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Pfizer presses Health Canada to increase doses taken from each vial – The Globe and Mail

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A health-care worker prepares a dose of the Pfizer-BioNTech COVID-19 vaccine at a UHN COVID-19 vaccine clinic in Toronto on Jan. 7, 2021.

Nathan Denette/The Canadian Press

Pfizer-BioNTech is pushing Health Canada to amend its COVID-19 vaccine label and formally recognize that each vial contains six doses rather than five, which would allow the company to send fewer vials to Canada but could complicate the vaccination program.

Pfizer submitted a request to Health Canada on Friday to amend the vaccine label, company spokesperson Christina Antoniou said on Tuesday. The company’s contract with Canada is based on delivering doses, rather than a set number of vials, she said.

“Obtaining six doses from the current multi-dose vial … can help minimize vaccine wastage and enable the most efficient use of the vaccine,” she said.

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Medical staff in Canada have sometimes been able to withdraw six doses, but officials have said it’s not consistent. However, Pfizer said with specialized syringes, a sixth dose can be reliably pulled from each vial. These syringes are in short supply around the world.

The United States and European Union have already accepted the requested change.

Canada is buying 40 million doses from Pfizer. If Health Canada approves the change, Canada could get about 6.7 million vials rather than eight million. The change could increase the number of people who can receive the vaccine worldwide. However, it could also be a challenge for Canada’s vaccination program, which has already hit several speed bumps.

SQUEEZING EVERY LAST DROP

Each dose of Pfizer’s COVID-19 vaccine must be 0.3 ml. The company says if low-dead space syringes are used then six doses can be withdrawn from each vial of the vaccine. However, if standard syringes are used then medical professionals may only be able to extract five doses.

High-dead space syringe

0.092 ml of fluid retained

Low-dead space syringe

THE GLOBE AND MAIL, SOURCE:

PUBLIC HEALTH ENGLAND

SQUEEZING EVERY LAST DROP

Each dose of Pfizer’s COVID-19 vaccine must be 0.3 ml. The company says if low-dead space syringes are used then six doses can be withdrawn from each vial of the vaccine. However, if standard syringes are used then medical professionals may only be able to extract five doses.

High-dead space syringe

0.092 ml of fluid retained

Low-dead space syringe

THE GLOBE AND MAIL, SOURCE: PUBLIC HEALTH ENGLAND

SQUEEZING EVERY LAST DROP

Each dose of Pfizer’s COVID-19 vaccine must be 0.3 ml. The company says if low-dead space syringes are used then six doses can be withdrawn from each vial of the vaccine. However, if standard syringes are used then medical professionals may only be able to extract five doses.

High-dead space syringe

0.092 ml of fluid retained

Low-dead space syringe

THE GLOBE AND MAIL, SOURCE: PUBLIC HEALTH ENGLAND

Shipments from Pfizer have had delays, and Canada will get no shots this week. Officials hope vaccine candidates from Johnson & Johnson and AstraZeneca will soon be approved in Canada, but so far no delivery is expected before April.

A spokesperson for Procurement Minister Anita Anand said she could not comment until Health Canada decides whether to change the product information.

Late Tuesday, Martin Bégin, a spokesperson for Health Canada, confirmed the regulator has received Pfizer’s request. He was unable to provide a timeline for a decision.

In a statement to The Globe on Monday, Health Canada spokesperson Maryse Durette said the extra volume per vial acts as “a safeguard against potential loss of volume that can occur during storage, preparation and administration of the vaccine, and can result in overages that may amount to an extra dose or two. The monograph of the product would not change because of extra volume in the vial.”

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If health professionals use what’s called a low dead space syringe to extract each dose, Ms. Antoniou said, six doses can be consistently drawn. Dead space is vaccine that is left in a syringe after an injection. “If standard syringes and needles are used, there may not be sufficient volume to extract a sixth dose from a single vial,” Ms. Antoniou said. Some needles can limit dead space.

Pfizer did not provide The Globe with the data to show how often six doses are retrieved from a vial. The Globe asked the Ontario, B.C. and Quebec governments, but they did not provide such information.

The low dead space syringes are a “niche” item, said Troy Kirkpatrick, a spokesperson for BD, the medical technology company supplying the United States with syringes. BD is selling syringes to Canada, but not low dead space ones. The federal government was unable to tell The Globe which company supplies those.

Of the 145 million syringes Canada has bought for the vaccination program, 37.5 million are the kind that would be required if Health Canada approves Pfizer’s request, Ms. Anand’s office said. Her office was unable to say on Tuesday when they would all be delivered.

Ms. Antoniou said six low dead space syringes are needed for each vial.

Until now, the syringes “have historically had low demand,” Mr. Kirkpatrick said, and “no vaccine manufacturer identified the need for these types of devices when production capacity was increased.” He said the company is meeting its current contracts, and advising governments it will “take time” to increase production.

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Canada has also bought 40 million vaccine doses from Moderna. On Tuesday, the company said its shots require standard syringes.

At the University Health Network in Toronto, one of Canada’s largest hospital groups, Emily Musing, a vice-president and professional pharmacist, said staff have been able to “more consistently” get a sixth dose when using a one-milliliter syringe.

However, the hospital ran out and had to use three-ml syringes. “We found with the larger syringes, we were not able to pull up as many sixth doses,” she said.

Neither of those is as reliable as the low dead space syringe, Ms. Antoniou said.

Even without the requirement for the specialized syringe, some public health units were facing supply challenges. In Ontario, one health unit is asking pet clinics for syringes that are specialized enough to get a sixth dose from a vial.

“With an aim to maximize the efficiency of our approach to vaccine delivery, we have reached out to local veterinary clinics and community partners to ask for contributions of syringes,” said Piotr Oglaza, medical officer of health at Hastings Prince Edward public health, which includes the city of Belleville.

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Andrew Blais, who works for a pet hospital in the region, said he was shocked to receive a request from the health unit on Monday for the clinic to donate 1 cc-size syringes. “It felt outrageous that they were even thinking about veterinary clinics,” he said. “I would have thought maybe they would start with public health agencies or other government-funded [agencies].”

“There was definitely a feeling of panic to it,” he said.

Alexandra Hilkene, a spokeswoman for Ontario Health Minister Christine Elliott, said it’s Ottawa’s responsibility to procure syringes for vaccinations. However, she said the province can get additional supplies to help local public health units. She said Ontario sent three-ml syringes to Hastings Prince Edward on Jan. 22 and 25 for a total of 1,000. But those are not the specialized syringes to extract six doses.

Alberta’s health authority said it is buying low dead space syringes and other supplies to supplement shipments from Ottawa.

The federal government has not disclosed how much it is paying Pfizer for the vaccines. A New York Times report suggests that the reduction in vials shipped by Pfizer won’t change how much the U.S. pays. Reuters reports that Sweden is withholding payment until it gets clarity on Pfizer’s billings. The company told a local newspaper it charged for six doses per vial.

With reports from James Keller, Andrea Woo and Les Perreaux.

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The #1 Skill I Look For When Hiring

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File this column under “for what it’s worth.”

“Communication is one of the most important skills you require for a successful life.” — Catherine Pulsifer, author.

I’m one hundred percent in agreement with Pulsifer, which is why my evaluation of candidates begins with their writing skills. If a candidate’s writing skills and verbal communication skills, which I’ll assess when interviewing, aren’t well above average, I’ll pass on them regardless of their skills and experience.

 

Why?

 

Because business is fundamentally about getting other people to do things—getting employees to be productive, getting customers to buy your products or services, and getting vendors to agree to a counteroffer price. In business, as in life in general, you can’t make anything happen without effective communication; this is especially true when job searching when your writing is often an employer’s first impression of you.

 

Think of all the writing you engage in during a job search (resumes, cover letters, emails, texts) and all your other writing (LinkedIn profile, as well as posts and comments, blogs, articles, tweets, etc.) employers will read when they Google you to determine if you’re interview-worthy.

 

With so much of our communication today taking place via writing (email, text, collaboration platforms such as Microsoft Teams, Slack, ClickUp, WhatsApp and Rocket.Chat), the importance of proficient writing skills can’t be overstated.

 

When assessing a candidate’s writing skills, you probably think I’m looking for grammar and spelling errors. Although error-free writing is important—it shows professionalism and attention to detail—it’s not the primary reason I look at a candidate’s writing skills.

 

The way someone writes reveals how they think.

 

  • Clear writing = Clear thinking
  • Structured paragraphs = Structured mind
  • Impactful sentences = Impactful ideas

 

Effective writing isn’t about using sophisticated vocabulary. Hemingway demonstrated that deceptively simple, stripped-down prose can captivate readers. Effective writing takes intricate thoughts and presents them in a way that makes the reader think, “Damn! Why didn’t I see it that way?” A good writer is a dead giveaway for a good thinker. More than ever, the business world needs “good thinkers.”

 

Therefore, when I come across a candidate who’s a good writer, hence a good thinker, I know they’re likely to be able to write:

 

  • Emails that don’t get deleted immediately and are responded to
  • Simple, concise, and unambiguous instructions
  • Pitches that are likely to get read
  • Social media content that stops thumbs
  • Human-sounding website copy
  • Persuasively, while attuned to the reader’s possible sensitivities

 

Now, let’s talk about the elephant in the room: AI, which job seekers are using en masse. Earlier this year, I wrote that AI’s ability to hyper-increase an employee’s productivity—AI is still in its infancy; we’ve seen nothing yet—in certain professions, such as writing, sales and marketing, computer programming, office and admin, and customer service, makes it a “fewer employees needed” tool, which understandably greatly appeals to employers. In my opinion, the recent layoffs aren’t related to the economy; they’re due to employers adopting AI. Additionally, companies are trying to balance investing in AI with cost-cutting measures. CEOs who’ve previously said, “Our people are everything,” have arguably created today’s job market by obsessively focusing on AI to gain competitive advantages and reduce their largest expense, their payroll.

 

It wouldn’t be a stretch to assume that most AI usage involves generating written content, content that’s obvious to me, and likely to you as well, to have been written by AI. However, here’s the twist: I don’t particularly care.

 

Why?

 

Because the fundamental skill I’m looking for is the ability to organize thoughts and communicate effectively. What I care about is whether the candidate can take AI-generated content and transform it into something uniquely valuable. If they can, they’re demonstrating the skills of being a good thinker and communicator. It’s like being a great DJ; anyone can push play, but it takes skill to read a room and mix music that gets people pumped.

 

Using AI requires prompting effectively, which requires good writing skills to write clear and precise instructions that guide the AI to produce desired outcomes. Prompting AI effectively requires understanding structure, flow and impact. You need to know how to shape raw information, such as milestones throughout your career when you achieved quantitative results, into a compelling narrative.

So, what’s the best way to gain and enhance your writing skills? As with any skill, you’ve got to work at it.

Two rules guide my writing:

 

  • Use strong verbs and nouns instead of relying on adverbs, such as “She dashed to the store.” instead of “She ran quickly to the store.” or “He whispered to the child.” instead of “He spoke softly to the child.”
  • Avoid using long words when a shorter one will do, such as “use” instead of “utilize” or “ask” instead of “inquire.” As attention spans get shorter, I aim for clarity, simplicity and, most importantly, brevity in my writing.

 

Don’t just string words together; learn to organize your thoughts, think critically, and communicate clearly. Solid writing skills will significantly set you apart from your competition, giving you an advantage in your job search and career.

_____________________________________________________________________

 

Nick Kossovan, a well-seasoned veteran of the corporate landscape, offers “unsweetened” job search advice. You can send Nick your questions to artoffindingwork@gmail.com.

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Politics likely pushed Air Canada toward deal with ‘unheard of’ gains for pilots

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MONTREAL – Politics, public opinion and salary hikes south of the border helped push Air Canada toward a deal that secures major pay gains for pilots, experts say.

Hammered out over the weekend, the would-be agreement includes a cumulative wage hike of nearly 42 per cent over four years — an enormous bump by historical standards — according to one source who was not authorized to speak publicly on the matter. The previous 10-year contract granted increases of just two per cent annually.

The federal government’s stated unwillingness to step in paved the way for a deal, noted John Gradek, after Prime Minister Justin Trudeau made it plain the two sides should hash one out themselves.

“Public opinion basically pressed the federal cabinet, including the prime minister, to keep their hands clear of negotiations and looking at imposing a settlement,” said Gradek, who teaches aviation management at McGill University.

After late-night talks at a hotel near Toronto’s Pearson airport, the country’s biggest airline and the union representing 5,200-plus aviators announced early Sunday morning they had reached a tentative agreement, averting a strike that would have grounded flights and affected some 110,000 passengers daily.

The relative precariousness of the Liberal minority government as well as a push to appear more pro-labour underlay the prime minister’s hands-off approach to the negotiations.

Trudeau said Friday the government would not step in to fix the impasse — unlike during a massive railway work stoppage last month and a strike by WestJet mechanics over the Canada Day long weekend that workers claimed road roughshod over their constitutional right to collective bargaining. Trudeau said the government respects the right to strike and would only intervene if it became apparent no negotiated deal was possible.

“They felt that they really didn’t want to try for a third attempt at intervention and basically said, ‘Let’s let the airline decide how they want to deal with this one,'” said Gradek.

“Air Canada ran out of support as the week wore on, and by the time they got to Friday night, Saturday morning, there was nothing left for them to do but to basically try to get a deal set up and accepted by ALPA (Air Line Pilots Association).”

Trudeau’s government was also unlikely to consider back-to-work legislation after the NDP tore up its agreement to support the Liberal minority in Parliament, Gradek said. Conservative Leader Pierre Poilievre, whose party has traditionally toed a more pro-business line, also said last week that Tories “stand with the pilots” and swore off “pre-empting” the negotiations.

Air Canada CEO Michael Rousseau had asked Ottawa on Thursday to impose binding arbitration pre-emptively — “before any travel disruption starts” — if talks failed. Backed by business leaders, he’d hoped for an effective repeat of the Conservatives’ move to head off a strike in 2012 by legislating Air Canada pilots and ground crew to stick to their posts before any work stoppage could start.

The request may have fallen flat, however. Gradek said he believes there was less anxiety over the fallout from an airline strike than from the countrywide railway shutdown.

He also speculated that public frustration over thousands of cancelled flights would have flowed toward Air Canada rather than Ottawa, prompting the carrier to concede to a deal yielding “unheard of” gains for employees.

“It really was a total collapse of the Air Canada bargaining position,” he said.

Pilots are slated to vote in the coming weeks on the four-year contract.

Last year, pilots at Delta Air Lines, United Airlines and American Airlines secured agreements that included four-year pay boosts ranging from 34 per cent to 40 per cent, ramping up pressure on other carriers to raise wages.

After more than a year of bargaining, Air Canada put forward an offer in August centred around a 30 per cent wage hike over four years.

But the final deal, should union members approve it, grants a 26 per cent increase in the first year alone, retroactive to September 2023, according to the source. Three wage bumps of four per cent would follow in 2024 through 2026.

Passengers may wind up shouldering some of that financial load, one expert noted.

“At the end of the day, it’s all us consumers who are paying,” said Barry Prentice, who heads the University of Manitoba’s transport institute.

Higher fares may be mitigated by the persistence of budget carrier Flair Airlines and the rapid expansion of Porter Airlines — a growing Air Canada rival — as well as waning demand for leisure trips. Corporate travel also remains below pre-COVID-19 levels.

Air Canada said Sunday the tentative contract “recognizes the contributions and professionalism of Air Canada’s pilot group, while providing a framework for the future growth of the airline.”

The union issued a statement saying that, if ratified, the agreement will generate about $1.9 billion of additional value for Air Canada pilots over the course of the deal.

Meanwhile, labour tension with cabin crew looms on the horizon. Air Canada is poised to kick off negotiations with the union representing more than 10,000 flight attendants this year before the contract expires on March 31.

This report by The Canadian Press was first published Sept. 16, 2024.

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Federal $500M bailout for Muskrat Falls power delays to keep N.S. rate hikes in check

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HALIFAX – Ottawa is negotiating a $500-million bailout for Nova Scotia’s privately owned electric utility, saying the money will be used to prevent a big spike in electricity rates.

Federal Natural Resources Minister Jonathan Wilkinson made the announcement today in Halifax, saying Nova Scotia Power Inc. needs the money to cover higher costs resulting from the delayed delivery of electricity from the Muskrat Falls hydroelectric plant in Labrador.

Wilkinson says that without the money, the subsidiary of Emera Inc. would have had to increase rates by 19 per cent over “the short term.”

Nova Scotia Power CEO Peter Gregg says the deal, once approved by the province’s energy regulator, will keep rate increases limited “to be around the rate of inflation,” as costs are spread over a number of years.

The utility helped pay for construction of an underwater transmission link between Newfoundland and Nova Scotia, but the Muskrat Falls project has not been consistent in delivering electricity over the past five years.

Those delays forced Nova Scotia Power to spend more on generating its own electricity.

This report by The Canadian Press was first published Sept. 16, 2024.

The Canadian Press. All rights reserved.

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