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Eliminating Drug Side Effects by Manipulating Molecular Chirality

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Dr. Jeffery Huang Zhifeng, associate professor in the Department of Physics at HKBU, has developed a novel approach to manipulating the chirality of drug molecules.

Hong Kong Baptist University

Scientists from Hong Kong Baptist University (HKBU) have developed a novel technique that can produce pure therapeutic drugs without the associated side effects.

The approach, which uses a nanostructure fabrication device, can manipulate the chirality of drug molecules by controlling the direction a substrate is rotated within the device, thus eliminating the possible side effects that can arise when people take drugs containing molecules with the incorrect chirality.

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Published in the scientific journal Nature Chemistry, the research findings pave the way towards the mass production of purer, cheaper, and safer drugs that can be made in a scalable and more environmentally-friendly way.

Control of molecular chirality improves drug safety

Many chemical molecules have two configurations, or chiral versions, that are mirror images of each other. While sharing the same molecular formula, the two chiral versions have different arrangements of their constituent atoms in space. The two versions of the molecules are characterized by left-handed and right-handed chiral configurations like human hands. Molecules with “left-handed” and “right-handed” chirality can have totally different biochemical effects.

More than half of the therapeutic drugs are made up of equal amounts of left-handed and right-handed chiral molecules, commonly known as “racemates;” one can cure specific diseases, but the other may have adverse effects. Separating and producing molecules with only the chiral arrangement (known as a single enantiomer) responsible for the therapeutic effects can help to produce drugs with improved safety and efficacy.

Macro-scale control of molecular chirality

In general, molecules have an extremely small size ranging from one-millionth to one hundred-thousandth of the diameter of a human hair. It is therefore extremely challenging to selectively produce one of the two chiral molecule versions using “macro-scale” control (i.e. the dimensional scale that can be seen using the naked eye and operated by hand). To produce single-enantiomer drugs, chemists have overwhelmingly used molecules called “chiral ligands” to effectively control the molecular chirality of drugs in the laboratory or industry at the molecular scale, a process called asymmetric synthesis. However, the existing technologies for producing single-enantiomer drugs are composed of complicated procedures, which are expensive and environmentally-unfriendly.


Dr. Jeffery Huang Zhifeng, associate professor in the Department of Physics at HKBU, and his research team devised a novel approach to manipulating molecular chirality through macro-scale control in collaboration with Sichuan University, Guangxi Medical University and the Southern University of Science and Technology. It involves mediating the manipulation with helical metal nanostructures (i.e. metal nanohelices) that are in the shape of a helical spring, and they have a characteristic size of one-thousandth of the diameter of a human hair.

Direction of rotation determines molecular chirality

The research team fabricated the metal nanohelices using a nanofabrication technique called glancing angle deposition (GLAD). Silver and copper were deposited onto a supporting substrate that was rotated clockwise and counterclockwise to fabricate the right-handed and left-handed metal nanohelices, respectively.

The research team then used ultraviolet light to induce a chemical reaction. This caused 2-anthracenecarboxylic acid (AC) molecules adsorbing on the metal nanohelices to undergo the chemical reaction and form chiral molecular products, which are similar to some chiral drugs. When AC was attached to the surface of the right-handed metal nanohelices and exposed to ultraviolet light, it preferentially produced “right-handed” chiral molecular products. By the same token, when AC was adsorbed on the surface of the left-handed metal nanohelices and exposed to ultraviolet light, it preferentially produced “left-handed” chiral molecular products. In other words, the chirality of the molecular product can be reliably determined by the chirality of the metal nanohelices, which is controlled by the direction of substrate rotation.

The research demonstrates that controlling the direction of substrate rotation at a macroscopic level can conveniently manipulate molecular chirality. This is an unprecedented application of the macro-scale method (through the control of the rotation direction of a 4-inch substrate holder) to manipulate chirality at the molecular-scale (chiral molecular products in the range of one-billionth of a meter).

Green approach to reducing drug side effects

“Our success in manipulating molecular chirality through macroscopic engineering allows the convenient synthesis of drugs in single-enantiomer forms with only left- or right-handedness. Hence, it will help get rid of the adverse, sometimes fatal, side effects of many therapeutic drugs,” said Huang.

The use of chiral ligands in the conventional method of asymmetric synthesis is inevitable, and it may cause pollution to enter the environment. In contrast, in this novel approach the metal nanohelices can be used repeatedly to produce single-enantiomer drugs without the use of chiral ligands. As a result, it paves the way towards the mass production of affordable therapeutic drugs that are made in a scalable manner with recyclable materials.

This press release was originally published on the Hong Kong Baptist University website

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Scientists Say They Have Found New Evidence Of An Unknown Planet… – 2oceansvibe News

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In the new work, scientists looked at a set of trans-Neptunian objects, or TNOs, which is the technical term for those objects that sit out at the edge of the solar system, beyond Neptune

The new work looked at those objects that have their movement made unstable because they interact with the orbit of Neptune. That instability meant they were harder to understand, so typically astronomers looking at a possible Planet Nine have avoided using them in their analysis.

Researchers instead looked towards those objects and tried to understand their movements. And, Dr Bogytin claimed, the best explanation is that they result from another, undiscovered planet.

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The team carried out a host of simulations to understand how those objects’ orbits were affected by a variety of things, including the giant planets around them such as Neptune, the “Galactic tide” that comes from the Milky Way, and passing stars.

The best explanation was from the model that included Planet 9, however, Dr Bogytin said. They noted that there were other explanations for the behaviour of those objects – including the suggestion that other planets once influenced their orbit, but have since been removed – but claim that the theory of Planet 9 remains the best explanation.

A better understanding of the existence or not of Planet 9 will come when the Vera C Rubin Observatory is turned on, the authors note. The observatory is currently being built in Chile, and when it is turned on it will be able to scan the sky to understand the behaviour of those distant objects.

Planet Nine is theorised to have a mass about 10 times that of Earth and orbit about 20 times farther from the Sun on average than Neptune. It may take between 10,000 and 20,000 Earth years to make one full orbit around the Sun.

You may be tempted to ask how an entire planet could ‘hide’ in our solar system when we have zooming capabilities such as the new iPhone 15 has, but consider this: If Earth was the size of a marble, the edge of our solar system would be 11 kilometres away. That’s a lot of space to hide a planet.

[source:independent]

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Dragonfly: NASA Just Confirmed The Most Exciting Space Mission Of Your Lifetime – Forbes

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NASA has confirmed that its exciting Dragonfly mission, which will fly a drone-like craft around Saturn’s largest moon, Titan, will cost $3.35 billion and launch in July 2028.

Titan is the only other world in the solar system other than Earth that has weather and liquid on the surface. It has an atmosphere, rain, lakes, oceans, shorelines, valleys, mountain ridges, mesas and dunes—and possibly the building blocks of life itself. It’s been described as both a utopia and as deranged because of its weird chemistry.

Set to reach Titan in 2034, the Dragonfly mission will last for two years once its lander arrives on the surface. During the mission, a rotorcraft will fly to a new location every Titan day (16 Earth days) to take samples of the giant moon’s prebiotic chemistry. Here’s what else it will do:

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  • Search for chemical biosignatures, past or present, from water-based life to that which might use liquid hydrocarbons.
  • Investigate the moon’s active methane cycle.
  • Explore the prebiotic chemistry in the atmosphere and on the surface.

Spectacular Mission

“Dragonfly is a spectacular science mission with broad community interest, and we are excited to take the next steps on this mission,” said Nicky Fox, associate administrator of the Science Mission Directorate at NASA Headquarters in Washington. “Exploring Titan will push the boundaries of what we can do with rotorcraft outside of Earth.”

It comes in the wake of the Mars Helicopter, nicknamed Ingenuity, which flew 72 times between April 2021 and its final flight in January 2023 despite only being expected to make up to five experimental test flights over 30 days. It just made its final downlink of data this week.

Dense Atmosphere

However, Titan is a completely different environment to Mars. Titan has a dense atmosphere on Titan, which will make buoyancy simple. Gravity on Titan is just 14% of the Earth’s. It sees just 1% of the sunlight received by Earth.

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The atmosphere is 98% nitrogen and 2% methane. Its seas and lakes are not water but liquid ethane and methane. The latter is gas in Titan’s atmosphere, but on its surface, it exists as a liquid in rain, snow, lakes, and ice on its surface.

COVID-Affected

Dragonfly was a victim of the pandemic. Slated to cost $1 billion when it was selected in 2019, it was meant to launch in 2026 and arrive in 2034 after an eight-year cruise phase. However, after delays due to COVID, NASA decided to compensate for the inevitable delayed launch by funding a heavy-lift launch vehicle to massively shorten the mission’s cruise phase.

The end result is that Dragonfly will take off two years later but arrive on schedule.

Previous Visit

Dragonfly won’t be the first time a robotic probe has visited Titan. As part of NASA’s landmark Cassini mission to Saturn between 2004 and 2017, a small probe called Huygens was despatched into Titan’s clouds on January 14, 2005. The resulting timelapse movie of its 2.5 hours descent—which heralded humanity’s first-ever (and only) views of Titan’s surface—is a must-see for space fans. It landed in an area of rounded blocks of ice, but on the way down, it saw ancient dry shorelines reminiscent of Earth as well as rivers of methane.

The announcement by NASA makes July 2028 a month worth circling for space fans, with a long-duration total solar eclipse set for July 22, 2028, in Australia and New Zealand.

Wishing you clear skies and wide eyes.

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Scientists claim evidence of 'Planet 9' in our solar system – Supercar Blondie

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A team of scientists claims to have evidence that there is another hidden planet – nicknamed ‘Planet 9’ – lurking in our solar system.

Of course, there have been changes to the number of planets in our solar system over recent – in space terms, anyway – years, as Pluto is no longer considered a proper planet.

Seems a bit harsh, doesn’t it?

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However, a team of astronomers now believe that they have the strongest evidence yet that there is another mysterious planet hovering around our sun.

READ MORE! James Webb Telescope observes light on Earth-like planet for the first time in history

The theory that there could be other planets orbiting our star has been around for years, as scientists have noticed some unusual phenomena on the edge of the solar system that suggest the existence of another celestial body.

The theory that another planet is responsible would also explain the orbit of other objects that are outliers in our system, sitting more than 250 times Earth’s distance from the sun.

Scientist Konstantin Bogytin and his team have long been proponents of this ‘Planet 9’ theory, and now they believe they have ‘the strongest statistical evidence yet that Planet 9 is really out there’.

As we know, it wouldn’t be the only strange thing in our solar system.

Or outside, for that matter.

Perhaps they just need to point a massive space telescope at it and they’ll find evidence of alien life out there.

This new study by Bogytin and his team focused on a number of Trans-Neptunian Objects (TNOs) that lie outside the orbit of Neptune towards the outer reaches of our solar system.

In analyzing the movements of these objects – which can be affected by the orbit of Neptune, as well as passing stars and the ‘galactic tide’ – the scientists concluded that there could be another unseen planet out there.

Dr Bogytin pointed out that there are other potential explanations for the behavior of these objects, but – he believes – Planet 9 is the best bet.

Once the Vera C. Rubin Observatory in Chile becomes active, we might get the best look we’ve had yet.

In a paper, the team wrote: “This upcoming phase of exploration promises to provide critical insights into the mysteries of our solar system’s outer reaches.”

That paper, entitled ‘Generation of Low-Inclination, Neptune-Crossing TNOs by Planet Nine’ is available to read here.

Images in this article were generated using AI

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