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These early signs made omicron different from previous Covid variants, experts say – Yahoo News

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When Jeremy Kamil got his first look at B.1.1.529, the coronavirus variant that would soon be named omicron, it didn’t take long to see the differences.

More than 30 mutations made the variant’s spike proteins, which cover the outside of the virus and are the main targets of vaccines and the body’s immune responses, different from those of the virus that first emerged in late 2019.

“The number of changes blew people’s minds,” said Kamil, an associate professor of microbiology and immunology at Louisiana State University Health Shreveport.

The World Health Organization has identified and tracked more than 20 variants. Yet unlike with others that popped up around the world before they mostly fizzled out (including the lambda variant, which was first documented in December in Peru, or the mu variant, which was detected a month later in Colombia), there were early signs that the omicron variant’s cocktail of mutations made it different and worthy of swift action — even overreaction — experts say.

While it’s too soon to know what the mutations mean for the effectiveness of vaccines or how sick people could become from the variant, the emergence of the omicron strain also highlights the frustrating reality of the Covid pandemic: Variants will continue to pose serious threats until countries around the world have more equal and ready access to vaccines, experts say.

“It’s definitely sobering,” Kamil said. “It’s an exaggeration to say we’re back at square one, but this is not a good development.”

Within hours of the WHO’s designating omicron a “variant of concern” Friday, dozens of countries imposed new travel bans, places that had loosened restrictions reintroduced mask mandates, and anxieties ran high.

It was the kind of quick and intense development reminiscent of early stages of the pandemic, prompting some concern that governments were overreacting before enough about the omicron variant was known.

“It’s partly why people started facetiously calling these things ‘scariants,’” said Dr. Amesh Adalja, an infectious disease doctor and a senior scholar at the Johns Hopkins Center for Health Security.

But even before it was given the “omicron” designation, the variant quickly gained attention among Covid researchers.

South Africa was the first to report clusters of cases involving the omicron variant last week. Days before, data about the newly identified variant had also been uploaded to GISAID, an online database for disease variants, by a research team in Hong Kong, followed by more early sequences from scientists in Botswana.

The number of mutations observed with the omicron variant hasn’t previously been seen with other strains, Adalja said. There are concerns that specific mutations to the spike protein could make the omicron variant less vulnerable to the so-called neutralizing antibodies generated by vaccines or natural immunity from previous Covid-19 infections.

“There’s a very good chance this variant will be very resistant to neutralizing antibodies, but we can’t yet say with any degree of certainty how resistant,” said Theodora Hatziioannou, a virologist at Rockefeller University in New York City.

Researchers have been preparing for this possibility.

In lab experiments with a virus that was genetically altered so it didn’t pose a threat to humans, Hatziioannou and her colleagues produced myriad combinations of spike protein mutations and tested how well they were able to evade Covid-19 antibodies.

One of their more worrisome outcomes was observed in a lab-produced spike protein that carried 20 mutations — more than had been observed in any other known variant at the time but fewer than in the omicron variant. It was largely resistant to neutralizing antibodies from both vaccines and natural immunity.

More research is needed to understand how the omicron variant behaves in real-world settings, but Hatziioannou said many of the variant’s mutations correspond to the types of changes she and her colleagues studied in the lab.

“Nature essentially reproduced our experiment, only at a much larger scale,” she said.

Scientists around the world are racing to characterize the omicron variant, focusing in particular on whether it is more contagious, causes more severe disease or can evade the protection of vaccines. Those open questions may awaken anxieties from early in the pandemic, but Carl Bergstrom, a professor of biology at the University of Washington, said drug therapies and the vaccines still offer crucial advantages.

“We have a whole bunch of tools now that we didn’t have before,” he said. “But it’s disappointing, for sure. There was kind of this general feeling that we’re coming off this delta wave, we’re triple-boosted, and it could almost be like 2019 again.”

Adalja said the emergence of the omicron variant should spur people to get vaccinated or to get booster shots. Countries should also increase testing for Covid-19 to track where — and how quickly — the variant is spreading.

Since omicron was designated a “variant of concern,” more than 40 countries have banned travel from southern Africa.

Hatziioannou said such sweeping measures, which may have been a “knee jerk reaction” to the most recent devastating wave of delta infections, are largely ineffective.

“The variant is likely already here,” she said. “Closing the barn door after the horses have bolted is useless.”

Cases involving the omicron variant have been detected in at least 16 countries. The variant hasn’t yet been confirmed in the U.S., but the country’s leading infectious disease expert, Dr. Anthony Fauci, the director of the National Institute of Allergy and Infectious Diseases, said it’s possible that the omicron variant is already spreading in the country.

“When you have a virus like this, it almost invariably is ultimately going to go essentially all over,” he said Saturday on NBC’s “Weekend TODAY.”

President Joe Biden, who said Monday that people should get fully vaccinated or get booster shots, tried to allay fears about the threat of the new strain.

“The variant is a cause for concern, not a cause for panic,” he said.

Kamil similarly said it’s too early to know what impact the omicron variant may have in the U.S. and around the world. He added, however, that it underscores the importance of vaccine equity and the need for wealthy countries to help provide that access.

“A booster shot in America has a far smaller effect of preventing variants than the first dose that someone gets in Chad or Benin or Togo,” he said. “If we do not protect other nations, we are all going to sink together.”

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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

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Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

___

Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Pediatric group says doctors should regularly screen kids for reading difficulties

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The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

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