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What are the differences between Canada’s approved COVID-19 vaccines? Here’s what we know – Global News

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Now that the Oxford-AstraZeneca vaccine has been approved for use in Canada, three different jabs are on the menu for Canadians hoping to protect themselves against the coronavirus.

However, while all the vaccines have the same goal — to inoculate the recipient against COVID-19 — the vaccines are by no means identical.

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Canada approves AstraZeneca’s COVID-19 vaccine

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And while Canada’s contracts secure enough doses from the three manufacturers to vaccinate everyone in the country by September, not everyone will be getting the same kind of jab.

Global News has broken down the key details of the three vaccines to help you understand which dose is going into your arm.

What kinds of COVID-19 vaccines are available?

  • Pfizer: mRNA
  • Moderna: mRNA
  • AstraZeneca: adenovirus-based

All of these vaccines use fairly new vaccine technologies, but they don’t all use the same kind.

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Pfizer and Moderna’s vaccines use mRNA technology, which delivers genetic instructions for our cells to make viral proteins themselves. The body then begins to train itself to fight these proteins, building its immunity to the same protein found in COVID-19.


Click to play video 'Coronavirus: The science behind the new Covid-19 mRNA vaccines'



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Coronavirus: The science behind the new Covid-19 mRNA vaccines


Coronavirus: The science behind the new Covid-19 mRNA vaccines – Jan 23, 2021

The Oxford-AstraZeneca vaccine works differently. It was built using a kind of virus called an adenovirus, which causes colds in chimpanzees. These adenovirus-based vaccines represent a newly approved method of vaccination that has been studied for decades. The adenovirus is altered to carry a gene for the coronavirus protein, which can then train a person’s immune system to recognize the actual coronavirus if it ever enters the body.

How effective are the COVID-19 vaccines?

  • Pfizer: 95 per cent
  • Moderna: 94.1 per cent
  • AstraZeneca: 62 per cent

Each of the vaccines has been found to be effective in combatting the coronavirus. However, they don’t all offer the same amount of protection.

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Pfizer and Moderna have a photo-finish for first place in terms of effectiveness. Clinical trials found Pfizer’s vaccine was 95 per cent effective, while Moderna’s vaccine nipped at Pfizer’s heels with an effectiveness of 94.1 per cent.

The distant bronze goes to the Oxford-AstraZeneca vaccine, which was found to be 62 per cent effective in a two-dose clinical trial.


Click to play video 'Tracking the global race to vaccinate against COVID-19'



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Tracking the global race to vaccinate against COVID-19


Tracking the global race to vaccinate against COVID-19 – Jan 24, 2021

However, researchers accidentally gave a sub-group of participants a half-dose on their first jab of the Oxford-AstraZeneca jab, followed up by a full second dose. This group saw a leap in the vaccine’s ability to shield them from the virus, with the outcome proving to be 90 per cent effective.

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Because this was just a sub-group within the clinical trial, the vaccine was only approved for use in its full, two-dose iteration — which is over 30 per cent less effective than Pfizer and Moderna’s vaccines.

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Still, at the end of the day, Canadians should feel confident that any one of the three approved vaccines will cut off COVID-19’s claws and protect them from the worst outcomes of the virus.

“If there is a vaccine and it’s been authorized by Health Canada, it means that it’s met standards,” said Dr. Supriya Sharma, chief medical advisor with the regulatory branch of Health Canada, said on Friday.

She explained that in clinical trials, all the vaccines were found to quash the worst outcomes in coronavirus patients.

“The number of cases of people that died from COVID-19 that got vaccine was zero. The number of people that were hospitalized because their COVID-19 disease was so severe was zero. The number of people that died because of an adverse event or an effect of the vaccine was zero,” Sharma said.

“So in the areas where we’re really looking to prevent serious illness, prevent hospitalizations and of course prevent death, all of these vaccines are good.”

How are the COVID-19 vaccines stored?

  • Pfizer: -70°C
  • Moderna: -25°C to -15°C
  • AstraZeneca: 2°C to 8°C

Just like people, some of these vaccines are pickier than others about the temperature they like to hang around in.

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Of the three vaccines, Pfizer is the most particular — and it likes things chilly. This vaccine requires ultra-cold storage, meaning it has to be transported and stored at -70 C. This makes the vaccine tricky to ship to remote regions, where the appropriate infrastructure is far more difficult to set up.


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Coronavirus: Tam says she has received no reports of COVID-19 vaccine ‘wastage’


Coronavirus: Tam says she has received no reports of COVID-19 vaccine ‘wastage’ – Jan 5, 2021

Enter the Moderna vaccine, which is a little less discerning. While this vaccine still likes the cold, it isn’t quite as particular as the Pfizer jab. The Moderna doses can be stored in a freezer between -25 C and -15 C. That’s why the territories have been guaranteed priority access to this particular vaccine, as it’s much easier to safely transport and store.

This category is also where AstraZeneca’s vaccine truly shines. The doses can be stored at normal fridge temperature — meaning the doses are much easier to both ship and keep.

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How many doses of each COVID-19 vaccine are required?

  • Pfizer: two
  • Moderna: two
  • AstraZeneca: two

Pfizer, Moderna and AstraZeneca’s vaccines are all two-dose shots — leaving little room for relief for those Canadians who get sweaty palms at the very thought of needles.

Some, including the head of Ontario’s vaccine rollout Gen. Rick Hillier, have pushed for Moderna to be approved as a single-dose vaccine, as the jab has proven to be about 80 per cent effective after the first injection.

However, no clinical trials have been conducted to prove whether that inoculation lasts long-term — and Moderna hasn’t shown any interest in conducting further trials to determine if less effective, one-time vaccine is a safe and effective option.

Who can take the COVID-19 vaccine?

  • Pfizer: 16+
  • Moderna: 18+
  • AstraZeneca: 18+

While Canada is on track to have tens of millions of doses available to Canadians this year, not everyone who may want the vaccine will be able to take it.

Pfizer’s clinical trials were only conducted on those over the age of 16, which means that until further studies are completed in younger age groups, anyone under 16 years old is ineligible for the jab. The same issue comes into play for both Moderna and AstraZeneca, which only conducted their clinical trials on Canadians over the age of 18.

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Click to play video 'When will kids be able to get the COVID-19 vaccine? Experts weigh in'



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When will kids be able to get the COVID-19 vaccine? Experts weigh in


When will kids be able to get the COVID-19 vaccine? Experts weigh in – Jan 26, 2021

Moderna is currently conducting additional studies in children over 12 years old, so teens may be able to access the jabs once that work is done.

However, age isn’t the only limitation those hoping to be vaccinated may face. Anyone who is allergic to the ingredients in the vaccines is not allowed to receive the injections, and pregnant or breastfeeding mothers have been asked to consult their doctors before moving ahead with their vaccinations.

Finally, if you have COVID-19, you can’t get the vaccine until you’re better.

How many doses is Canada getting?

  • Pfizer: 40 million doses
  • Moderna: 40 million doses
  • AstraZeneca: 20 million doses

Out of the three approved vaccines, individual Canadians are most likely to wind up receiving the Moderna vaccine. Canada’s agreement with Moderna is for 40 million doses — although the feds have the option of purchasing another 16 million in addition to that. The 40 million doses are enough to inoculate 20 million Canadians, over half of the population.

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Meanwhile, Canada has 40 million Pfizer doses secured in its agreement with the manufacturer. That’s enough to inoculate another 20 million Canadians, which means that between Pfizer and Moderna alone, Canada has enough doses to vaccine every Canadian and then some.


Click to play video 'Trudeau confirms Pfizer vaccine delivery schedule, reiterates promise of COVID-19 vaccines for all Canadians ‘who want one’ by September'



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Trudeau confirms Pfizer vaccine delivery schedule, reiterates promise of COVID-19 vaccines for all Canadians ‘who want one’ by September


Trudeau confirms Pfizer vaccine delivery schedule, reiterates promise of COVID-19 vaccines for all Canadians ‘who want one’ by September – Feb 12, 2021

As for the agreement with AstraZeneca, Canada has purchased 20 million doses — enough to vaccine another 10 million Canadians. That means that between the three agreements, Canada has enough doses to inoculate 40 million people, which is more than the entire population, within the year.

Should Canada opt to purchase more of any of the vaccines, there’s no guarantee they’d arrive any faster than the initial 80 million doses. Any additional doses would be entirely dependent on the manufacturer’s production capacity, which is under serious strain as every country battles to get the vaccines.

Either way, Canada’s current vaccine agreements point in an optimistic direction: every Canadian who wants a vaccine should be able to access one in 2021.

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© 2021 Global News, a division of Corus Entertainment Inc.

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Decrease in COVID-19 in Prince Albert according to wastewater report

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Graphic courtesy HFCM Communicatie, via Wikimedia This is a representation of what the Covid-19 virus would look like under a powerful microscope.

The USask Global Institute for Water Security wastewater survey for Prince Albert shows that the COVID-19 viral RNA load in Prince Albert’s has decreased by 46.5 per cent.

This was after there was a single decrease in last week’s report.

The number is based on averages of three individual daily measurements in this reporting period up to May 22 which are then compared to the weekly average of the previous week.

This week’s viral load of approximately 10,000 gene copies / 100 mL SARS-CoV-2 is the 85th-highest value observed during the pandemic.

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This concentration of viral particles is considered Low because it is below the range and regarded as low in Prince Albert.

This week’s viral RNA load indicates that the SARS-CoV-2 infections in Prince Albert are reducing.

Whole genome sequencing confirmed the presence of BQ.1, BQ.1.1, BQ.1.1.4, BQ.1.18, XBB.1.5, BA.5.2.1 and BE.1.1 in earlier samples; which have S:Y144del, S:R346T, S:K444T, S:N460K mutations associated with immune escape. In addition, the sequences of the most recently collected sample relative to the previously collected samples indicate the level of presence of BA.2 and BA.5 in Prince Albert’s wastewater to be 94 per cent and 78 per cent stable respectively.

All data has been shared with Saskatchewan health authorities.

USask and Global Water Futures researchers are using wastewater-based epidemiology to monitor for SARS-CoV-2 (the virus causing COVID-19) in Saskatoon, Prince Albert and North Battleford wastewater, providing early warning of infection outbreaks. This work is being done in partnership with the Saskatchewan Health Authority, Public Health Agency of Canada, City of Saskatoon, City of Prince Albert and City of North Battleford.

This variant tracking data should be seen merely as an indicator of trends which need to be verified using sequencing technology through the Public Health Agency of Canada. Because individuals are at varying stages of infection when shedding the virus, the variant levels detected in sewage are not necessarily directly comparable to the proportion of variant cases found in individual swab samples confirmed through provincial genetic sequencing efforts.

editorial@paherald.sk.ca

 

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Just when we were starting to see COVID and RSV rates drop this spring, another type of virus contributed to a spike in respiratory infections

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Josep Suria/Shutterstock
  • Human metapneumovirus spiked this spring as cases of COVID and RSV fell.
  • According to the CDC, 19.6% of antigen tests and nearly 11% of PCR tests for HMPV, were positive in the US in early March.
  • Symptoms of HMPV include cough, fever, nasal congestion, and shortness of breath.

Cases of another type of respiratory virus have spiked this spring, just as COVID-19 and RSV rates were finally falling in the US.

According to the CDC, 19.6% of antigen tests and nearly 11% of PCR tests for human metapneumovirus, or HMPV, were positive in the US in early March.

The nearly 11% of positive PCR cases is up 36% since before the COVID-19 pandemic when PCR tests for HMPV were coming back with a rate of 7% positivity, according to the CDC.

In contrast, COVID-19 cases were down nearly 30% at the beginning of March, according to the World Health Organization, and the number of people being hospitalized for RSV was down to 1.2 people per 100,000 in March from 4.5 people per 100,000 in January, according to the CDC.

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Symptoms of HMPV include cough, fever, nasal congestion, and shortness of breath, according to the CDC. The symptoms could progress into bronchitis, pneumonia, or other similar viruses that cause upper and lower respiratory infections.

The CDC said some might be sicker for longer than others, and the duration of the virus depends on the severity, but for the most part, is similar in length to other respiratory infections caused by viruses.

The virus is spread by coughs and sneezes, close personal contact, and touching surfaces infected with the virus, then touching the mouth, nose, or eyes.

According to CNN, there’s no vaccine for HMPV, nor is there an antiviral drug to treat it.

 

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Health

Just when we were starting to see COVID and RSV rates drop this spring, another type of virus contributed to a spike in respiratory infections

Published

 on

Josep Suria/Shutterstock
  • Human metapneumovirus spiked this spring as cases of COVID and RSV fell.
  • According to the CDC, 19.6% of antigen tests and nearly 11% of PCR tests for HMPV, were positive in the US in early March.
  • Symptoms of HMPV include cough, fever, nasal congestion, and shortness of breath.

Cases of another type of respiratory virus have spiked this spring, just as COVID-19 and RSV rates were finally falling in the US.

According to the CDC, 19.6% of antigen tests and nearly 11% of PCR tests for human metapneumovirus, or HMPV, were positive in the US in early March.

The nearly 11% of positive PCR cases is up 36% since before the COVID-19 pandemic when PCR tests for HMPV were coming back with a rate of 7% positivity, according to the CDC.

In contrast, COVID-19 cases were down nearly 30% at the beginning of March, according to the World Health Organization, and the number of people being hospitalized for RSV was down to 1.2 people per 100,000 in March from 4.5 people per 100,000 in January, according to the CDC.

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Symptoms of HMPV include cough, fever, nasal congestion, and shortness of breath, according to the CDC. The symptoms could progress into bronchitis, pneumonia, or other similar viruses that cause upper and lower respiratory infections.

The CDC said some might be sicker for longer than others, and the duration of the virus depends on the severity, but for the most part, is similar in length to other respiratory infections caused by viruses.

The virus is spread by coughs and sneezes, close personal contact, and touching surfaces infected with the virus, then touching the mouth, nose, or eyes.

According to CNN, there’s no vaccine for HMPV, nor is there an antiviral drug to treat it.

Read the original article on Insider

 

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