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Detection of unreported infections based on SARS-CoV-2 antibody seroprevalence

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In the United States, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic, was first detected in late January 2020. Since then, several COVID-19 waves have occurred due to the emergence of highly infectious SARS-CoV-2 variants, such as B.1.617.2 (Delta) and B.1.1.529 (Omicron).

COVID-19 burden is monitored over time based on the number of infections, deaths, hospital visits, and hospital admissions. In contrast, seroprevalence within a population is determined at a particular point in time.

Study: Estimated SARS-CoV-2 antibody seroprevalence trends and relationship to reported case prevalence from a repeated, cross-sectional study in the 50 states and the District of Columbia, United States—October 25, 2020–February 26, 2022. Image Credit: Cryptographer / Shutterstock.com

Background

Sero-surveillance studies, whether cohort or cross-section-based, have been challenged due to their inability to determine the national burden of COVID-19. One of the reasons for this limitation is that sero-surveillance is conducted in subnational geographical areas or targeted to a specific patient population.

A new The Lancet Regional Health study analyzed data from all cross-sectional, national, repeated, and all-aged SARS-CoV-2 seroprevalence studies to elucidate the nationwide temporal trends of COVID-19 prevalence. The main aim of this study was to determine the overall antibody seroprevalence trends in different subgroups based on age, sex, and urbanicity. Additionally, the authors analyzed changes in the serological estimates at different phases of the pandemic and across geographical areas.

About the study

Remnant sera samples were collected from commercial laboratories between October 25, 2020, and February 26, 2022. These laboratories regularly obtained sera specimens from all 50 U.S. states and the District of Columbia (D.C.) for routine screening, diagnostic, or clinical care.

These sera samples were used to determine SARS-CoV-2 antibodies using commercially available test kits that received Emergency Use Authorization from the U.S. Food and Drug Administration (FDA).

Initially, SARS-CoV-2 antibodies were estimated biweekly. After a break of 56 days, antibodies were tested monthly.

The authors obtained additional data, including the sex, age, state, ZIP code, and specimen collection dates. However, the study did not include vaccination status, race, and ethnicity.

Study findings

In the study period, a total of 1,469,792 remnant serum samples were obtained, of which 58.9% belonged to women.

The most significant percentage of samples belonged to individuals between the ages of 18 and 49 years, while the smallest percentage was from those between 0 and 17 years of age. In addition, most samples came from metro areas, and several SARS-CoV-2 infection waves were recorded.

Interestingly, infection-induced seroprevalence was correlated with age, with the youngest group of zero- to 17-year-olds exhibiting the highest seroprevalence. An increase in seroprevalence was observed from 10.4% to 75.7% during the study period. An increase in seroprevalence from 9.2% to 64.5% was observed in individuals aged 18-49 years.

The lowest seroprevalence was found in people aged 65 years or older. Both males and females exhibited similar infection-induced seroprevalence estimates.

As compared to non-metro areas, metro areas consistently showed a lower seroprevalence. Conversely, the highest seroprevalence prevailed in midwestern and southern regions of the U.S.

Throughout the study period, a convex pattern was observed in the change ratio, defined as the ratio of the change in seroprevalence to the change in reported case prevalence. For example, southern U.S. states exhibited the highest ratios during the winters at 3.2 compared to approximately 1.5 during other periods.

Implications

Analysis of sero-surveillance data is critical because it provides insights into infection burden. The change ratio helps understand the infection burden based on officially reported case rates.

A sudden increase in the infection rate also questions vaccine efficacy. In the current study, the researchers observed that the change ratio was highest during periods of high viral transmission, particularly in the winter.

A change in seroprevalence may be observed relative to the changes in reported cases because of the availability and use of home testing for COVID-19. This emphasizes the importance of continual sero-surveillance, which can provide better insights into the actual infection burden.

Serosurveys could help detect population subgroups at the highest risk of infection and target them for interventions. Children, for example, had the highest seroprevalence and higher infection-to-case ratios, even though seroprevalence in children is typically underestimated compared to adults.

Conclusions

The current study has many limitations, including the lack of probabilistic sampling, a potential source of bias in serosurveys. Additionally, excluding samples from individuals frequently subjected to SARS-CoV-2 antibody testing could lead to an underestimation of seroprevalence.

Nevertheless, the current study indicated that sero-surveillance data did not fully capture the SARS-CoV-2 infection burden in the U.S. between late 2020 and early 2022.

Sero-surveillance data is crucial to understand vaccine effectiveness. It also provides a better understanding of the effect of COVID-19 at the community level and identifies subgroups at higher risk of infection. This information could help scientists and policymakers formulate better strategies to protect vulnerable populations.

Journal reference:
  • Wiegand, E. R., Deng, Y., Deng, X., et al. (2022) Estimated SARS-CoV-2 antibody seroprevalence trends and relationship to reported case prevalence from a repeated, cross-sectional study in the 50 states and the District of Columbia, United States—October 25, 2020–February 26, 2022. The Lancet Regional Health 18. doi:10.1016/j.lana.2022.100403

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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

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Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

___

Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Pediatric group says doctors should regularly screen kids for reading difficulties

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The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

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