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AstraZeneca’s deals to produce and supply its COVID-19 vaccine

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AstraZeneca signed a deal on Wednesday in Japan to produce the COVID-19 vaccine, Vaxzevria, that it developed with Oxford University.

AstraZeneca has signed manufacturing deals with at least 20 firms for distribution worldwide.

Here are the deals it has signed, with the most recent first:

SUPPLY DEALS

REGION/GROUP DOSES FUNDING EXPECTED FURTHER

DELIVERIES

4 Last

Mexico, million Undisclosed week of May 2021

Argentina

 

African Afreximbank had [nL1N2M10IP]

Union Dropped plans to earlier planned Ongoing

secure the to provide

vaccines for advance

members from the procurement

Serum Institute of commitment

India to avoid guarantees of

duplicating up to $2

efforts by COVAX. billion to the

manufacturers

 

COVAX

aims to deliver

600 million shots

 

 

Bahrain Undisclosed Undisclosed Received first

delivery from

Serum in January

Japan Will procure 120 Undisclosed Undisclosed

million doses from

domestic makers

Chile Had a pre-deal to Undisclosed Undisclosed

purchase 14.4

million doses but

eventually signed

to buy 4 million

Saudi Arabia 3 Undisclosed

million from Serum January 2021

 

Ecuador Allocated some Mass vaccination

Approximately 5 $200 million started in March

million overall to buy

vaccines

Germany 3 million doses Undisclosed In February

Mali Wants to buy more Over 31 billion At the end of

than 8.4 million CFA francs with March

doses financial

assistance from

GAVI

Morocco 2 million Undisclosed Received in

January

Bolivia 5 million from Undisclosed 228,000 doses

Serum arrived in March

India 110 To be

million from Serum Federal govt delivered in May,

Institute as of received doses June and July

Apr 28, according at 150 Indian

to govt rupees per dose

 

Kenya 24 million Undisclosed

Arrived in second

week of February

Peru 14 million Undisclosed Supply not due to

begin arriving

until September

Vietnam 30 million Undisclosed Unknown

Indonesia 50 million Undisclosed One

batch arrived in

April 2021

 

Malaysia 6.4 million Undisclosed Unknown

Colombia 10 million Undisclosed Unknown

Philippines 17 million, Undisclosed Due to

including a receive 2.6 mln

private sector shots in May;

agreement for 2.6 received 525,600

million doses through

COVAX

 

Thailand Previously First batch

Initially 26 approved budget expected to be {nL4N2IC2R6]

million doses, of 6 billion available in

addition under baht ($199 mid-2021 ?Status

further agreement million)

unknown

 

Bangladesh 30 million from Undisclosed

Serum Received over 9

mln doses from

Serum earlier; in

March, India gifts

1.2 mln free doses

 

Spain 31.6 million under Undisclosed Between Dec. 2020

European Union and June 2021

scheme

Switzerland 5.3 million Undisclosed Unknown

Canada Up to 20 million Undisclosed Unknown

doses

Australia “Enough” for Undisclosed Unknown

population of 25

million, free of

cost

European 300 million, 750 million Some

Union option of euros for 300 by end-2020

additional 100 million doses

million dropped

after delays

Latin Initially produce Estimated at First half 2021

America, 150 million doses, $600 million

excluding and eventually for the first

Brazil make at least 400 150 million

million doses

Japan 120 million doses Undisclosed 30 million doses

by March 2021

China Undisclosed Some

Private deal aimed by end-2020

for annual

production

capacity of at

least 100 million

doses in 2020, and

at least 200

million doses by

the end 2021

South Korea 20 million Undisclosed First

shipment was in

February

 

Russia Unknown Undisclosed Unknown

Israel Unknown Undisclosed Unknown

Brazil Initially receive $356 million Unknown

100 million doses

Serum One billion Undisclosed 400 million before

Institute of end-2020 were

India expected

previously

Epidemic 300 million $750 million, Some before end-

response with $383 from 2020

group CEPI CEPI

and Vaccine

alliance

GAVI

United 300 million $1.2 billion Was earlier

States expected by Oct.

2020

United 100 million 84 million 4 million in 2020.

Kingdom pounds Earlier about 30

million doses were

expected with

initial deliveries

by Sept/Oct. 2020.

MANUFACTURING DEALS

FIRM BASED IN DEAL VALUE FOR FURTHER

Filling the

Nipro Corp Japan Undisclosed shot into vials and

packaging it, due to

start in June 2021

 

Preparing

KM Biologics, Japan Undisclosed and bottling doses

part of Meiji

holdings

 

IDT Biologika Germany Undisclosed Contract manufacturing

expected to speed up

output of finished

COVID-19 vaccine in the

second quarter

CSL Ltd Australia Undisclosed Additional 20 million

requested by Australian

government,

approximately 30

million doses already

being manufactured

Halix B.V. Netherlands Undisclosed Commercial manufacture

of the vaccine

Siam Thailand Undisclosed Manufacture and supply

Bioscience, the vaccine in Thailand

SCG and other nations in

Southeast Asia

Albany U.S. Undisclosed Produce millions of

Molecular doses through finishing

Research services at

manufacturing plant in

Albuquerque, New Mexico

Oxford UK 15 million Unknown number of doses

Biomedica pounds to for large-scale

reserve commercial manufacture

manufacturin under expanded deal. In

g capacity, May, company said AZ

further 35 commissioned more

million batches from it for H2

pounds plus 2021

costs

payable in

certain

situations

Catalent U.S. Undisclosed Making the drug

substance at its

Maryland facility. AZ’s

second deal with firm

Foundation of Mexico Undisclosed Latin American supply

Mexican with Argentina,

billionaire excluding Brazil, could

Carlos Slim reach 250 million

mAbxience of Argentina Undisclosed Initially producing 150

the INSUD million doses for Latin

Group America, excluding

Brazil

Kangtai Bio China Undisclosed Aimed for

Annual production

capacity of at least

100 million doses in

2020, and at least 200

million doses by

end-2021

Emergent U.S. $174 million Undisclosed doses in

BioSolutions second deal with AZ.

Cut manufacturing for

AZ vaccine at its

Baltimore plant in

April

SK Bioscience South Korea Undisclosed Undiluted solutions of

the vaccine until early

2021

R-Pharm Russia Undisclosed Unknown doses

Daiichi Japan Undisclosed Unknown doses

Sankyo

Fundação Brazil $127 million About 30 million doses

Osvaldo Cruz

(Fiocruz)

Symbiosis Scotland Undisclosed Clinical trial supply

Pharmaceutica

l

Cobra U.S. Undisclosed One million doses per

Biosciences month

Catalent U.S. Undisclosed Vial filling and

packaging capacity at

its manufacturing

facility in Anagni,

Italy

Emergent U.S. $87 million 300 million doses

BioSolutions

Serum India Undisclosed One billion doses for

Institute of low and middle-income

India countries. 400 million

before end-2020 were

expected previously

Oxford UK Undisclosed Manufacturing unknown

Biomedica number of doses

Sources: Company statements, Government reports, WHO, Reuters reporting

 

(Reporting by Pushkala Aripaka and Vishwadha Chander in Bengaluru; Editing by Jason Neely and Clarence Fernandez)

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Health Canada approves updated Moderna COVID-19 vaccine

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TORONTO – Health Canada has authorized Moderna’s updated COVID-19 vaccine that protects against currently circulating variants of the virus.

The mRNA vaccine, called Spikevax, has been reformulated to target the KP.2 subvariant of Omicron.

It will replace the previous version of the vaccine that was released a year ago, which targeted the XBB.1.5 subvariant of Omicron.

Health Canada recently asked provinces and territories to get rid of their older COVID-19 vaccines to ensure the most current vaccine will be used during this fall’s respiratory virus season.

Health Canada is also reviewing two other updated COVID-19 vaccines but has not yet authorized them.

They are Pfizer’s Comirnaty, which is also an mRNA vaccine, as well as Novavax’s protein-based vaccine.

This report by The Canadian Press was first published Sept. 17, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

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These people say they got listeria after drinking recalled plant-based milks

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TORONTO – Sanniah Jabeen holds a sonogram of the unborn baby she lost after contracting listeria last December. Beneath, it says “love at first sight.”

Jabeen says she believes she and her baby were poisoned by a listeria outbreak linked to some plant-based milks and wants answers. An investigation continues into the recall declared July 8 of several Silk and Great Value plant-based beverages.

“I don’t even have the words. I’m still processing that,” Jabeen says of her loss. She was 18 weeks pregnant when she went into preterm labour.

The first infection linked to the recall was traced back to August 2023. One year later on Aug. 12, 2024, the Public Health Agency of Canada said three people had died and 20 were infected.

The number of cases is likely much higher, says Lawrence Goodridge, Canada Research Chair in foodborne pathogen dynamics at the University of Guelph: “For every person known, generally speaking, there’s typically 20 to 25 or maybe 30 people that are unknown.”

The case count has remained unchanged over the last month, but the Public Health Agency of Canada says it won’t declare the outbreak over until early October because of listeria’s 70-day incubation period and the reporting delays that accompany it.

Danone Canada’s head of communications said in an email Wednesday that the company is still investigating the “root cause” of the outbreak, which has been linked to a production line at a Pickering, Ont., packaging facility.

Pregnant people, adults over 60, and those with weakened immune systems are most at risk of becoming sick with severe listeriosis. If the infection spreads to an unborn baby, Health Canada says it can cause miscarriage, stillbirth, premature birth or life-threatening illness in a newborn.

The Canadian Press spoke to 10 people, from the parents of a toddler to an 89-year-old senior, who say they became sick with listeria after drinking from cartons of plant-based milk stamped with the recalled product code. Here’s a look at some of their experiences.

Sanniah Jabeen, 32, Toronto

Jabeen says she regularly drank Silk oat and almond milk in smoothies while pregnant, and began vomiting seven times a day and shivering at night in December 2023. She had “the worst headache of (her) life” when she went to the emergency room on Dec. 15.

“I just wasn’t functioning like a normal human being,” Jabeen says.

Told she was dehydrated, Jabeen was given fluids and a blood test and sent home. Four days later, she returned to hospital.

“They told me that since you’re 18 weeks, there’s nothing you can do to save your baby,” says Jabeen, who moved to Toronto from Pakistan five years ago.

Jabeen later learned she had listeriosis and an autopsy revealed her baby was infected, too.

“It broke my heart to read that report because I was just imagining my baby drinking poisoned amniotic fluid inside of me. The womb is a place where your baby is supposed to be the safest,” Jabeen said.

Jabeen’s case is likely not included in PHAC’s count. Jabeen says she was called by Health Canada and asked what dairy and fresh produce she ate – foods more commonly associated with listeria – but not asked about plant-based beverages.

She’s pregnant again, and is due in several months. At first, she was scared to eat, not knowing what caused the infection during her last pregnancy.

“Ever since I learned about the almond, oat milk situation, I’ve been feeling a bit better knowing that it wasn’t something that I did. It was something else that caused it. It wasn’t my fault,” Jabeen said.

She’s since joined a proposed class action lawsuit launched by LPC Avocates against the manufacturers and sellers of Silk and Great Value plant-based beverages. The lawsuit has not yet been certified by a judge.

Natalie Grant and her seven year-old daughter, Bowmanville, Ont.

Natalie Grant says she was in a hospital waiting room when she saw a television news report about the recall. She wondered if the dark chocolate almond milk her daughter drank daily was contaminated.

She had brought the girl to hospital because she was vomiting every half hour, constantly on the toilet with diarrhea, and had severe pain in her abdomen.

“I’m definitely thinking that this is a pretty solid chance that she’s got listeria at this point because I knew she had all the symptoms,” Grant says of seeing the news report.

Once her daughter could hold fluids, they went home and Grant cross-checked the recalled product code – 7825 – with the one on her carton. They matched.

“I called the emerg and I said I’m pretty confident she’s been exposed,” Grant said. She was told to return to the hospital if her daughter’s symptoms worsened. An hour and a half later, her fever spiked, the vomiting returned, her face flushed and her energy plummeted.

Grant says they were sent to a hospital in Ajax, Ont. and stayed two weeks while her daughter received antibiotics four times a day until she was discharged July 23.

“Knowing that my little one was just so affected and how it affected us as a family alone, there’s a bitterness left behind,” Grant said. She’s also joined the proposed class action.

Thelma Feldman, 89, Toronto

Thelma Feldman says she regularly taught yoga to friends in her condo building before getting sickened by listeria on July 2. Now, she has a walker and her body aches. She has headaches and digestive problems.

“I’m kind of depressed,” she says.

“It’s caused me a lot of physical and emotional pain.”

Much of the early days of her illness are a blur. She knows she boarded an ambulance with profuse diarrhea on July 2 and spent five days at North York General Hospital. Afterwards, she remembers Health Canada officials entering her apartment and removing Silk almond milk from her fridge, and volunteers from a community organization giving her sponge baths.

“At my age, 89, I’m not a kid anymore and healing takes longer,” Feldman says.

“I don’t even feel like being with people. I just sit at home.”

Jasmine Jiles and three-year-old Max, Kahnawake Mohawk Territory, Que.

Jasmine Jiles says her three-year-old son Max came down with flu-like symptoms and cradled his ears in what she interpreted as a sign of pain, like the one pounding in her own head, around early July.

When Jiles heard about the recall soon after, she called Danone Canada, the plant-based milk manufacturer, to find out if their Silk coconut milk was in the contaminated batch. It was, she says.

“My son is very small, he’s very young, so I asked what we do in terms of overall monitoring and she said someone from the company would get in touch within 24 to 48 hours,” Jiles says from a First Nations reserve near Montreal.

“I never got a call back. I never got an email”

At home, her son’s fever broke after three days, but gas pains stuck with him, she says. It took a couple weeks for him to get back to normal.

“In hindsight, I should have taken him (to the hospital) but we just tried to see if we could nurse him at home because wait times are pretty extreme,” Jiles says, “and I don’t have child care at the moment.”

Joseph Desmond, 50, Sydney, N.S.

Joseph Desmond says he suffered a seizure and fell off his sofa on July 9. He went to the emergency room, where they ran an electroencephalogram (EEG) test, and then returned home. Within hours, he had a second seizure and went back to hospital.

His third seizure happened the next morning while walking to the nurse’s station.

In severe cases of listeriosis, bacteria can spread to the central nervous system and cause seizures, according to Health Canada.

“The last two months have really been a nightmare,” says Desmond, who has joined the proposed lawsuit.

When he returned home from the hospital, his daughter took a carton of Silk dark chocolate almond milk out of the fridge and asked if he had heard about the recall. By that point, Desmond says he was on his second two-litre carton after finishing the first in June.

“It was pretty scary. Terrifying. I honestly thought I was going to die.”

Cheryl McCombe, 63, Haliburton, Ont.

The morning after suffering a second episode of vomiting, feverish sweats and diarrhea in the middle of the night in early July, Cheryl McCombe scrolled through the news on her phone and came across the recall.

A few years earlier, McCombe says she started drinking plant-based milks because it seemed like a healthier choice to splash in her morning coffee. On June 30, she bought two cartons of Silk cashew almond milk.

“It was on the (recall) list. I thought, ‘Oh my God, I got listeria,’” McCombe says. She called her doctor’s office and visited an urgent care clinic hoping to get tested and confirm her suspicion, but she says, “I was basically shut down at the door.”

Public Health Ontario does not recommend listeria testing for infected individuals with mild symptoms unless they are at risk of developing severe illness, such as people who are immunocompromised, elderly, pregnant or newborn.

“No wonder they couldn’t connect the dots,” she adds, referencing that it took close to a year for public health officials to find the source of the outbreak.

“I am a woman in my 60s and sometimes these signs are of, you know, when you’re vomiting and things like that, it can be a sign in women of a bigger issue,” McCombe says. She was seeking confirmation that wasn’t the case.

Disappointed, with her stomach still feeling off, she says she decided to boost her gut health with probiotics. After a couple weeks she started to feel like herself.

But since then, McCombe says, “I’m back on Kawartha Dairy cream in my coffee.”

This report by The Canadian Press was first published Sept. 16, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

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B.C. mayors seek ‘immediate action’ from federal government on mental health crisis

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VANCOUVER – Mayors and other leaders from several British Columbia communities say the provincial and federal governments need to take “immediate action” to tackle mental health and public safety issues that have reached crisis levels.

Vancouver Mayor Ken Sim says it’s become “abundantly clear” that mental health and addiction issues and public safety have caused crises that are “gripping” Vancouver, and he and other politicians, First Nations leaders and law enforcement officials are pleading for federal and provincial help.

In a letter to Prime Minister Justin Trudeau and Premier David Eby, mayors say there are “three critical fronts” that require action including “mandatory care” for people with severe mental health and addiction issues.

The letter says senior governments also need to bring in “meaningful bail reform” for repeat offenders, and the federal government must improve policing at Metro Vancouver ports to stop illicit drugs from coming in and stolen vehicles from being exported.

Sim says the “current system” has failed British Columbians, and the number of people dealing with severe mental health and addiction issues due to lack of proper care has “reached a critical point.”

Vancouver Police Chief Adam Palmer says repeat violent offenders are too often released on bail due to a “revolving door of justice,” and a new approach is needed to deal with mentally ill people who “pose a serious and immediate danger to themselves and others.”

This report by The Canadian Press was first published Sept. 16, 2024

The Canadian Press. All rights reserved.

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