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In treating sepsis, Lawson researchers find promise in carbon monoxide-releasing molecules – Globalnews.ca

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Scientists at London’s Lawson Health Research Institute are studying the promising use of carbon monoxide-releasing molecules in the treatment of sepsis, the potentially fatal condition wherein the body overreacts to an infection, leading to an overwhelming inflammatory response.

That inflammatory response from sepsis, triggered by microbial pathogens such as a virus, bacterium or fungi, can spread through the body causing damage to organs such as the heart, liver, lungs or brain.

Researcher Dr. Gedas Cepinskas says that with sepsis, the immune system becomes so activated that it attacks cell tissues, resulting in damage to affected organs.

“Unfortunately, there is no specific therapy or treatment. It is well-accepted, the use of antibiotics, fluids and supply of oxygen just to keep organs working. That’s why any new potential therapy in treating systemic inflammation, in general, is very desired,” Cepinskas told London Live with Mike Stubbs on Tuesday.

“Carbon monoxide is not just the poisonous gas, but rather has very potent, protective anti-inflammatory cytoprotective characteristics,” in small, non-toxic concentrations, he notes.

Read more:
COVID-19: Potential sepsis treatment moves to human trials in London, Ont.

Carbon monoxide is produced naturally by practically every cell in the human body, Cepinskas says, and is used as a defence mechanism — an “acute or early protective response against various cell-damaging signals or stresses.”

“We evolved on this idea … and we tried to use, not inhaled carbon monoxide, but rather specific molecules which are called carbon monoxide-releasing molecules or CORMs … in treating various inflammatory conditions in preclinical models,” he said.

They found success, according to a statement from Lawson, which noted a recent study published in Experimental Biology and Medicine found efficacy in using CORMs in preclinical models to “protect individual cells in the liver and lungs of sepsis-induced inflammation.”

“We were very lucky to be one of the first to demonstrate very potent anti-inflammatory effects of (CORMs) in experimental models of sepsis and even severe traumatic injuries, for example, compartment syndrome,” Cepinskas said.

“All these pathologies, compartment syndrome, sepsis, and even organ transplantation … have one common denominator or feature, which is systemic inflammation,” he added.

According to Lawson, Cepinskas is working with LHSC clinicians to study the use of CORMs in treating limb compartment syndrome and to improve organ transplantation, and is working with the pharmaceutical industry to move the promising therapy into clinical trials.


Click to play video: 'Meet Dr. Cepinskas, researcher at Lawson and Western University Schulich School of Medicine, Dentistry'



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Meet Dr. Cepinskas, researcher at Lawson and Western University Schulich School of Medicine, Dentistry


Meet Dr. Cepinskas, researcher at Lawson and Western University Schulich School of Medicine, Dentistry – Sep 23, 2020

According to the World Health Organization, 48.9 million cases of sepsis and 11 million sepsis-related deaths were reported around the world in 2017. Almost half of all sepsis cases that year involved children.

Diarrhoeal diseases and lower respiratory infections were the largest contributors to sepsis cases and sepsis-related deaths in 2017, linked to 9.2 to 15 million annual cases and 1.8 to 2.8 million annual cases, respectively, the WHO said. Nearly half of all deaths were due to underlying injury or chronic disease.

In Canada, just over 16,300 people died of sepsis from the start of 2015 through the end of 2019, an average of about 2,728 per year, according to the most recent data from Statistics Canada.

Read more:
What you need to know about sepsis, septic shock and stem cells

A study published late last year found that sepsis or systemic inflammation was among the most common complications associated with COVID-19, alongside pneumonia, respiratory failure, and kidney failure.

“Statistics indicate that every 2.8 seconds a person dies from sepsis globally,” Cepinskas said.

“Sepsis is one of the most expensive disease condition(s) to treat, and it costs to (the) Canadian health system $1 billion each and every year, and the expense is going up, unfortunately.”


Click to play video: 'Health Matters: Sepsis kills more people than heart disease and cancer'



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Health Matters: Sepsis kills more people than heart disease and cancer


Health Matters: Sepsis kills more people than heart disease and cancer – Jan 17, 2020

According to the Canadian Sepsis Foundation (CSF), those at risk of developing sepsis include those 75 or older; those with chronic disease; those engaged in drug use, especially by injection; those who consume tobacco and tobacco products; and those on immunosuppressive agents like chemotherapy.

According to CSF, the delaying of treatment for health conditions such as appendicitis, pneumonia, or even influenza may provoke an immune response leading to sepsis. COVID-19 and parasites such as malaria can also lead to sepsis.

Sepsis can also stem from infections caused by invasive procedures, like open-heart surgeries, where bacteria can be introduced directly into the bloodstream.

Symptoms may vary depending on the primary infection, but CSF says common symptoms of sepsis include an altered mental state, decreased urination, feeling extremely ill (severe pain or discomfort), fever and/or chills, and a rapid heart rate and/or rapid breathing.

Read more:
July 2020: McMaster research leads Canada-wide research initiative to address sepsis

The research into carbon monoxide-releasing molecules isn’t the only work being done at Lawson when it comes to the treatment of sepsis.

A potentially groundbreaking drug more than 20 years in the making, developed by a team at Lawson led by Dr. Qingping Feng, entered clinical trials earlier this year involving local COVID-19 patients with sepsis.

The trial is looking into the effectiveness of a sepsis treatment using a manufactured form of annexin A5, a human protein believed to help counter inflammation and coagulation.

Pre-clinical studies showed promising results in treating sepsis in animal models, and in late 2020, the team reported that annexin A5 could be effective in 40 per cent of sepsis cases, a significant jump from current treatments which work roughly six per cent of the time, according to Lawson.

— With files from Jacquelyn LeBel

© 2021 Global News, a division of Corus Entertainment Inc.

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Health Canada approves updated Moderna COVID-19 vaccine

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TORONTO – Health Canada has authorized Moderna’s updated COVID-19 vaccine that protects against currently circulating variants of the virus.

The mRNA vaccine, called Spikevax, has been reformulated to target the KP.2 subvariant of Omicron.

It will replace the previous version of the vaccine that was released a year ago, which targeted the XBB.1.5 subvariant of Omicron.

Health Canada recently asked provinces and territories to get rid of their older COVID-19 vaccines to ensure the most current vaccine will be used during this fall’s respiratory virus season.

Health Canada is also reviewing two other updated COVID-19 vaccines but has not yet authorized them.

They are Pfizer’s Comirnaty, which is also an mRNA vaccine, as well as Novavax’s protein-based vaccine.

This report by The Canadian Press was first published Sept. 17, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

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These people say they got listeria after drinking recalled plant-based milks

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TORONTO – Sanniah Jabeen holds a sonogram of the unborn baby she lost after contracting listeria last December. Beneath, it says “love at first sight.”

Jabeen says she believes she and her baby were poisoned by a listeria outbreak linked to some plant-based milks and wants answers. An investigation continues into the recall declared July 8 of several Silk and Great Value plant-based beverages.

“I don’t even have the words. I’m still processing that,” Jabeen says of her loss. She was 18 weeks pregnant when she went into preterm labour.

The first infection linked to the recall was traced back to August 2023. One year later on Aug. 12, 2024, the Public Health Agency of Canada said three people had died and 20 were infected.

The number of cases is likely much higher, says Lawrence Goodridge, Canada Research Chair in foodborne pathogen dynamics at the University of Guelph: “For every person known, generally speaking, there’s typically 20 to 25 or maybe 30 people that are unknown.”

The case count has remained unchanged over the last month, but the Public Health Agency of Canada says it won’t declare the outbreak over until early October because of listeria’s 70-day incubation period and the reporting delays that accompany it.

Danone Canada’s head of communications said in an email Wednesday that the company is still investigating the “root cause” of the outbreak, which has been linked to a production line at a Pickering, Ont., packaging facility.

Pregnant people, adults over 60, and those with weakened immune systems are most at risk of becoming sick with severe listeriosis. If the infection spreads to an unborn baby, Health Canada says it can cause miscarriage, stillbirth, premature birth or life-threatening illness in a newborn.

The Canadian Press spoke to 10 people, from the parents of a toddler to an 89-year-old senior, who say they became sick with listeria after drinking from cartons of plant-based milk stamped with the recalled product code. Here’s a look at some of their experiences.

Sanniah Jabeen, 32, Toronto

Jabeen says she regularly drank Silk oat and almond milk in smoothies while pregnant, and began vomiting seven times a day and shivering at night in December 2023. She had “the worst headache of (her) life” when she went to the emergency room on Dec. 15.

“I just wasn’t functioning like a normal human being,” Jabeen says.

Told she was dehydrated, Jabeen was given fluids and a blood test and sent home. Four days later, she returned to hospital.

“They told me that since you’re 18 weeks, there’s nothing you can do to save your baby,” says Jabeen, who moved to Toronto from Pakistan five years ago.

Jabeen later learned she had listeriosis and an autopsy revealed her baby was infected, too.

“It broke my heart to read that report because I was just imagining my baby drinking poisoned amniotic fluid inside of me. The womb is a place where your baby is supposed to be the safest,” Jabeen said.

Jabeen’s case is likely not included in PHAC’s count. Jabeen says she was called by Health Canada and asked what dairy and fresh produce she ate – foods more commonly associated with listeria – but not asked about plant-based beverages.

She’s pregnant again, and is due in several months. At first, she was scared to eat, not knowing what caused the infection during her last pregnancy.

“Ever since I learned about the almond, oat milk situation, I’ve been feeling a bit better knowing that it wasn’t something that I did. It was something else that caused it. It wasn’t my fault,” Jabeen said.

She’s since joined a proposed class action lawsuit launched by LPC Avocates against the manufacturers and sellers of Silk and Great Value plant-based beverages. The lawsuit has not yet been certified by a judge.

Natalie Grant and her seven year-old daughter, Bowmanville, Ont.

Natalie Grant says she was in a hospital waiting room when she saw a television news report about the recall. She wondered if the dark chocolate almond milk her daughter drank daily was contaminated.

She had brought the girl to hospital because she was vomiting every half hour, constantly on the toilet with diarrhea, and had severe pain in her abdomen.

“I’m definitely thinking that this is a pretty solid chance that she’s got listeria at this point because I knew she had all the symptoms,” Grant says of seeing the news report.

Once her daughter could hold fluids, they went home and Grant cross-checked the recalled product code – 7825 – with the one on her carton. They matched.

“I called the emerg and I said I’m pretty confident she’s been exposed,” Grant said. She was told to return to the hospital if her daughter’s symptoms worsened. An hour and a half later, her fever spiked, the vomiting returned, her face flushed and her energy plummeted.

Grant says they were sent to a hospital in Ajax, Ont. and stayed two weeks while her daughter received antibiotics four times a day until she was discharged July 23.

“Knowing that my little one was just so affected and how it affected us as a family alone, there’s a bitterness left behind,” Grant said. She’s also joined the proposed class action.

Thelma Feldman, 89, Toronto

Thelma Feldman says she regularly taught yoga to friends in her condo building before getting sickened by listeria on July 2. Now, she has a walker and her body aches. She has headaches and digestive problems.

“I’m kind of depressed,” she says.

“It’s caused me a lot of physical and emotional pain.”

Much of the early days of her illness are a blur. She knows she boarded an ambulance with profuse diarrhea on July 2 and spent five days at North York General Hospital. Afterwards, she remembers Health Canada officials entering her apartment and removing Silk almond milk from her fridge, and volunteers from a community organization giving her sponge baths.

“At my age, 89, I’m not a kid anymore and healing takes longer,” Feldman says.

“I don’t even feel like being with people. I just sit at home.”

Jasmine Jiles and three-year-old Max, Kahnawake Mohawk Territory, Que.

Jasmine Jiles says her three-year-old son Max came down with flu-like symptoms and cradled his ears in what she interpreted as a sign of pain, like the one pounding in her own head, around early July.

When Jiles heard about the recall soon after, she called Danone Canada, the plant-based milk manufacturer, to find out if their Silk coconut milk was in the contaminated batch. It was, she says.

“My son is very small, he’s very young, so I asked what we do in terms of overall monitoring and she said someone from the company would get in touch within 24 to 48 hours,” Jiles says from a First Nations reserve near Montreal.

“I never got a call back. I never got an email”

At home, her son’s fever broke after three days, but gas pains stuck with him, she says. It took a couple weeks for him to get back to normal.

“In hindsight, I should have taken him (to the hospital) but we just tried to see if we could nurse him at home because wait times are pretty extreme,” Jiles says, “and I don’t have child care at the moment.”

Joseph Desmond, 50, Sydney, N.S.

Joseph Desmond says he suffered a seizure and fell off his sofa on July 9. He went to the emergency room, where they ran an electroencephalogram (EEG) test, and then returned home. Within hours, he had a second seizure and went back to hospital.

His third seizure happened the next morning while walking to the nurse’s station.

In severe cases of listeriosis, bacteria can spread to the central nervous system and cause seizures, according to Health Canada.

“The last two months have really been a nightmare,” says Desmond, who has joined the proposed lawsuit.

When he returned home from the hospital, his daughter took a carton of Silk dark chocolate almond milk out of the fridge and asked if he had heard about the recall. By that point, Desmond says he was on his second two-litre carton after finishing the first in June.

“It was pretty scary. Terrifying. I honestly thought I was going to die.”

Cheryl McCombe, 63, Haliburton, Ont.

The morning after suffering a second episode of vomiting, feverish sweats and diarrhea in the middle of the night in early July, Cheryl McCombe scrolled through the news on her phone and came across the recall.

A few years earlier, McCombe says she started drinking plant-based milks because it seemed like a healthier choice to splash in her morning coffee. On June 30, she bought two cartons of Silk cashew almond milk.

“It was on the (recall) list. I thought, ‘Oh my God, I got listeria,’” McCombe says. She called her doctor’s office and visited an urgent care clinic hoping to get tested and confirm her suspicion, but she says, “I was basically shut down at the door.”

Public Health Ontario does not recommend listeria testing for infected individuals with mild symptoms unless they are at risk of developing severe illness, such as people who are immunocompromised, elderly, pregnant or newborn.

“No wonder they couldn’t connect the dots,” she adds, referencing that it took close to a year for public health officials to find the source of the outbreak.

“I am a woman in my 60s and sometimes these signs are of, you know, when you’re vomiting and things like that, it can be a sign in women of a bigger issue,” McCombe says. She was seeking confirmation that wasn’t the case.

Disappointed, with her stomach still feeling off, she says she decided to boost her gut health with probiotics. After a couple weeks she started to feel like herself.

But since then, McCombe says, “I’m back on Kawartha Dairy cream in my coffee.”

This report by The Canadian Press was first published Sept. 16, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

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B.C. mayors seek ‘immediate action’ from federal government on mental health crisis

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VANCOUVER – Mayors and other leaders from several British Columbia communities say the provincial and federal governments need to take “immediate action” to tackle mental health and public safety issues that have reached crisis levels.

Vancouver Mayor Ken Sim says it’s become “abundantly clear” that mental health and addiction issues and public safety have caused crises that are “gripping” Vancouver, and he and other politicians, First Nations leaders and law enforcement officials are pleading for federal and provincial help.

In a letter to Prime Minister Justin Trudeau and Premier David Eby, mayors say there are “three critical fronts” that require action including “mandatory care” for people with severe mental health and addiction issues.

The letter says senior governments also need to bring in “meaningful bail reform” for repeat offenders, and the federal government must improve policing at Metro Vancouver ports to stop illicit drugs from coming in and stolen vehicles from being exported.

Sim says the “current system” has failed British Columbians, and the number of people dealing with severe mental health and addiction issues due to lack of proper care has “reached a critical point.”

Vancouver Police Chief Adam Palmer says repeat violent offenders are too often released on bail due to a “revolving door of justice,” and a new approach is needed to deal with mentally ill people who “pose a serious and immediate danger to themselves and others.”

This report by The Canadian Press was first published Sept. 16, 2024

The Canadian Press. All rights reserved.

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