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The future of medical psychedelics in Canada

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Bruce Tobin became interested in psilocybin, the psychoactive compound in magic mushrooms, 10 years ago when he was approached by a woman who had been diagnosed with terminal cancer.

She was suffering from intense depression, anxiety and hopelessness and the prospect of imminent death.

Fortunately, good treatment sent her cancer into remission. Yet she continued to experience these agonizing psychological symptoms, and conventional medical options proved ineffective in curbing them.

“The cancer was behind her, but there was this constant fear that it was going to return,” said Tobin, a psychotherapist based in Victoria, B.C., who has been practising for 35 years.

 

 

After exhausting other options, the woman tried psilocybin mushrooms. In a short period of time, her perspective drastically improved.

 

“She reported great gains in optimism, spiritual well-being, quality of life and an increased sense of acceptance of her death, whenever that happens,” Tobin said.

Her experience is in line with recent studies that have shown how psilocybin can help terminal cancer patients cope with anxiety stemming from their diagnosis. Other emerging research is showing the potential of psychedelics, some of which have been granted “breakthrough therapy” status by the U.S. Food and Drug Administration, to possibly treat and cure a range of medical concerns from Alzheimer’s to depression to addiction.

Since his patients’ positive mushroom experience, Tobin has devoted himself to fighting for patient access to psilocybin and is willing to take his battle to the courts, similar to the way cannabis patients and advocates fought for access.

 

Tobin is part of a growing number of health-care providers and researchers around the world who are championing the possibilities of mushrooms and other psychedelics that have been banned in Canada and the U.S. since the 1970s, but are now in the midst of a renaissance.

This fall, the University of Toronto launched the Centre for Psychedelic Studies, which will host the world’s first clinical trials on microdosing psilocybin. It joins a number of other prominent institutions devoting resources to psychedelics research, including other research centres at Johns Hopkins University and Imperial College London.

And in the year since cannabis became legal for recreational use in Canada, the world of psychedelics has also been attracting a number of cannabis executives who see it as the next frontier for therapeutic innovation.

Meanwhile, there are competing forces emerging across the country, differentiated by those who are willing to break the law to provide access to psychedelics and those who see legal channels as the best way forward.

 

In 2017, Tobin submitted an application to Health Canada requesting a special exemption to the current drug laws that would allow him to procure synthetic psilocybin and provide it to a group of terminal cancer patients who are experiencing end-of-life distress for which other treatments haven’t worked.

“They become depressed, demoralized, and life seems to lose its meaning. There’s no sense of future,” Tobin said.

Including his group of patients, Tobin estimates there are nearly 3,000 people in Canada for whom medical psilocybin could be beneficial.

He’s revised his application to Health Canada a number of times over the years, obtaining letters of support from members of psilocybin research teams across the United States, including from Johns Hopkins University.

But he says it’s been months since he’s heard from the federal health agency. If he gets rejected or doesn’t receive a response, Tobin says he plans to take the matter to court sometime next year.

 

“We’re talking about several thousands of Canadians that are suffering every day that treatment continues to be withheld from them,” Tobin said. “Treatment delayed is treatment denied.”

Health Canada would not comment on the specifics of the exemption applications that it receives, citing privacy reasons, but said it has received two applications regarding psilocybin, including one from 2017.

 

Tobin’s arguments in favour of providing psilocybin are similar to those of the medical cannabis advocates whose successful court battles eventually forced Health Canada to create special regimes to allow patients to obtain licences to use and grow cannabis.

Tobin sees these precedents as laying the groundwork for his own case. However, he said he’s not in favour of psychedelics being decriminalized, as was done earlier this year in Denver, Colorado.

I am not supporting the liberalization of psilocybin for spiritual or recreational purposes. I am confining my message to the medical use of psilocybin,” he said.

While Tobin is fighting for access for psilocybin on behalf of his patients, he’s clear that he’s not an “underground therapist.” The patients are responsible for obtaining the substance themselves.

“I’ve always had the sense that if I go to court and I’ve been engaged in illegal activities, that could come back to bite me,” Tobin said. “So I’ve played the squeaky clean role here. But I’m not going to go away.”

Dana Larsen is taking the opposite approach.

The longtime cannabis rights advocate from Vancouver is known for protesting against drug laws by flagrantly violating them, and he has now set his sights on psychedelic mushrooms. While he shares Tobin’s goal of ensuring medical access to psilocybin, he eventually would like to see it fully legalized or decriminalized.

This summer, he opened an illegal mail-order website, The Medicinal Mushroom Dispensary, and plans to open a physical space next year where people can consume psychedelics with supervision.

“Expanding into psychedelics is a really natural progression. The time is right,” Larsen said.

His is one of a number of illicit online mushroom stores in Canada, but Larsen appears to be the only operator who’s open about his operation.

Other dispensaries have been ordered by Health Canada to cease operations altogether. In July, the health agency sent a letter to Mungus.ca stating that its operations violated Canada’s drug laws.

 

“You are required to immediately suspend all activities in relation to psilocybin mushroom and to remove any content from your website related to the sale of a controlled substance,” states the letter, posted on the Mungus.ca site.

Health Canada confirmed in an email that the Mungus letter is authentic and that it is one of a total of 6 such letters it has sent to websites offering psilocybin.

For Larsen, who has faced numerous cannabis charges, his mushroom dispensary is part of a broader push to normalize psychedelics and eventually get them legalized.

“The civil disobedience movement was not the only reason cannabis was legalized in Canada, but I don’t think it would have happened without it,” Larsen said. “And I think we’re going to see similar things with mushrooms and psychedelics.”

Larsen’s online venture offers its members a microdosing “regimen,” which, in this case, is a low dose of mushrooms meant to be taken a couple times a week. This is different from taking a dose large enough to induce a trip, which can last several hours.

Like many illegal or so-called “grey market” dispensaries that operated before cannabis legalization, Larsen says he will only sell to people located in Canada who provide proof of a diagnosis or a recommendation for psilocybin from a health-care practitioner.

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This includes providing the substance to minors “if the parents consent in certain circumstances.”

Larsen says the mushroom dispensary’s membership has swelled to more than 1,000 people in the six months since he launched the site.

“It’s growing faster than when I was doing cannabis stuff, starting dispensaries and other projects 10 years ago,” he said. “But cannabis itself was easier to access to regular people, but mushrooms, especially microdoses, you have to know somebody.”

 

 

Former cannabis executives and researchers who are delving into psychedelics say that rigorous science and regulations must be pursued first to do justice to the burgeoning industry.

“My argument always has been that cannabis exists everywhere. Ignoring it helps illegal operators. It’s the exact same thing with psychedelics,” said Bruce Linton, formerly the co-CEO of cannabis giant Canopy Growth, who recently joined Toronto-based medical psychedelic firm Mind Medicine Inc.

“The job of the government is not to ignore. In this space, they should regulate, educate and monetize,” Linton, who still has one foot in the cannabis realm, said from a cannabis conference in Las Vegas. “Anybody who is opening illicit activities simply gives a stronger, compelling argument to the government to just smarten up.”

 

Canopy Growth Corp.’s former co-CEO Bruce Linton welcomes media to a new visitor centre at Canopy Growth’s Tweed facility in Smiths Falls, Ont., Thursday, Aug. 23, 2018. THE CANADIAN PRESS/Sean Kilpatrick

Linton’s company, also known as “Mindmed,” announced in September that it had invested in a molecule based on ibogaine, another psychedelic, to pursue its potential as a form of treatment for opioid addiction.

The company raised more than $6 million in new investment earlier this year, and it’s planning to go public in Canada in 2020.

Though Linton says the current scientific research around psychedelics is exciting and is in many ways more advanced than the science around cannabis, he doubts there will be a flood of cannabis execs like him entering the sector. To him, it requires harder work and more complicated ideas.

“You’re more likely to see researchers come out of the woodwork if there’s a proper way they can present themselves and not have the concern of access to capital or career,” Linton said.

Over the last 40 to 50 years, he said, much of the research has been “done in the shadows.”

“Now you have to be smart and pick jurisdictions where you can get work done and not be out of sight. What you don’t want to say is, ‘I’m going to change the rules in Canada and then do the work.’ No, go do the work and use the work to change the rules.”

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Indonesia swears in Prabowo Subianto as the country’s eighth president

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JAKARTA, Indonesia (AP) — Prabowo Subianto was inaugurated Sunday as the eighth president of the world’s most populous Muslim-majority nation, completing his journey from an ex-general accused of rights abuses during the dark days of Indonesia’s military dictatorship to the presidential palace.

The former defense minister, who turned 73 on Thursday, was cheered through the streets by thousands of waving supporters after taking his oath on the Quran, the Muslim holy book, in front of lawmakers and foreign dignitaries. Banners and billboards to welcome the new president filled the streets of the capital, Jakarta, where tens of thousands gathered for festivities including speeches and musical performances along the city’s major throughfare.

Subianto was a longtime rival of the immensely popular President Joko Widodo, who ran against him for the presidency twice and refused to accept his defeat on both occasions, in 2014 and 2019.

But Widodo appointed Subianto as defense chief after his reelection, paving the way for an alliance despite their rival political parties. During the campaign, Subianto ran as the popular outgoing president’s heir, vowing to continue signature policies like the construction of a multibillion-dollar new capital city and limits on exporting raw materials intended to boost domestic industry.

Backed by Widodo, Subianto swept to a landslide victory in February’s direct presidential election on promises of policy continuity.

Subianto was sworn in with his new vice president, 37-year-old Surakarta ex-Mayor Gibran Rakabuming Raka. He chose Raka, who is Widodo’s son, as his running mate, with Widodo favoring Subianto over the candidate of his own former party. The former rivals became tacit allies, even though Indonesian presidents don’t typically endorse candidates.

But how he’ll govern the biggest economy in Southeast Asia — where nearly 90% of Indonesia’s 282 million people are Muslims — remains uncertain after a campaign in which he made few concrete promises besides continuity with the popular former president.

Subianto, who comes from one of the country’s wealthiest families, is a sharp contrast to Widodo, the first Indonesian president to emerge from outside the political and military elite who came from a humble background and as president often mingled with working-class crowds.

Subianto was a special forces commander until he was expelled by the army in 1998 over accusations that he played a role in the kidnappings and torture of activists and other abuses. He never faced trial and went into self-imposed exile in Jordan in 1998, although several of his underlings were tried and convicted.

Jordanian King Abdullah II bin Al-Hussein was expected to attend Sunday’s ceremony, but canceled at the last minute because of escalating Middle East tensions, instead deciding to send Foreign Affairs Minister Nancy Namrouqa as his special envoy. Subianto and Abdullah met in person in June for talks in Amman on humanitarian assistance to people affected by the war in Gaza.

Subianto, who has never held elective office, will lead a massive, diverse archipelago nation whose economy has boomed amid strong global demand for its natural resources. But he’ll have to contend with global economic distress and regional tensions in Asia, where territorial conflicts and the United States-China rivalry loom large.

Leaders and senior officials from more than 30 countries flew in to attend the ceremony, including Chinese Vice President Han Zheng and leaders of Southeast Asia countries. U.S. President Joe Biden sent Linda Thomas-Greenfield, the U.S. ambassador to the United Nations. Adm. Samuel Paparo, the U.S. Commander of the Indo-Pacific Command, was also among the American delegation.

Army troops and police, along with armored vehicles, fire trucks and ambulances, were deployed across the capital, and major roads were closed to secure the swearing-in.

The election outcome capped a long comeback for Subianto, who was banned for years from traveling to the United States and Australia.

He has vowed to continue Widodo’s modernization efforts, which have boosted Indonesia’s economic growth by building infrastructure and leveraging the country’s abundant resources. A signature policy required nickel, a major Indonesian export and a key component of electric car batteries, to be processed in local factories rather than exported raw.

He has also promised to push through Widodo’s most ambitious and controversial project: the construction of a new capital on Borneo, about 2,000 kilometers (1,240 miles) away from congested Jakarta.

Before February’s presidential election, he also promised to provide free school lunches and milk to 78.5 million students at more than 400,000 schools across the country, aiming to reduce malnutrition and stunted growth among children.

Indonesia is a bastion of democracy in Southeast Asia, a diverse and economically bustling region of authoritarian governments, police states and nascent democracies. After decades of dictatorship under President Suharto, the country was convulsed by political, ethnic and religious unrest in the late 1990s and early 2000s. Since then, it has consolidated its democratic transition as the world’s third-largest democracy, and is home to a rapidly expanding middle class.

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Associated Press journalists Edna Tarigan and Andi Jatmiko contributed to this report.

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Voters in Arizona and Nebraska will face competing ballot measures. What happens if they both pass?

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Voters in Nebraska and Arizona will see competing measures on their November ballots — in one case about abortion, in the other about primary elections. If voters approve them all, what happens next could be up to the courts to decide.

Like more than a dozen other states, Arizona and Nebraska have constitutions stating that if two or more conflicting ballot measures are approved at the same election, the measure receiving the most affirmative votes prevails.

That sounds simple. But it’s actually a bit more complicated.

That’s because the Arizona and Nebraska constitutions apply the most-votes rule to the specifically conflicting provisions within each measure — opening the door to legal challenges in which a court must decide which provisions conflict and whether some parts of each measure can take effect.

The scenario may may sound odd. But it’s not unheard of.

Conflicting ballot measures “arise frequently enough, and the highest-vote rule is applied frequently enough that it merits some consideration,” said Michael Gilbert, vice dean of the University of Virginia School of Law, who analyzed conflicting ballot measures as a graduate student two decades ago when his curiosity was peaked by competing measures in California.

What’s going on in Nebraska?

After the U.S. Supreme Court overturned a nationwide right to abortion, Nebraska enacted a law last year prohibiting abortion starting at 12 weeks of pregnancy except in medical emergencies or when pregnancy results from sexual assault or incest.

Abortion-rights supporters gathered initiative signatures for a proposed constitutional amendment that would create “a fundamental right to abortion until fetal viability, or when needed to protect the life or health” of a pregnant woman, without interference from the state. Fetal viability generally is considered to be some time after 20 weeks. The amendment is similar to abortion-rights measures going before voters in eight other states.

Abortion opponents, meanwhile, pursued their own initiative to essentially enshrine the current law into the constitution. That measure would prohibit abortion in the second and third trimesters, except in medical emergencies or pregnancies resulting from sexual assault or incent.

The Nebraska Constitution says the winning measure with the most votes shall become law “as to all conflicting provisions.” State law says the governor shall proclaim which provision is paramount. Lawsuits could follow.

If the measure creating a right to abortion until fetal viability gets the most votes, it could be construed as fully conflicting with the restrictive measure and thus prevail in its entirety, said Brandon Johnson, an assistant law professor at the University of Nebraska.

But if the restrictive measure gets the most votes, a court could determine it conflicts with the abortion-rights measure only in the second and third trimesters, Johnson said. That could create a scenario where abortion is elevated as a fundamental right during the first trimester but restricted in the second and third.

“There’s a decent legal argument, based on the language that talks about conflicting provisions of the measures, that you can synchronize the two,” Johnson said.

What’s going on in Arizona?

Arizona, like most states, currently uses partisan primaries to choose candidates for the general election.

The Republican-led Legislature, on a party-line vote, placed an amendment on the November ballot that would enshrine partisan primaries in the state constitution, reaffirming that each party can advance a candidate for each office to the general election.

A citizens initiative seeks to change the current election method. It would create open primaries in which candidates of all parties appear on the same ballot, with multiple candidates advancing to the general election. It would be up to lawmakers or the secretary of state to enact requirements for exactly how many should advance. If at least three make it to a general election, then ranked choice voting would be used to determine the winner of the general election.

The Arizona Constitution says the winning ballot measure with the most votes shall prevail “in all particulars as to which there is conflict.”

In the past, the Arizona Supreme Court has cited that provision to merge parts of competing measures. For example, in 1992, voters approved two amendments dealing with the state mine inspector. One measure extended the term of office from two to four years. The other measure, which got more votes, limited the mine inspector to serving four, two-year terms.

In a case decided 10 years later, the Supreme Court said parts of both measures should take effect, ruling the mine inspector could serve four, four-year terms. That could have implications for Arizona’s future elections if voters approve both competing measures on this year’s ballot.

“The court really goes out of its way to harmonize the two,” said Joseph Kanefield, an attorney and former state election director who teaches election law at the University of Arizona. Striking one measure entirely “is something that the court will try to avoid unless they absolutely determine the two cannot exist together.”

What’s happened in other states?

When Gilbert’s curiosity was peaked about conflicting ballot proposals, he teamed up with a fellow graduate student at the University of California, Berkeley, to examine 56 instances of competing ballot measures in eight states between 1980 and 2006. In some cases, the measures appeared to directly conflict. In others, the measures merely addressed similar topics.

Their research found that the measure getting the most affirmative votes often was the one that made the least change from the status quo.

But sometimes, the highest-vote rule never comes into play, because voters approve one measure while rejecting the other. Or voters defeat both measures.

In 2022, California voters were presented with two rival proposals to legalize sports betting. Interest groups spent roughly $450 million promoting or bashing the proposals, a national record for ballot measures. But both were overwhelmingly defeated.

In 2018, Missouri voters faced three different citizen-initiated proposals to legalize medical marijuana. Voters approved one and rejected two others.

“It is not unusual to have conflicting measures,” said John Matsusaka, executive director of the Initiative and Referendum Institute at the University of Southern California. “But my observation is that voters usually understand the game and approve one and turn down the other.”

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From showgirl feathers to shimmering chandeliers, casino kitsch finds new life

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LAS VEGAS (AP) — Crystal chandeliers that once glimmered above a swanky lounge, bright blue costume feathers that cloaked shimmying showgirls, and fake palm trees that evoked a desert oasis are just some the artifacts making their way from the latest casino graveyards of Las Vegas into Sin City history.

The kitsch comes from the Tropicana, which was demolished in a spectacular implosion Oct. 9 to make room for a new baseball stadium; and from The Mirage, the Strip’s first megaresort, which dealt its last cards in July and is set to reopen as a new casino nearly 40 years after it originally debuted.

As the neon lights dimmed and the final chips were cashed in, a different kind of spectacle unfolded behind the casino doors. Millions of items big and small were meticulously sorted and sold, donated and discarded.

“You take this hotel-casino and you turn it upside down, shake everything out of it until it’s empty,” said Frank Long, whose family business, International Content Liquidations, led the effort to unload the Tropicana’s merchandise before its implosion.

Long, 70, a third-generation auctioneer, likes to say he’s in the business of “going, going, gone.” He jokes that his Ohio home is “decorated in early hotel,” having helped clear out dozens of them as well as casinos across the country. In Las Vegas, that includes the Dunes, Aladdin and Landmark.

“Vegas buyers are special,” Long said. “This is their community, and they want a piece of it.”

Trolling for a piece of history

On a hot day in June, two months after the Tropicana shut its doors, Long welcomed buyers onto the casino floor.

The whirring slot machines were long gone, transferred to other casinos. In their place sat an odd collection of things: desks and chairs, rattan night stands, table lamps, pillows and sofas. Piled high in what was once the high-limit gambling room were mattresses and box springs. Small crystal chandeliers going for $1,000 hung suspended from old luggage carts.

“Fill up your entire truck for 100 bucks,” Long told shoppers, grinning.

Buyers of all ages filled wagons and luggage carts with arm chairs priced at $25, mirrors at $6, floor lamps at $28. Behind red velvet ropes where guests used to check in, customers waiting to pay stood in line with 43-inch flatscreen televisions. One man hugged a mattress and box spring, trying to keep them from toppling over.

In the Tropicana’s vast conference hall, piles of large vintage spotlights labeled “FOLIES” sat in waist-high bins marked for donation. They were off-limits to buyers, destined for the Las Vegas Showgirl Museum.

The Tropicana was home to the city’s longest-running show, “Folies Bergere,” a topless revue imported from Paris. Its nearly 50-year run helped make the feathered showgirl one of the most recognizable Las Vegas icons.

Elvis’ image among the forgotten treasures

One of Long’s favorite parts about the job is sifting through forgotten corners of casinos.

Inside the Tropicana, his team rescued black-and-white photographs of stars who wined, dined and headlined there. His favorite was a candid photo of Elvis Presley found in an unused office.

In its heyday, the casino played host to A-list stars including Elizabeth Taylor and Debbie Reynolds, Frank Sinatra and Sammy Davis Jr.

Long said his people have fun with the job, too. The tedium of collecting several thousand pillows from the Tropicana’s two hotel towers turned into “the world’s biggest pillow fight.”

When Sarah Quigley learned the Tropicana was closing, she knew she needed to act fast if she wanted some of the casino’s historical records for the Special Collections and Archives at the University of Nevada, Las Vegas.

Quigley, director of the special collections, wasn’t the first to call.

But after a meeting with the Tropicana’s management team, UNLV’s special collections acquired five boxes of records from 1956 to 2024, including vintage 1970s ads for the Tropicana’s showroom, old restaurant menus, architectural blueprints and original film reels of the dancing “Folies” showgirls rehearsing in the mid-1970s.

Salvaging the neon Vegas is famed for

The Neon Museum, which rescues iconic Las Vegas signs, got the Tropicana’s red one and The Mirage’s original archway that welcomed guests for 35 years. In a herculean effort, the 30-foot sign was placed on a flatbed truck in August. A chunk of the Strip closed so the piece could be slowly driven to its new home at the museum.

The Mirage opened with a Polynesian theme in 1989, spurring a building boom on the Strip that stretched through the 1990s. Its volcano fountain was one of the first sidewalk attractions, and tourists flocked to the casino to see Cirque du Soleil set to The Beatles or Siegfried and Roy taming white tigers.

In just a few years, the Strip’s skyline will look different. The Mirage will become the Hard Rock Las Vegas in 2027, with a hotel tower shaped like a guitar. The following year, the new baseball stadium is expected to open on the former site of the Tropicana.

While the last of the Tropicana’s buildings came tumbling down in 22 seconds, pieces of the Las Vegas landmark have found a new life in nearby museums, curated collections and homes.

“There’s history here,” said Aaron Berger, executive director of the Neon Museum. “You just have to look past the glitter to find it.”

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Associated Press video journalist Ty O’Neil in Las Vegas contributed to this report.

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