A novel coronavirus originating in Wuhan City, China has sickened more than 7,800 people and killed 170 since scientists first discovered it in December. The virus has spread to 18 countries outside of China and in 4 of those countries—including the US—there have been cases of human-to-human transmission. On Thursday, the World Health Organization declared the outbreak a public health emergency of international concern in hopes of helping nations stop the spread of the virus.
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A novel coronavirus hits China – Chemical & Engineering News
By the Numbers:
7818
People confirmed to be infected by the novel coronavirus
170
People who have died of novel coronavirus infection
19
Number of countries reporting novel coronavirus infections, including China
Source: World Health Organization Jan. 30, 2020 situation report
As research teams worldwide race to characterize the virus, called 2019-nCoV and also known as the Wuhan coronavirus, governments have taken drastic action to contain its spread. The residents of Wuhan City have been quarantined. Airlines have canceled some flights in and out of China, and several countries, including the US, have imposed an isolation period for anyone returning from the affected region. On Friday, the US government decided to quarantine 195 people who were evacuated from Wuhan to the US.
Here is what we know—and don’t know—about 2019-nCoV.
Where did 2019-nCoV come from?
Coronaviruses are endemic to several species, and until 2019-nCoV popped up, there were five that could infect humans, says Tracey Goldstein, a wildlife infectious disease expert at the University of California, Davis. These spherical, 120–nm-wide viruses have an RNA genome that is relatively unstable, and mutates frequently.
Coronavirus infection
Credit: Scientificanimations.com/C&EN/Shutterstock
Goldstein says that 2019-nCoV is similar to the coronavirus that caused severe acute respiratory syndrome (SARS) in 2003, so it’s likely that transmission of the Wuhan virus is similar. Bats are the original reservoir for these viruses. Mutations to the viral genome allow a virus to infect a secondary animal, further mutations enable it to infect humans, and possibly more mutations allow it to quickly spread from human to human. The intermediate animal in the spread of the SARS virus was a cat-like creature called the civet. Researchers are still trying to figure out what the intermediate animal is for the Wuhan virus.
This novel coronavirus is thought to have originated in a “wet” market in Wuhan City where live and dead animals are sold. Scientists report that live animals available at the market just before the outbreak included seafood, hedgehogs, badgers, snakes, and birds (bioRxiv 2020, DOI:10.1101/2020.01.24.919183). These animal markets are considered a hot spot for cross-species transmission of viruses.
“The danger of zoonotic transmission was clear, so I was not completely surprised by the outbreak,” says Rolf Hilgenfeld, a researcher at the University of Lubeck who is currently in China to develop small-molecule inhibitors for coronaviruses. “But the timing was not predictable, and the magnitude is surprising.”
SARS also made its zoonotic jump to people in a Chinese “wet” market. Peter Hotez, an infectious-diseases expert at Baylor College of Medicine, says that the Chinese government had an opportunity to prevent this outbreak. “After SARS happened, the government’s plan was to outlaw them, but clearly that law was not enforced,” he says.
Hilgenfeld says that the SARS coronavirus and 2019-nCoV are similar. The part of the glycoprotein that binds human cells on the Wuhan coronavirus appears to be identical to the binding site of the SARS coronavirus glycoprotein, he says. Hilgenfeld and others think that the Wuhan virus likely attaches to the same cell-surface molecule as the SARS virus does, angiotensin-converting enzyme 2 or ACE2 (bioRxiv 2020, DOI: 10.1101/2020.01.26.919985).
Mode of transmission
Credit: C&EN/Shutterstock
What are the characteristics of the disease?
According to the Centers for Disease Control and Prevention, coronaviruses, in general, cause respiratory illness, with fevers, runny noses, coughs, and sore throats. This new coronavirus appears to be no different. Disease severity for 2019-nCoV has been variable, with some people requiring hospitalization and others reporting mild symptoms.
The World Health Organization reported that the novel coronavirus’ R0, which is a number that describes a disease’s spread, is between 1.4 and 2.5, meaning every infected person will, on average, infect about two more people. A team of researchers in China calculated the R0 as between 2.24 and 3.58 (bioRxiv 2020, DOI: 10.1101/2020.01.23.916395v2). The R0 of seasonal flu is about 1.4, but varies. For measles, it’s between 12 and 18.
The Chinese government is reporting spread between humans who are not showing symptoms of the disease, so some virus carriers might be missed in these calculations.
Some infected people are being treated with interferon and a combination HIV drug called Kaletra (iopinavir and ritonavir) sold by AbbVie. Researchers from the Chinese Academy of Sciences have published a list of drugs they say could work against the coronavirus’ main protease, including the antibiotic colistin, several antitumor drugs, and perphenazine, an antipsychotic. Knocking out the virus’s protease prevents it from successfully replicating. Hilgenfeld hopes to collaborate with local Chinese researchers to test his inhibitor of the coronavirus main protease inhibitor on cells in culture. This alpha-keto amide compound works against the SARS virus, so he thinks it will also work on the Wuhan coronavirus. He would still need to do clinical trials with the compound, so he has no illusions that his compound will be deployed during this outbreak.
Chemical & Engineering News
ISSN 0009-2347
Copyright © 2020 American Chemical Society
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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season
Give the gift of great skin this holiday season Skinstitut Holiday Gift Kits take the stress out of gifting Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group. In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis. “These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season. There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes. Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent. Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59. In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.
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Here is how to prepare your online accounts for when you die
LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?
It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.
Here’s how you can prepare your digital life for your survivors:
Apple
The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.
For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.
You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.
Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.
Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.
When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.
You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.
There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.
Facebook and Instagram
Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.
When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.
The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.
You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.
TikTok
The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.
Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.
X
It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.
Passwords
Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?
Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.
But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.
___
Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.
Health
Pediatric group says doctors should regularly screen kids for reading difficulties
The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.
New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.
The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.
Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.
Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.
“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.
“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”
McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.
But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.
The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.
He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.
“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.
“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.
McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”
McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.
He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.
“Early identification of reading difficulty can truly change the trajectory of a child’s life.”
This report by The Canadian Press was first published Oct. 23, 2024.
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