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As the world begins its vaccination push, delayed rollouts draw criticism and concern – CNN

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But vaccination efforts are rolling out slower than promised, raising doubts about an imminent way out of the crisis.
In nations where vaccines have been authorized, criticism is mounting over shortages and delays to getting shots into people’s arms. And solutions devised to stretch supplies — from administering half doses to spreading out the time between two doses — have raised concerns from some experts.
Some governments are pointing the finger at manufacturers for bottlenecks, while vaccine developers say it’s an issue of supply. Others cite complications with distribution plans and a lack of trained staff to administer shots. But most public health experts say the slow pace is the inevitable consequence of creating a new vaccine rollout in real time.
Just weeks after the United Kingdom became the world’s first nation to begin vaccinating its citizens with a fully vetted and authorized Covid-19 shot, its government is facing questions over how many doses are available.
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The English city of Birmingham reported it was running out of the Pfizer/BioNTech vaccine last week and doctors are demanding to know where deliveries are.
“The question in the UK is, is there a supply problem, or is there a problem with the infrastructure for rollout? And we don’t actually know that. The manufacturers say there isn’t a supply problem, but the government say there is,” said Martin McKee, professor of European public health at the London School of Hygiene and Tropical Medicine.
A report from Britain’s Scientific Advisory Group for Emergencies (SAGE), of which McKee is a member, urged the UK government to be transparent on supplies, noting evidence that “some of those involved in implementing the vaccine strategy lack confidence in its organisation.” Asked by CNN how many doses had been delivered, UK government officials said they were not able to provide detail about the size of supplies and future deliveries for security reasons.
Some 2 million people have received at least one dose in the UK since the campaign started on December 8, but Prime Minister Boris Johnson has promised to ramp up vaccinations to 2 million per week. The UK trails Israel, the United Arab Emirates, Bahrain, the United States and Denmark in the rate of doses administered per 100 people, according to a global tracking website affiliated with Oxford University.
McKee said European governments also must be clear about whether delays are down to a shortage of vaccine or an infrastructure issue, saying that it was “simply unbelievable” that countries like France seemed to be floundering. “Many people are looking with incredulity at the failure of a number of European countries to have robust plans in place,” he added.
A member of the medical staff at a hospital in Lyon, France receives the Pfizer/BioNTech vaccine on January 6.
France has been under fire for its sluggish pace since the campaign started on December 27. Only 516 people were vaccinated in the first week, according to data from the French health authority on January 1. French Health Minister Olivier Veran told reporters Saturday he expected 100,000 to be vaccinated by the end of the weekend. In his New Year’s Eve address, French President Emmanuel Macron said he would not tolerate any “unjustified slowness” in the country’s vaccination campaign, even as health officials argue the rollout is deliberately cautious to help convince the country’s sizable population of vaccine skeptics to get it.
Germany, which started its campaign on the same date as France, has administered over 500,000 shots (less than half of the doses delivered), but is still facing criticisms. Amid calls for the country to take control over purchases from European Union authorities, Health Minister Jens Spahn said there will be “enough vaccine” and urged patience.
The Netherlands only started its campaign on Wednesday, making it the last European country to do so.
Members of the EU vaccine procurement scheme, agreed in June, are reliant on European regulators granting authorization of Covid vaccines — but the EU has taken longer than the UK, the US and Canada to give the green light. So far, the European Medicines Agency has authorized the BioNTech/Pfizer vaccine and, last week, the Moderna vaccine — with initial orders for 300 million doses of the BioNTech/Pfizer vaccine and 160 million of Moderna.
Asked why it had not secured more vaccine doses last Monday, the European Commission defended its strategy — pointing to the 2 billion doses from six producers already agreed. “We’re all judging this as if this campaign is over; in fact, it is just starting,” EC spokesman Eric Mamer told reporters in Brussels.
But the founder of BioNTech said the EU had been slow to secure doses and warned of possible gaps in supply amid surging demand. “At the moment it doesn’t look good — a hole is appearing because there’s a lack of other approved vaccines and we have to fill the gap with our own vaccine,” Ugur Sahin told news weekly Spiegel. On Friday, European Commission President Ursula von der Leyen said the EU had extended its contract with BioNTech/Pfizer for up to double the agreed doses.
Employees carry boxes with the Pfizer/BioNTech vaccine to a  Covid-19 center near Magdeburg, Germany on January 8.Employees carry boxes with the Pfizer/BioNTech vaccine to a  Covid-19 center near Magdeburg, Germany on January 8.
In Canada, Prime Minister Justin Trudeau has admitted even he is frustrated to see vaccines in freezers and not in people’s arms. As of Sunday, Canada had managed to administer around 315,000 doses since the campaign started on December 14 — about half of the vaccine doses that have so far been delivered.
Federal officials in the US, meanwhile, have been struggling to explain why only 6.7 million people had been vaccinated, when three times that number of doses have been distributed; they had promised 20 million people would have been inoculated by the end of 2020. The US also started its rollout on December 14.
“Clearly no excuses. We should have gotten 20 distributed, and 20 into the arms of people,” Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, told the Economic Club of Washington. But Fauci said it should “pick up momentum” now the holiday period is over.
President-elect Joe Biden said Friday he would aim to release nearly every available dose of the coronavirus vaccine when he takes office, a break with the Trump administration’s strategy of holding back half of US vaccine production to ensure second doses are available.
US government officials have so far pinned the blame for initial delays on distribution issues at the state and local level. Without a federal mandate for how to administer the vaccine in the US, it’s up to the states to decide who gets the vaccine and when, creating a confusing patchwork of rules that varies greatly across the country.
When asked last week about the discrepancy between the number of vaccines distributed and those administered, Moncef Slaoui, head of Operation Warp Speed, the multi-agency effort to accelerate vaccine development and procurement, said: “We agree that there is a lag. We’ll work with the states. We need specific requests for help, frankly, it’s not for me to decide whether stadiums should be used.”
Seniors and first responders wait in line to receive a vaccine in Fort Myers, Florida on December 30.Seniors and first responders wait in line to receive a vaccine in Fort Myers, Florida on December 30.
Some states have acknowledged on-the-ground issues that delayed vaccinations, but many have said for months they need more federal funding to execute complex rollout plans.
Gen. Gustave Perna, in charge of logistics for Operation Warp Speed, took responsibility for initial delays and confusion around the vaccine rollout in a number of states, after a misunderstanding over the approval process led to miscalculations in the doses that would be available in late December.
Each individual batch of vaccine has to undergo independent testing before it can go into the distribution chain, a process that can take up to three weeks. The step, which is essential to assuring quality and safety, has also been referred to as the “red tape” hampering delivery in the UK.
Another difficulty has been the vaccines’ complicated ultracold storage and transport needs — systems that have had to be set up from scratch. The BioNTech/Pfizer vaccine must be stored at -70 degrees Celsius, or -94 Fahrenheit, far below the capacity of standard freezers. Establishing that infrastructure is easier in developed countries, but by no means simple.
Much can go wrong in the complex chain from production to vialing, distribution and administration to patients but experts say the manufacturing side, which started before vaccines were even authorized, is going smoothly.
“There were going to be natural hiccups in the manufacturing, especially for vaccines that have never been produced at commercial scale. I think it’s gone relatively well in fact. I actually would have expected more problems,” said Robin Robinson, the founding director of the Biomedical Advanced Research and Development Authority (BARDA), a branch of the US Department of Health and Human Services.
Boxes containing the Moderna vaccine are prepared to be shipped at the McKesson distribution center in Olive Branch, Mississippi on December 20.Boxes containing the Moderna vaccine are prepared to be shipped at the McKesson distribution center in Olive Branch, Mississippi on December 20.
Ron Piervincenzi, chief executive officer of the United States Pharmacopeia (USP), whose organization helps drugmakers meet quality standards, agreed that manufacturing has been relatively predictable so far — just slightly delayed. But the delays feel more acute as the death toll climbs.
“It’ll be messy, for you know, a couple months, it’ll be messy as it rolls out to each new country and region as they go through. But they’re not insolvable [problems]. This isn’t a scientific challenge, like we can’t make the vaccine. This is we have the vaccine, how do we get it to you,” Piervincenzi said.
“In six months time we’re going to be talking about the true bottlenecks rather than the messy stuff that’s going to eventually be cleaned up.”
Grappling with a slower-than-expected pace, officials are rushing to find workarounds and solutions to the massive demand — even lowering required dosages to stretch out supplies.
Britain’s medicines regulator is allowing second doses of coronavirus vaccines to be delayed by several weeks to inoculate more people (a move also being considered in Germany and the US). Separately, the UK government suggested that it was “reasonable” to use a different vaccine for the second dose if the same vaccine used for the first one was unavailable, or if a person was high-risk or unlikely to return to the doctor for a shot.
In the US, the Food and Drug Administration has said it may be possible to yield six or even seven doses of the BioNTech/Pfizer’s Covid-19 vaccines from the vials instead of the five indicated on the label, because the company overfills them. The FDA will consider giving half-doses of Moderna’s Covid-19 vaccine to people aged 18 to 55.
But as countries try to eke out more doses, health experts say the focus should be on securing “the last mile” of the vaccination process — the steps from when a vaccine is made to when doses are administered to people — and ensuring no one is left out.
Ground staff at the Indira Gandhi International Airport in Delhi, India, which will be used as a handling and distribution center.Ground staff at the Indira Gandhi International Airport in Delhi, India, which will be used as a handling and distribution center.
An estimated 70-90% of the world’s 7.8 billion people would need to receive the vaccine before achieving the so-called “herd immunity” required for people to return to normal life, Fauci has said. Most of the vaccines require two doses per person, that means distributing roughly 10 to 14 billion doses — a logistical challenge the likes of which the world has never seen. Researchers at Duke Global Health Innovation Center estimate the last people in line may not receive vaccines until 2024.
As the West frets over the speed of the vaccine rollout, countries are still scrambling to lock down supplies while others try to ring-fence doses. German Chancellor Angela Merkel has been discussing with Russian President Vladimir Putin the “possible prospects for joint production of vaccines,” according to the Kremlin. And India’s government has restricted vials of AstraZeneca’s Covishield coronavirus vaccine for the domestic market until March or April, raising fears over vaccine nationalism.
“The higher income countries are grabbing what they can grab. And they’re getting the first dibs on these vaccines, there’s no question about it,” Piervincenzi said. “Given the delays that you see even in higher income countries, that’s going to be a pretty long time off to have excess supplies of those same vaccines.”
COVAX, a partnership between Gavi, the Coalition for Epidemic Preparedness Innovations and the World Health Organization to promote global access to vaccines, is essential to getting doses to developing countries. But hedging by wealthy nations is leaving low- and middle-income nations in the lurch.
Vaccine deliveries under the COVAX facility could start as early as this month, WHO immunization director Kate O’Brien said on Thursday. But the global scheme is reportedly struggling from a lack of funds, supply risks and contractual issues and faces a “very high” risk of failure, according to a leaked internal report obtained by Reuters.
“We need to move from somewhat piecemeal approaches to concerted multinational planning and implementation, with very thoughtful and respectful use of a scarce and incredibly valuable commodity,” David Nabarro, WHO special envoy on Covid-19 and chair of global health at Imperial College London said, emphasizing collaboration over speed.
“The focus on numbers of arms being jabbed is missing the point.”

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Health Canada approves updated Moderna COVID-19 vaccine

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TORONTO – Health Canada has authorized Moderna’s updated COVID-19 vaccine that protects against currently circulating variants of the virus.

The mRNA vaccine, called Spikevax, has been reformulated to target the KP.2 subvariant of Omicron.

It will replace the previous version of the vaccine that was released a year ago, which targeted the XBB.1.5 subvariant of Omicron.

Health Canada recently asked provinces and territories to get rid of their older COVID-19 vaccines to ensure the most current vaccine will be used during this fall’s respiratory virus season.

Health Canada is also reviewing two other updated COVID-19 vaccines but has not yet authorized them.

They are Pfizer’s Comirnaty, which is also an mRNA vaccine, as well as Novavax’s protein-based vaccine.

This report by The Canadian Press was first published Sept. 17, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

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These people say they got listeria after drinking recalled plant-based milks

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TORONTO – Sanniah Jabeen holds a sonogram of the unborn baby she lost after contracting listeria last December. Beneath, it says “love at first sight.”

Jabeen says she believes she and her baby were poisoned by a listeria outbreak linked to some plant-based milks and wants answers. An investigation continues into the recall declared July 8 of several Silk and Great Value plant-based beverages.

“I don’t even have the words. I’m still processing that,” Jabeen says of her loss. She was 18 weeks pregnant when she went into preterm labour.

The first infection linked to the recall was traced back to August 2023. One year later on Aug. 12, 2024, the Public Health Agency of Canada said three people had died and 20 were infected.

The number of cases is likely much higher, says Lawrence Goodridge, Canada Research Chair in foodborne pathogen dynamics at the University of Guelph: “For every person known, generally speaking, there’s typically 20 to 25 or maybe 30 people that are unknown.”

The case count has remained unchanged over the last month, but the Public Health Agency of Canada says it won’t declare the outbreak over until early October because of listeria’s 70-day incubation period and the reporting delays that accompany it.

Danone Canada’s head of communications said in an email Wednesday that the company is still investigating the “root cause” of the outbreak, which has been linked to a production line at a Pickering, Ont., packaging facility.

Pregnant people, adults over 60, and those with weakened immune systems are most at risk of becoming sick with severe listeriosis. If the infection spreads to an unborn baby, Health Canada says it can cause miscarriage, stillbirth, premature birth or life-threatening illness in a newborn.

The Canadian Press spoke to 10 people, from the parents of a toddler to an 89-year-old senior, who say they became sick with listeria after drinking from cartons of plant-based milk stamped with the recalled product code. Here’s a look at some of their experiences.

Sanniah Jabeen, 32, Toronto

Jabeen says she regularly drank Silk oat and almond milk in smoothies while pregnant, and began vomiting seven times a day and shivering at night in December 2023. She had “the worst headache of (her) life” when she went to the emergency room on Dec. 15.

“I just wasn’t functioning like a normal human being,” Jabeen says.

Told she was dehydrated, Jabeen was given fluids and a blood test and sent home. Four days later, she returned to hospital.

“They told me that since you’re 18 weeks, there’s nothing you can do to save your baby,” says Jabeen, who moved to Toronto from Pakistan five years ago.

Jabeen later learned she had listeriosis and an autopsy revealed her baby was infected, too.

“It broke my heart to read that report because I was just imagining my baby drinking poisoned amniotic fluid inside of me. The womb is a place where your baby is supposed to be the safest,” Jabeen said.

Jabeen’s case is likely not included in PHAC’s count. Jabeen says she was called by Health Canada and asked what dairy and fresh produce she ate – foods more commonly associated with listeria – but not asked about plant-based beverages.

She’s pregnant again, and is due in several months. At first, she was scared to eat, not knowing what caused the infection during her last pregnancy.

“Ever since I learned about the almond, oat milk situation, I’ve been feeling a bit better knowing that it wasn’t something that I did. It was something else that caused it. It wasn’t my fault,” Jabeen said.

She’s since joined a proposed class action lawsuit launched by LPC Avocates against the manufacturers and sellers of Silk and Great Value plant-based beverages. The lawsuit has not yet been certified by a judge.

Natalie Grant and her seven year-old daughter, Bowmanville, Ont.

Natalie Grant says she was in a hospital waiting room when she saw a television news report about the recall. She wondered if the dark chocolate almond milk her daughter drank daily was contaminated.

She had brought the girl to hospital because she was vomiting every half hour, constantly on the toilet with diarrhea, and had severe pain in her abdomen.

“I’m definitely thinking that this is a pretty solid chance that she’s got listeria at this point because I knew she had all the symptoms,” Grant says of seeing the news report.

Once her daughter could hold fluids, they went home and Grant cross-checked the recalled product code – 7825 – with the one on her carton. They matched.

“I called the emerg and I said I’m pretty confident she’s been exposed,” Grant said. She was told to return to the hospital if her daughter’s symptoms worsened. An hour and a half later, her fever spiked, the vomiting returned, her face flushed and her energy plummeted.

Grant says they were sent to a hospital in Ajax, Ont. and stayed two weeks while her daughter received antibiotics four times a day until she was discharged July 23.

“Knowing that my little one was just so affected and how it affected us as a family alone, there’s a bitterness left behind,” Grant said. She’s also joined the proposed class action.

Thelma Feldman, 89, Toronto

Thelma Feldman says she regularly taught yoga to friends in her condo building before getting sickened by listeria on July 2. Now, she has a walker and her body aches. She has headaches and digestive problems.

“I’m kind of depressed,” she says.

“It’s caused me a lot of physical and emotional pain.”

Much of the early days of her illness are a blur. She knows she boarded an ambulance with profuse diarrhea on July 2 and spent five days at North York General Hospital. Afterwards, she remembers Health Canada officials entering her apartment and removing Silk almond milk from her fridge, and volunteers from a community organization giving her sponge baths.

“At my age, 89, I’m not a kid anymore and healing takes longer,” Feldman says.

“I don’t even feel like being with people. I just sit at home.”

Jasmine Jiles and three-year-old Max, Kahnawake Mohawk Territory, Que.

Jasmine Jiles says her three-year-old son Max came down with flu-like symptoms and cradled his ears in what she interpreted as a sign of pain, like the one pounding in her own head, around early July.

When Jiles heard about the recall soon after, she called Danone Canada, the plant-based milk manufacturer, to find out if their Silk coconut milk was in the contaminated batch. It was, she says.

“My son is very small, he’s very young, so I asked what we do in terms of overall monitoring and she said someone from the company would get in touch within 24 to 48 hours,” Jiles says from a First Nations reserve near Montreal.

“I never got a call back. I never got an email”

At home, her son’s fever broke after three days, but gas pains stuck with him, she says. It took a couple weeks for him to get back to normal.

“In hindsight, I should have taken him (to the hospital) but we just tried to see if we could nurse him at home because wait times are pretty extreme,” Jiles says, “and I don’t have child care at the moment.”

Joseph Desmond, 50, Sydney, N.S.

Joseph Desmond says he suffered a seizure and fell off his sofa on July 9. He went to the emergency room, where they ran an electroencephalogram (EEG) test, and then returned home. Within hours, he had a second seizure and went back to hospital.

His third seizure happened the next morning while walking to the nurse’s station.

In severe cases of listeriosis, bacteria can spread to the central nervous system and cause seizures, according to Health Canada.

“The last two months have really been a nightmare,” says Desmond, who has joined the proposed lawsuit.

When he returned home from the hospital, his daughter took a carton of Silk dark chocolate almond milk out of the fridge and asked if he had heard about the recall. By that point, Desmond says he was on his second two-litre carton after finishing the first in June.

“It was pretty scary. Terrifying. I honestly thought I was going to die.”

Cheryl McCombe, 63, Haliburton, Ont.

The morning after suffering a second episode of vomiting, feverish sweats and diarrhea in the middle of the night in early July, Cheryl McCombe scrolled through the news on her phone and came across the recall.

A few years earlier, McCombe says she started drinking plant-based milks because it seemed like a healthier choice to splash in her morning coffee. On June 30, she bought two cartons of Silk cashew almond milk.

“It was on the (recall) list. I thought, ‘Oh my God, I got listeria,’” McCombe says. She called her doctor’s office and visited an urgent care clinic hoping to get tested and confirm her suspicion, but she says, “I was basically shut down at the door.”

Public Health Ontario does not recommend listeria testing for infected individuals with mild symptoms unless they are at risk of developing severe illness, such as people who are immunocompromised, elderly, pregnant or newborn.

“No wonder they couldn’t connect the dots,” she adds, referencing that it took close to a year for public health officials to find the source of the outbreak.

“I am a woman in my 60s and sometimes these signs are of, you know, when you’re vomiting and things like that, it can be a sign in women of a bigger issue,” McCombe says. She was seeking confirmation that wasn’t the case.

Disappointed, with her stomach still feeling off, she says she decided to boost her gut health with probiotics. After a couple weeks she started to feel like herself.

But since then, McCombe says, “I’m back on Kawartha Dairy cream in my coffee.”

This report by The Canadian Press was first published Sept. 16, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

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B.C. mayors seek ‘immediate action’ from federal government on mental health crisis

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VANCOUVER – Mayors and other leaders from several British Columbia communities say the provincial and federal governments need to take “immediate action” to tackle mental health and public safety issues that have reached crisis levels.

Vancouver Mayor Ken Sim says it’s become “abundantly clear” that mental health and addiction issues and public safety have caused crises that are “gripping” Vancouver, and he and other politicians, First Nations leaders and law enforcement officials are pleading for federal and provincial help.

In a letter to Prime Minister Justin Trudeau and Premier David Eby, mayors say there are “three critical fronts” that require action including “mandatory care” for people with severe mental health and addiction issues.

The letter says senior governments also need to bring in “meaningful bail reform” for repeat offenders, and the federal government must improve policing at Metro Vancouver ports to stop illicit drugs from coming in and stolen vehicles from being exported.

Sim says the “current system” has failed British Columbians, and the number of people dealing with severe mental health and addiction issues due to lack of proper care has “reached a critical point.”

Vancouver Police Chief Adam Palmer says repeat violent offenders are too often released on bail due to a “revolving door of justice,” and a new approach is needed to deal with mentally ill people who “pose a serious and immediate danger to themselves and others.”

This report by The Canadian Press was first published Sept. 16, 2024

The Canadian Press. All rights reserved.

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