Verity Pharma and India's SII apply to distribute AstraZeneca vaccine in Canada | Canada News Media
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Verity Pharma and India’s SII apply to distribute AstraZeneca vaccine in Canada

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By Allison Martell and Euan Rocha

TORONTO/NEW DELHI (Reuters) – Verity Pharmaceuticals and Serum Institute of India (SII) have applied to distribute SII’s licensed version of AstraZeneca’s COVID-19 vaccine in Canada, potentially easing shortages as European manufacturing sites struggle to meet global demand.

AstraZeneca Canada had filed a rolling application for its vaccine with Health Canada in October, but online records show Canada‘s Verity Pharmaceuticals and SII on Jan. 23 filed a separate application to sell the vaccine developed by AstraZeneca and Oxford University researchers.

SII, the world’s biggest vaccine maker, has capacity to produce roughly 2.4 million doses per day at its campus in Pune, western India.

“Verity Pharmaceuticals is providing important support to Serum Institute of India related to its regulatory registration, importation and distribution of the vaccine in Canada, pending Health Canada approval,” AstraZeneca Canada and Verity said in a joint statement.

A source close to the matter said discussions are ongoing between SII and Verity but it is too early to provide details on delivery timelines or volumes that SII could ship to Canada.

SII did not immediately respond to a request for comment.

The Indian company’s chief executive, Adar Poonawalla, told Reuters last week that SII was happy to support AstraZeneca to meet any supply needs, but he emphasised that its primary focus was India and other poorer nations in Asia and Africa.

SII has already stepped in to help AstraZeneca to fulfil some orders in South Africa, Brazil, Saudi Arabia and other nations.

Canada, with a population of about 38 million, has ordered more vaccine doses per capita than any other country and was among the first to approve the Pfizer-BioNtech and Moderna vaccines, though deliveries have been sluggish.

Pharmaceutical manufacturing is a major industry in India, and several COVID-19 vaccines are being produced in the country at scale. Canada, by contrast, is entirely dependent on imports from European manufacturing sites, and both Pfizer and Moderna have cut planned deliveries in recent weeks.

Last week the European Union rolled out a new export control regime for vaccines, including a mechanism that could block certain exports. Canadian officials say they have been assured that shipments to Canada should not be affected, but Canada is not officially exempt from the regime.

Poonawalla last week told Reuters that SII had no plans to divert supplies to Europe.

SII, which had a stockpile of about 60 million doses of the vaccine last month, is adding a third production line by March. That would allow it to produce more than 3 million doses a day of COVISHIELD, the brand name under which it markets the AstraZeneca shot.

Beyond supplying India’s vaccination drive, however, SII has also committed to supply tens of millions of doses to the GAVI/WHO-backed COVAX initiative to help to accelerate vaccinations in poorer nations.

 

(Reporting by Allison Martell in Toronto and Euan Rocha in New Delhi; Editing by David Goodman)

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Canada to donate up to 200,000 vaccine doses to combat mpox outbreaks in Africa

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The Canadian government says it will donate up to 200,000 vaccine doses to fight the mpox outbreak in Congo and other African countries.

It says the donated doses of Imvamune will come from Canada’s existing supply and will not affect the country’s preparedness for mpox cases in this country.

Minister of Health Mark Holland says the donation “will help to protect those in the most affected regions of Africa and will help prevent further spread of the virus.”

Dr. Madhukar Pai, Canada research chair in epidemiology and global health, says although the donation is welcome, it is a very small portion of the estimated 10 million vaccine doses needed to control the outbreak.

Vaccine donations from wealthier countries have only recently started arriving in Africa, almost a month after the World Health Organization declared the mpox outbreak a public health emergency of international concern.

A few days after the declaration in August, Global Affairs Canada announced a contribution of $1 million for mpox surveillance, diagnostic tools, research and community awareness in Africa.

On Thursday, the Africa Centres for Disease Control and Prevention said mpox is still on the rise and that testing rates are “insufficient” across the continent.

Jason Kindrachuk, Canada research chair in emerging viruses at the University of Manitoba, said donating vaccines, in addition to supporting surveillance and diagnostic tests, is “massively important.”

But Kindrachuk, who has worked on the ground in Congo during the epidemic, also said that the international response to the mpox outbreak is “better late than never (but) better never late.”

“It would have been fantastic for us globally to not be in this position by having provided doses a much, much longer time prior than when we are,” he said, noting that the outbreak of clade I mpox in Congo started in early 2023.

Clade II mpox, endemic in regions of West Africa, came to the world’s attention even earlier — in 2022 — as that strain of virus spread to other countries, including Canada.

Two doses are recommended for mpox vaccination, so the donation may only benefit 100,000 people, Pai said.

Pai questioned whether Canada is contributing enough, as the federal government hasn’t said what percentage of its mpox vaccine stockpile it is donating.

“Small donations are simply not going to help end this crisis. We need to show greater solidarity and support,” he said in an email.

“That is the biggest lesson from the COVID-19 pandemic — our collective safety is tied with that of other nations.”

This report by The Canadian Press was first published Sept. 13, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

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How many Nova Scotians are on the doctor wait-list? Number hit 160,000 in June

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HALIFAX – The Nova Scotia government says it could be months before it reveals how many people are on the wait-list for a family doctor.

The head of the province’s health authority told reporters Wednesday that the government won’t release updated data until the 160,000 people who were on the wait-list in June are contacted to verify whether they still need primary care.

Karen Oldfield said Nova Scotia Health is working on validating the primary care wait-list data before posting new numbers, and that work may take a matter of months. The most recent public wait-list figures are from June 1, when 160,234 people, or about 16 per cent of the population, were on it.

“It’s going to take time to make 160,000 calls,” Oldfield said. “We are not talking weeks, we are talking months.”

The interim CEO and president of Nova Scotia Health said people on the list are being asked where they live, whether they still need a family doctor, and to give an update on their health.

A spokesperson with the province’s Health Department says the government and its health authority are “working hard” to turn the wait-list registry into a useful tool, adding that the data will be shared once it is validated.

Nova Scotia’s NDP are calling on Premier Tim Houston to immediately release statistics on how many people are looking for a family doctor. On Tuesday, the NDP introduced a bill that would require the health minister to make the number public every month.

“It is unacceptable for the list to be more than three months out of date,” NDP Leader Claudia Chender said Tuesday.

Chender said releasing this data regularly is vital so Nova Scotians can track the government’s progress on its main 2021 campaign promise: fixing health care.

The number of people in need of a family doctor has more than doubled between the 2021 summer election campaign and June 2024. Since September 2021 about 300 doctors have been added to the provincial health system, the Health Department said.

“We’ll know if Tim Houston is keeping his 2021 election promise to fix health care when Nova Scotians are attached to primary care,” Chender said.

This report by The Canadian Press was first published Sept. 11, 2024.

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Newfoundland and Labrador monitoring rise in whooping cough cases: medical officer

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ST. JOHN’S, N.L. – Newfoundland and Labrador‘s chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.

Dr. Janice Fitzgerald says that so far this year, the province has recorded 230 confirmed cases of the vaccine-preventable respiratory tract infection, also known as pertussis.

Late last month, Quebec reported more than 11,000 cases during the same time period, while Ontario counted 470 cases, well above the five-year average of 98. In Quebec, the majority of patients are between the ages of 10 and 14.

Meanwhile, New Brunswick has declared a whooping cough outbreak across the province. A total of 141 cases were reported by last month, exceeding the five-year average of 34.

The disease can lead to severe complications among vulnerable populations including infants, who are at the highest risk of suffering from complications like pneumonia and seizures. Symptoms may start with a runny nose, mild fever and cough, then progress to severe coughing accompanied by a distinctive “whooping” sound during inhalation.

“The public, especially pregnant people and those in close contact with infants, are encouraged to be aware of symptoms related to pertussis and to ensure vaccinations are up to date,” Newfoundland and Labrador’s Health Department said in a statement.

Whooping cough can be treated with antibiotics, but vaccination is the most effective way to control the spread of the disease. As a result, the province has expanded immunization efforts this school year. While booster doses are already offered in Grade 9, the vaccine is now being offered to Grade 8 students as well.

Public health officials say whooping cough is a cyclical disease that increases every two to five or six years.

Meanwhile, New Brunswick’s acting chief medical officer of health expects the current case count to get worse before tapering off.

A rise in whooping cough cases has also been reported in the United States and elsewhere. The Pan American Health Organization issued an alert in July encouraging countries to ramp up their surveillance and vaccination coverage.

This report by The Canadian Press was first published Sept. 10, 2024.

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