Health
UM scientist makes Arthritis Society Canada’s Top 10 Research Advances list again
|
|
March 2, 2023 —
A Rady Faculty of Health Sciences researcher might have found a way to predict how a person with early rheumatoid arthritis will respond to treatments based on a sample of their joint lining tissue and the discovery has made Arthritis Society Canada’s Top 10 Research Advances of 2022.
“I’m humbled,” said Dr. Vidyanand Anaparti, a research associate in the department of internal medicine at the Max Rady College of Medicine. “I’m honoured my research made the list.”
But this isn’t the first time Anaparti’s work has made the annual list highlighting research breakthroughs in the area of arthritis. Anaparti’s findings have been featured on the list for 2019 and 2020.
The research that most recently made the list began 12 years ago, when samples of synovial tissue were collected from the knees of 17 patients with early rheumatoid arthritis. Synovial tissue is a connective tissue that surrounds joints. It’s where rheumatoid arthritis begins, Anaparti said.
After the synovial tissue was collected, the patients’ clinical data was gathered over 12 years and the scientists discovered that the patients could be placed into two groups. One group of patients had significantly high levels of matrix metalloproteinase (MMP) and the other group of patients had low levels. MMP is a group of enzymes that break down proteins found in spaces between cells in tissues. The enzymes were responsible for tissue degradation of synovial tissue and increased inflammation, Anaparti said.
The research team observed that people with high MMP responded well to treatment, had lower joint inflammation and a reduction in swollen joint count than those who had low MMP levels. The study was published in Frontiers of Medicine last year.
“We can predict by analyzing the genes expressed in the tissue biopsy of an individual who will respond to treatment better and who will resist treatment,” Anaparti said. “We need to collect more samples and conduct more studies to validate our model, but this is definitely a big start and a step closer to a precision medicine based approach to treating rheumatoid arthritis.”
Dr. Siân Bevan, chief science officer, Arthritis Society Canada, said that one in five Manitobans has arthritis and it’s time to transform how we understand and treat this disease.
“By revealing new insights about the molecular features and outcomes of people with rheumatoid arthritis, this research could help tackle the common problem of patients going through trial-and-error cycles before finding the best treatment for them,” Bevan said.
This research will not only benefit patients but the health-care system as well, Anaparti said. The system will save money because patients won’t be on treatments that don’t work for them, he said.
“My sincerest congratulations to Vidyanand on this important accomplishment,” said Dr. Hani El-Gabalawy, professor of internal medicine and immunology at the Max Rady College of Medicine, who is Anaparti’s supervisor along with Dr. Neeloffer Mookherjee, professor of internal medicine and immunology. “The basic and translational research he has undertaken at the Manitoba Centre for Proteomics and Systems Biology provided new insights into how the early molecular and cellular patterns found in the inflamed joints can predict the outcomes of rheumatoid arthritis up to 15 year later.”
<!–
isIE8 = true;
Date.now = Date.now || function() return +new Date; ;
Alberta Health Services (AHS) has confirmed a case of measles in Edmonton, and is advising the public that the individual was out in public while infectious.
Measles is an extremely contagious disease that is spread easily through the air, and can only be prevented through immunization.
AHS says individuals who were in the following locations during the specified dates and times, may have been exposed to measles.
- April 16
- Edmonton International Airport, international arrivals and baggage claim area — between 3:20 p.m. and 6 p.m.
- April 20
- Stollery Children’s Hospital Emergency Department — between 5 a.m. to 3 p.m.
- April 22
- 66th Medical Clinic (13635 66 St NW Edmonton) — between 12:15 p.m. to 3:30 p.m.
- Pharmacy 66 (13637 66 St NW Edmonton) — between 12:15 p.m. to 3:30 p.m.
- April 23
- Stollery Children’s Hospital Emergency Department — between 4:40 a.m. to 9:33 a.m.
AHS says anyone who attended those locations during those times is at risk of developing measles if they’ve not had two documented doses of measles-containing vaccine.
Those who have not had two doses, who are pregnant, under one year of age, or have a weakened immune system are at greatest risk of getting measles and should contact Health Link at 1-877-720-0707.
Symptoms
Symptoms of measles include a fever of 38.3° C or higher, cough, runny nose, and/or red eyes, a red blotchy rash that appears three to seven days after fever starts, beginning behind the ears and on the face and spreading down the body and then to the arms and legs.
If you have any of these symptoms stay home and call Health Link.
In Alberta, measles vaccine is offered, free of charge, through Alberta’s publicly funded immunization program. Children in Alberta typically receive their first dose of measles vaccine at 12 months of age, and their second dose at 18 months of age.
Health
U.S. tightens rules for dairy cows a day after bird flu virus fragments found in pasteurized milk samples – Toronto Star
/* OOVVUU Targeting */
const path = ‘/news/canada’;
const siteName = ‘thestar.com’;
let domain = ‘thestar.com’;
if (siteName === ‘thestar.com’)
domain = ‘thestar.com’;
else if (siteName === ‘niagarafallsreview.ca’)
domain = ‘niagara_falls_review’;
else if (siteName === ‘stcatharinesstandard.ca’)
domain = ‘st_catharines_standard’;
else if (siteName === ‘thepeterboroughexaminer.com’)
domain = ‘the_peterborough_examiner’;
else if (siteName === ‘therecord.com’)
domain = ‘the_record’;
else if (siteName === ‘thespec.com’)
domain = ‘the_spec’;
else if (siteName === ‘wellandtribune.ca’)
domain = ‘welland_tribune’;
else if (siteName === ‘bramptonguardian.com’)
domain = ‘brampton_guardian’;
else if (siteName === ‘caledonenterprise.com’)
domain = ‘caledon_enterprise’;
else if (siteName === ‘cambridgetimes.ca’)
domain = ‘cambridge_times’;
else if (siteName === ‘durhamregion.com’)
domain = ‘durham_region’;
else if (siteName === ‘guelphmercury.com’)
domain = ‘guelph_mercury’;
else if (siteName === ‘insidehalton.com’)
domain = ‘inside_halton’;
else if (siteName === ‘insideottawavalley.com’)
domain = ‘inside_ottawa_valley’;
else if (siteName === ‘mississauga.com’)
domain = ‘mississauga’;
else if (siteName === ‘muskokaregion.com’)
domain = ‘muskoka_region’;
else if (siteName === ‘newhamburgindependent.ca’)
domain = ‘new_hamburg_independent’;
else if (siteName === ‘niagarathisweek.com’)
domain = ‘niagara_this_week’;
else if (siteName === ‘northbaynipissing.com’)
domain = ‘north_bay_nipissing’;
else if (siteName === ‘northumberlandnews.com’)
domain = ‘northumberland_news’;
else if (siteName === ‘orangeville.com’)
domain = ‘orangeville’;
else if (siteName === ‘ourwindsor.ca’)
domain = ‘our_windsor’;
else if (siteName === ‘parrysound.com’)
domain = ‘parrysound’;
else if (siteName === ‘simcoe.com’)
domain = ‘simcoe’;
else if (siteName === ‘theifp.ca’)
domain = ‘the_ifp’;
else if (siteName === ‘waterloochronicle.ca’)
domain = ‘waterloo_chronicle’;
else if (siteName === ‘yorkregion.com’)
domain = ‘york_region’;
let sectionTag = ”;
try
if (domain === ‘thestar.com’ && path.indexOf(‘wires/’) = 0)
sectionTag = ‘/business’;
else if (path.indexOf(‘/autos’) >= 0)
sectionTag = ‘/autos’;
else if (path.indexOf(‘/entertainment’) >= 0)
sectionTag = ‘/entertainment’;
else if (path.indexOf(‘/life’) >= 0)
sectionTag = ‘/life’;
else if (path.indexOf(‘/news’) >= 0)
sectionTag = ‘/news’;
else if (path.indexOf(‘/politics’) >= 0)
sectionTag = ‘/politics’;
else if (path.indexOf(‘/sports’) >= 0)
sectionTag = ‘/sports’;
else if (path.indexOf(‘/opinion’) >= 0)
sectionTag = ‘/opinion’;
} catch (ex)
const descriptionUrl = ‘window.location.href’;
const vid = ‘mediainfo.reference_id’;
const cmsId = ‘2665777’;
let url = `https://pubads.g.doubleclick.net/gampad/ads?iu=/58580620/$domain/video/oovvuu$sectionTag&description_url=$descriptionUrl&vid=$vid&cmsid=$cmsId&tfcd=0&npa=0&sz=640×480&ad_rule=0&gdfp_req=1&output=vast&unviewed_position_start=1&env=vp&impl=s&correlator=`;
url = url.split(‘ ‘).join(”);
window.oovvuuReplacementAdServerURL = url;
Infected cows were already prohibited from being transported out of state, but that was based on the physical characteristics of the milk, which looks curdled when a cow is infected, or a cow has decreased lactation or low appetite, both symptoms of infection.
function buildUserSwitchAccountsForm()
var form = document.getElementById(‘user-local-logout-form-switch-accounts’);
if (form) return;
// build form with javascript since having a form element here breaks the payment modal.
var switchForm = document.createElement(‘form’);
switchForm.setAttribute(‘id’,’user-local-logout-form-switch-accounts’);
switchForm.setAttribute(‘method’,’post’);
switchForm.setAttribute(‘action’,’https://www.thestar.com/tncms/auth/logout/?return=https://www.thestar.com/users/login/?referer_url=https%3A%2F%2Fwww.thestar.com%2Fnews%2Fcanada%2Fu-s-tightens-rules-for-dairy-cows-a-day-after-bird-flu-virus-fragments-found%2Farticle_985b0bac-0252-11ef-abc6-eb884d6a1f0c.html’);
switchForm.setAttribute(‘style’,’display:none;’);
var refUrl = document.createElement(‘input’); //input element, text
refUrl.setAttribute(‘type’,’hidden’);
refUrl.setAttribute(‘name’,’referer_url’);
refUrl.setAttribute(‘value’,’https://www.thestar.com/news/canada/u-s-tightens-rules-for-dairy-cows-a-day-after-bird-flu-virus-fragments-found/article_985b0bac-0252-11ef-abc6-eb884d6a1f0c.html’);
var submit = document.createElement(‘input’);
submit.setAttribute(‘type’,’submit’);
submit.setAttribute(‘name’,’logout’);
submit.setAttribute(‘value’,’Logout’);
switchForm.appendChild(refUrl);
switchForm.appendChild(submit);
document.getElementsByTagName(‘body’)[0].appendChild(switchForm);
function handleUserSwitchAccounts()
window.sessionStorage.removeItem(‘bd-viafoura-oidc’); // clear viafoura JWT token
// logout user before sending them to login page via return url
document.getElementById(‘user-local-logout-form-switch-accounts’).submit();
return false;
buildUserSwitchAccountsForm();
console.log(‘=====> bRemoveLastParagraph: ‘,0);
The Ultimate Recap of Sea Otter 2024 – Pinkbike.com
April 22nd to 30th is Immunization Awareness Week – Oldies 107.7
Why the Bank of Canada decided to hold interest rates in April – Financial Post
Silver investment demand jumped 12% in 2019
12 Bizarre Things People Did Just To Make Social Media Content
Global Media Markets, 2015-2020, 2020-2025F, 2030F – TV and Radio Broadcasting, Film and Music, Information Services, Web Content, Search Portals And Social Media, Print Media, & Cable – GlobeNewswire
-
News23 hours ago
Amid concerns over ‘collateral damage’ Trudeau, Freeland defend capital gains tax change
-
Art20 hours ago
The unmissable events taking place during London’s Digital Art Week
-
News24 hours ago
U.K. tabloids abuzz with Canadian’s ‘Loch Ness monster’ photo
-
Politics24 hours agoPolitics Briefing: Saskatchewan residents to get carbon rebates despite province’s opposition to pricing program
-
News22 hours ago
What is a halal mortgage? How interest-free home financing works in Canada
-
Politics15 hours ago
Opinion: Fear the politicization of pensions, no matter the politician
-
Economy21 hours ago
German Business Outlook Hits One-Year High as Economy Heals
-
Media14 hours ago
B.C. puts online harms bill on hold after agreement with social media companies
