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Deep sleep, memory formation go hand-in-hand. Scientists are also finding links to dementia | RCI

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Study found decrease in deep sleep associated with higher risk of dementia in people aged 60 and up

Shift workers sleeping at erratic hours. Students pulling all-nighters. Menopausal women tossing and turning in bed from hot flashes.

There are a host of reasons why people have periods of poor sleep. And anyone who’s endured back-to-back nights of sub-par slumber likely knows the result: Feelings of brain fog, grogginess or even memory issues.

In the short-term, those cognitive hiccups are usually manageable. Take new parents for instance, says a sleep scientist affiliated with the Canadian Institutes of Health Research.

It can be a couple of years of pretty serious sleep loss, and they still push through, said John Peever. But whether or not they could sustain that over many years, I think the answer to that question would be no.

A growing body of research points to clear links between deep sleep and memory formation and, on the flip side, the possibility of dire consequences when someone’s sleep quality erodes over time.

A new paper published in JAMA Neurology (new window) found even a one per cent reduction in deep sleep each year in individuals aged 60 and up was associated with a significantly higher risk of developing dementia.

The scientists looked at roughly 350 participants enrolled in the Framingham Heart Study (new window) — a long-term, multigenerational American research project — who completed two overnight sleep studies as part of the research.

During nearly two decades of follow-up, the team identified 52 cases of dementia among the participants. The researchers adjusted for other factors such as age, sex and sleeping medication use, and still found each percentage decrease in deep sleep per year was linked to a 27 per cent higher dementia risk.

That data couldn’t say whether the sleep decline caused the dementia — or which came first — but we do know sleep matters for our mental functioning.

Good sleep seems to be involved in so many things that are important for a healthy and well-functioning brain, noted lead researcher Matthew Pase, a sleep scientist from the Monash School of Psychological Sciences and the Turner Institute for Brain and Mental Health in Melbourne, Australia.

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How lack of sleep could be affecting your memory | In-Depth

Back in 2005, Canadians averaged about eight hours of sleep a night. By 2013, that dropped to seven. Now about 40 per cent of Canadians are dealing with some kind of sleep disorder. Something about sleep keeps our bodies and minds from falling apart. The lack of it has been linked to obesity, heart disease, stroke, diabetes and depression. Researchers are now discovering some fascinating things about how important sleep is to the way our brains store memories and learn things.

Research suggests poor sleep impacts cognition

The link between sleep and memory is a thread scientists have tugged on for centuries.

As far back as the mid-1700s, English philosopher David Hartley speculated (new window) that dream-filled sleep could be tied to the formation of memories inside the human brain. By the 1900s, modern researchers began to prove him right, showing how distinct sleep stages impact the process of memory development.

Evidence now suggests that sleep is important in the processing of newly acquired information and for the long-term storage of memory, neuroscientist and sleep researcher Matthew Walker wrote in 2009.

That evidence includes research from the last two decades suggesting just a day and a half without sleep is enough to disrupt someone’s ability to play a basic memory game (new window), or slow down their reaction times (new window)Another study (new window) involving American nurses found people who both under- or overslept — either five hours or less a night, or nine hours or more — showed worse performance on cognitive tests. The researchers estimated those groups were mentally two years older than their counterparts getting seven or eight hours of sleep each night.

Some research even suggests sleep deprivation mimics the feeling of being drunk, with one Australian research team (new window) likening a single day of sleep deprivation with the mental impairment of a blood alcohol concentration of 0.10 per cent.

By 2013, the U.S. Centers for Disease Control and Prevention declared (new window) that insufficient sleep was a public health epidemic.

Yet the conversation around what constitutes a good night’s sleep — and how sleep impacts memory loss and formation — continues to shift.

While most people still get hung up on the total hours of shut-eye, modern sleep scientists say there’s growing consensus that the quality of your sleep matters even more.

Impact of ‘slow-wave sleep’

Whether you typically sleep for six hours a night, or need nine hours of shut-eye, everyone’s body goes through a cycle of sleep stages. Once you doze off, your body enters a light sleep, which usually only lasts a few minutes. Then your heart rate and body temperature drop as you head into deeper sleep.

Eventually, you hit the restorative period that scientists call slow-wave sleep.

That’s the specific sleep stage Pase’s team studied where people fall into the deepest slumber. It’s also thought to be a period when the brain repairs itself.

Dr. Brian Murray, a professor of neurology at the University of Toronto and head of the neurology division at Sunnybrook Health Sciences Centre, said it’s a bit like rebooting a computer — giving it a chance to clear out stray signals. In the case of the human brain, that can mean removing misfolded protein garbage that builds up during waking hours.

<q data-attributes=””lang”:”value”:”fr”,”label”:”Français”,”value”:”html”:”This is critically important for neurodegenerative diseases, like Alzheimer’s [and]Parkinson’s,”,”text”:”This is critically important for neurodegenerative diseases, like Alzheimer’s [and]Parkinson’s,””>This is critically important for neurodegenerative diseases, like Alzheimer’s [and] Parkinson’s, he said.

The connection between good quality sleep and that junk removal process has only recently been identified, added Murray.

The latest findings from Pase and his team build on that, suggesting slow-wave sleep loss may be a dementia risk factor that people can actually try to mitigate. But Pase stressed his research doesn’t prove getting less slow-wave sleep can cause dementia.

Aging and memory loss also go hand-in-hand with comorbidities — which can disrupt sleep — and might result in someone living long-term in environments that aren’t conducive to quality slumber like brightly-lit hospitals or care homes, he noted.

The question becomes: Is altered sleep the side effect of dementia itself? Or is altered sleep facilitating dementia? echoed Peever, the Canadian sleep scientist. <q data-attributes=””lang”:”value”:”fr”,”label”:”Français”,”value”:”html”:”Soa ‘chicken and the egg’ story that is always almost impossible to unravel.”,”text”:”Soa ‘chicken and the egg’ story that is always almost impossible to unravel.””>So a ‘chicken and the egg’ story that is always almost impossible to unravel.

Still, Peever said the paper offers another piece of the evolving puzzle.

What they’ve shown is, if you take all patients across time — those with dementia, and those without incident dementia — there is a decline in how much slow-wave sleep they experience, he said. But the decline in dementia patients was significantly greater.

Dr. Eric Zhou, an assistant professor in the division of sleep medicine at Harvard Medical School, agreed the study was rigorous and compelling. The findings also fit into broader research linking poor sleep quality to an array of health issues, from stroke to cancer to mental health conditions.

You name the health problem, Zhou said, and chronically not getting enough sleep — or chronically not sleeping well — will accelerate your risk of developing it, or exacerbate the condition if you have it already.

Melatonin won’t help everyone’s sleep issues, experts say

The use of melatonin as a sleep aid has significantly increased over the past two decades, but experts say it isn’t a cure-all, and taking too much can cause health problems.

Challenges of studying sleep

Yet researching sleep, and showing clear cause-and-effect on various health issues, remains a distinct challenge. Sleep studies are notoriously difficult to run, time-consuming and often prohibitively expensive, Zhou noted. Ethically, scientists can’t randomly assign healthy adults to getting really miserable sleep, he said. Sleep studies also require a cumbersome step for participants: Staying in a lab overnight.

It’s not a blood draw, Zhou continued. It’s not one check of their pulse.

To really figure out the impacts of sleep on long-term memory loss, scientists also need a massive pool of people, and it’s almost impossible to gain funding to do complex sleep studies at a population level, Zhou said. Even decades-worth of data from hundreds of participants only gave Pase’s research team 52 dementia cases to analyze, he noted.

Pase himself agreed, and said the dual nature of his research presented an additional challenge.

The thing about dementia is, although it’s common in a population, everyone’s chance of getting it at any given time is kind of low. So, it’s a difficult thing to study.

The bottom line is that emerging research linking sleep and memory loss may be persuasive, but it’s not conclusive, Peever stressed. It’s worth striving for better sleep, he added, but there’s also no reason to panic: The vast majority of the population experiences a deterioration in sleep quality over time for reasons scientists don’t fully understand.

So clearly, sleep quality — as it declines with age — is not causing dementia in everybody.

 

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Health Canada approves updated Moderna COVID-19 vaccine

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TORONTO – Health Canada has authorized Moderna’s updated COVID-19 vaccine that protects against currently circulating variants of the virus.

The mRNA vaccine, called Spikevax, has been reformulated to target the KP.2 subvariant of Omicron.

It will replace the previous version of the vaccine that was released a year ago, which targeted the XBB.1.5 subvariant of Omicron.

Health Canada recently asked provinces and territories to get rid of their older COVID-19 vaccines to ensure the most current vaccine will be used during this fall’s respiratory virus season.

Health Canada is also reviewing two other updated COVID-19 vaccines but has not yet authorized them.

They are Pfizer’s Comirnaty, which is also an mRNA vaccine, as well as Novavax’s protein-based vaccine.

This report by The Canadian Press was first published Sept. 17, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

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These people say they got listeria after drinking recalled plant-based milks

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TORONTO – Sanniah Jabeen holds a sonogram of the unborn baby she lost after contracting listeria last December. Beneath, it says “love at first sight.”

Jabeen says she believes she and her baby were poisoned by a listeria outbreak linked to some plant-based milks and wants answers. An investigation continues into the recall declared July 8 of several Silk and Great Value plant-based beverages.

“I don’t even have the words. I’m still processing that,” Jabeen says of her loss. She was 18 weeks pregnant when she went into preterm labour.

The first infection linked to the recall was traced back to August 2023. One year later on Aug. 12, 2024, the Public Health Agency of Canada said three people had died and 20 were infected.

The number of cases is likely much higher, says Lawrence Goodridge, Canada Research Chair in foodborne pathogen dynamics at the University of Guelph: “For every person known, generally speaking, there’s typically 20 to 25 or maybe 30 people that are unknown.”

The case count has remained unchanged over the last month, but the Public Health Agency of Canada says it won’t declare the outbreak over until early October because of listeria’s 70-day incubation period and the reporting delays that accompany it.

Danone Canada’s head of communications said in an email Wednesday that the company is still investigating the “root cause” of the outbreak, which has been linked to a production line at a Pickering, Ont., packaging facility.

Pregnant people, adults over 60, and those with weakened immune systems are most at risk of becoming sick with severe listeriosis. If the infection spreads to an unborn baby, Health Canada says it can cause miscarriage, stillbirth, premature birth or life-threatening illness in a newborn.

The Canadian Press spoke to 10 people, from the parents of a toddler to an 89-year-old senior, who say they became sick with listeria after drinking from cartons of plant-based milk stamped with the recalled product code. Here’s a look at some of their experiences.

Sanniah Jabeen, 32, Toronto

Jabeen says she regularly drank Silk oat and almond milk in smoothies while pregnant, and began vomiting seven times a day and shivering at night in December 2023. She had “the worst headache of (her) life” when she went to the emergency room on Dec. 15.

“I just wasn’t functioning like a normal human being,” Jabeen says.

Told she was dehydrated, Jabeen was given fluids and a blood test and sent home. Four days later, she returned to hospital.

“They told me that since you’re 18 weeks, there’s nothing you can do to save your baby,” says Jabeen, who moved to Toronto from Pakistan five years ago.

Jabeen later learned she had listeriosis and an autopsy revealed her baby was infected, too.

“It broke my heart to read that report because I was just imagining my baby drinking poisoned amniotic fluid inside of me. The womb is a place where your baby is supposed to be the safest,” Jabeen said.

Jabeen’s case is likely not included in PHAC’s count. Jabeen says she was called by Health Canada and asked what dairy and fresh produce she ate – foods more commonly associated with listeria – but not asked about plant-based beverages.

She’s pregnant again, and is due in several months. At first, she was scared to eat, not knowing what caused the infection during her last pregnancy.

“Ever since I learned about the almond, oat milk situation, I’ve been feeling a bit better knowing that it wasn’t something that I did. It was something else that caused it. It wasn’t my fault,” Jabeen said.

She’s since joined a proposed class action lawsuit launched by LPC Avocates against the manufacturers and sellers of Silk and Great Value plant-based beverages. The lawsuit has not yet been certified by a judge.

Natalie Grant and her seven year-old daughter, Bowmanville, Ont.

Natalie Grant says she was in a hospital waiting room when she saw a television news report about the recall. She wondered if the dark chocolate almond milk her daughter drank daily was contaminated.

She had brought the girl to hospital because she was vomiting every half hour, constantly on the toilet with diarrhea, and had severe pain in her abdomen.

“I’m definitely thinking that this is a pretty solid chance that she’s got listeria at this point because I knew she had all the symptoms,” Grant says of seeing the news report.

Once her daughter could hold fluids, they went home and Grant cross-checked the recalled product code – 7825 – with the one on her carton. They matched.

“I called the emerg and I said I’m pretty confident she’s been exposed,” Grant said. She was told to return to the hospital if her daughter’s symptoms worsened. An hour and a half later, her fever spiked, the vomiting returned, her face flushed and her energy plummeted.

Grant says they were sent to a hospital in Ajax, Ont. and stayed two weeks while her daughter received antibiotics four times a day until she was discharged July 23.

“Knowing that my little one was just so affected and how it affected us as a family alone, there’s a bitterness left behind,” Grant said. She’s also joined the proposed class action.

Thelma Feldman, 89, Toronto

Thelma Feldman says she regularly taught yoga to friends in her condo building before getting sickened by listeria on July 2. Now, she has a walker and her body aches. She has headaches and digestive problems.

“I’m kind of depressed,” she says.

“It’s caused me a lot of physical and emotional pain.”

Much of the early days of her illness are a blur. She knows she boarded an ambulance with profuse diarrhea on July 2 and spent five days at North York General Hospital. Afterwards, she remembers Health Canada officials entering her apartment and removing Silk almond milk from her fridge, and volunteers from a community organization giving her sponge baths.

“At my age, 89, I’m not a kid anymore and healing takes longer,” Feldman says.

“I don’t even feel like being with people. I just sit at home.”

Jasmine Jiles and three-year-old Max, Kahnawake Mohawk Territory, Que.

Jasmine Jiles says her three-year-old son Max came down with flu-like symptoms and cradled his ears in what she interpreted as a sign of pain, like the one pounding in her own head, around early July.

When Jiles heard about the recall soon after, she called Danone Canada, the plant-based milk manufacturer, to find out if their Silk coconut milk was in the contaminated batch. It was, she says.

“My son is very small, he’s very young, so I asked what we do in terms of overall monitoring and she said someone from the company would get in touch within 24 to 48 hours,” Jiles says from a First Nations reserve near Montreal.

“I never got a call back. I never got an email”

At home, her son’s fever broke after three days, but gas pains stuck with him, she says. It took a couple weeks for him to get back to normal.

“In hindsight, I should have taken him (to the hospital) but we just tried to see if we could nurse him at home because wait times are pretty extreme,” Jiles says, “and I don’t have child care at the moment.”

Joseph Desmond, 50, Sydney, N.S.

Joseph Desmond says he suffered a seizure and fell off his sofa on July 9. He went to the emergency room, where they ran an electroencephalogram (EEG) test, and then returned home. Within hours, he had a second seizure and went back to hospital.

His third seizure happened the next morning while walking to the nurse’s station.

In severe cases of listeriosis, bacteria can spread to the central nervous system and cause seizures, according to Health Canada.

“The last two months have really been a nightmare,” says Desmond, who has joined the proposed lawsuit.

When he returned home from the hospital, his daughter took a carton of Silk dark chocolate almond milk out of the fridge and asked if he had heard about the recall. By that point, Desmond says he was on his second two-litre carton after finishing the first in June.

“It was pretty scary. Terrifying. I honestly thought I was going to die.”

Cheryl McCombe, 63, Haliburton, Ont.

The morning after suffering a second episode of vomiting, feverish sweats and diarrhea in the middle of the night in early July, Cheryl McCombe scrolled through the news on her phone and came across the recall.

A few years earlier, McCombe says she started drinking plant-based milks because it seemed like a healthier choice to splash in her morning coffee. On June 30, she bought two cartons of Silk cashew almond milk.

“It was on the (recall) list. I thought, ‘Oh my God, I got listeria,’” McCombe says. She called her doctor’s office and visited an urgent care clinic hoping to get tested and confirm her suspicion, but she says, “I was basically shut down at the door.”

Public Health Ontario does not recommend listeria testing for infected individuals with mild symptoms unless they are at risk of developing severe illness, such as people who are immunocompromised, elderly, pregnant or newborn.

“No wonder they couldn’t connect the dots,” she adds, referencing that it took close to a year for public health officials to find the source of the outbreak.

“I am a woman in my 60s and sometimes these signs are of, you know, when you’re vomiting and things like that, it can be a sign in women of a bigger issue,” McCombe says. She was seeking confirmation that wasn’t the case.

Disappointed, with her stomach still feeling off, she says she decided to boost her gut health with probiotics. After a couple weeks she started to feel like herself.

But since then, McCombe says, “I’m back on Kawartha Dairy cream in my coffee.”

This report by The Canadian Press was first published Sept. 16, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

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B.C. mayors seek ‘immediate action’ from federal government on mental health crisis

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VANCOUVER – Mayors and other leaders from several British Columbia communities say the provincial and federal governments need to take “immediate action” to tackle mental health and public safety issues that have reached crisis levels.

Vancouver Mayor Ken Sim says it’s become “abundantly clear” that mental health and addiction issues and public safety have caused crises that are “gripping” Vancouver, and he and other politicians, First Nations leaders and law enforcement officials are pleading for federal and provincial help.

In a letter to Prime Minister Justin Trudeau and Premier David Eby, mayors say there are “three critical fronts” that require action including “mandatory care” for people with severe mental health and addiction issues.

The letter says senior governments also need to bring in “meaningful bail reform” for repeat offenders, and the federal government must improve policing at Metro Vancouver ports to stop illicit drugs from coming in and stolen vehicles from being exported.

Sim says the “current system” has failed British Columbians, and the number of people dealing with severe mental health and addiction issues due to lack of proper care has “reached a critical point.”

Vancouver Police Chief Adam Palmer says repeat violent offenders are too often released on bail due to a “revolving door of justice,” and a new approach is needed to deal with mentally ill people who “pose a serious and immediate danger to themselves and others.”

This report by The Canadian Press was first published Sept. 16, 2024

The Canadian Press. All rights reserved.

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