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This COVID study has been tracking immunity for 3 years. Now it’s running out of money

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A long-running study into COVID-19 immunity has unearthed promising insights on the still-mysterious disease, one of its lead researchers says — but she’s concerned its funding could soon dry up.

The Stop the Spread project, a collaboration by the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa, has been monitoring antibody responses to COVID-19 in hundreds of people since October 2020.

For the first 10 months of the project, about 1,000 people sent in monthly samples of their blood, saliva or sputum — a mixture of saliva and mucus — for analysis.

The researchers then winnowed that group to about 300 and kept following them as vaccines were developed and new variants emerged.

While there are other longitudinal COVID-19 studies underway, Stop the Spread is notable because it launched so early in the pandemic that some participants hadn’t even fallen ill yet, said Dr. Angela Crawley, a cellular immunologist with OHRI and one of the project’s co-investigators.

That gave them access to cells and plasma untouched by the COVID-19 virus — a unique baseline, Crawley said, from which they’ve since tracked changes in immune responses and antibody levels.

But with the pandemic approaching the four-year mark, she and other researchers worry enthusiasm to fund COVID-19 research like Stop the Spread is waning — and that could have implications for how Canada tackles future outbreaks.

“Research funding has dwindled, and, you know, things change,” she said. “So a lot of what we’ve built is under threat of collapse.”

Stop the Spread is one of nearly 1,000 projects that has received funding from the Canadian Institutes for Health Research, or CIHR, since the beginning of the COVID-19 pandemic. (Associated Press/Ted Warren)

Biological sex and antibodies

Stop the Spread got roughly $2 million from the Canadian Institutes of Health Research (CIHR), the country’s health research granting agency, to follow that first 10-month cohort, and then leveraged that initial work to keep the money flowing for several more years.

During that time, and thanks in large part to advanced machine learning — a form of artificial intelligence that allows computers to adapt and draw inferences from data without explicitly being programmed to do so — the team teased out intriguing relationships from all the COVID-19 data in their hands.

For instance, Crawley said they’ve uncovered “pretty compelling” evidence of a link between one’s biological sex and one’s ability to generate and maintain antibodies.

Across all age categories, the data seems to suggest women are slower to shed antibodies than men, Crawley said. The distinction is sharpest in younger age groups, with rates of antibody loss gradually converging the older people get.

That sort of data, Crawley said, can help “fine-tune” future public health responses to COVID-19, which could include vaccines that better account for those differences in age and sex.

“How sophisticated our antibody response is relates to how well we can neutralize the virus,” said Crawley. “We’re not talking about protection against infection — that’s a different conversation — but protection against disease severity, which means a lot when you talk about respiratory infections.”

In addition to the CIHR funding, Stop the Spread also got money from the COVID-19 Immunity Task Force (CITF), which was established by the Public Health Agency of Canada (PHAC) in the pandemic’s early days.

Its mandate is — among other things — to fund research into COVID-19 immunity that would help Canadian policymakers make “evidence-based decisions.” According to PHAC, It’s handed out nearly $230 million to support scientific endeavours since launching in 2020.

It’s definitely a labour of love, but there’s so much to learn from this.– Angela Crawley

But there’s increasing worry among researchers who study COVID-19 that the overall pot of money is evaporating, said Dawn Bowdish, a professor at McMaster University and Canada Research Chair in Aging and Immunity.

“The number of outbreaks that we have for COVID is still disrupting care. It’s still costing people their health and their lives,” said Bowdish, who’s been following more than 1,000 long-term care residents as part of her own COVID-19 research.

“But there’s just no appetite to acknowledge that this is still a problem, and it’s incredibly frustrating, because the work that we do applies to all sorts of different infections.”

An older man and woman pose for a photo in front of a tree in autumn.
Christine and Jim Bonta, two longtime Stop the Spread participants, say a premature end to the study would mark a lost opportunity to learn more about pathogens like COVID-19. (Trevor Pritchard/CBC)

‘Breaking our hearts’

The federal government has invested $430 million through CIHR into nearly 1,000 COVID-19 research projects since the start of the pandemic, said PHAC spokesperson André Gagnon.

The agency still acknowledges the virus “poses a grave health threat,” Gagnon wrote in an email to CBC, with CIHR now home to a research centre focusing on pandemic preparedness and other health-care crises. And while it’s still funding projects on topics such as COVID-19 misinformation and long COVID, it also “recognizes the need to shift funding priorities to respond to current events.”

“[CIHR continues] to run 100+ funding competitions every year to invest research into other priority areas for people in Canada, such as cancer, heart disease, dementia, the opioid crisis and ways to strengthen Canada’s health-care systems,” he wrote.

The CITF, meanwhile, is slated to wrap up its work in March 2024, Gagnon added.

Bowdish says her research only has funding until the end of this year. Crawley, meanwhile, says Stop the Spread’s CIHR funding is running out in March, and they’re trying to stretch that out to follow a smaller cohort of about 100 people until mid-2025.

(Crawley is conducting parallel research into T-cells and immunity that’s only funded through CITF until the end of this year. With all the work they have ahead, she says there’s no way they’ll get that done to her satisfaction.)

“It’s literally breaking our hearts. We hope that we can find a way to sustain this for Canadians,” she said.

Ending the Stop the Spread project would make for a missed opportunity, said participants Jim and Christine Bonta, who’ve been part of the cohort since 2020 and recently signed on to continue into 2024.

“It would be knowledge lost, in particular about the effects of long COVID,” said Jim Bonta. “I don’t have long COVID, but I guess I would be [part of] a comparison group.”

“COVID is still circulating. And we don’t know when this is going to go away, if it will go away, and what else is going to emerge,” added Christine Bonta, a retired nurse.

“We need to be prepared to deal with that, [because] in 2020, we were not prepared.”

A woman wearing a black jacket and a black-and-white scarf poses for a photo outside a hospital on a fall day.
Crawley says her team has uncovered ‘pretty compelling’ evidence suggesting a link between one’s biological sex and one’s ability to generate and maintain antibodies that fight the COVID-19 virus. That work is now being submitted to a ‘high-impact journal,’ she added. (Trevor Pritchard/CBC)

The ideal scenario

For Crawley, the ideal scenario would be to get enough funding to continue Stop the Spread beyond 2025 while also establishing a truly national “biobank”: a physical facility with samples stored in freezers, with back-end infrastructure that would allow other researchers across Canada to easily access the data and share their own findings.

All the contracts would be in place so that scientists, governments and industry could all get at that information — something that would “break down silos” in scientific research and foster collaboration, she said.

“When there’s a pandemic, it’s no longer about, how can my career advance?” said Crawley. “It shouldn’t be like that. It should be, how can we all work together?”

Crawley also said her team has great respect for the Bontas and everyone else who’s committed three-plus years of their lives to Stop the Spread.

They feel an almost “crushing responsibility,” she added, to eke as much knowledge as possible out of the data they’ve collected — and continue to collect, at least for another year and a half.

“It’s definitely a labour of love, but there’s so much to learn from this,” she said. “And we do feel a pretty strong responsibility to make sure that we can learn as much as possible.”

 

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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

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Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

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Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Pediatric group says doctors should regularly screen kids for reading difficulties

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The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

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