adplus-dvertising
Connect with us

Science

Scientists receive US$15 million to resurrect woolly mammoth – CTV News

Published

 on


Bringing extinct creatures back to life is the lifeblood of science fiction. At its most tantalizing, think Jurassic Park and its stable of dinosaurs.

Advances in genetics, however, are making resurrecting lost animals a tangible prospect. Scientists have already cloned endangered animals and can sequence DNA extracted from the bones and carcasses of long-dead, extinct animals.

Geneticists, led by Harvard Medical School’s George Church, aim to bring the woolly mammoth, which disappeared 4,000 years ago, back to life, imagining a future where the tusked ice age giant is restored to its natural habitat.

The efforts got a major boost on Monday with the announcement of a US$15 million investment.

Proponents say bringing back the mammoth in an altered form could help restore the fragile Arctic tundra ecosystem, combat the climate crisis, and preserve the endangered Asian elephant, to whom the woolly mammoth is most closely related. However, it’s a bold plan fraught with ethical issues.

The goal isn’t to clone a mammoth — the DNA that scientists have managed to extract from woolly mammoth remains frozen in permafrost is far too fragmented and degraded — but to create, through genetic engineering, a living, walking elephant-mammoth hybrid that would be visually indistinguishable from its extinct forerunner.

“Our goal is to have our first calves in the next four to six years,” said tech entrepreneur Ben Lamm, who with Church has cofounded Colossal, a bioscience and genetics company to back the project.

‘NOW WE CAN ACTUALLY DO IT’

The new investment and focus brought by Lamm and his investors marks a major step forward, said Church, the Robert Winthrop Professor of Genetics at Harvard Medical School.

“Up until 2021, it has been kind of a backburner project, frankly. … but now we can actually do it,” Church said.

“This is going to change everything.”

Church has been at the cutting edge of genomics, including the use of CRISPR, the revolutionary gene editing tool that has been described as rewriting the code of life, to alter the characteristics of living species. His work creating pigs whose organs are compatible with the human body means a kidney for a patient in desperate need of a transplant might one day come from a swine.

“We had to make a lot of (genetic) changes, 42 so far to make them human compatible. And in that case we have very healthy pigs that are breeding and donating organs for preclinical trials at Massachusetts General Hospital,” he said.

“With the elephant, it’s a different goal but it’s a similar number of changes.”

The research team has analyzed the genomes of 23 living elephant species and extinct mammoths, Church said. The scientists believe they will need to simultaneously program “upward of 50 changes” to the genetic code of the Asian elephant to give it the traits necessary to survive and thrive in the Arctic.

These traits, Church said, include a 10-centimeter layer of insulating fat, five different kinds of shaggy hair including some that is up to a meter long, and smaller ears that will help the hybrid tolerate the cold. The team also plans to try to engineer the animal to not have any tusks so they won’t be a target for ivory poachers.

Once a cell with these and other traits has successfully been programmed, Church plans to use an artificial womb to make the step from embryo to baby — something that takes 22 months for living elephants. However, this technology is far from nailed down, and Church said they hadn’t ruled out using live elephants as surrogates.

“The editing, I think, is going to go smoothly. We’ve got a lot of experience with that, I think, making the artificial wombs is not guaranteed. It’s one of the few things that is not pure engineering, there’s maybe a tiny bit of science in there as well, which always increases uncertainty and delivery time,” he said.

SKEPTICISM

Love Dalén, professor of evolutionary genetics at the Centre for Palaeogenetics in Stockholm who works on mammoth evolution, believes there is scientific value in the work being undertaken by Church and his team, particularly when it comes to conservation of endangered species that have genetic diseases or a lack of genetic variation as result of inbreeding.

“If endangered species have lost genes that are important to them … the ability to put them back in the endangered species, that might prove really important,” said Dalén, who is not involved in the project.

“I still wonder what the bigger point would be. First of all, you’re not going to get a mammoth. It’s a hairy elephant with some fat deposits.

“We, of course, have very little clue about what genes make a mammoth a mammoth. We know a little, bit but we certainly don’t know anywhere near enough.”

Others say it’s unethical to use living elephants as surrogates to give birth to a genetically engineered animal. Dalén described mammoths and Asian elephants as being as different as humans and chimpanzees.

“Let’s say it works, and there’s no horrible consequences. No surrogate elephant moms die,” said Tori Herridge, an evolutionary biologist and mammoth specialist at the Natural History Museum in London, who is not involved in the project.

“The idea that by bringing mammoths back and by placing them into the Arctic, you engineer the Arctic to become a better place for carbon storage. That aspect I have number of issues with.”

Some believe large that, before their extinction, grazing animals like mammoths, horses and bison maintained the grasslands in our planet’s northern reaches and kept the earth frozen underneath by tramping down the grass, knocking down trees and compacting snow. Reintroducing mammoths and other large mammals to these places will help revitalize these environments and slow down permafrost thaw and the release of carbon.

However, both Dalén and Herridige said there was no evidence to back up this hypothesis, and it was hard to imagine herds of cold-adapted elephants making any impact on an environment that’s grappling with wild fires, riddled with mires and warming faster than anywhere else in the world.

“There’s absolutely nothing that says that putting mammoths out there will have any, any effect on climate change whatsoever,” Dalén said.

Ultimately, the stated end goal of herds of roaming mammoths as ecosystem engineers may not matter, and neither Herridge nor Dalén knock Church and Lamm for embarking on the project. Many people might be happy to pay to get up close to a proxy mammoth.

“Maybe it’s fun to showcase them in the zoo. I don’t have a big problem with that if they want to put them in a park somewhere and, you know, make kids more interested in the past,” Dalén said.

There is “zero pressure” for the project to make money, Lamm said. He is banking on the endeavor resulting in innovations that have applications in biotechnology and health care. He compared it to how the Apollo project got people caring about space exploration but also resulted in a lot of incredible technology, including GPS.

“I am absolutely fascinated by this. I’m drawn to people who are technologically adventurous and it is possible it will make a positive difference,” Herridge, the mammoth expert, said.

Adblock test (Why?)

728x90x4

Source link

Continue Reading

News

Here’s how Helene and other storms dumped a whopping 40 trillion gallons of rain on the South

Published

 on

 

More than 40 trillion gallons of rain drenched the Southeast United States in the last week from Hurricane Helene and a run-of-the-mill rainstorm that sloshed in ahead of it — an unheard of amount of water that has stunned experts.

That’s enough to fill the Dallas Cowboys’ stadium 51,000 times, or Lake Tahoe just once. If it was concentrated just on the state of North Carolina that much water would be 3.5 feet deep (more than 1 meter). It’s enough to fill more than 60 million Olympic-size swimming pools.

“That’s an astronomical amount of precipitation,” said Ed Clark, head of the National Oceanic and Atmospheric Administration’s National Water Center in Tuscaloosa, Alabama. “I have not seen something in my 25 years of working at the weather service that is this geographically large of an extent and the sheer volume of water that fell from the sky.”

The flood damage from the rain is apocalyptic, meteorologists said. More than 100 people are dead, according to officials.

Private meteorologist Ryan Maue, a former NOAA chief scientist, calculated the amount of rain, using precipitation measurements made in 2.5-mile-by-2.5 mile grids as measured by satellites and ground observations. He came up with 40 trillion gallons through Sunday for the eastern United States, with 20 trillion gallons of that hitting just Georgia, Tennessee, the Carolinas and Florida from Hurricane Helene.

Clark did the calculations independently and said the 40 trillion gallon figure (151 trillion liters) is about right and, if anything, conservative. Maue said maybe 1 to 2 trillion more gallons of rain had fallen, much if it in Virginia, since his calculations.

Clark, who spends much of his work on issues of shrinking western water supplies, said to put the amount of rain in perspective, it’s more than twice the combined amount of water stored by two key Colorado River basin reservoirs: Lake Powell and Lake Mead.

Several meteorologists said this was a combination of two, maybe three storm systems. Before Helene struck, rain had fallen heavily for days because a low pressure system had “cut off” from the jet stream — which moves weather systems along west to east — and stalled over the Southeast. That funneled plenty of warm water from the Gulf of Mexico. And a storm that fell just short of named status parked along North Carolina’s Atlantic coast, dumping as much as 20 inches of rain, said North Carolina state climatologist Kathie Dello.

Then add Helene, one of the largest storms in the last couple decades and one that held plenty of rain because it was young and moved fast before it hit the Appalachians, said University of Albany hurricane expert Kristen Corbosiero.

“It was not just a perfect storm, but it was a combination of multiple storms that that led to the enormous amount of rain,” Maue said. “That collected at high elevation, we’re talking 3,000 to 6000 feet. And when you drop trillions of gallons on a mountain, that has to go down.”

The fact that these storms hit the mountains made everything worse, and not just because of runoff. The interaction between the mountains and the storm systems wrings more moisture out of the air, Clark, Maue and Corbosiero said.

North Carolina weather officials said their top measurement total was 31.33 inches in the tiny town of Busick. Mount Mitchell also got more than 2 feet of rainfall.

Before 2017’s Hurricane Harvey, “I said to our colleagues, you know, I never thought in my career that we would measure rainfall in feet,” Clark said. “And after Harvey, Florence, the more isolated events in eastern Kentucky, portions of South Dakota. We’re seeing events year in and year out where we are measuring rainfall in feet.”

Storms are getting wetter as the climate change s, said Corbosiero and Dello. A basic law of physics says the air holds nearly 4% more moisture for every degree Fahrenheit warmer (7% for every degree Celsius) and the world has warmed more than 2 degrees (1.2 degrees Celsius) since pre-industrial times.

Corbosiero said meteorologists are vigorously debating how much of Helene is due to worsening climate change and how much is random.

For Dello, the “fingerprints of climate change” were clear.

“We’ve seen tropical storm impacts in western North Carolina. But these storms are wetter and these storms are warmer. And there would have been a time when a tropical storm would have been heading toward North Carolina and would have caused some rain and some damage, but not apocalyptic destruction. ”

___

Follow AP’s climate coverage at https://apnews.com/hub/climate

___

Follow Seth Borenstein on Twitter at @borenbears

___

Associated Press climate and environmental coverage receives support from several private foundations. See more about AP’s climate initiative here. The AP is solely responsible for all content.

Source link

Continue Reading

Science

‘Big Sam’: Paleontologists unearth giant skull of Pachyrhinosaurus in Alberta

Published

 on

 

It’s a dinosaur that roamed Alberta’s badlands more than 70 million years ago, sporting a big, bumpy, bony head the size of a baby elephant.

On Wednesday, paleontologists near Grande Prairie pulled its 272-kilogram skull from the ground.

They call it “Big Sam.”

The adult Pachyrhinosaurus is the second plant-eating dinosaur to be unearthed from a dense bonebed belonging to a herd that died together on the edge of a valley that now sits 450 kilometres northwest of Edmonton.

It didn’t die alone.

“We have hundreds of juvenile bones in the bonebed, so we know that there are many babies and some adults among all of the big adults,” Emily Bamforth, a paleontologist with the nearby Philip J. Currie Dinosaur Museum, said in an interview on the way to the dig site.

She described the horned Pachyrhinosaurus as “the smaller, older cousin of the triceratops.”

“This species of dinosaur is endemic to the Grand Prairie area, so it’s found here and nowhere else in the world. They are … kind of about the size of an Indian elephant and a rhino,” she added.

The head alone, she said, is about the size of a baby elephant.

The discovery was a long time coming.

The bonebed was first discovered by a high school teacher out for a walk about 50 years ago. It took the teacher a decade to get anyone from southern Alberta to come to take a look.

“At the time, sort of in the ’70s and ’80s, paleontology in northern Alberta was virtually unknown,” said Bamforth.

When paleontogists eventually got to the site, Bamforth said, they learned “it’s actually one of the densest dinosaur bonebeds in North America.”

“It contains about 100 to 300 bones per square metre,” she said.

Paleontologists have been at the site sporadically ever since, combing through bones belonging to turtles, dinosaurs and lizards. Sixteen years ago, they discovered a large skull of an approximately 30-year-old Pachyrhinosaurus, which is now at the museum.

About a year ago, they found the second adult: Big Sam.

Bamforth said both dinosaurs are believed to have been the elders in the herd.

“Their distinguishing feature is that, instead of having a horn on their nose like a triceratops, they had this big, bony bump called a boss. And they have big, bony bumps over their eyes as well,” she said.

“It makes them look a little strange. It’s the one dinosaur that if you find it, it’s the only possible thing it can be.”

The genders of the two adults are unknown.

Bamforth said the extraction was difficult because Big Sam was intertwined in a cluster of about 300 other bones.

The skull was found upside down, “as if the animal was lying on its back,” but was well preserved, she said.

She said the excavation process involved putting plaster on the skull and wooden planks around if for stability. From there, it was lifted out — very carefully — with a crane, and was to be shipped on a trolley to the museum for study.

“I have extracted skulls in the past. This is probably the biggest one I’ve ever done though,” said Bamforth.

“It’s pretty exciting.”

This report by The Canadian Press was first published Sept. 25, 2024.

The Canadian Press. All rights reserved.

Source link

Continue Reading

News

The ancient jar smashed by a 4-year-old is back on display at an Israeli museum after repair

Published

 on

 

TEL AVIV, Israel (AP) — A rare Bronze-Era jar accidentally smashed by a 4-year-old visiting a museum was back on display Wednesday after restoration experts were able to carefully piece the artifact back together.

Last month, a family from northern Israel was visiting the museum when their youngest son tipped over the jar, which smashed into pieces.

Alex Geller, the boy’s father, said his son — the youngest of three — is exceptionally curious, and that the moment he heard the crash, “please let that not be my child” was the first thought that raced through his head.

The jar has been on display at the Hecht Museum in Haifa for 35 years. It was one of the only containers of its size and from that period still complete when it was discovered.

The Bronze Age jar is one of many artifacts exhibited out in the open, part of the Hecht Museum’s vision of letting visitors explore history without glass barriers, said Inbal Rivlin, the director of the museum, which is associated with Haifa University in northern Israel.

It was likely used to hold wine or oil, and dates back to between 2200 and 1500 B.C.

Rivlin and the museum decided to turn the moment, which captured international attention, into a teaching moment, inviting the Geller family back for a special visit and hands-on activity to illustrate the restoration process.

Rivlin added that the incident provided a welcome distraction from the ongoing war in Gaza. “Well, he’s just a kid. So I think that somehow it touches the heart of the people in Israel and around the world,“ said Rivlin.

Roee Shafir, a restoration expert at the museum, said the repairs would be fairly simple, as the pieces were from a single, complete jar. Archaeologists often face the more daunting task of sifting through piles of shards from multiple objects and trying to piece them together.

Experts used 3D technology, hi-resolution videos, and special glue to painstakingly reconstruct the large jar.

Less than two weeks after it broke, the jar went back on display at the museum. The gluing process left small hairline cracks, and a few pieces are missing, but the jar’s impressive size remains.

The only noticeable difference in the exhibit was a new sign reading “please don’t touch.”

The Canadian Press. All rights reserved.

Source link

Continue Reading

Trending