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Canada signs vaccine deals with Pfizer and Moderna

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This article is a preview of The Logic’s Daily Briefing newsletter, sent every weekday. Sign up for a free trial.

It’s day 148 since Canada’s 100th coronavirus case. The number of cases is 118,038 as of publication time, up 246 since yesterday—a 13 per cent decrease from the seven-day prior average of 284 new cases. At its peak on May 3, the seven-day average was 1,603 new cases a day.

Over the last week, one person has died every 80 seconds from COVID-19 in the United States, and the pace at which those 7,486 people died seems to be accelerating.

The federal government announced $78 million for COVID-19 research and development on Wednesday, including $59 million for vaccine clinical trials and $19 million for broader research related to the virus.

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The lion’s share of the vaccine funding—$56 million from the federal Strategic Innovation Fund—will go to Variation Biotechnologies (VBI), an Ottawa-based wholly owned subsidiary of U.S. firm VBI Vaccines, for clinical testing of its COVID-19 vaccine candidate. The funding for VBI comes from the $600 million previously announced to support COVID-19-related clinical trials and Canada’s bio-manufacturing sector. Another $3 million will go to Nova Scotia-based IMV to help fund clinical trials of its coronavirus vaccine candidate.

The government announced the funding on the advice of the newly appointed COVID-19 Vaccine Task Force, also revealed Wednesday. The group, formed to advise on treatments, is led by Dalhousie University professor Joanne Langley and J. Mark Lievonen, a former Canadian executive for pharmaceutical giant Sanofi.

The announcements came the same day Procurement Minister Anita Anand confirmed that the government signed deals with pharmaceutical companies Pfizer and Moderna to secure millions of doses of their COVID-19 vaccine candidates when they’re ready to deploy them. Both Moderna and Pfizer, which is developing its vaccine with German biotech firm BioNTech, are in the third and final phases of clinical trials and claim they could have “emergency” vaccines ready as early as this fall. Vaccines also need Health Canada approval before being used in Canada.

Canada had been lagging other countries in vaccine preorders, raising concerns Canadians would have to wait longer than others for immunity once treatments were available. Wednesday’s announcements signal a push to diversify potential treatment sources in preparation for “mass vaccination,” and ensuring “Canadians are at the front of the line when a vaccine becomes available,” said Anand. The minister would not say how many doses the government has ordered so far or how much it’s spending on the vaccines, citing ongoing negotiations with multiple suppliers.

Drinking from the firehose:

  • Canada saw 88,187 business closures in April, up 126 per cent year over year, while new-firm creation dropped 18 per cent to 32,803, according to new data from Statistics Canada. The numbers of companies starting and stopping in any given month are typically quite similar.
  • The Council of Canadian Innovators is calling for Ottawa to extend the Innovation Assistance Program, the National Research Council-administered measure for firms that don’t qualify for the Canada Emergency Wage Subsidy, until December. The business lobby group also wants the funding focused on firms with “a proven track-record of R&D expenditure and IP generation.”
  • Canada’s merchandise trade deficit hit $3.2 billion in June, up from $1.3 billion the previous month, as imports grew faster than exports. Both remain more than a tenth below February levels.
  • BigCommerce raised US$216 million in its Nasdaq IPO. Shares jumped as much as 292 per cent in the first day of trading, as investors piled into Shopify’s smaller competitor amid a pandemic-induced online-shopping boom.
  • New York City will set up “checkpoints” as part of an effort to enforce a quarantine for travellers from other parts of the U.S. Meanwhile, Chicago, the most populous city in the Midwest, has announced that public school students will start the school year learning from home.
  • Uber employees can continue to work remotely until July 2021, and the company will pay for up to US$500 in home-office setup costs.
  • English football club Arsenal is laying off 55 staff, citing the loss of commercial and matchday revenue during the pandemic. U.S. billionaire Stanley Kroenke owns the team, which recently qualified for a lucrative European competition.

Green shoots: The Calgary Zoo is worried about procuring the right kind of bamboo to feed Er Shun and Da Mao, after experiencing delays getting the permits to send the giant pandas to China, in part because of COVID-19 quarantine rules.

 

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New technology to advance women’s cancer care at Southlake

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NEWS RELEASE
SOUTHLAKE REGIONAL HEALTH CENTRE
**************************
This Cancer Awareness Month, Southlake is adding advanced technologies to detect and treat breast cancer and other women’s cancers thanks to generous community donor support, most recently through the HERE is Where Cancer Meets its Match campaign. New cancer care technology, including new mammography machines, the MyoSure System and the MOLLI 2® System will make a measurable impact in diagnosing and treating women’s cancers in the communities Southlake serves.

Southlake is installing three new mammography machines to expand its breast cancer screening program to 1,500 more women each year. Two of these machines have new biopsy capabilities that will reduce the number of cancelled exams due to equipment failure, ensuring timely care for women. Women ages 40 to 49 years old will be able to self-refer for publicly funded mammograms through the Ontario Breast Screening Program starting this fall.

“Early detection is critical when treating breast cancer and other women’s cancers,” said Lorrie Reynolds, Director, Regional Cancer Program at Southlake. “We treat more than 1,700 breast cancer patients at Southlake every year. By adding advanced technology, like the new mammography machines, we’re ensuring women have the best experience at Southlake.”

Southlake is also introducing the MyoSure System, an innovative technology that can help detect female reproductive cancers. Damaged tissue in a woman’s uterus such as fibroids and polyps can now be removed in a precise, minimally invasive procedure that leaves the rest of the uterus intact. This will improve the overall patient experience by supporting faster recovery, reducing the risk of infection and giving more women the option to have children. An estimated 200 women per year will benefit from the MyoSure System.

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The new mammography machines and the MyoSure System build on Southlake’s recent investment in the MOLLI 2® System, a made-in-Canada wire-free breast localization technology.  This technology is considerably less invasive and more accurate when compared to wire-guided localization, resulting in a better patient experience and improved cosmetic outcomes.  More than 200 women each year will benefit from this innovative medical device as they are treated for breast cancer at Southlake.

“As a clinician caring for women with cancer in our community, I’m incredibly proud of the work Southlake is doing to advance women’s health and improve patient experiences,” said Sara Temple, MD, Surgical Oncologist and Chief of Surgery at Southlake. “Women who visit Southlake can be confident that they are receiving leading edge care, close to home when they need it most.”

The World Health Organization anticipates a 77 per cent increase in cancer diagnoses by 2050.  Southlake serves some of the fastest growing communities in Canada and anticipates that the number of patients requiring cancer care will grow. By investing in new technology, Southlake is ensuring that women in the communities it serves have access to leading edge cancer care. All of these investments were funded with support from community donors who generously gave to Southlake to support investments into women’s health at the hospital.

“The generosity of our donor community and the impact they have made for women receiving cancer diagnosis and treatment at Southlake is something we can all take great pride in,” said Jennifer Ritter, President and CEO of Southlake Foundation. “From our Women’s Health Initiative donors supporting new mammography machines, to the Ladies in Philanthropy for Southlake funding the MOLLI 2 System, to our long-standing partners The Edge Benefits and Pheasant Run Golf Club enabling the introduction of MyoSure System through their joint annual charity golf tournament, we are incredibly lucky to share a vision of access to exceptional care for everyone who depends on Southlake when they need us most. Thank you, to every donor who contributed to these important upgrades to care for women.”

Southlake Foundation’s HERE is Where Cancer Meets its Match campaign supports the Stronach Regional Cancer Centre at Southlake. For more information or to make a donation, visit: southlake.ca/HERE.

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Pasteurized milk includes remnants of H5N1 bird flu, U.S. officials say

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The U.S. Food and Drug Administration says that samples of pasteurized milk have tested positive for remnants of the bird flu virus that has infected dairy cows.

The agency stressed that the material is inactivated and that the findings “do not represent actual virus that may be a risk to consumers.” Officials added that they’re continuing to study the issue.

“To date, we have seen nothing that would change our assessment that the commercial milk supply is safe,” the FDA said in a statement on Tuesday.

The announcement comes nearly a month after an avian influenza virus that has sickened millions of wild and commercial birds in recent years was detected in dairy cows in at least eight states. The Agriculture Department (USDA) says 33 herds have been affected to date.

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FDA officials didn’t indicate how many samples they tested or where they were obtained. The agency has been evaluating milk during processing and from grocery stores, officials said. Results of additional tests are expected in “the next few days to weeks.”

WATCH | Bird flu spread in U.S. cows:

 

Bird flu is spreading in cows. Are humans at risk? | About That

15 days ago

Duration 8:54

For the first time ever, avian influenza, or H5N1 bird flu, was detected in roughly a dozen dairy cow herds across the U.S. About That producer Lauren Bird explores why scientists and public health officials are concerned about the cross-species transmission and whether humans are now at higher risk.

The polymerase chain reaction (PCR) lab test the FDA used would have detected viral genetic material even after live virus was killed by pasteurization, or heat treatment, said Lee-Ann Jaykus, an emeritus food microbiologist and virologist at North Carolina State University

“There is no evidence to date that this is infectious virus, and the FDA is following up on that,” Jaykus said.

Officials with the FDA and the USDA had previously said milk from affected cattle did not enter the commercial supply. Milk from sick animals is supposed to be diverted and destroyed. Federal regulations require milk that enters interstate commerce to be pasteurized.

Tests for viable virus underway, agency says

Because the detection of the bird flu virus known as Type A H5N1 in dairy cattle is new and the situation is evolving, no studies on the effects of pasteurization on the virus have been completed, FDA officials said. But past research shows that pasteurization is “very likely” to inactivate heat-sensitive viruses like H5N1, the agency added.

The agency said it has been evaluating milk from affected animals, in the processing system and on the shelves. It said it is completing a large, representative national sample to understand the extent of the findings.

The FDA said it is further assessing any positive findings through egg inoculation tests, which it described as a gold standard for determining viable virus.

Matt Herrick, a spokesperson for the International Dairy Foods Association, said that time and temperature regulations for pasteurization ensure that the commercial U.S. milk supply is safe. Remnants of the virus “have zero impact on human health,” he wrote in an email.

Scientists confirmed the H5N1 virus in dairy cows in March after weeks of reports that cows in Texas were suffering from a mysterious malady. The cows were lethargic and saw a dramatic reduction in milk production. Although the H5N1 virus is lethal to commercial poultry, most infected cattle seem to recover within two weeks, experts said.

To date, two people in the U.S. have been infected with bird flu. A Texas dairy worker who was in close contact with an infected cow recently developed a mild eye infection and has recovered. In 2022, a prison inmate in a work program caught it while killing infected birds at a Colorado poultry farm. His only symptom was fatigue, and he recovered.


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Remnants of bird flu virus found in pasteurized milk, FDA says

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The U.S. Food and Drug Administration said Tuesday that samples of pasteurized milk had tested positive for remnants of the bird flu virus that has infected dairy cows.

The agency stressed that the material is inactivated and that the findings “do not represent actual virus that may be a risk to consumers.” Officials added that they’re continuing to study the issue.

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