Connect with us


Which COVID-19 vaccine has the lowest rate of breakthrough infections? –



Unvaccinated people currently account for most new cases of COVID-19 in the U.S., but a small proportion of cases are in vaccinated people; these cases are known as breakthrough infections. But is there a difference in how often people get breakthrough infections depending on which vaccine they got?

The short answer is, we don’t know exactly, but there are some hints in the data. The Johnson & Johnson vaccine does seem to have higher rates of breakthrough infection than the Pfizer and Moderna vaccines, but that was expected based on the results of clinical trials. Some very early hints show a slightly lower rate of breakthrough infections with the Moderna vaccine than with the Pfizer vaccine, but that early finding is based on data on a few million people from only two locations and thus may not represent the overall picture in the country.  

Related: 5 dangerous myths about vaccines


Because no vaccine is 100% effective, breakthrough infections have been expected from the start of the vaccine rollout. In the context of clinical trials, about 0.04% of people given the Pfizer vaccine got infected with SARS-CoV-2, versus about 0.07% with Moderna and 0.59% with Johnson & Johnson. 

Now that the vaccines are authorized, scientists have the chance to track how many breakthrough infections occur in the real-world, beyond clinical trials. When breakthroughs do occur, most people experience mild symptoms, if they fall ill at all, and a small percentage develop severe disease, require hospitalization or die, current data suggests. 

The recent rise of the highly-transmissible delta variant might raise the risk of breakthrough infections, though. For example, a recent Centers for Disease Control and Prevention (CDC) study, published Aug. 6 as a Morbidity and Mortality Weekly Report (MMWR) report, found that the delta variant surged in Mesa County, Colorado between May and June; at the same time, the county accrued a “significantly higher” proportion of breakthrough cases compared with other Colorado counties, where delta was less prevalent. 

Reporting of breakthrough infections now falls largely on the states, and of the 25 or so states that report breakthrough infections, most don’t yet provide data on the number of cases linked to each vaccine brand, Live Science found in a search of state health department websites.

However, Oklahoma and Washington, D.C., do make this information public. These data could provide “early signals” regarding how well the vaccines are working, particularly as new variants emerge, the DC Health website states. That said, there are many limitations: The data sets are small, each vaccine was given to different numbers of people and the timing of the doses makes it hard to interpret the data.  

Related: Coronavirus variants: Here’s how the SARS-CoV-2 mutants stack up

Still, as of Aug. 1, more than 299,000 D.C. residents had been fully vaccinated, according to data from DC Health. Of these people, nearly 151,000 received the two-dose Pfizer vaccine, about 124,700 got the two-dose Moderna vaccine and about 24,000 received the one-dose Johnson & Johnson vaccine.

In this population, the highest rate of breakthroughs was seen in those who got the Johnson & Johnson shot: 77 people, or 0.32% of the roughly 24,000 recipients. The second highest rate was seen among Pfizer recipients, of whom 308 people, or 0.2%, tested positive for the virus. Finally, 161, or 0.13%, of the Moderna recipients caught a breakthrough infection.

These numbers include asymptomatic, mild, moderate and severe breakthrough cases. Some people with asymptomatic or mild infections may not get tested, so their cases would be missed, meaning this is probably an undercount of breakthroughs.

Related: 20 of the worst epidemics and pandemics in history

Oklahoma has reported similar results. 

As of Aug. 2, more than 1.5 million Oklahomans had been fully vaccinated, according to a report from the Oklahoma State Department of Health. About 817,000 had received Pfizer shots, 674,000 received Moderna and 102,000 got Johnson & Johnson. Again, the Johnson & Johnson recipients showed the highest rate of breakthrough cases, with 215, or 0.21%, testing positive for the virus; 1,468 Pfizer recipients, or 0.17% of the total, caught a breakthrough infection; and 831 Moderna recipients, or 0.12%, tested positive for the virus.

These snapshots from Oklahoma and D.C. likely offer an incomplete picture of breakthrough cases in each region, however, and for now, it’s unclear if the observed patterns are representative of the country as a whole. To accurately compare the vaccine brands, particularly with the delta variant still running rampant, we simply need more data, Robert Darnell, a physician scientist at The Rockefeller University in New York, told National Geographic

That said, other preliminary research also suggests Moderna’s vaccine offers more protection against the delta variant than Pfizer’s, which could help explain the differences in breakthrough rates, Reuters reported. One study, posted Aug. 8 on the preprint database bioRxiv, included more than 50,000 patients in the Mayo Clinic Health System and found that the Moderna vaccine’s real-world effectiveness fell from 86% to 76% between January and July, when delta gained prominence. In the same time window, Pfizer’s effectiveness fell from 76% to 42%. 

However, that study has not been peer-reviewed yet, so the results still need to be confirmed.

Originally published on Live Science. 

Adblock test (Why?)


Source link

Continue Reading


The close: TSX notches biggest gain of 2023 as stocks rally on U.S. jobs data, debt default deal



U.S. and Canadian stocks closed higher on Friday after a labour market report showing moderating wage growth in May indicated the Federal Reserve may skip a rate hike in two weeks, while investors welcomed a Washington deal that avoided a catastrophic debt default. It was the biggest gain in seven months for the TSX, with energy and financial shares among the biggest winners in a broad-based rally.

Bond yields spiked as a risk-on tone to markets had investors shunning the bond market.

The tech-heavy Nasdaq index surged to a 13-month intraday high and posted its sixth-straight week of gains that mark its best winning streak since January 2020.

U.S. job growth accelerated in May but a surge in the unemployment rate to a seven-month high of 3.7% as more people looked for employment indicated labour market conditions were easing.


The jump in the unemployment rate from a 53-year low of 3.4% in April reflected a drop in household employment and a rise in the overall workforce. A bigger labour pool is easing pressure on businesses to raise wages and helping decelerate inflation.

Average hourly earnings climbed 0.3% after rising 0.4% in April. That lowered the year-on-year increase in wages to 4.3% after an advance of 4.4% in April. Annual wage growth averaged about 2.8% prior to the pandemic.

“While it appears to be a hot number on the actual number of people employed, the wage rate is not increasing as fast,” said Kim Forrest, chief investment officer at Bokeh Capital Partners in Pittsburgh. “That is a softening effect and is this the mythical soft landing? Looks like that.”

The data brought relief to investors who mostly expect the Fed to pause hiking rates at its policy meeting on June 13-14. It would be the first halt since the Fed started its aggressive anti-inflation policy tightening more than a year ago.

But some pointed to the much hotter-than-expected jobs data as a sign the Fed still has not yet tamed inflation.

“Our view is and has been that the market is completely wrong on assessing what the Federal Reserve is doing,” said Phil Orlando, chief equity strategist at Federated Hermes in New York.

“The market’s perception is that this economy was going to cool, inflation was going to collapse and the Fed was going to turn around and start cutting interest rates. That’s wrong.”

Fed funds futures showed a 66.6% probability that the Fed will hold rates steady in two weeks, down from 79.6% on Thursday, according to CME Group’s FedWatch Tool.

The yield on the 10-year U.S. Treasury climbed to 3.70% from 3.60% late Thursday. The two-year Treasury yield, which moves more on expectations for Fed action, jumped to 4.52% from 4.34%. Canadian bonds saw a similar jump in yields.

Markets now await data on key consumer prices a day before the Fed’s rate decision.

The Toronto Stock Exchange’s S&P/TSX composite index ended up 352.38 points, or 1.8%, at 20,024.63, its biggest advance since November 2022. For the week, it was up 0.5%.

“It is all these little factors that the market is holding on to, looking for any reason to be bullish and they’re finding it,” said Philip Petursson, chief investment strategist at IG Wealth Management. “It’s definitely risk-on today.”

The TSX energy sector rallied 2.8% as oil settled 2.3% higher at US$71.74 a barrel ahead of a meeting of OPEC and its allies this weekend.

Suncor Energy Inc was up 3.2% after the company told employees it plans to cut 1,500 jobs this year.

“It appears that some activist investors are trying to make Suncor more efficient over the long term by getting them to cut costs and that’s good to see for investors,” said Greg Taylor, chief investment officer at Purpose Investments.

Heavily-weighted financials rose 2.1% and industrials were up 2.2%.

The real estate sector also advanced 2.2% as data showed home prices in the Greater Toronto Area increased in May from April and sales rose sharply.

In contrast, shares of Canaccord Genuity Group Inc fell 6.8% after a management-led consortium said its C$1.13 billion take-private offer may not result in a deal.

In the U.S., the Senate passing a bill late on Thursday to lift the government’s US$31.4 trillion debt ceiling avoided what would have been a catastrophic, first-ever default.

Passage of the vote eased investor concerns as Wall Street’s fear gauge, the CBOE volatility index, fell to its lowest since November 2021, down 1.1 points at 14.6 points.

The Dow Jones Industrial Average rose 701.19 points, or 2.12%, to 33,762.76, the S&P 500 gained 61.35 points, or 1.45%, to 4,282.37 and the Nasdaq Composite added 139.78 points, or 1.07%, to 13,240.77.

Shares of Verizon Communications Inc, AT&T Inc and T-Mobile US Inc declined after a report said Inc was in talks with the U.S. telecoms to offer low-cost wireless services to its Prime members.

Verizon slid 3.2%, while AT&T and T-Mobile declined 3.8% and 5.6%, respectively; Amazon gained 1.2%.

All 11 S&P 500 sectors advanced, with the materials index leading, up 3.4%, and the consumer discretionary sector, housing Amazon, close behind, rising 2.2%.

Nvidia Corp slid 1.1% for a second day of declines after briefly entering on Wednesday the elite club of megacap stocks valued at $1 trillion or more on hopes artificial intelligence will deliver significant future returns.

But Nvidia’s almost 170% rise year to date highlights investors face of a market dominated by the out-performance of megacaps while most other companies tread water.

“Nobody’s really explained to me how they’re going to make any money from it,” said Michael Landsberg, chief investment officer at Landsberg Bennett Private Wealth Management in Punta Gorda, Florida. “A company like Nvidia going up so much in such a short period of time, that doesn’t make any rational sense.”

Advancing issues outnumbered declining ones on the NYSE by a 4.75-to-1 ratio; on Nasdaq, a 2.73-to-1 ratio favored advancers. The S&P 500 posted 15 new 52-week highs and two new lows; the Nasdaq Composite recorded 74 new highs and 40 new lows. Volume on U.S. exchanges was 11.05 billion shares, compared with about 10.58 billion average for the full session over the last 20 trading days.

Reuters, Globe staff



Source link

Continue Reading


Gold prices struggling as 339K jobs created in May but unemployment rate rises to 3.7% – Kitco NEWS



Editor note Get all the essential market news and expert opinions in one place with our daily newsletter. Receive a comprehensive recap of the day’s top stories directly to your inbox. Sign up here!

(Kitco News) – The gold market is trying to hold its ground within striking distance of $2,000 but could face an uphill battle as the U.S. labor market remains healthy and robust.  

U.S. nonfarm payrolls rose by 339,000 last month, according to the Bureau of Labor Statistics. The monthly figure was significantly above the market consensus estimate of 193,000. April’s employment data was revised up to 294,000 jobs.

However, looking past the headline number, the report said the unemployment rate rose sharply to 3.7% missing market consensus calls of 3.5% for May. The unemployment rate it at its highest level since December 2022.


The gold market is seeing some selling pressure in initial reaction to the latest employment data. August gold futures last traded at $1,993.90 an ounce, down 0.08% on the day.

The report also said that wage growth rose in line with expectations, rising by 11 cents or 0.3% to 33.44 in May.

“Over the past 12 months, average hourly earnings have increased by 4.3 percent,” the report said.

While the gold market is seeing rising selling pressure, the latest employment data is not having much impact on interest rate expectations. According to the CME FedWatch Tool, markets still see a more than 65% chance that the central bank leaves interest rates unchanged when it meets later this month.

However, according to some analysts, the robust employment data indicates that while the central bank could pause, it has not yet finished raising interest rates. Some analysts have that this this longer-term shift in rate expectations could weigh on gold.

Adblock test (Why?)


Source link

Continue Reading


One-quarter of Air Canada flights delayed Friday as schedule recovers from IT issue – Yahoo Canada Finance



More than one-quarter of Air Canada flights experienced delays on Friday as the airline worked to return service to normal following a technical malfunction the previous day.

Air Canada had warned travellers early Friday morning they should be prepared for further flight disruptions. In its daily travel outlook, the carrier said that while its IT system was stable, flights may be affected at nine of Canada’s busiest airports, including Toronto’s Pearson, Montreal, Vancouver and Calgary.

Thursday’s outage led to more than 500 flights — over three quarters of its trips — to be delayed or cancelled on the day, creating what the airline said were “rollover effects” just prior to the weekend.


A total of 144 Air Canada flights, or 27 per cent of the airline’s scheduled load, had been delayed Friday as of around 4:30 p.m. EDT, along with 33 cancellations, according to tracking service

An additional 56 flights with Air Canada Rouge saw delays, one-third of its daily load, plus 23 cancellations.

“Air Canada has stabilized its communicator system and it is functioning normally. However, due to the effects of Thursday’s IT issues on our schedule, some flights may be delayed this morning as we reposition aircraft and crew,” it said in an emailed statement.

“Customers are advised to check the status of their flight before going to the airport. Our flexible travel policy remains in effect for customers to change their travel plans at no charge.”

The airline did not clarify when it expected its flight schedule to fully return to normal.

Thursday’s disruption, sourced to the system used by the airline to communicate with aircraft and monitor their performance, came one week after Air Canada grounded its planes for about an hour when the same system experienced a separate issue.

That day, 241 Air Canada flights — 46 per cent of its trips — were delayed, according to FlightAware. Another 19 flights were also cancelled.

Air Canada said it has been in the process of upgrading the communicator system.

This report by The Canadian Press was first published June 2, 2023.

Companies in this story: (TSX:AC)

Sammy Hudes, The Canadian Press

Adblock test (Why?)


Source link

Continue Reading