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Rady Faculty researchers receive more than $8.3 million in CIHR funding – UM Today

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February 9, 2024 — 

Researchers from the Rady Faculty of Health Sciences have been awarded more than $8.3 million in the latest round of Canadian Institutes of Health Research (CIHR) project funding.

The funding for 10 UM research projects was awarded through the CIHR’s Project Grant Program, which is designed to support ideas with the greatest potential to advance health research, health-related fundamental or applied knowledge, health systems, health care or health outcomes.   

“Congratulations to the individuals from the Rady Faculty that secured funding for their important research,” said Dr. Mario Pinto, UM vice-president (research and international). “I’m thrilled to see that three of the teams were ranked No. 1 by their respective peer review committees. This demonstrates the leading-edge health research being conducted at UM.”

Dr. Peter Nickerson, dean of the Rady Faculty of Health Sciences, said the projects also reflect the diversity of health research taking place at UM.

“The studies are led by scientists from many different fields – from community health sciences to oral biology to pharmacology and therapeutics. This funding will help our researchers carry out their projects which will inevitably have an impact on the health of Manitobans, Canadians and people around the world,” Nickerson said.  

One of the UM grant recipients is Dr. Soheila Karimi, professor of physiology and pathophysiology, Max Rady College of Medicine, and founding director of the Manitoba Multiple Sclerosis Research Centre. She and her team received $1,143,675 over five years to study what could one day be a new treatment for progressive multiple sclerosis (MS).

“MS happens when the body’s immune system attacks and damages myelin, a protective layer around nerve fibers of the brain and spinal cord. My research group has identified that Neuregulin-1, which is an important protein for proper function of the brain and spinal cord, is depleted in MS lesions. We have strong evidence that Neuregulin-1 holds promise as a potential treatment to promote myelin repair in progressive MS when repair fails, resulting in increased neurological impairments,” said Karimi, who is also a researcher with the Children’s Hospital Research Institute of Manitoba (CHRIM).

Karimi’s project will evaluate Neuregulin-1 as a future treatment to prevent the progression of MS and support tissue repair. A new treatment is much needed, Karimi said, because Canada is home to the world’s highest prevalence of MS and current medications are minimally effective for the progressive phase of the disease.

“We are really hoping that this research will set the groundwork for conclusive findings which would justify going to clinical trials, especially for progressive MS, because there is a critical treatment gap,” Karimi said.

Learn about the other UM projects funded through the latest round of CIHR’s Project Grant Program. More information about the research teams and the work they’ll be doing is available here.

Dr. Tracie Afifi, professor of community health sciences, Max Rady College of Medicine; Canada Research Chair in childhood adversity and resilience; researcher, CHRIM

Grant: $100,000 (one year)

Afifi will focus on updating and expanding her 10-year-old study related to child maltreatment across Canada. The team will update national and provincial prevalence of child abuse statistics and aim to understand the experiences of child abuse among those with different gender and sexual identities and how this impacts mental health and substance use outcome across age groups.

Portrait of Dr. Heather Armstrong. Dr. Heather Armstrong, assistant professor of internal medicine, Max Rady College of Medicine; Canada Research Chair in integrative bioscience; researcher, CHRIM

Grant: $814,725 (five years)

Armstrong’s team will study the reasons why some dietary fibres are not well tolerated in patients with inflammatory bowel diseases (IBD). She hopes these findings support development of personalized dietary fibre guidelines for IBD patients, based on the individual’s gut and microbiome health to ensure only safe fibres are consumed, therefore promoting improved microbe and gut health.

Portrait of Dr. Prashen Chelikani.Dr. Prashen Chelikani, professor of oral biology, Dr. Gerald Niznick College of Dentistry

Grant: $1,319,625 (five years)

Chelikani and the team will work to understand why some dental fungi are associated with tooth decay in preschool children and the local environmental factors that might influence them. This research on the dental mycobiome associated with severe tooth decay will assist with the development of new tooth decay prevention strategies for young Indigenous children.   

Portrait of Dr. Keith Fowke. Dr. Keith Fowke, department head and professor of medical microbiology and infectious diseases, Max Rady College of Medicine

Grant: $956,250 (five years)

Fowke will partner with organizations and community members in Nairobi, Kenya, to better understand the immune system among women who clear human papilloma virus (HPV) infection. The project aims to identify the immune cells that are important in the natural clearance of HPV with the goal of identifying these HPV clearance associated immune factors that are important for a therapeutic HPV vaccine to mimic.

Portrait of Dr. Nathan Nickel. Dr. Nathan Nickel, associate professor of community health sciences, Max Rady College of Medicine; director and senior research scientist, Manitoba Centre for Health Policy; researcher, CHRIM

Grant: $577,574 (three years)

In partnership with the Manitoba Métis Federation, Nickel and his team’s study will shed light on whether a Manitoba Health campaign that promoted the importance of childhood vaccinations improved childhood vaccination among Métis families. The study’s findings will support the development of strategies aimed at keeping childhood vaccination rates high in Manitoba as well as nation-specific strategies for Red River Métis citizens.

Portrait of Dr. Christopher Pascoe. Dr. Christopher Pascoe, assistant professor of physiology and pathophysiology, Max Rady College of Medicine; researcher, CHRIM

Grant: $784,125 (five years)

Pascoe seeks to better understand why exposure to diabetes during pregnancy makes airways twitchier in asthma. The team will learn whether reducing blood glucose levels during pregnancy is an effective way to prevent changes from occurring and this information may allow them the ability to stop asthma in children exposed to diabetes from developing before it’s a problem that requires treatment.

Portrait of Dr. Joel Pearson. Dr. Joel Pearson, assistant professor of pharmacology and therapeutics, Max Rady College of Medicine; researcher, Paul Albrechtsen Research Institute, CancerCare Manitoba

Grant: $983,025 (five years)

Pearson will lead a study aimed at understanding the underlying causes of small cell lung cancer (SCLC) and how non-small cell lung cancer can change to SCLC. This research will help them identify new and improved treatments for SCLC so patients living with this cancer will have longer lives and better outcomes.

Portrait of Dr. Souradet Shaw. Dr. Souradet Shaw, assistant professor of community health sciences, Max Rady College of Medicine; Canada Research Chair in program science and global public health

Grant: $883,576 (four years)

Shaw’s study seeks to develop a deeper understanding of trends, determinants and responses to sexually transmitted and bloodborne infections (STBBI) in Manitoba over a 30-year period. Collaborations between community, public health and academics will be at the forefront of this project, with the goal of co-learning and co-designing interventions to ensure no one is left behind while addressing current and future STBBI outbreaks.

Portrait of Dr. Roberta Woodgate. Dr. Roberta Woodgate, distinguished professor of nursing, College of Nursing; Canada Research Chair in child and family engagement in health research and healthcare; researcher, CHRIM

Grant: $768,824 (four years)

Woodgate will lead a study to gather evidence to inform the co-design of policies and research priorities meant to enhance the health and well-being of young people who care for family members or other loved ones. Young carers will co-design the policy recommendations and research priorities by gathering evidence grounded in their experiences and providing them with a leadership role in the process.

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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

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Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

___

Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Pediatric group says doctors should regularly screen kids for reading difficulties

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The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

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