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USask-led research project receives more than $1.3 million to study bone strength development in children with diabetes

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Titled the “Canadian Bone Strength Development in Children with Type 1 Diabetes Study,” the five-year project was awarded $1,352,140 by the Canadian Institutes of Health Research (CIHR) Project Grant program.

The team, co-led by Dr. Saija Kontulainen (PhD) with the College of Kinesiology and Dr. Munier Nour (MD) with the College of Medicine, will take the helm of a project supported by researchers at facilities across Canada.

“I like the team effort. It’s great we have a USask-led national team,” Kontulainen said. “We want to use this opportunity to place Canada in a leading position to study and advance bone health in children with diabetes.”

The project will compare bone development of preteen-aged children with and without Type 1 diabetes over the course of four years. Using a technique called high-resolution peripheral quantitative computed tomography (HR-pQCT), as well as other scanners used to diagnose bone diseases like osteoporosis, Kontulainen and her team will attempt to map the bone development of children during the time of their growth spurt when rapid skeletal development occurs.

“Our hypothesis is that the bone growth in children with Type 1 diabetes differs, but we need to know how it differs, when it differs,” Kontulainen said.

The goal of this project, she said, is to answer those key questions, important for prevention of bone fragility life-long. Findings will guide the development of therapies or treatments to optimize bone growth.

Kontulainen lauded the nation-wide team of specialists working on the project, and said she was excited to continue the tradition of former USask scholars working in this field before her.

“This is building on the legacy of world-renowned longitudinal bone studies that were carried out at the University of Saskatchewan,” she said.

The project is raising the bar when it comes to the scale of this kind of research, and Kontulainen said the implications of their work would stretch far beyond Canada’s borders.

“It’s unique, and it will bring globally important information,” she said. “We will know how the bones are changing … This is the collaborative way we should do research.”

This project is one of several USask projects to receive a total of $1,852,140 from the CIHR Project Grant — Fall 2022 Competition. The other USask projects receiving funding through this grant program are:

Dr. Neeraj Dhar (VIDO) –$100,000 for a one-year project – Role of phenotypic heterogeneity in mycobacterial persistence: Prospects for more effective treatment regimens.

Dr. Alyson Kelvin et al. (VIDO) – $100,000 for a one-year project – Preclinical Models for Monkeypox Virus Infection and Therapeutic Development.

Dr. Alyson Kelvin (VIDO) – $100,000 for a one-year project – Understanding mechanisms coronavirus cross-reactivity, immune durability, and pan-coronavirus vaccine protection.

Dr. Scot Leary (Biochemistry, Microbiology and Immunology) – $100,000 for a one-year project – Disrupting mitochondrial function in the liver: implications for immune suppression.

Dr. Cordell Neudorf (Community Health and Epidemiology) – $100,000 for a one-year project – Multilevel estimation of the relative impacts of social determinants on income-related health inequalities in urban Canada: Toward a new Canadian Social Determinants Urban Laboratory.

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The US is mailing Americans COVID tests again. Here’s how to get them

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WASHINGTON (AP) — Americans can once again order COVID-19 tests, without being charged, sent straight to their homes.

The U.S. government reopened the program on Thursday, allowing any household to order up to four at-home COVID nasal swab kits through the website, covidtests.gov. The tests will begin shipping, via the United States Postal Service, as soon as next week.

The website has been reopened on the heels of a summer COVID-19 virus wave and heading into the fall and winter respiratory virus season, with health officials urging Americans to get an updated COVID-19 booster and their yearly flu shot.

“Before you visit with your family and friends this holiday season, take a quick test and help keep them safe from COVID-19,” U.S. Health and Human Services Assistant Secretary for Preparedness and Response Dawn O’Connell said in a statement.

U.S. regulators approved an updated COVID-19 vaccine that is designed to combat the recent virus strains and, they hope, forthcoming winter ones, too. Vaccine uptake is waning, however. Most Americans have some immunity from prior infections or vaccinations, but under a quarter of U.S. adults took last fall’s COVID-19 shot.

Using the swab, people can detect current virus strains ahead of the fall and winter respiratory virus season and the holidays. Over-the-counter COVID-19 at-home tests typically cost around $11, as of last year. Insurers are no longer required to cover the cost of the tests.

Before using any existing at-home COVID-19 tests, you should check the expiration date. Many of the tests have been given an extended expiration from the date listed on the box. You can check on the Food and Drug Administration’s website to see if that’s the case for any of your remaining tests at home.

Since COVID-19 first began its spread in 2020, U.S. taxpayers have poured billions of dollars into developing and purchasing COVID-19 tests as well as vaccines. The Biden administration has given out 1.8 billion COVID-19 tests, including half distributed to households by mail. It’s unclear how many tests the government still has on hand.

The Canadian Press. All rights reserved.

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Free COVID tests are back. Here’s how to order a test to your home

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WASHINGTON (AP) — Americans can once again order free COVID-19 tests sent straight to their homes.

The U.S. government reopened the program on Thursday, allowing any household to order up to four at-home COVID nasal swab kits through the website, covidtests.gov. The tests will begin shipping, via the United States Postal Service, as soon as next week.

The website has been reopened on the heels of a summer COVID-19 virus wave and heading into the fall and winter respiratory virus season, with health officials urging Americans to get an updated COVID-19 booster and their yearly flu shot.

U.S. regulators approved an updated COVID-19 vaccine that is designed to combat the recent virus strains and, they hope, forthcoming winter ones, too. Vaccine uptake is waning, however. Most Americans have some immunity from prior infections or vaccinations, but under a quarter of U.S. adults took last fall’s COVID-19 shot.

Using the swab, people can detect current virus strains ahead of the fall and winter respiratory virus season and the holidays. Over-the-counter COVID-19 at-home tests typically cost around $11, as of last year. Insurers are no longer required to cover the cost of the tests.

Since COVID-19 first began its spread in 2020, U.S. taxpayers have poured billions of dollars into developing and purchasing COVID-19 tests as well as vaccines. The Biden administration has given out 1.8 billion COVID-19 tests, including half distributed to households by mail. It’s unclear how many tests the government still has on hand.

The Canadian Press. All rights reserved.

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Disability rights groups launching Charter challenge against MAID law

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TORONTO – A coalition of disability rights groups says it is launching a Charter challenge against a part of Canada’s law on medical assistance in dying.

The group, which also includes two individual plaintiffs, argues that what’s known as track two of the MAID law has resulted in premature deaths.

Under the law, patients whose natural deaths are not reasonably foreseeable but whose condition leads to intolerable suffering can apply for a track-two assisted death.

The coalition says track two of the MAID law has had a direct effect on the lives of people with disabilities and argues medically assisted death should only be available to those whose natural death is reasonably foreseeable.

The executive vice-president of Inclusion Canada – which is part of the coalition – says there has been an alarming trend where people with disabilities are seeking assisted death due to social deprivation, poverty and a lack of essential supports.

Krista Carr says those individuals should instead be supported in order to live better lives.

This report by The Canadian Press was first published Sept. 26, 2024.

The Canadian Press. All rights reserved.

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