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What protection to expect from updated COVID vaccines this fall – CBC News

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Canada has just approved an updated COVID-19 vaccine to target the first highly contagious Omicron variant, with doses expected to start rolling out within days. But what exactly can we expect from these new shots when they land in the real world? 

The updated Moderna vaccine is a combination of two strains, also known as a “bivalent” vaccine, that targets both the original virus and the Omicron variant BA.1 that emerged late last year and drove the largest wave of infection and hospitalization in the pandemic.

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While the new shot doesn’t directly target dominant Omicron subvariants BA.4 and BA.5, which the U.S. approved an updated shot for this week, Pfizer submitted an application for Health Canada approval for its BA.4-5 vaccine Friday and Moderna is expected to soon.

“The evidence we have to date shows that the bivalent vaccine with BA.1 offers good protection against BA.4 and BA.5,” Deputy Chief Public Health Officer Dr. Howard Njoo said during a technical briefing Thursday.

“Certainly as the situation evolves we’ll have to look at the evidence and see what happens with real-world effectiveness.”

But what an updated booster can do for you depends on how vulnerable your immune system is, whether you’re one of the millions of Canadians who’ve recently been infected with COVID and when you last had a vaccine. 

WATCH | Health Canada approves updated vaccine targeting Omicron variant: 

Vaccine for Omicron variant approved by Health Canada

2 days ago

Duration 2:52

Health Canada has approved a new bivalent COVID-19 vaccine from Moderna, which targets the Omicron variant. It’s the first vaccine of its type in Canada, but officials say another batch of booster shots, specifically targeting Omicron’s BA.4 and BA.5 subvariants, could arrive later this fall.

Will updated vaccines stop COVID spread?

Infectious diseases experts, virologists, epidemiologists and immunologists are hopeful updated vaccines will be more effective at preventing transmission than the original shots — at least initially — but also caution Canadians not to expect them to be a silver bullet. 

With limited data on the impact these vaccines will have, all eyes will be on the effect they have on slowing rates of infection and transmission and whether they better protect vulnerable groups in the population heading into the fall and winter months.

“We do not know what the impact is because that is not available,” Chief Public Health Officer Dr. Theresa Tam said during a news conference Thursday when asked by CBC News how effective the updated vaccines will be at stopping the spread of the virus. 

Chief Public Health Officer Theresa Tam said she is hopeful that the new bivalent vaccine boosts protection against infection and transmission, at least through the fall. (Adrian Wyld/The Canadian Press)

Tam said she is hopeful that the new bivalent BA.1-targeted vaccine from Moderna boosts protection against infection and transmission — at least through the fall.

Clinical trial data on the BA.1-targeted vaccines from Moderna and Pfizer-BioNTech suggests they provide slightly stronger immune protection against Omicron than the original vaccines, but exactly what that translates to in the real world remains to be seen.

“The immune responses to these variant-tuned boosters are modestly encouraging, but we are still waiting for definitive clinical evidence,” said Dr. David Naylor, who co-chairs the federal government’s COVID-19 Immunity Task Force.

“That said, even if their marginal advantages are small, they could have a meaningfully positive impact if their novelty rekindles public interest in getting boosted.” 

A new preprint modelling study, that has not been peer reviewed, suggested that updated vaccines may not be much more effective than existing boosters in a population with hybrid immunity from vaccination and infection — especially when it comes to protection against severe illness.

But that could still lead to significant protection at a population level, with the preprint also suggesting that for every 1,000 people vaccinated with an updated booster, an average of eight fewer people would be hospitalized compared with the original vaccines. 

“We don’t know yet the magnitude of this improvement, but it will likely be pretty limited,” said Dr. Gaston De Serres, an epidemiologist at the Quebec National Institute of Public Health (INSPQ). 

“Especially against severe outcomes like hospitalization for which, up until now, the original [vaccines] have been quite successful.”

What can updated COVID vaccines do for you?

More than half of Canadians have been infected with COVID since the emergence of Omicron and its highly contagious subvariants, and the added protection from prior infection in a vaccinated population appears to be providing an edge. 

A new research letter published in the New England Journal of Medicine looked at the risk of BA.5 infection among people in Portugal who had a prior infection with past variants, including BA.1 and BA.2, and found they had strong protection against the newer variant. 

That’s in part because Portugal has such high levels of vaccination, with more than 98 per cent of the population studied having at least two doses, meaning that much like in Canada our high levels of two-dose vaccination and infection provide strong immune protection.

Two Canadian preprint studies from May and June, which have not been peer reviewed, also found prior Omicron infections provided robust immunity against future reinfection and hospitalization — especially when combined with vaccination.

“In general, we can anticipate that those who have hybrid immunity are going to be better protected,” said Dr. Danuta Skowronski, a vaccine effectiveness expert and epidemiology lead at the B.C. Centre for Disease Control and co-author of the preprints. 

“And it is also true that vaccine strains that are a better match to the circulating variant will likely provide better protection.”

The longer you wait after your last infection or vaccination is also important to consider, with emerging evidence suggesting getting a booster too closely after being infected or vaccinated can impact how effective the shot is.

A new small preprint study, which has not been peer reviewed, found that getting a booster within two months of an infection could negatively impact B cells that help generate immune protection against severe disease.

NACI recommends waiting three months after an infection before getting another shot, and three to six months between doses, but also said in its most recent guidance that anyone at high risk of severe COVID in Canada should be offered a fall booster. 

“Timing is everything and in general the recommendations are to wait a few months following infection before receiving a booster dose,” Skowronski said. 

She added that people shouldn’t immediately rush out to get a booster after infection because it could actually interfere with the immune response.

Updated vaccines ‘will help,’ but not a ‘miracle’

Canada still has a “worrisome gap” in third dose coverage, Naylor said, with less than half of Canadians having received a booster even though it provides significant added protection against severe COVID-19. Only about 12 per cent have received a fourth dose. 

“As we start to head into the fall and we start to see almost certainly cases rise again, the updated booster is definitely going to be better than not getting a booster at all,” said Deepta Bhattacharya, an immunobiology professor at the University of Arizona. 

“Given that BA.5 is still circulating, I don’t see that there’s really any downside at all to picking up these boosters and they’ll probably work better than just another shot of the original.”

Less than half of Canadians have received a booster even though it provides significant added protection against severe COVID-19. Only about 12 per cent have received a fourth dose. (Darryl Dyck/The Canadian Press)

Bill Hanage, an epidemiologist at Harvard’s T.H. Chan School of Public Health in Boston, said it’s important to consider that even though the original vaccines were far from an exact match to Omicron — they still provided strong protection against severe illness.

“But the closer matches now should do more,” he said in an email. “Notably, there may well be a period following the shot when people are immune to infection.”

Bhattacharya said the “big question” that is top of mind right now is how effective the updated vaccines will be at stopping transmission in the real world — and for how long.

“Do we start to restore some of the protection against any infection or symptomatic infection with these boosters? I expect we will,” he said. “Exactly how long that effect will last, I think, is to be determined.”

Dr. Allison McGeer, a medical microbiologist and infectious disease specialist at Toronto’s Mount Sinai Hospital, said the updated shots may provide a slight boost in neutralizing antibodies that can prevent transmission — and that added protection is “not nothing.” 

“An extra dose of the original vaccine results in substantial increased protection against BA.4 and BA.5. It’s not perfect, but I think we’re finding out nothing is perfect,” she said. “The bivalent vaccines, they may be a little better, but they’re not going to be a miracle.”

Bhattacharya said that while clinical trials showed there is only about a twofold increase in protective antibodies against the BA.1, BA.4 and BA.5 variants targeted by Moderna and Pfiizer in their bivalent vaccines — it’s still significant protection. 

“If you look at the data, it’s a ton more antibodies that are being made,” he said. “So I have every reason to expect that they will help — and probably help a lot.”

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Gildan replacing five directors ahead of AGM, will back two Browning West nominees – Yahoo Canada Finance

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MONTREAL — Gildan Activewear Inc. is making changes to its board of directors in an attempt to head off a move by an activist shareholder looking to replace a majority of the board at its annual meeting next month.

U.S. investment firm Browning West wants to replace eight of Gildan’s 12 directors with its own nominees in a move to bring back founder Glenn Chamandy as chief executive.

Gildan, which announced late last year that Chamandy would be replaced by Vince Tyra, said Monday it will replace five members of its board of directors ahead of its annual meeting set for May 28.

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It also says current board members Luc Jobin and Chris Shackelton will not run for re-election and that it will recommend shareholders vote for Karen Stuckey and J.P. Towner, who are two of Browning West’s eight nominees.

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The new directors who will join the Gildan board on May 1 are Tim Hodgson, Lee Bird, Jane Craighead, Lynn Loewen and Les Viner. They will replace Donald Berg, Maryse Bertrand, Shirley Cunningham, Charles Herington and Craig Leavitt.

Hodgson, who served as chief executive of Goldman Sachs Canada from 2005 to 2010, is expected to replace Berg as chair.

“I look forward to working with this highly qualified board and management team to realize the full benefits of Vince’s ambitious yet realistic plan to drive growth by enhancing the Gildan sustainable growth strategy,” Hodgson said in a statement.

“The refreshed board and I fully believe in Vince and his talented team as well as Gildan’s leading market position and growth prospects.”

Gildan has been embroiled in controversy ever since it announced Chamandy was being replaced by Tyra.

The company has said Chamandy had no credible long-term strategy and had lost the board’s confidence. But several of Gildan’s investors have criticized the company for the move and called for his return.

Those investors include the company’s largest shareholder, Jarislowsky Fraser, as well as Browning West and Turtle Creek Asset Management.

In announcing the board changes, Gildan said it met with shareholders including those who Browning West has counted as supportive.

“Our slate strikes a balance between ensuring the board retains historical continuity during a period of transition and provides fresh perspectives to ensure it continues to serve its important oversight function on behalf of all shareholders,” the company said.

Gildan said last month that it has formed a special committee of independent directors to consider a “non-binding expression of interest” from an unnamed potential purchaser and contact other potential bidders.

But Browning West and Turtle Creek have said the current board cannot be trusted to oversee a sale of the company.

The company said Monday that there continues to be external interest in acquiring the company and the process is ongoing.

This report by The Canadian Press was first published April 22, 2024.

Companies in this story: (TSX:GIL)

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Ottawa puts up $50M in federal budget to hedge against job-stealing AI – CP24

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Anja Karadeglija, The Canadian Press


Published Sunday, April 21, 2024 4:02PM EDT


Last Updated Sunday, April 21, 2024 4:04PM EDT

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Worried artificial intelligence is coming for your job? So is the federal government — enough, at least, to set aside $50 million for skills retraining for workers.

One of the centrepiece promises in the federal budget released Tuesday was $2.3 billion in investments aiming to boost adoption of the technology and the artificial intelligence industry in Canada.

But tucked alongside that was a promise to invest $50 million over four years “to support workers who may be impacted by AI.” Workers in “potentially disrupted sectors and communities” will receive new skills training through the Sectoral Workforce Solutions Program.

“There is a significant transformation of the economy and society on the horizon around artificial intelligence,” said Joel Blit, an associate professor of economics at the University of Waterloo.

Some jobs will be lost, others will be created, “but there’s going to be a transition period that could be somewhat chaotic.”

While jokes about robots coming to take jobs predate the emergence of generative AI systems in late 2022, the widespread availability of systems like ChatGPT made those fears real for many, even as workers across industries began integrating the technology into their workday.

In June 2023, a briefing note for Finance Minister Chrystia Freeland warned the impact of generative AI “will be felt across all industries and around 40 per cent of all working hours could be impacted.”

“Banking, insurance and energy appear to have higher potential for automation compared to other sectors,” says the note, obtained through access to information and citing information from Accenture.

“This could have substantial impacts on jobs and skills requirements.”

The budget only singles out “creative industries” as an affected sector that will be covered by the program. In February, the Canadian TV, film, and music industries asked MPs for protection against AI, saying the tech threatens their livelihood and reputations.

Finance Canada did not respond to questions asking what other sectors or types of jobs would be covered under the program.

“The creative industries was used as an illustrative example, and not intended as an exclusion of other affected areas,” deputy Finance spokesperson Caroline Thériault said in a statement.

In an interview earlier this year, Bea Bruske, president of the Canadian Labour Congress, said unions representing actors and directors have been very worried about how their likenesses or their work could be used by AI systems. But the “reality is that we have to look at the implication of AI in all jobs,” she said.

Blit explained large language models and other generative AI can write, come up with new ideas and then test those ideas, analyze data, as well as generate computer programming code, music, images, and video.

Those set to be affected are individuals in white-collar professions, like people working in marketing, health care, law and accounting.

In the longer run, “it’s actually quite hard to predict who is going to be impacted,” he said. “What’s going to happen is that entire industries, entire processes are going to be reimagined around this new technology.”

AI is an issue “across sectors, but certainly clerical and customer service jobs are more vulnerable,” Hugh Pouliot, a spokesperson for the Canadian Union of Public Employees, said in an email.

The federal government has used AI in nearly 300 projects and initiatives, new research published earlier this month revealed.

According to Viet Vu, manager of economic research at Toronto Metropolitan University’s the Dais, the impact of AI on workers in a sector like the creative industry doesn’t have to be negative.

“That’s only the case if you adopt it irresponsibly,” he said, pointing out creative professionals have been adopting new digital tools in their work for years.

He noted only four per cent of Canadian businesses are using any kind of artificial intelligence or machine learning. “And so we’re really not there yet for these frontier models and frontier technologies” to be making an impact.

When it comes to the question of how AI will affect the labour market, it’s more useful to think about what types of tasks technology can do better, as opposed to whether it will replace entire jobs, Vu said.

“A job is composed of so many different tasks that sometimes even if a new technology comes along and 20, 30 per cent of your job can be done using AI, you still have that 60, 70 per cent left,” he said.

“So it’s rare that (an) entire occupation is actually sort of erased out of existence because of technology.”

Finance Canada also did not respond to questions about what new skills the workers would be learning.

Vu said there are two types of skills it makes sense to focus on in retraining — computational thinking, or understanding how computers operate and make decisions, and skills dealing with data.

There is no AI system in the world that does not use data, he said. “And so being able to actually understand how data is curated, how data is used, even some basic data analytics skills, will go a really long way.”

But given the scope of the change the AI technology is set to trigger, critics say a lot more than $50 million will be necessary.

Blit said the money is a good first step but won’t be “close to enough” when it comes to the scale of the coming transformation, which will be comparable to globalization or the adoption of computers.

Valerio De Stefano, Canada research chair in innovation law and society at York University, agreed more resources will be necessary.

“Jobs may be reduced to an extent that reskilling may be insufficient,” and the government should look at “forms of unconditional income support such as basic income,” he said.

The government should also consider demanding AI companies “contribute directly to pay for any social initiative that takes care of people who lose their jobs to technology” and asking “employers who reduce payrolls and increase profits thanks to AI to do the same.”

“Otherwise, society will end up subsidizing tech businesses and other companies as they increase profit without giving back enough for technology to benefit us all.”

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Honda to build electric vehicles and battery plant in Ontario, sources say – Global News

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Honda Canada is set to build an electric vehicle battery plant near its auto manufacturing facility in Alliston, Ont., where it also plans to produce fully electric vehicles, The Canadian Press has learned.

Senior sources with information on the project confirmed the federal and Ontario governments will make the announcement this week, but were not yet able to give any dollar figures.

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However, comments Monday from Ontario Premier Doug Ford and Economic Development Minister Vic Fedeli suggest it is a project worth around $14 billion or $15 billion.

Ford told a First Nations conference that there will be an announcement this week about a new deal he said will be double the size of a Volkswagen deal announced last year. That EV battery plant set to be built in St. Thomas, Ont., comes with a $7-billion capital price tag.

Fedeli would not confirm if Ford was referencing Honda, but spoke coyly after question period Monday about the amount of electric vehicle investment in the province.

“We went from zero to $28 billion in three years and if the premier, if his comments are correct, then next week, we’ll be announcing $43 billion … in and around there,” he said.

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The Honda facility will be the third electric vehicle battery plant in Ontario, following in the footsteps of Volkswagen and a Stellantis LG plant in Windsor, and while those two deals involved billions of dollars in production subsidies as a way of competing with the United States’ Inflation Reduction Act subsidies, Honda’s is expected to involve capital commitments and tax credits.


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Federal Finance Minister Chrystia Freeland’s recent budget announced a 10-per-cent Electric Vehicle Supply Chain investment tax credit on the cost of buildings related to EV production as long as the business invests in assembly, battery production and cathode active material production in Canada.

That’s on top of an existing 30-per-cent Clean Technology Manufacturing investment tax credit on the cost of investments in new machinery and equipment.

Honda’s deal also involves two key parts suppliers for their batteries — cathodes and separators — with the locations of those facilities elsewhere in Ontario set to be announced at a later date.

The deal comes after years of meetings and discussions between Honda executives and the Ontario government, the sources said.

Prime Minister Justin Trudeau, Premier Doug Ford and Honda executives were on hand in March 2022 in Alliston when the Japanese automaker announced hybrid production at the facility, with $131.6 million in assistance from each of the two levels of government.

Around the time of that announcement, conversations began about a larger potential investment into electric vehicles, the sources said, and negotiations began that summer.

Fedeli travelled to Japan that fall, the first of three visits to meet with Honda Motor executives about the project. Senior officials from the company in Japan also travelled to Toronto three times to meet with government officials, including twice with Ford.

During a trip by the Honda executives to Toronto in March 2023, Ontario officials including Fedeli pitched the province as a prime destination for electric vehicle and battery investments, part of a strong push from the government to make Ford’s vision of an end-to-end electric vehicle supply chain in the province a reality.

Negotiations took a major step forward that July, when Ontario sent a formal letter to Honda Canada, signalling its willingness to offer incentives for a battery plant and EV production. Honda Canada executives then met with Ford in November and December.

The latter meeting sealed the deal, the sources said.

Honda approached the federal government a few months ago, a senior government official said, and Freeland led her government’s negotiations with the company.

The project is expected to involve the construction of several plants, according to the source.

— With files from Nojoud Al Mallees in Ottawa.

&copy 2024 The Canadian Press

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