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WHO says mysterious illness in China likely being caused by new virus – STAT

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The World Health Organization confirmed on Wednesday that Chinese authorities believe a new coronavirus — from the family that produced SARS and MERS — may be the cause of mysterious pneumonia cases in the city of Wuhan.

The Chinese government has not yet publicly stated that a coronavirus is the cause of the illness, which has infected at least 59 people. But the Wall Street Journal reported that was the case earlier Wednesday, citing unnamed sources.

“Coronaviruses are a large family of viruses that range from the common cold to SARS. Some cause less-severe disease, some more severe. Some transmit easily from person to person, while others don’t,” the WHO statement said.

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The virus can cause severe illness in some patients, the agency said, adding that it does not “transmit readily” between people. Earlier statements from the Wuhan Municipal Health Authority said there has been no person-to-person spread — a claim disease experts say is impossible to make at this stage in the exploration of a new disease.

“I don’t know how you know that at all,” said Matthew Frieman, a coronavirus expert at the University of Maryland School of Medicine. He noted the number of cases reported makes it seem unlikely that animal-to-human transmission is the only way this virus spread.

The WHO said that as authorities home in on the cause — and develop better detection tools — the number of cases associated with this outbreak may rise.

The Centers for Disease Control and Prevention sent out an alert to health care providers — a Health Alert Network or HAN — notifying them of the outbreak and urging them to ask patients with severe respiratory infections if they had traveled recently to Wuhan, which is 700 miles south of Beijing.

The fact that a coronavirus may be responsible will come as no surprise to the infectious diseases experts who have been watching the situation unfold. The type of illness and the fact that it is emerging in China — where a number of SARS-like and other coronaviruses have been isolated from bats — has pointed in that direction.

Experts said it will now be important for China to share more information, including enough of a genetic sequence so that health facilities outside of China know what to look for when faced with a pneumonia case with a recent travel history to Wuhan.

As it currently stands, Hong Kong is isolating any such cases until they can be tested for influenza, rhinoviruses, and other viruses that cause colds and flu. Given it is flu season in the Northern Hemisphere, telling countries to be on the look out for travelers with fevers and cold-like symptoms casts a very broad net.

“It really behooves them to at least provide enough information to allow the global community to be ready to do testing,” said Ralph Baric, a coronavirus expert at the University of North Caroline. “Otherwise you’re just doing screening for fever — in the middle of respiratory disease season? Financial nightmare.”

It will also be critical to figure out how the virus transmitted to people. The outbreak has been linked to a large seafood market that also sells live exotic animals for consumption. The market was closed and decontaminated on Jan. 1.

Baric said investigations will be underway to identify which species — singular or plural — was infected in the market.

“Understanding the reservoir is critical for eliminating that whole aspect of animal-to-human jump,” Frieman said.

Identifying the reservoir of the virus will also require tracing the animals suspected of being infected back to their suppliers so that it can be determined whether other markets might also have received infected animals.

During the 2003 SARS outbreak — in which more than 8,000 people were infected and nearly 800 died — the source of the virus was traced to palm civets that are eaten as a delicacy in parts of China. The Chinese government ordered a mass culling of the animals as part of its effort to stop the outbreak.

News of the pneumonia cases first emerged on Dec. 30, when the local health authority told hospitals to be on the lookout for cases. The next day Chinese authorities informed the WHO that they were dealing with what looked like an outbreak caused by an unknown virus.

In its most recent update, the Wuhan Municipal Health Authority said there had been 59 cases, seven of which were in critical condition. The statement said the first known case began showing signs of illness on Dec. 12 and the last case of illness onset was Dec. 29.

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U.S. tightens rules for dairy cows a day after bird flu virus fragments found in pasteurized milk samples – Toronto Star

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Infected cows were already prohibited from being transported out of state, but that was based on the physical characteristics of the milk, which looks curdled when a cow is infected, or a cow has decreased lactation or low appetite, both symptoms of infection.

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New technology to advance women’s cancer care at Southlake

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NEWS RELEASE
SOUTHLAKE REGIONAL HEALTH CENTRE
**************************
This Cancer Awareness Month, Southlake is adding advanced technologies to detect and treat breast cancer and other women’s cancers thanks to generous community donor support, most recently through the HERE is Where Cancer Meets its Match campaign. New cancer care technology, including new mammography machines, the MyoSure System and the MOLLI 2® System will make a measurable impact in diagnosing and treating women’s cancers in the communities Southlake serves.

Southlake is installing three new mammography machines to expand its breast cancer screening program to 1,500 more women each year. Two of these machines have new biopsy capabilities that will reduce the number of cancelled exams due to equipment failure, ensuring timely care for women. Women ages 40 to 49 years old will be able to self-refer for publicly funded mammograms through the Ontario Breast Screening Program starting this fall.

“Early detection is critical when treating breast cancer and other women’s cancers,” said Lorrie Reynolds, Director, Regional Cancer Program at Southlake. “We treat more than 1,700 breast cancer patients at Southlake every year. By adding advanced technology, like the new mammography machines, we’re ensuring women have the best experience at Southlake.”

Southlake is also introducing the MyoSure System, an innovative technology that can help detect female reproductive cancers. Damaged tissue in a woman’s uterus such as fibroids and polyps can now be removed in a precise, minimally invasive procedure that leaves the rest of the uterus intact. This will improve the overall patient experience by supporting faster recovery, reducing the risk of infection and giving more women the option to have children. An estimated 200 women per year will benefit from the MyoSure System.

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The new mammography machines and the MyoSure System build on Southlake’s recent investment in the MOLLI 2® System, a made-in-Canada wire-free breast localization technology.  This technology is considerably less invasive and more accurate when compared to wire-guided localization, resulting in a better patient experience and improved cosmetic outcomes.  More than 200 women each year will benefit from this innovative medical device as they are treated for breast cancer at Southlake.

“As a clinician caring for women with cancer in our community, I’m incredibly proud of the work Southlake is doing to advance women’s health and improve patient experiences,” said Sara Temple, MD, Surgical Oncologist and Chief of Surgery at Southlake. “Women who visit Southlake can be confident that they are receiving leading edge care, close to home when they need it most.”

The World Health Organization anticipates a 77 per cent increase in cancer diagnoses by 2050.  Southlake serves some of the fastest growing communities in Canada and anticipates that the number of patients requiring cancer care will grow. By investing in new technology, Southlake is ensuring that women in the communities it serves have access to leading edge cancer care. All of these investments were funded with support from community donors who generously gave to Southlake to support investments into women’s health at the hospital.

“The generosity of our donor community and the impact they have made for women receiving cancer diagnosis and treatment at Southlake is something we can all take great pride in,” said Jennifer Ritter, President and CEO of Southlake Foundation. “From our Women’s Health Initiative donors supporting new mammography machines, to the Ladies in Philanthropy for Southlake funding the MOLLI 2 System, to our long-standing partners The Edge Benefits and Pheasant Run Golf Club enabling the introduction of MyoSure System through their joint annual charity golf tournament, we are incredibly lucky to share a vision of access to exceptional care for everyone who depends on Southlake when they need us most. Thank you, to every donor who contributed to these important upgrades to care for women.”

Southlake Foundation’s HERE is Where Cancer Meets its Match campaign supports the Stronach Regional Cancer Centre at Southlake. For more information or to make a donation, visit: southlake.ca/HERE.

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Pasteurized milk includes remnants of H5N1 bird flu, U.S. officials say

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The U.S. Food and Drug Administration says that samples of pasteurized milk have tested positive for remnants of the bird flu virus that has infected dairy cows.

The agency stressed that the material is inactivated and that the findings “do not represent actual virus that may be a risk to consumers.” Officials added that they’re continuing to study the issue.

“To date, we have seen nothing that would change our assessment that the commercial milk supply is safe,” the FDA said in a statement on Tuesday.

The announcement comes nearly a month after an avian influenza virus that has sickened millions of wild and commercial birds in recent years was detected in dairy cows in at least eight states. The Agriculture Department (USDA) says 33 herds have been affected to date.

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FDA officials didn’t indicate how many samples they tested or where they were obtained. The agency has been evaluating milk during processing and from grocery stores, officials said. Results of additional tests are expected in “the next few days to weeks.”

WATCH | Bird flu spread in U.S. cows:

 

Bird flu is spreading in cows. Are humans at risk? | About That

15 days ago

Duration 8:54

For the first time ever, avian influenza, or H5N1 bird flu, was detected in roughly a dozen dairy cow herds across the U.S. About That producer Lauren Bird explores why scientists and public health officials are concerned about the cross-species transmission and whether humans are now at higher risk.

The polymerase chain reaction (PCR) lab test the FDA used would have detected viral genetic material even after live virus was killed by pasteurization, or heat treatment, said Lee-Ann Jaykus, an emeritus food microbiologist and virologist at North Carolina State University

“There is no evidence to date that this is infectious virus, and the FDA is following up on that,” Jaykus said.

Officials with the FDA and the USDA had previously said milk from affected cattle did not enter the commercial supply. Milk from sick animals is supposed to be diverted and destroyed. Federal regulations require milk that enters interstate commerce to be pasteurized.

Tests for viable virus underway, agency says

Because the detection of the bird flu virus known as Type A H5N1 in dairy cattle is new and the situation is evolving, no studies on the effects of pasteurization on the virus have been completed, FDA officials said. But past research shows that pasteurization is “very likely” to inactivate heat-sensitive viruses like H5N1, the agency added.

The agency said it has been evaluating milk from affected animals, in the processing system and on the shelves. It said it is completing a large, representative national sample to understand the extent of the findings.

The FDA said it is further assessing any positive findings through egg inoculation tests, which it described as a gold standard for determining viable virus.

Matt Herrick, a spokesperson for the International Dairy Foods Association, said that time and temperature regulations for pasteurization ensure that the commercial U.S. milk supply is safe. Remnants of the virus “have zero impact on human health,” he wrote in an email.

Scientists confirmed the H5N1 virus in dairy cows in March after weeks of reports that cows in Texas were suffering from a mysterious malady. The cows were lethargic and saw a dramatic reduction in milk production. Although the H5N1 virus is lethal to commercial poultry, most infected cattle seem to recover within two weeks, experts said.

To date, two people in the U.S. have been infected with bird flu. A Texas dairy worker who was in close contact with an infected cow recently developed a mild eye infection and has recovered. In 2022, a prison inmate in a work program caught it while killing infected birds at a Colorado poultry farm. His only symptom was fatigue, and he recovered.


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