adplus-dvertising
Connect with us

Health

Are old malaria drugs really the COVID-19 'game changer' some people believe? Not so fast, warn health officials – National Post

Published

 on


U.S. president Donald Trump considers them a COVID-19 “game changer,” his top infectious diseases advisor says the evidence is flimsy, while ethicists worry pouring millions of the tablets into hospitals is a long shot that could make people sicker.

Two old anti-malaria medications are being pushed as potential treatments in the scramble to find something, anything, to neutralize the virus causing COVID-19.

Already, U.S. media are reporting a run on the drugs since Trump said they hold “tremendous promise.” In Nigeria, two people have overdosed after self-medicating with the pills, and Lagos State health authorities are urging against massive consumption of the tablets chloroquine and hydroxychloroquine.

There are concerns people could start hoarding the pills, the way many did with the anti-viral Tamiflu during the bird flu fright in 2005, and self-medicate in the hope of staving off the virus.

“You should not take medication without the scientific evidence,” Dr. Theresa Tam, Canada’s chief public health officer, said Monday. “These drugs are not without side effects. In fact, they have quite significant side effects.

“People have to be really, really careful about this. Don’t do it.”

One million doses of hydroxychloroquine are being donated to Canadian hospitals by Quebec-based JAMP Pharma Group. The company says its offer is twofold: to make the drugs available for people hospitalized with COVID-19, and to avoid a shortage of the pills for people who already need them to survive. Hydroxychloroquine, a less toxic version of chloroquine, is a common generic drug that’s used to treat lupus and rheumatoid arthritis, and lupus organizations are already reporting people are having problems filling prescriptions because of Trump’s exuberance. Those living with lupus are immune-compromised, putting them at greater risk of COVID-19.

Both drugs have shown activity against the virus that causes COVID-19 in vitro, meaning in tissue cultures. But some papers suggest the drugs can increase viral replication. “That is to say it can hurt you potentially,” said Dr. Anand Kumar, a critical care doctor at Winnipeg Health Sciences Centre, who is also trained in infectious diseases.

“There is the odd study that says these compounds could help, but there are just as many that fail to show any benefit and others that go the other way and suggest potential harm, Kumar said.

“Absolutely, it should be studied in a randomized trial, I have no problem with that. But the idea that people should start taking chloroquine because it’s a game-changer, I think is just nuts, frankly.”


Researchers at the University of Minnesota work with coronavirus samples as a trial begins to see whether malaria treatment hydroxychloroquine can treat COVID-19, March 19, 2020.

Craig Lassig/Reuters

The drug is already being given to hospitalized COVID-19 patients on an “uncontrolled basis” in multiple countries, including the U.S., according to the U.S. Centers for Disease Control and Prevention. It’s one of several drugs under investigation in a mega trial sponsored by the World Health Organization — Solidarity — that’s looking at whether existing drugs can be repurposed to fight COVID-19.

But there’s no agreement on optimal dosing, and while the antimalarials are generally well tolerated in the healthy, it may not be true for the frail and the sick.

“It would be much better if the government could come up with a policy that said, for dying or severely compromised patients we will try some agents and we’ll do it in an organized manner so that we can figure out if anything helps and we don’t cause a slew of unexpected side effects,” said Dr. Arthur Caplan, head of the division of bioethics at NYU Langone Medical School. Caplan says the data from China is hyper-weak and “pouring zillions of pills into the world’s population achieves nothing but risking side-effects, at present.”

Outside of randomized controlled trials, several of which are underway in Canada, including to test whether hydroxychloroquine could prevent infections in frontline health-care workers, Kumar said the pills might be used as “salvage” therapy, when doctors have nothing left. “But frankly, the probability of it being useful in that situation is extremely low, slim to zero.”

In every single pandemic, everybody has hundreds of solutions they think might work

One theory is that the drug may dampen down an over-exuberant cytokine storm. Normally when exposed to a virus, the body stimulates the immune cells to produce chemicals to throw off the invader. But the cells can become so hyper-stimulated they start attacking the self, your own tissue.

Other contenders include Gilead Sciences’ Remdesivir, which Trump also mentioned last week. The drug has been given to hundreds of infected people in the U.S., Europe and Japan on an emergency access basis. Demand has flooded the company’s emergency treatment access system, which was never set up to handle a pandemic. The company has temporarily halted access while it pivots to a new system.

“If it works well, and that’s a big if, that could be a game-changer,” Kumar said. However a similar drug was used years ago in SARS and failed, because toxicity was too great.

“In every single pandemic, everybody has hundreds of solutions they think might work,” Tam said. “We can’t rule out the fact they don’t work, but let’s prioritize the top ones that world scientists think are important and do proper trials.”

• Email: skirkey@postmedia.com | Twitter:

Let’s block ads! (Why?)

728x90x4

Source link

Continue Reading

Health

What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

Published

 on

Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Continue Reading

Health

Here is how to prepare your online accounts for when you die

Published

 on

 

LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

___

Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

Source link

Continue Reading

Health

Pediatric group says doctors should regularly screen kids for reading difficulties

Published

 on

 

The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

Source link

Continue Reading

Trending