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Yale Cancer Center Study Explores New Path to Treat Advanced Triple-Negative Breast Cancer – Yale School of Medicine

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A new study by researchers at Yale Cancer Center shows inhibition of the CECR2 gene prevents triple-negative breast cancer from advancing or metastasizing. The discovery is an early step in finding new therapeutics for triple-negative breast cancer (TNBC), one of the most difficult disease sub-types to treat. The findings are published online today in the journal Science Translational Medicine.

“These study results are very encouraging as there are few effective treatments for triple-negative breast cancer once it has metastasized,” said senior study author Qin Yan, PhD, Associate Professor of Pathology and Director of Center for Epigenetics and Biomarkers in the Department of Pathology at Yale School of Medicine, co-leader of Genomics, Genetics and Epigenetics Research Program and Scientific Co-Director of Center for Breast Cancer of Yale Cancer Center. “We are constantly searching for new effective therapeutic strategies to help patients with this potentially deadly disease.”

In this study, researchers profiled 13 pairs of primary and metastatic breast tumor samples from patients with breast cancer. They identified a therapeutic target, a gene called CECR2, that increased expression in the tumors that have spread to distant organs. The research team discovered that CECR2 allowed the breast cancer cells to migrate and invade to adjacent tissues and evade surveillance by the host immune system. As the result, CECR2 targeting resulted in the activation of T cells and prevented the tumor from spreading. Researchers also discovered that small molecule inhibitors of CECR2 can suppress the ability of TNBC cells to spread in cell cultures and animal models, providing a new avenue of therapeutic strategy to treat advanced disease. According to researchers, the findings could translate to an increased response to current immunotherapies, which had modest efficacy on breast cancer as monotherapies.

“We will continue to study these important findings,” added Yan. “We are working on characterizing the mechanisms by which CECR2 modulates gene expression and tumor microenvironment using multiple cutting-edge technologies. In addition, we hope to develop small molecule inhibitors of CECR2 for clinical studies.”

The study was funded by the Department of Defense Breast Cancer Research Program, the National Institutes of Health, a Yale Cancer Center Class of ’61 Cancer Research Award, and the James Hudson Brown-Alexander Brown Coxe Postdoctoral Fellowship.

Meiling Zhang, PhD, also from Yale, is lead author of the study. Other Yale scientists contributing to this research include: Yao Li, MD, Jon Morrow, MD, PhD, Lajos Pusztai, MD, DPhil, David Rimm, MD, PhD, Jocelyn F. Chen, Lok Hei Chan, and Sabine M. Lang, PhD.

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Toronto Public Health hosting pop-up COVID-19 vaccination clinics throughout Canada Day weekend – Toronto.com

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Toronto Public Health continues to host summer pop-up vaccination clinics across the city in partnership with Toronto’s Canada Day festivals and special events. This is part of Team Toronto’s continued efforts to bring COVID-19 vaccination opportunities to places residents live, work and play.

“As people gather to celebrate Canada Day across the city, Team Toronto will be out helping residents get vaccinated against COVID-19 and keep their vaccinations up to date,” said Mayor John Tory. “We have made such progress thanks to our world-leading vaccination efforts, and that’s why we’re continuing to work throughout this holiday and into the summer to help deliver vaccine doses.”

TPH will host the following vaccination clinics in early July:

• High Park Canada Day Festival at High Park, 1873 Bloor St. W., Friday, July 1, 10 a.m. to 2 p.m.

• East York Canada Day Festival at Stan Wadlow Park. 373 Cedarvale Ave., Friday, July 1, 11 a.m. to 5 p.m.

• Canada Day event at Mel Lastman Square, 5100 Yonge St. Friday, July 1, 2 to 7 p.m.

• CIMA Mayor’s Cricket Trophy event at Sunnybrook Park, 1132 Leslie St. Saturday, July 2, 9 a.m. to 4 p.m.

• Lakeshore Ribfest at 1 Colonel Samuel Smith Park Dr. Saturday July 2 and Sunday, July 3, 11 a.m. to 6 p.m.

• Afrofest at Woodbine Park, 1695 Queen St. E. Saturday, July 9 and Sunday, July 10, 1 to 7:30 p.m.

• Dragon Boat Challenge (GWN Sport Regatta) at Marilyn Bell Park, 1095 Lakeshore Blvd. W. Saturday July 9, 8:30 a.m. to 3:30 p.m.

These family-friendly and youth-friendly clinics will provide first, second, third, fourth and children’s COVID-19 doses to eligible residents age five and up on a walk-in basis, with no appointment or health card required. Pfizer and Moderna vaccines will be offered by TPH nurses, who will also answer COVID-19 and vaccine-related questions.

Residents can continue to get vaccinated at city-run immunization clinics, primary care offices and more than 525 pharmacies. A full list of clinic locations and hours is available on the City’s COVID-19: Where to Get Vaccinated webpage.

As of Monday, July 4, the city-run immunization clinic at Metro Hall will operate Monday to Friday noon to 6 p.m. and Saturday and Sunday 10 a.m. to 4 p.m. Residents can find a pharmacy offering COVID-19 vaccination by using the Government of Ontario’s COVID-19 pharmacy vaccine locations webpage.

All eligible residents are encouraged to get their third and fourth dose as soon as possible. As with vaccines for other diseases, people are protected best when they stay up to date. COVID-19 vaccines have been scientifically proven to lower the risk of illness, hospitalization and death while protecting oneself, loved ones and the community, and residents with three doses had the lowest rates of hospitalization, ICU and death over any other level of vaccination.

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Style File: Smart sunscreens – Montreal Gazette

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Postmedia may earn an affiliate commission from purchases made through our links on this page.

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Sunscreen is always a good idea.

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Skin cancers are the most common forms of cancer in Canada, according to Statistics Canada. And severe sunburns are noted as “an important risk factor for melanoma and non-melanoma skin cancers,” according to the agency.

With this in mind, it’s important to slather, smooth, spray — or whatever your chosen format of sun protection may be — this summer.

Here are four smart sunscreen options to consider adding to your daily sun-protection plan:

Tint time

From the French brand La Roche-Posay, this “ultralight” sunscreen formula features a universal tint to match most skin tones. See you later, face makeup. The Anthelios Mineral Tinted Ultra Fluid boasts a sun protection factor (that’s the SPF) of 50, thanks to 100 per cent mineral filters. Suitable for sensitive skin, the broad-spectrum sunscreen — it blocks both UVA and UVB rays, is sweat resistant and water resistant for up to 40 minutes.

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$35.95 | Shoppers Drug Mart, Laroche-posay.ca

Double duty

This advanced sunscreen formula from Shiseido acts as a moisturizer, sunscreen and face primer all-in-one formula. The Urban Environment Oil-Free Sunscreen has an SPF of 42 and features skin-loving ingredients such as spirulina and hyaluronic acid to hydrate and smooth skin while broad-spectrum UV filters protect against ultraviolet rays.

$45 | Sephora, Shiseido.com

Smooth operator

Perfect for those who struggle with acne, this Clear as Day SPF 46 from the brand Starface is vegan and cruelty-free, while also being oil-free and non-comedogenic. The fragrance-free formula features a unique gel texture and is completely clear so there’s no fear of a white cast on skin. Water resistant for up to 80 minutes, so you can spend a little extra time splish-splashing about.

$32 | Starfaceworld.ca

All-over option

Sun protection doesn’t stop at the face, neck and décolletage. Introduce head-to-toe coverage to your summer routine with the Garnier Ombrelle Sensitive Expert Body Lotion SPF 60. The hypoallergenic sunscreen formula features broad-spectrum coverage, is fragrance-free, dermatologist-tested, non-comedogenic and water resistant for up to 80 minutes. Plus, the lotion formula is easy to apply, and absorbs quickly.

$24.99 | London Drugs, Londondrugs.com

Aharris@postmedia.com

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Mysterious staggering disease in cats down to previously unknown virus – New Scientist

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A previously unknown rustrela virus might be the cause of a staggering disease that affects cats in some parts of Europe



Life



1 July 2022

Pet cats in some parts of Europe can sometimes develop a mysterious disease

Laurie 4593/Shutterstock

The cause of a brain disease in cats that makes them develop symptoms such as staggering is a previously unknown virus, a study suggests. The pathogen is a rustrela virus and is probably carried by wood mice.

The findings show that rustrela viruses are more diverse and widespread than previously thought, according to Kaspar Matiasek at the Ludwig Maximilian University of Munich and his colleagues. They write that the viruses might cause neurological diseases in other mammals …

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