adplus-dvertising
Connect with us

Health

Canadian government announces deal with two leading COVID-19 vaccine candidates – Brockville Recorder and Times

Published

 on


The government announced Wednesday it had placed orders with Pfizer and Moderna, two companies with candidates in the third and final stage of trials

Brazilian pediatric doctor Monica Levi, a volunteer who received a potential COVID-19 vaccine, works at the Specialized Clinic in Infectious and Parasitic Diseases and Immunizations (CEDIPI), in Sao Paulo, Brazil, on July 24, 2020.

NELSON ALMEIDA/AFP via Getty Images

OTTAWA – Following the lead of other countries, the federal government has purchased early access to two of the leading candidates for a COVID-19 vaccine.

300x250x1

The government announced Wednesday they had placed orders with Pfizer and Moderna, two of the companies with candidates in the third and final stage of clinical trials for COVID-19 vaccines, which could be ready by the end of the year.

Procurement Minister Anita Anand said she was pleased to have reached deals that will give Canadians access to the vaccines, provided they are successful, in 2021.

“We are extremely pleased to be among the first countries to establish these agreements,” she said.

Anand said the government has secured millions of doses, but didn’t specify exactly how many, what they would cost or when in 2021 they would be delivered. Anand said the government will make those details public in time, but for now it can’t because of ongoing negotiations with other suppliers.

“Canada is pursuing agreements with a number of international and domestic companies to guarantee a supply base of potential vaccine,” she said. “We owe it to Canadians to explore every options for vaccines.”

She said the government is negotiating secure orders with options to get millions more doses. The government has also placed orders for millions of syringes, alcohol swabs and other equipment for a mass vaccination campaign when a vaccine is ready.

Moderna and Pfizer’s vaccines are both in the third and final stage of clinical trials. Assuming those trials are successful, Pfizer, which is partnering with another company called BioNTech said it can produce up to 100 million doses of its vaccine this year and another 1.3 billion in 2021.

Related

Moderna has also entered into a series of partnerships to be able to manufacture one billion doses of its vaccine per year.

Both vaccines are messenger ribonucleic acid or mRNA vaccines, which essentially trick the body into making spike proteins, similar to the spike proteins that allow COVID-19 to infect cells. Once those spike proteins are there, the body’s own immune system can learn to attack them, preventing infection.

Canada is not the first country to strike a deal for one of these vaccines. The U.S. government secured a deal in mid July with Pfizer to provide up to 100 million doses for $1.95 billion, with an option to provide 500 million more doses.

In June, a European consortium made up of France, Germany, the Netherlands and Italy has a deal with AstraZeneca, which is manufacturing the Oxford University vaccine, to provide up to 400 million doses.

The U.S., U.K. and India also have deals struck for the Oxford vaccine and the company said it believes it could make up to two billion doses spread across several countries.

The whole process of making better vaccines has been accelerated by this pandemic

Conservative MP Matt Jeneroux said getting to the table finally is a welcome move, but he is worried the government waited too long and Canada is now at the back of the line.

“Finally, Canada’s decided to realize that vaccines are an important component of recovery, however we’re months behind the other countries,” he said. “It’s frustrating to see that this government continues to be months behind the rest of the world.”

Immunologist and University of Toronto professor Tania Watts had been concerned about Canada’s lack of purchase agreements, but she said she is pleased with Wednesday’s announcement.

“We don’t know what they’re negotiating in detail — how many doses and when they will get them — but I think those are among the front runners,” she said.

She said the mRNA process both companies are using allows for mass production and with the billions of doses they say they can make, Canada should still be able to get some.

“Even though a lot of other countries have ordered them, I think it is a safe bet that there will be some for Canada.”

She said the government should also invest in Canadian vaccines and production capability, which could have a lasting legacy after the pandemic.

“The whole process of making better vaccines has been accelerated by this pandemic and we found ourselves without much manufacturing capability, without a pipeline from discovery and yet we have very good scientists.”

Finally, Canada’s decided to realize that vaccines are an important component of recovery

The government did announce $56 million in funding to Variation Biotechnologies Inc, a Canadian firm that is developing a COVID-19 vaccine. The funding will help the company move into clinical trials.

Dr. Zain Chagla, a specialist in infectious diseases and an assistant professor at McMaster University, said the vaccine purchase announcement is a good step forward. The two companies’ mRNA technology is new, but he said it’s also very promising

“There has never been a vaccine used in humankind that is mRNA targeted. It’s using the building blocks of the viral proteins to manufacture those proteins internally and then use that to provoke an immune response.”

Chagla said the technology may be new, but the science behind it is solid and holds great promise not just for this pandemic, but for other viruses moving forward.

“This is the proof of principle,” he said. “If this works it is a big win for humanity.”

David Fisman, a professor of epidemiology at the University of Toronto’s Dalla Lana School of Public Health, said both vaccines have proven themselves in early trials and hold a lot of promise.

He said unlike with other vaccines that require growing a virus, the mRNA technology is manufactured more easily and can be scaled up quickly.

“You are basically just making a chemical, just like any other pharmaceutical,” he said.

He said the vaccine mimics functions the body already does and appears safe.

“It is a very elegant approach and there is no reason to be concerned about it,” he said.

He also applauded the government for getting eggs in more than one basket, because he said there could be unexpected issues that prevent a vaccine from being successful.

“Industrial scale manufacturing can have unexpected problems.”

Canada’s chief public health officer Dr. Theresa Tam said Tuesday she was optimistic about the vaccine research underway, but she cautioned not to allow the promise of a future vaccine to cloud the need for public health measures now.

“We can’t at this stage put all of our focus in the hopes this is the silver bullet solution,” she said. “It is a very important solution if we get a safe and effective vaccine but I would say the public health measures that we have in place, the personal daily measures that we take are going to have to continue.”

Twitter:
Email: rtumilty@postmedia.com

Let’s block ads! (Why?)

728x90x4

Source link

Continue Reading

Health

Nunavut sets up mobile tuberculosis clinic in Naujaat as outbreak grows – Eye on the Arctic

Published

 on


Nunavut’s Health department is holding a TB screening clinic in Naujaat until May 30. (Havard Gould/CBC News )

3 have died since outbreak began, 21 diagnosed with active TB

Nunavut’s Health department has opened a community-wide mobile testing clinic in Naujaat, in the hopes of testing as many people as possible for tuberculosis.

It’s been almost a year since a TB outbreak was first declared in the community of 1,200 people on May 16, 2023.

300x250x1

Kevin Tegumiar, Naujaat’s mayor, said the hamlet has been asking for such a clinic for several months.

“Without accurate numbers, we’re not really sure where we are. This clinic will help clear things up,” Tegumiar said.

Tegumiar said three Naujaat residents have died since the outbreak began in the community. Nunavut’s Health department confirmed those numbers in a recent interview with CBC.

Since January 2023, 21 people in Naujaat have been diagnosed with active TB.

Another 118 others have been diagnosed with latent TB, according to the department, which is almost double the number reported in November last year.

Hundreds of tests

Health officials have set a goal to test 1,000 people in Naujaat for TB by the end of the clinic, on May 30.

“We hope that every one of them are coming and get screened during the time that we are here,” said Ekua Agyemang, Nunavut’s deputy chief public health officer. “When TB is identified early, the disease is very easy to treat in the community.”

The Health department said they will deploy a team of health-care workers, including a doctor, four nurses, an epidemiologist, a radiology technician and laboratory technician.

Canada’s chief public health officer, Dr. Theresa Tam, will also visit Naujaat this week as part of a tour alongside Nunavut Tunngavik Inc. officials and the territory’s health minister. Tam will also visit Pond Inlet and Iqaluit.

“Though TB will be a focus of the entire visit, Dr. Tam will also meet with community groups and organizations to discuss homelessness, health education, mental health, and health research initiatives in Nunavut, among other topics,” a news release from NTI said.

Agyemang said in February, the department visited schools and organized a community event to raise awareness about tuberculosis in Naujaat.

Two other outbreaks

Two other TB outbreaks are still ongoing in Pangnirtung and Pond Inlet.

A screening clinic was held in Pangnirtung last fall, which allowed about 70 per cent of the population to be tested.

“There’s definitely ongoing work that still needs to be done, but at this point in time, they’re at a good place in Pangnirtung,” Agyeman said.

Agyeman said at this point, the department does not intend to hold a clinic in Pond Inlet. She also could not provide specific information about the number of cases in the community.

Adblock test (Why?)

728x90x4

Source link

Continue Reading

Health

Experts say Canada's cancer screening guidelines are outdated – CityNews Calgary

Published

 on


A group of doctors say Canadian cancer screening guidelines set by a national task force are out-of-date and putting people at risk because their cancers aren’t detected early enough. 

“I’m faced with treating too many patients dying of prostate cancer on a daily basis due to delayed diagnosis,” Dr. Fred Saad, a urological oncologist and director of prostate cancer research at the Montreal Cancer Institute, said at a news conference in Ottawa on Monday. 

The Canadian Task Force on Preventive Health Care, established by the Public Health Agency of Canada, sets clinical guidelines to help family doctors and nurse practitioners decide whether and when to recommend screening and other prevention and early detection health-care measures to their patients.

300x250x1

Its members include primary-care physicians and nurse practitioners, as well as specialists, a spokesperson for the task force said in an email Monday. 

But Saad and other doctors associated with the Coalition for Responsible Healthcare Guidelines, which organized the news conference, said the task force’s screening guidelines for breast, prostate, lung and cervical cancer are largely based on older research and conflict with the opinions of specialists in those areas. 

For example, the task force recommends against wide use of the prostate specific antigen test, commonly known as a PSA test, for men who haven’t already had prostate cancer. Saad called that advice, which dates back to 2014, “outdated” and “overly simplistic.” 

The task force’s recommendation is based on the harms of getting false positive results that lead to unnecessary biopsies and treatment, he said. 

But that reasoning falsely assumes that everyone who gets a positive PSA test will automatically get a biopsy, Saad said. 

“We are way beyond the era of every abnormal screening test leading to a biopsy and every biopsy leading to treatment,” he said, noting that MRIs can be used to avoid some biopsies.

“Canadian men deserve (to) have the right to decide what is important to them, and family physicians need to stop being confused by recommendations that go against logic and evidence.”


RELATED: World Cancer Day 2024: WHO estimates 1 in 5 people will be diagnosed with cancer


Dr. Martin Yaffe, co-director of the Imaging Research Program at the Ontario Institute for Cancer Research, raised similar concerns about the task force’s breast cancer screening guideline, which doesn’t endorse mammograms for women younger than 50.

That’s despite the fact that the U.S. task force says women 40 and older may decide to get one after discussing the risks and benefits with their primary-care provider. 

The Canadian task force is due to update its guidance on breast cancer screening in the coming months, but Yaffe said he’s still concerned.

“The task force leadership demonstrates a strong bias against earlier detection of disease,” he said.

Like Saad, Yaffe believes it puts too much emphasis on the potential harm of false positive results.

“It’s very hard for us and for patients to balance this idea of being called back and being anxious transiently for a few days while things are sorted out, compared to the chance of having cancer go undetected and you end up either dying from it or being treated for very advanced disease.”

But Dr. Eddy Lang, a member of the task force, said the harms of false positives should not be underestimated. 

“We’ve certainly recommended in favour of screening when the benefits clearly outweigh the harms,” said Lang, who is an emergency physician and a professor at the University of Calgary’s medical school. 

“But we’re cautious and balanced and want to make sure that we consider all perspectives.” 

For example, some men get prostate cancer that doesn’t progress, Lang said, but if they undergo treatments they face risks including possible urinary incontinence and erectile dysfunction. 


READ MORE: Dry February encourages people to drink less, reduce cancer risk


Lang also said the task force monitors research “all the time for important studies that will change our recommendations.” 

“And if one of them comes along, we prioritize the updating of that particular guideline,” he said. 

The Canadian Cancer Society pulled its endorsement from the task force’s website in December 2022, saying it hadn’t acted quickly enough to review and update its breast cancer screening guidelines to consider including women between 40 and 50. 

“(The Canadian Cancer Society) believes there is an obligation to ensure guidelines are keeping pace with the changing environment and new research findings to ensure people in Canada are supported with preventative health care,” it said in an emailed statement Monday evening. 

Some provinces have implemented more proactive early detection programs, including screening for breast cancer at younger ages, using human papillomavirus (HPV) testing to screen for cervical cancer and implementing CT scanning to screen for lung cancer, doctors with the Coalition for Responsible Healthcare Guidelines said. 

But that leads to “piecemeal” screening systems and unequal access across the country, said Dr. Shushiela Appavoo, a radiologist with the University of Alberta.

Plus, many primary-care providers rely on the national task force guidelines in their discussions with patients, she said. 

“The strongest association … with a woman actually going for her breast cancer screen is whether or not her doctor recommends it to her. So if her doctor is not recommending it to her, it doesn’t matter what the provincial guideline allows,” Appavoo said. 

In addition to updating its guideline for breast cancer screening this spring, the task force is due to review its guidelines for cervical cancer screening in 2025 and for lung cancer and prostate cancer screening in 2026, according to its website.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

Adblock test (Why?)

728x90x4

Source link

Continue Reading

Health

Mobile Health Clinic in Bridgewater this week

Published

 on

Nova Scotia Health’s mobile primary care clinic. Photo: NS Health.

Nova Scotia Health’s mobile primary care clinic will be retunring to Bridgewater this week for two sessions on Wednesday and Sunday.

They will be setting up at the South Shore Community Health building located at 35 North Street. On Wednesday, April 17 the clinic will be open from 5:30 p.m. until 9:00 p.m., and on Sunday, April 21 it will operate from 9:30 a.m. until 3:00 p.m,.

300x250x1

The clinic is intended to help those without a family doctor, or those unable to book an appointment with their family doctor for non-urgent medical issues.

Types of concerns that may be addressed at the mobile primary care clinic include:

  • Prescription refills or renewals (except for controlled substances)
  • Minor respiratory symptoms
  • Sore throat
  • Earaches
  • Fever
  • Headache
  • Rashes
  • Minor gastrointestinal concerns (vomiting and diarrhea)
  • Cough, flu, or cold symptoms
  • Urinary tract infections
  • Muscle pain

Adblock test (Why?)

728x90x4

Source link

Continue Reading

Trending