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WHO advisers to consider whether obesity medication should be added to Essential Medicines List

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Advisers to the World Health Organization will consider next month whether to add liraglutide, the active ingredient in certain diabetes and obesity medications, to its list of essential medicines.

The list, which is updated every two years, includes medicines “that satisfy the priority health needs of the population,” WHO says. “They are intended to be available within the context of function health systems at all times, in adequate amounts in the appropriate dosage forms, of assured quality and at prices that individuals and the community can afford.”

As the market for new weight loss drugs soars, people with diabetes pay the price

 

The list is “a guide for the development and updating of national and institutional essential medicine lists to support the procurement and supply of medicines in the public sector, medicines reimbursement schemes, medicine donations, and local medicine production.”

The WHO Expert Committee on the Selection and Use of Essential Medicines is scheduled to meet April 24-28 to discuss revisions and updates involving dozens of medications. The request to add GLP-1 receptor agonists such as liraglutide came from four researchers at US institutions including Yale University and Brigham and Women’s Hospital.

These drugs mimic the effects of an appetite-regulating hormone, GLP-1, and stimulate the release of insulin. This helps lower blood sugar and slows the passage of food through the gut. Liraglutide was developed to treat diabetes but approved in the US as a weight-loss treatment in 2014; its more potent cousin, semaglutide, has been approved for diabetes since 2017 and as an obesity treatment in 2021.

Ozempic prescriptions can be easy to get online. Its popularity for weight loss is hurting those who need it most

 

The latter use has become well-known thanks to promotions from celebrities and on social media. It’s sold under the name Ozempic for diabetes and Wegovy for weight loss. Studies suggest that semaglutide may help people lose an average of 10% to 15% of their starting weight – significantly more than with other medications. But because of this high demand, some versions of the medication have been in shortage in the US since the middle of last year.

The US patent on liraglutide is set to expire this year, and drugmaker Novo Nordisk says generic versions could be available in June 2024.

The company has not been involved in the application to WHO, it said in a statement, but “we welcome the WHO review and look forward to the readout and decision.”

“At present, there are no medications included in the [Essential Medicines List] that specifically target weight loss for the global burden of obesity,” the researchers wrote in their request to WHO. “At this time, the EML includes mineral supplements for nutritional deficiencies yet it is also described that most of the population live in ‘countries where overweight and obesity kills more people than underweight.’ “

WHO’s advisers will make recommendations on which drugs should be included in this year’s list, expected to come in September.

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“This particular drug has a certain history, but the use of it probably has not been long enough to be able to see it on the Essential Medicines List,” Dr. Francesco Blanca, WHO director for nutrition and food safety, said at a briefing Wednesday. “There’s also issues related to the cost of the treatment. At the same time, WHO is looking at the use of drugs to reduce weight excess in the context of a systematic review for guidelines for children and adolescents. So we believe that it is a work in progress, but we’ll see what the Essential Medicines List committee is going to conclude.”

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Decrease in COVID-19 in Prince Albert according to wastewater report

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Graphic courtesy HFCM Communicatie, via Wikimedia This is a representation of what the Covid-19 virus would look like under a powerful microscope.

The USask Global Institute for Water Security wastewater survey for Prince Albert shows that the COVID-19 viral RNA load in Prince Albert’s has decreased by 46.5 per cent.

This was after there was a single decrease in last week’s report.

The number is based on averages of three individual daily measurements in this reporting period up to May 22 which are then compared to the weekly average of the previous week.

This week’s viral load of approximately 10,000 gene copies / 100 mL SARS-CoV-2 is the 85th-highest value observed during the pandemic.

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This concentration of viral particles is considered Low because it is below the range and regarded as low in Prince Albert.

This week’s viral RNA load indicates that the SARS-CoV-2 infections in Prince Albert are reducing.

Whole genome sequencing confirmed the presence of BQ.1, BQ.1.1, BQ.1.1.4, BQ.1.18, XBB.1.5, BA.5.2.1 and BE.1.1 in earlier samples; which have S:Y144del, S:R346T, S:K444T, S:N460K mutations associated with immune escape. In addition, the sequences of the most recently collected sample relative to the previously collected samples indicate the level of presence of BA.2 and BA.5 in Prince Albert’s wastewater to be 94 per cent and 78 per cent stable respectively.

All data has been shared with Saskatchewan health authorities.

USask and Global Water Futures researchers are using wastewater-based epidemiology to monitor for SARS-CoV-2 (the virus causing COVID-19) in Saskatoon, Prince Albert and North Battleford wastewater, providing early warning of infection outbreaks. This work is being done in partnership with the Saskatchewan Health Authority, Public Health Agency of Canada, City of Saskatoon, City of Prince Albert and City of North Battleford.

This variant tracking data should be seen merely as an indicator of trends which need to be verified using sequencing technology through the Public Health Agency of Canada. Because individuals are at varying stages of infection when shedding the virus, the variant levels detected in sewage are not necessarily directly comparable to the proportion of variant cases found in individual swab samples confirmed through provincial genetic sequencing efforts.

editorial@paherald.sk.ca

 

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Just when we were starting to see COVID and RSV rates drop this spring, another type of virus contributed to a spike in respiratory infections

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Josep Suria/Shutterstock
  • Human metapneumovirus spiked this spring as cases of COVID and RSV fell.
  • According to the CDC, 19.6% of antigen tests and nearly 11% of PCR tests for HMPV, were positive in the US in early March.
  • Symptoms of HMPV include cough, fever, nasal congestion, and shortness of breath.

Cases of another type of respiratory virus have spiked this spring, just as COVID-19 and RSV rates were finally falling in the US.

According to the CDC, 19.6% of antigen tests and nearly 11% of PCR tests for human metapneumovirus, or HMPV, were positive in the US in early March.

The nearly 11% of positive PCR cases is up 36% since before the COVID-19 pandemic when PCR tests for HMPV were coming back with a rate of 7% positivity, according to the CDC.

In contrast, COVID-19 cases were down nearly 30% at the beginning of March, according to the World Health Organization, and the number of people being hospitalized for RSV was down to 1.2 people per 100,000 in March from 4.5 people per 100,000 in January, according to the CDC.

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Symptoms of HMPV include cough, fever, nasal congestion, and shortness of breath, according to the CDC. The symptoms could progress into bronchitis, pneumonia, or other similar viruses that cause upper and lower respiratory infections.

The CDC said some might be sicker for longer than others, and the duration of the virus depends on the severity, but for the most part, is similar in length to other respiratory infections caused by viruses.

The virus is spread by coughs and sneezes, close personal contact, and touching surfaces infected with the virus, then touching the mouth, nose, or eyes.

According to CNN, there’s no vaccine for HMPV, nor is there an antiviral drug to treat it.

 

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Just when we were starting to see COVID and RSV rates drop this spring, another type of virus contributed to a spike in respiratory infections

Published

 on

Josep Suria/Shutterstock
  • Human metapneumovirus spiked this spring as cases of COVID and RSV fell.
  • According to the CDC, 19.6% of antigen tests and nearly 11% of PCR tests for HMPV, were positive in the US in early March.
  • Symptoms of HMPV include cough, fever, nasal congestion, and shortness of breath.

Cases of another type of respiratory virus have spiked this spring, just as COVID-19 and RSV rates were finally falling in the US.

According to the CDC, 19.6% of antigen tests and nearly 11% of PCR tests for human metapneumovirus, or HMPV, were positive in the US in early March.

The nearly 11% of positive PCR cases is up 36% since before the COVID-19 pandemic when PCR tests for HMPV were coming back with a rate of 7% positivity, according to the CDC.

In contrast, COVID-19 cases were down nearly 30% at the beginning of March, according to the World Health Organization, and the number of people being hospitalized for RSV was down to 1.2 people per 100,000 in March from 4.5 people per 100,000 in January, according to the CDC.

300x250x1

Symptoms of HMPV include cough, fever, nasal congestion, and shortness of breath, according to the CDC. The symptoms could progress into bronchitis, pneumonia, or other similar viruses that cause upper and lower respiratory infections.

The CDC said some might be sicker for longer than others, and the duration of the virus depends on the severity, but for the most part, is similar in length to other respiratory infections caused by viruses.

The virus is spread by coughs and sneezes, close personal contact, and touching surfaces infected with the virus, then touching the mouth, nose, or eyes.

According to CNN, there’s no vaccine for HMPV, nor is there an antiviral drug to treat it.

Read the original article on Insider

 

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