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Immune Response to COVID mRNA Vaccination Is Unaffected by Pregnancy

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The long-term immune response to SARS-CoV-2 mRNA vaccination was similar in pregnant individuals compared with non-pregnant individuals of reproductive age, according to a study by investigators at Weill Cornell Medicine and NewYork-Presbyterian. The similarity in protection is noteworthy, given that pregnancy alters the immune system, and potentially the response to vaccination.

The findings, published Nov. 2 in the American Journal of Obstetrics & Gynecology MFM, add further support to current recommendations for SARS-CoV-2 vaccination at any point during pregnancy, including booster doses after the initial two-dose series, to help protect pregnant people from severe COVID-19. The researchers also found that SARS-CoV-2 mRNA vaccination during pregnancy transferred protection to unborn babies, an essential benefit since babies must be at least six months old to receive their first COVID-19 vaccination.

“We and others have shown mRNA vaccination results in a strong initial immune response in pregnant individuals but the longer-term protection was unclear,” said co-lead study author Dr. Yawei Jenny Yang, assistant professor of pathology and laboratory medicine at Weill Cornell Medicine and a pathologist at NewYork-Presbyterian/Weill Cornell Medical Center. “We believe our study is unique in that it longitudinally evaluates the longer-term immunity in pregnant and non-pregnant individuals up to 10 months after their first two SARS-CoV-2 mRNA vaccines.”

For their study, which involved extensive collaboration among multiple departments, Dr. Yang and colleagues collected and analyzed blood samples from 53 pregnant and 21 non-pregnant individuals receiving care at Weill Cornell Medicine who received their first two doses of the Pfizer or Moderna SARS-CoV-2 mRNA vaccine between Dec. 2020 and June 2021. The vaccines targeted the original Wuhan strain of SARS-CoV-2, and no study participants had ever had COVID-19. Researchers collected blood at the time of the first and second vaccine doses, two weeks after the second dose and at regular intervals over 42 weeks.

The investigators found that the vaccination resulted in robust levels of immunoglobulin G (IgG) antibodies specific to the spike protein on SARS-CoV-2, called anti-spike IgG antibodies, the most abundant, potent and longest-lasting antibodies the immune system makes after mRNA vaccination. The antibodies bind to the virus and attack it directly or block it from infecting cells.

The study results showed that anti-spike IgG antibody levels were similar in pregnant and non-pregnant individuals. The peak immune response to vaccination occurred about two weeks after vaccination, regardless of when vaccination was initiated during pregnancy. The quantities of these antibodies declined at a similar rate in pregnant and non-pregnant individuals, down to 64 to 77 percent of peak by about six to eight months after vaccination. This finding further supports the benefits of booster doses for maintaining optimal protection against COVID-19, regardless of pregnancy status.

Additionally, Dr. Yang and colleagues found anti-spike IgG antibodies in cord blood from the vaccinated pregnant individuals who gave birth at NewYork-Presbyterian Alexandra Cohen Hospital for Women and Newborns, confirming earlier reports of SARS-CoV-2 mRNA vaccination passing on strong protection to babies. “We are grateful to the participants who enrolled in the study so they could help others,” she said.

“Early in the pandemic, clinicians recommended vaccination based on the need to protect pregnant individuals from the devastating effects of COVID-19,” said senior study author Dr. Laura Riley, chair of the Department of Obstetrics and Gynecology and the Given Foundation Professor in Clinical Obstetrics and Gynecology at Weill Cornell Medicine and obstetrician and gynecologist-in-chief at NewYork-Presbyterian/Weill Cornell Medical Center. “Now we can definitively say that following vaccination, pregnant individuals mount as robust an immune response as non-pregnant individuals. Our data, and the accumulated research on COVID-19 vaccines in pregnant individuals, indicate the vaccines protect pregnant individuals from the effects of COVID and protect their babies as well.”

“We hope our findings encourage more pregnant individuals to get vaccinated,” she said.

Reference: Prabhu M, Yang YJ, Johnston CD, et al. Longitudinal antibody response kinetics following SARS-CoV-2 messenger RNA vaccination in pregnant and nonpregnant persons. Am J Obstet Gynecol MFM. 2023;5(2):100796. doi: 10.1016/j.ajogmf.2022.100796

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Canada to donate up to 200,000 vaccine doses to combat mpox outbreaks in Africa

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The Canadian government says it will donate up to 200,000 vaccine doses to fight the mpox outbreak in Congo and other African countries.

It says the donated doses of Imvamune will come from Canada’s existing supply and will not affect the country’s preparedness for mpox cases in this country.

Minister of Health Mark Holland says the donation “will help to protect those in the most affected regions of Africa and will help prevent further spread of the virus.”

Dr. Madhukar Pai, Canada research chair in epidemiology and global health, says although the donation is welcome, it is a very small portion of the estimated 10 million vaccine doses needed to control the outbreak.

Vaccine donations from wealthier countries have only recently started arriving in Africa, almost a month after the World Health Organization declared the mpox outbreak a public health emergency of international concern.

A few days after the declaration in August, Global Affairs Canada announced a contribution of $1 million for mpox surveillance, diagnostic tools, research and community awareness in Africa.

On Thursday, the Africa Centres for Disease Control and Prevention said mpox is still on the rise and that testing rates are “insufficient” across the continent.

Jason Kindrachuk, Canada research chair in emerging viruses at the University of Manitoba, said donating vaccines, in addition to supporting surveillance and diagnostic tests, is “massively important.”

But Kindrachuk, who has worked on the ground in Congo during the epidemic, also said that the international response to the mpox outbreak is “better late than never (but) better never late.”

“It would have been fantastic for us globally to not be in this position by having provided doses a much, much longer time prior than when we are,” he said, noting that the outbreak of clade I mpox in Congo started in early 2023.

Clade II mpox, endemic in regions of West Africa, came to the world’s attention even earlier — in 2022 — as that strain of virus spread to other countries, including Canada.

Two doses are recommended for mpox vaccination, so the donation may only benefit 100,000 people, Pai said.

Pai questioned whether Canada is contributing enough, as the federal government hasn’t said what percentage of its mpox vaccine stockpile it is donating.

“Small donations are simply not going to help end this crisis. We need to show greater solidarity and support,” he said in an email.

“That is the biggest lesson from the COVID-19 pandemic — our collective safety is tied with that of other nations.”

This report by The Canadian Press was first published Sept. 13, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

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How many Nova Scotians are on the doctor wait-list? Number hit 160,000 in June

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HALIFAX – The Nova Scotia government says it could be months before it reveals how many people are on the wait-list for a family doctor.

The head of the province’s health authority told reporters Wednesday that the government won’t release updated data until the 160,000 people who were on the wait-list in June are contacted to verify whether they still need primary care.

Karen Oldfield said Nova Scotia Health is working on validating the primary care wait-list data before posting new numbers, and that work may take a matter of months. The most recent public wait-list figures are from June 1, when 160,234 people, or about 16 per cent of the population, were on it.

“It’s going to take time to make 160,000 calls,” Oldfield said. “We are not talking weeks, we are talking months.”

The interim CEO and president of Nova Scotia Health said people on the list are being asked where they live, whether they still need a family doctor, and to give an update on their health.

A spokesperson with the province’s Health Department says the government and its health authority are “working hard” to turn the wait-list registry into a useful tool, adding that the data will be shared once it is validated.

Nova Scotia’s NDP are calling on Premier Tim Houston to immediately release statistics on how many people are looking for a family doctor. On Tuesday, the NDP introduced a bill that would require the health minister to make the number public every month.

“It is unacceptable for the list to be more than three months out of date,” NDP Leader Claudia Chender said Tuesday.

Chender said releasing this data regularly is vital so Nova Scotians can track the government’s progress on its main 2021 campaign promise: fixing health care.

The number of people in need of a family doctor has more than doubled between the 2021 summer election campaign and June 2024. Since September 2021 about 300 doctors have been added to the provincial health system, the Health Department said.

“We’ll know if Tim Houston is keeping his 2021 election promise to fix health care when Nova Scotians are attached to primary care,” Chender said.

This report by The Canadian Press was first published Sept. 11, 2024.

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Newfoundland and Labrador monitoring rise in whooping cough cases: medical officer

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ST. JOHN’S, N.L. – Newfoundland and Labrador‘s chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.

Dr. Janice Fitzgerald says that so far this year, the province has recorded 230 confirmed cases of the vaccine-preventable respiratory tract infection, also known as pertussis.

Late last month, Quebec reported more than 11,000 cases during the same time period, while Ontario counted 470 cases, well above the five-year average of 98. In Quebec, the majority of patients are between the ages of 10 and 14.

Meanwhile, New Brunswick has declared a whooping cough outbreak across the province. A total of 141 cases were reported by last month, exceeding the five-year average of 34.

The disease can lead to severe complications among vulnerable populations including infants, who are at the highest risk of suffering from complications like pneumonia and seizures. Symptoms may start with a runny nose, mild fever and cough, then progress to severe coughing accompanied by a distinctive “whooping” sound during inhalation.

“The public, especially pregnant people and those in close contact with infants, are encouraged to be aware of symptoms related to pertussis and to ensure vaccinations are up to date,” Newfoundland and Labrador’s Health Department said in a statement.

Whooping cough can be treated with antibiotics, but vaccination is the most effective way to control the spread of the disease. As a result, the province has expanded immunization efforts this school year. While booster doses are already offered in Grade 9, the vaccine is now being offered to Grade 8 students as well.

Public health officials say whooping cough is a cyclical disease that increases every two to five or six years.

Meanwhile, New Brunswick’s acting chief medical officer of health expects the current case count to get worse before tapering off.

A rise in whooping cough cases has also been reported in the United States and elsewhere. The Pan American Health Organization issued an alert in July encouraging countries to ramp up their surveillance and vaccination coverage.

This report by The Canadian Press was first published Sept. 10, 2024.

The Canadian Press. All rights reserved.

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