whooping cough can be treated with antibiotics, but vaccination is the most effective way to control the spread of the disease. As a result, the province has expanded immunization efforts this school year. While booster doses are already offered in Grade 9, the vaccine is now being offered to Grade 8 students as well.

Public health officials say whooping cough is a cyclical disease that increases every two to five or six years.

Meanwhile, New Brunswick’s acting chief medical officer of health expects the current case count to get worse before tapering off.

A rise in whooping cough cases has also been reported in the United States and elsewhere. The Pan American Health Organization issued an alert in July encouraging countries to ramp up their surveillance and vaccination coverage.

This report by The Canadian Press was first published Sept. 10, 2024.

The Canadian Press. All rights reserved.

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