Health
UM scientist makes Arthritis Society Canada’s Top 10 Research Advances list again
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March 2, 2023 —
A Rady Faculty of Health Sciences researcher might have found a way to predict how a person with early rheumatoid arthritis will respond to treatments based on a sample of their joint lining tissue and the discovery has made Arthritis Society Canada’s Top 10 Research Advances of 2022.
“I’m humbled,” said Dr. Vidyanand Anaparti, a research associate in the department of internal medicine at the Max Rady College of Medicine. “I’m honoured my research made the list.”
But this isn’t the first time Anaparti’s work has made the annual list highlighting research breakthroughs in the area of arthritis. Anaparti’s findings have been featured on the list for 2019 and 2020.
The research that most recently made the list began 12 years ago, when samples of synovial tissue were collected from the knees of 17 patients with early rheumatoid arthritis. Synovial tissue is a connective tissue that surrounds joints. It’s where rheumatoid arthritis begins, Anaparti said.
After the synovial tissue was collected, the patients’ clinical data was gathered over 12 years and the scientists discovered that the patients could be placed into two groups. One group of patients had significantly high levels of matrix metalloproteinase (MMP) and the other group of patients had low levels. MMP is a group of enzymes that break down proteins found in spaces between cells in tissues. The enzymes were responsible for tissue degradation of synovial tissue and increased inflammation, Anaparti said.
The research team observed that people with high MMP responded well to treatment, had lower joint inflammation and a reduction in swollen joint count than those who had low MMP levels. The study was published in Frontiers of Medicine last year.
“We can predict by analyzing the genes expressed in the tissue biopsy of an individual who will respond to treatment better and who will resist treatment,” Anaparti said. “We need to collect more samples and conduct more studies to validate our model, but this is definitely a big start and a step closer to a precision medicine based approach to treating rheumatoid arthritis.”
Dr. Siân Bevan, chief science officer, Arthritis Society Canada, said that one in five Manitobans has arthritis and it’s time to transform how we understand and treat this disease.
“By revealing new insights about the molecular features and outcomes of people with rheumatoid arthritis, this research could help tackle the common problem of patients going through trial-and-error cycles before finding the best treatment for them,” Bevan said.
This research will not only benefit patients but the health-care system as well, Anaparti said. The system will save money because patients won’t be on treatments that don’t work for them, he said.
“My sincerest congratulations to Vidyanand on this important accomplishment,” said Dr. Hani El-Gabalawy, professor of internal medicine and immunology at the Max Rady College of Medicine, who is Anaparti’s supervisor along with Dr. Neeloffer Mookherjee, professor of internal medicine and immunology. “The basic and translational research he has undertaken at the Manitoba Centre for Proteomics and Systems Biology provided new insights into how the early molecular and cellular patterns found in the inflamed joints can predict the outcomes of rheumatoid arthritis up to 15 year later.”
Nearby regions report spike in whopping cough
Lambton Public Health on Exmouth Street in Sarnia. 27 April 2020. (BlackburnNews.com photo by Colin Gowdy)
March 24, 2023 12:01pm
While some communities in southwestern Ontario are seeing an increase in pertussis, commonly referred to as whooping cough, Lambton Public Health (LPH) has not noted any recent cases within its jurisdiction.
The last case of pertussis reported in Sarnia-Lambton was in 2019.
Earlier this week, the health units in Windsor-Essex and Huron-Perth reported increases in whooping cough cases.
There have been 18 cases since November 2022 in Windsor-Essex, and in Huron-Perth there have been 21 confirmed cases so far this year.
“As always, Lambton Public Health encourages parents and caregivers of children to stay up-to-date on their routine immunizations, which include pertussis, as this greatly reduces the risk of outbreaks and serious illness,” read an emailed statement to Sarnia News Today.
“Other eligible populations for pertussis vaccine include adolescents around 14 to 16 years of age, pregnant individuals preferably between 27 and 32 weeks of gestation, and one adult booster dose for those 18 years of age and older.”
Pertussis is a contagious infection in the lungs and is most dangerous for infants.
In February, LPH said 6,589 letters would be sent to students about routine immunizations.
Health
Waterloo regional COVID-19, cold and flu care clinic closing its doors | CTV News – CTV News Kitchener
It might be a sign of change in the pandemic that has gripped the world for three years.
The regional COVID-19 Cold & Flu Care Clinic run by Grand River Hospital is closing its doors.
The clinic has been open for the last six months, first at 66 Pinebush Road in Cambridge and later at 50 Sportsworld Drive in Kitchener, after the hospital announced it would be expanding the services offered by the clinic.
Healthcare workers said it’s a bittersweet day, noting there is still a need for its services in the community.
“At our peak, we were seeing up to 400 patients per week, and it was incredible to see the way this team would perform. Everyone did their part, everybody held their own,” Lisa Anstey, manager of the regional COVID care clinic, said.
She added that it never felt chaotic or busy at the clinic because it was well organized.
“The patients were all very pleased with the care they received,” she said.
The clinic has cared for over 8,000 patients over the last six months.
The hospital said the clinic`s closure comes with the return of warmer weather and anticipated seasonal decline of cold and flu.
“If their symptoms are severe and worsening they should go to a local emergency department… pharmacies are a wonderful resource as well. They can provide Plaxlovid prescriptions or they can support through PCR testing,” said Anstey.
Care will now transition to family physicians, urgent care clinics and community pharmacies.
The hospital says the regional clinic grew out of the COVID-19 assessment clinics which were run by local hospitals starting in 2020. Their goal was to divert patients away from hospitals and get the COVID-19, cold and flu care they need.
The clinic’s doors closed at 4 p.m. Friday.
Nurses Marilyn Boehm and Lannie Butler have been working side-by-side since March 2020, the pair taking on the pandemic together.
They have worked at the drive-thru testing clinic, vaccine clinic and at the regional COVID-19, Cold & Flu Care Clinic.
“This is our final journey, we’re sad it’s closing,” the duo said. “We worry about what’s going to happen to our patients out there in our community.”
“That’s the only recourse that some of the sicker folks have is to go to the emergency department and we know about the long waits and the high volumes there.”
The clinic has helped divert patients from the emergency rooms, and they say the closure could place the burden back on hospitals.
The Ontario Pharmacist Association also has concerns.
“There can be a challenge with needing to ramp those efforts up again very rapidly given the challenges everyone is facing with workforce, health human resources,” Jen Belcher, vice-president of member relations with the Ontario Pharmacist Association, said
The association is stressing that the pandemic isn’t over yet, despite mandates being dropped.
“It’s absolutely not from what we’ve seen from the impact of the disease on our population both through new infection and some of those longer-term complications associated with people with long COVID for example,” Belcher said.
As for Boehm and Butler, they say they will return if they get called back to the frontlines to continue fighting COVID-19.
OTHER CLINICS SET TO CLOSE
The Grand River Hospital’s COVID-19 clinic is not the only one closing in southern Ontario.
On Friday, the Huron Perth Healthcare Alliance (HPHA) said it will be closing its COVID-19, cold and flu care clinic.
According to the HPHA, the last day of operation for COVID-19 testing will be March 30.
“The contribution this team has made to the quality of our local health system during the pandemic has been outstanding,” said Andrew Williams, President and CEO of HPHA in a news release. “As we close our CCFCC a huge thank you is extended to our community partners including the Stratford Rotary Complex, the wonderful staff at the Stratford Family Health Team, Emad Salama of PrinceRx Pharmacy for generously paying the parking fees for all the CCFCC patients and, of course, all the staff and physicians that worked tirelessly provide this service.”
THE HPHA said over 54,000 PCR tests and over 2,000 clinical assessments have been completed.
Over in Guelph, the Guelph-Wellington-Dufferin Public Health unit said it will be closing its clinic on March 31.
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The Huron Perth Healthcare Alliance’s (HPHA) COVID, Cold and Flu Care Clinic (CCFCC) will be closing due to a steady decline in patients.
The last day of operation for COVID-19 testing will be Thursday, March 30. The last day for physician assessment will be Friday, March 31.
“The contribution this team has made to the quality of our local health system during the pandemic has been outstanding,” said President and CEO Andrew Williams. “As we close our CCFCC, a huge thank you is extended to our community partners including the Stratford Rotary Complex, the wonderful staff at the Stratford Family Health Team, Emad Salama of PrinceRx Pharmacy for generously paying the parking fees for all the CCFCC patients and, of course, all the staff and physicians that worked tirelessly to provide this service.”
For patients seeking COVID-19 assessment, testing, or antiviral treatment after March 31, contact your family doctor or visit Ontario’s COVID-19 web page.
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