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UK to use lower dose of monkeypox vaccine to stretch supply – Welland Tribune

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LONDON (AP) — British health authorities will begin offering eligible people just a fraction of the normal monkeypox vaccine dose to stretch supplies by about five times, in line with similar decisions to extend available doses in Europe and the U.S.

In a statement Monday, Britain’s Health Security Agency said patients at clinics in Manchester and London would soon get just one fifth the regular monkeypox vaccine dose as part of ongoing research, citing earlier work suggesting the smaller dose provided as effective an immune response as a full dose.

Last week, the European Medicines Agency authorized the move for its 27 members across the continent, echoing the decision made by U.S. regulators earlier this month.

“Adopting this tried and tested technique will help to maximize the reach of our remaining stock,“ said Dr. Mary Ramsay, head of immunization at Britain’s Health Security Agency. She said the lowered doses would enable health workers to vaccinate “many more thousands of people.”

Last week, British officials said there were early signs the monkeypox outbreak is slowing and that case numbers are declining. Nearly 3,200 cases have been reported in the U.K. since May, with 99% of infections among men who are gay, bisexual or have sex with other men. About 70% of cases are in London.

As of last week, U.K. authorities said more than 35,000 vaccines had been administered primarily to men who have sex with men, their close contacts, and health workers.

Globally, the supply of monkeypox vaccines is extremely limited. There is only one supplier — Denmark’s Bavarian Nordic —and most doses have already been bought by the U.S., Canada, Europe and other rich countries.

Bavarian Nordic estimated its production capacity for this year was about 30 million doses. No monkeypox vaccines have so far been allotted to Africa, which has reported more than 70 suspected deaths, the highest number anywhere.

To date, more than 41,000 cases of monkeypox have appeared worldwide in 94 countries. The World Health Organization and other health agencies do not recommend mass vaccination, but have advised countries to improve their monkeypox surveillance, testing and encouraged other measures to slow the disease’s spread.

WHO has recommended that men at high risk of the disease temporarily consider reducing their number of sex partners or refrain from group or anonymous sex.

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Feds lift border vaccine requirements, mandatory masks on planes and trains

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OTTAWA — Federal ministers say all COVID-19 border restrictions will be removed as of Saturday, including mandatory vaccination, testing and quarantine of international travellers, as well as the requirement for masks on planes and trains.

The cabinet order maintaining COVID-19 border measures will not be renewed when it expires on Sept. 30.

But Health Minister Jean-Yves Duclos is once again warning that pandemic restrictions could be reinstated if they are needed.

“We have learned over the last (two-and-a-half) years the type of measures that can work,” Duclos said Monday.

“We will therefore leave open all possible options when it comes to protecting the health and safety of Canadians.”

The changes mean foreign nationals will no longer require an approved series of vaccinations to enter the country.

In addition, Canada-bound travellers will no longer be subject to random COVID-19 tests, and unvaccinated Canadians will not need to isolate when they return to the country.

Cruise passengers will not have to do pre-board tests or prove they have been vaccinated.

And people who enter the country after Saturday will not need to monitor and report if they develop signs or symptoms of COVID-19.

The five federal ministers making the announcement said the changes are informed by science and epidemiology, adding that modelling indicates the peak of the latest wave of the disease has “largely passed.”

But they did face questions about whether the move is at least partially politically motivated as the Liberals contend with the newly elected Opposition leader, Pierre Poilievre.

The Public Health Agency of Canada is still strongly recommending that people wear masks, particularly in crowded environments such as planes and trains.

“The science is clear: wearing a mask is clearly a means of personal protection that is extremely effective,” said Dr. Howard Njoo, Canada’s deputy chief health officer.

“I hope Canadians will make an enlightened decision about this.”

Duclos said the negative attitudes of some passengers have made things very difficult for airlines and crews to enforce the mask mandate in recent months, and cited that as a factor in the decision.

“The transmission of the variants of COVID are domestic-based, for the most part, and therefore, this is what we should stress: masking is highly recommended … but it is not something that can be, in a sense, forced.”

That is a change in messaging from earlier in the summer, when the government and public health officials insisted that maintaining measures at the border was necessary to track and prevent the introduction of new variants.

Public Safety Minister Marco Mendicino said there have been 38 million entries at the border in 2022 so far, more than double the number in all of last year. “We want to keep that momentum going.”

The controversial ArriveCan app will no longer be mandatory when the order expires.

“Going forward, use of ArriveCan will be optional, allowing travellers who so choose to submit their customs declaration in advance at major airports,” Mendicino said.

So far that option is available at international airports in Toronto, Montreal and Vancouver, but that will be expanded to include Calgary, Edmonton, Winnipeg, Ottawa, Quebec City, Halifax and Billy Bishop airport in Toronto.

In addition, the Canada Border Services Agency is looking at adding features to ArriveCan to be able to provide information such as border wait times.

The changes do not remove the quarantine or testing requirements for people who enter Canada before Saturday.

This report by The Canadian Press was first published Sept. 26, 2022.

 

The Canadian Press

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Using artificial sweeteners may raise the risk of heart disease, study shows – Prestige Online Malaysia

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‘Debilitating’ heart palpitations could be sign of Long Covid – do you have the condition? – Express

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Heart palpitations can be a sign of several different problems – both mental and physical. Often, they’re caused by stress and anxiety. But over the course of the last few years, Long Covid has reportedly caused palpitations. A recent study has explored why this might happen.

Long Covid is when people suffer ongoing symptoms of Covid, 12 weeks after infection.

Some people with the condition have struggled with heart palpitations, chest pain, dizziness, or feeling faint.

Researchers, observing their patients, have concluded that these symptoms could be caused by problems with the autonomic nervous system – the part of your nervous system that monitors automatic activities such as heart rate, breathing, and blood pressure.

Doctors and nurses at Hammersmith Hospital and Imperial College London believe that the “debilitating” palpitations and other symptoms were caused by “orthostatic intolerance syndrome”.

READ MORE: Princess Beatrice’s ongoing difficulty with ‘muddled’ thoughts swirling in her head

Orthostatic intolerance syndromes are when moving from a sitting or lying position to an upright position causes a low blood pressure in your arteries.

The British Heart Foundation explains: “When a healthy person stands up, some of the blood in the body will flow downwards with the pull of gravity.

“The body responds to prevent blood pressure falling – blood vessels narrow and there is a slight increase in heart rate.

“But in people with orthostatic problems, these automatic changes don’t happen.

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“Moving to an upright position causes a drop in the blood supply to the heart and brain and a fast heart rate as the body tries to compensate.”

For people that struggle with these issues with moving to an upright position, the study by Hammersmith Hospital and Imperial College London made recommendations.

It suggested: “Non-upright exercise such as cycling on a recumbent exercise bike and swimming are encouraged.”

It added: “The patient should be advised on rising cautiously from a lying or seated position and avoiding exacerbating factors such as prolonged standing, warm environments, and dehydration.”

READ MORE: Princess Beatrice’s ongoing difficulty with ‘muddled’ thoughts swirling in her head

Shingles, memory loss, tinnitus, itchy skin, and tremors were among the more abnormal symptoms experienced.

Some studies have suggested that long Covid is an autoimmune disease, similar to Parkinson’s disease. An autoimmune disease is when the body’s immune system attacks itself.

The body cannot tell the difference between your own cells and foreign cells so causes the body to attack healthy cells.

According to one small study from 2021, 44 percent of long Covid patients involved had high levels of a type of antibody connected with other autoimmune diseases and lupus.

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