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Canada's COVAX program use draws criticism for unequal vaccine distribution – Yahoo News Canada

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The Canadian Press

‘New chance at life’: Man gets face, hands in rare surgery

NEW YORK — Almost six months after a rare face and hands transplant, Joe DiMeo is relearning how to smile, blink, pinch and squeeze. The 22-year-old New Jersey resident had the operation last August, two years after being badly burned in a car crash. “I knew it would be baby steps all the way,” DiMeo told The Associated Press recently. “You’ve got to have a lot of motivation, a lot of patience. And you’ve got to stay strong through everything.” Experts say it appears the surgery at NYU Langone Health was a success, but warn it’ll take some time to say for sure. Worldwide, surgeons have completed at least 18 face transplants and 35 hand transplants, according to the United Network for Organ Sharing, or UNOS, which oversees the U.S. transplant system. But simultaneous face and double hand transplants are extremely rare and have only been tried twice before. The first attempt was in 2009 on a patient in Paris who died about a month later from complications. Two years later, Boston doctors tried it again on a woman who was mauled by a chimpanzee, but ultimately had to remove the transplanted hands days later. “The fact they could pull it off is phenomenal,” said Dr. Bohdan Pomahac, a surgeon at Boston’s Brigham and Women’s Hospital who led the second such attempt. “I know firsthand it’s incredibly complicated. It’s a tremendous success.” DiMeo will be on lifelong medications to avoid rejecting the transplants, as well as continued rehabilitation to gain sensation and function in his new face and hands. In 2018, DiMeo fell asleep at the wheel, he said, after working a night shift as a product tester for a drug company. The car hit a curb and utility pole, flipped over, and burst into flames. Another driver who saw the accident pulled over to rescue DiMeo. Afterward, he spent months in a medically induced coma and underwent 20 reconstructive surgeries and multiple skin grafts to treat his extensive third-degree burns. Once it became clear conventional surgeries could not help him regain full vision or use of his hands, DiMeo’s medical team began preparing for the risky transplant in early 2019. “Within the world of transplantation, they’re probably the most unusual,” said Dr. David Klassen, UNOS chief medical officer. Almost immediately, the NYU team encountered challenges including finding a donor. Doctors estimated he only had a 6% chance of finding a match compatible with his immune system. They also wanted to find someone with the same gender, skin tone and hand dominance. Then during the search for a donor, the pandemic hit and organ donations plummeted. During New York City’s surge, members of the transplant unit were reassigned to work in COVID-19 wards. In early August, the team finally identified a donor in Delaware and completed the 23-hour procedure a few days later. They amputated both of DiMeo’s hands, replacing them mid-forearm and connecting nerves, blood vessels and 21 tendons with hair-thin sutures. They also transplanted a full face, including the forehead, eyebrows, nose, eyelids, lips, both ears and underlying facial bones. “The possibility of us being successful based on the track record looked slim,” said Dr. Eduardo Rodriguez, who led the medical team of more than 140 people. “It’s not that someone has done this many times before and we have a kind of a schedule, a recipe to follow.” So far, DiMeo has not shown any signs of rejecting his new face or hands, said Rodriguez. Since leaving the hospital in November, DiMeo has been in intensive rehabilitation, devoting hours daily to physical, occupational and speech therapy. “Rehab was pretty intense,” DiMeo said, and involves a lot of “retraining yourself to do stuff on your own again.” During a recent session, he practiced raising his eyebrows, opening and closing his eyes, puckering his mouth, giving a thumbs up and whistling. DiMeo can feel his new forehead and hands get cold, and often reaches up to push his long hair off of his face. DiMeo, who lives with his parents, can now dress and feed himself. He shoots pool and plays with his dog Buster. Once an avid gym-goer, DiMeo is also working out again — benching 50 pounds and practicing his golf swing. “You got a new chance at life. You really can’t give up,” he said. As with any transplant, the danger of rejection is highest early on, but lasts indefinitely. The medications he takes also leave him vulnerable, for the rest of his life, to infections. “You’re never free from that risk,” Klassen said. “Transplantation for any patient is a process that plays out over a long period of time.” Still, Rodriguez said he’s amazed to see that DiMeo has been able to master skills like zipping up his jacket and putting on his shoes. “It’s very gratifying to all of us,” Rodriguez said. “There’s a tremendous sense of pride.” ___ Follow Marion Renault on Twitter: @MarionRenault ___ The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. Marion Renault And Marshall Ritzel, The Associated Press

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Japan’s SoftBank returns to profit after gains at Vision Fund and other investments

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TOKYO (AP) — Japanese technology group SoftBank swung back to profitability in the July-September quarter, boosted by positive results in its Vision Fund investments.

Tokyo-based SoftBank Group Corp. reported Tuesday a fiscal second quarter profit of nearly 1.18 trillion yen ($7.7 billion), compared with a 931 billion yen loss in the year-earlier period.

Quarterly sales edged up about 6% to nearly 1.77 trillion yen ($11.5 billion).

SoftBank credited income from royalties and licensing related to its holdings in Arm, a computer chip-designing company, whose business spans smartphones, data centers, networking equipment, automotive, consumer electronic devices, and AI applications.

The results were also helped by the absence of losses related to SoftBank’s investment in office-space sharing venture WeWork, which hit the previous fiscal year.

WeWork, which filed for Chapter 11 bankruptcy protection in 2023, emerged from Chapter 11 in June.

SoftBank has benefitted in recent months from rising share prices in some investment, such as U.S.-based e-commerce company Coupang, Chinese mobility provider DiDi Global and Bytedance, the Chinese developer of TikTok.

SoftBank’s financial results tend to swing wildly, partly because of its sprawling investment portfolio that includes search engine Yahoo, Chinese retailer Alibaba, and artificial intelligence company Nvidia.

SoftBank makes investments in a variety of companies that it groups together in a series of Vision Funds.

The company’s founder, Masayoshi Son, is a pioneer in technology investment in Japan. SoftBank Group does not give earnings forecasts.

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Yuri Kageyama is on X:

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Trump campaign promises unlikely to harm entrepreneurship: Shopify CFO

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Shopify Inc. executives brushed off concerns that incoming U.S. President Donald Trump will be a major detriment to many of the company’s merchants.

“There’s nothing in what we’ve heard from Trump, nor would there have been anything from (Democratic candidate) Kamala (Harris), which we think impacts the overall state of new business formation and entrepreneurship,” Shopify’s chief financial officer Jeff Hoffmeister told analysts on a call Tuesday.

“We still feel really good about all the merchants out there, all the entrepreneurs that want to start new businesses and that’s obviously not going to change with the administration.”

Hoffmeister’s comments come a week after Trump, a Republican businessman, trounced Harris in an election that will soon return him to the Oval Office.

On the campaign trail, he threatened to impose tariffs of 60 per cent on imports from China and roughly 10 per cent to 20 per cent on goods from all other countries.

If the president-elect makes good on the promise, many worry the cost of operating will soar for companies, including customers of Shopify, which sells e-commerce software to small businesses but also brands as big as Kylie Cosmetics and Victoria’s Secret.

These merchants may feel they have no choice but to pass on the increases to customers, perhaps sparking more inflation.

If Trump’s tariffs do come to fruition, Shopify’s president Harley Finkelstein pointed out China is “not a huge area” for Shopify.

However, “we can’t anticipate what every presidential administration is going to do,” he cautioned.

He likened the uncertainty facing the business community to the COVID-19 pandemic where Shopify had to help companies migrate online.

“Our job is no matter what comes the way of our merchants, we provide them with tools and service and support for them to navigate it really well,” he said.

Finkelstein was questioned about the forthcoming U.S. leadership change on a call meant to delve into Shopify’s latest earnings, which sent shares soaring 27 per cent to $158.63 shortly after Tuesday’s market open.

The Ottawa-based company, which keeps its books in U.S. dollars, reported US$828 million in net income for its third quarter, up from US$718 million in the same quarter last year, as its revenue rose 26 per cent.

Revenue for the period ended Sept. 30 totalled US$2.16 billion, up from US$1.71 billion a year earlier.

Subscription solutions revenue reached US$610 million, up from US$486 million in the same quarter last year.

Merchant solutions revenue amounted to US$1.55 billion, up from US$1.23 billion.

Shopify’s net income excluding the impact of equity investments totalled US$344 million for the quarter, up from US$173 million in the same quarter last year.

Daniel Chan, a TD Cowen analyst, said the results show Shopify has a leadership position in the e-commerce world and “a continued ability to gain market share.”

In its outlook for its fourth quarter of 2024, the company said it expects revenue to grow at a mid-to-high-twenties percentage rate on a year-over-year basis.

“Q4 guidance suggests Shopify will finish the year strong, with better-than-expected revenue growth and operating margin,” Chan pointed out in a note to investors.

This report by The Canadian Press was first published Nov. 12, 2024.

Companies in this story: (TSX:SHOP)

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RioCan cuts nearly 10 per cent staff in efficiency push as condo market slows

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TORONTO – RioCan Real Estate Investment Trust says it has cut almost 10 per cent of its staff as it deals with a slowdown in the condo market and overall pushes for greater efficiency.

The company says the cuts, which amount to around 60 employees based on its last annual filing, will mean about $9 million in restructuring charges and should translate to about $8 million in annualized cash savings.

The job cuts come as RioCan and others scale back condo development plans as the market softens, but chief executive Jonathan Gitlin says the reductions were from a companywide efficiency effort.

RioCan says it doesn’t plan to start any new construction of mixed-use properties this year and well into 2025 as it adjusts to the shifting market demand.

The company reported a net income of $96.9 million in the third quarter, up from a loss of $73.5 million last year, as it saw a $159 million boost from a favourable change in the fair value of investment properties.

RioCan reported what it says is a record-breaking 97.8 per cent occupancy rate in the quarter including retail committed occupancy of 98.6 per cent.

This report by The Canadian Press was first published Nov. 12, 2024.

Companies in this story: (TSX:REI.UN)

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