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Joint vaccine trial 'not terminated'; Chinese virologists worry data safety in Canada – Global Times

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A medical worker shows the inactivated COVID-19 vaccine candidate developed by SinoPharm at the company’s vaccine candidate production plant on April 10. Photo: Xinhua

Chinese vaccine developer CanSino Biologics said on Thursday that its collaboration with a Canadian research team on late-stage clinical trials of a COVID-19 vaccine candidate “has not been terminated,” refuting reports by Canadian media which said the cooperation was called off for rising tensions between the two countries.

CanSino sent an English clarification announcement to the Global Times on Thursday night, in which it said the collaboration with the National Research Council of Canada (NRC) has not been terminated. None of the management of the company has accepted any interview in relation to the clinical trials for Ad5-nCoV in Canada.

CanSino also said in the Thursday announcement that it noticed misleading media reports related to the clinical trials for the vaccine candidate in Canada. 

Canadian media CBC News on Wednesday reported that the cooperation of the two sides which was announced in May was “abandoned amid rising tensions between the two countries.” The report quoted an emailed statement from the NRC as saying that the Chinese Customs had not approved the vaccine candidate, named Ad5-nCoV, to be sent to Canada.

CanSino said on August 18 that the Phase III clinical trials with Canada had not yet started.

Canadian media even called the delayed shipments as an “apparent retaliation” from China for the arrest of Huawei CFO Meng Wanzhou.

Aside from saying it is currently driving the international multi-center phase III clinical trial for Ad5-nCoV with several countries, CanSino did not provide further details on the cooperation with the NRC in the announcement and NRC has not responded to a Global Times request as of press time.

However, some virologists reached by the Global Times believe that scientific, elements may have played a role in the twists and turns of the collaboration, though Canada’s damage to legal and diplomatic relations may also be a factor.

The types of COVID-19 that have spread in North America are different from those in Asia or Europe, making Canada a less ideal place for clinical trials of this China-based vaccine, said Yang Zhanqiu, a professor at the pathogen biology department of Wuhan University.

“Also, the number of infected patients in Canada is fewer than many other countries,” Yang told the Global Times on Thursday, saying that made Canada a less favorable destination for clinical trials of a recombinant vaccine that requires a large group of volunteers facing a higher risk of infection.

Canada has reported more than 128,000 cases of COVID19 so far, with a downward trend since early May. 

Another Beijing-based virologist who asked not to be named said that property rights disputes or other legal concerns may also put obstacles to the cooperation, as media reported the Ad5-nCoV used a piece of Canadian technology – a cell line modified by the NRC – which the NRC had provided to CanSino for use in Ebola vaccine R&D in 2014 and coronavirus vaccine research in 2020.

The twists of the cooperation deal may have also reflected China’s possible doubts about the safety of conducting trials in Canada over concerns Chinese vaccine R&D data may be leaked under outside pressure. Canada has already betrayed Chinese companies due to US pressure, Tao Lina, a Shanghai-based immunological expert, told the Global Times on Thursday.

China, along with other countries such as Russia and Saudi Arabia, has made progress in Phase III trials cooperation of the COVID-19 vaccine, Tao said.

Volunteers of joint China-Russia trials on the same vaccine candidate are scheduled to be all vaccinated by the end of September, and the results will be released by late fall, the Global Times learned on Sunday from Petrovax, a leading Russian pharmaceutical products developer.

“China has long rejected vaccine nationalism or politicization of coronavirus vaccines, as can be seen in its extensive cooperation with other countries,” Tao added.

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Stop Asking Your Interviewer Cliché Questions

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Most job search advice is cookie-cutter. The advice you’re following is almost certainly the same advice other job seekers follow, making you just another candidate following the same script.

In today’s hyper-competitive job market, standing out is critical, a challenge most job seekers struggle with. Instead of relying on generic questions recommended by self-proclaimed career coaches, which often lead to a forgettable interview, ask unique, thought-provoking questions that’ll spark engaging conversations and leave a lasting impression.

English philosopher Francis Bacon once said, “A prudent question is one half of wisdom.”

The questions you ask convey the following:

  • Your level of interest in the company and the role.
  • Contributing to your employer’s success is essential.
  • You desire a cultural fit.

Here are the top four questions experts recommend candidates ask; hence, they’ve become cliché questions you should avoid asking:

  • “What are the key responsibilities of this position?”

Most likely, the job description answers this question. Therefore, asking this question indicates you didn’t read the job description. If you require clarification, ask, “How many outbound calls will I be required to make daily?” “What will be my monthly revenue target?”

  • “What does a typical day look like?”

Although it’s important to understand day-to-day expectations, this question tends to elicit vague responses and rarely leads to a deeper conversation. Don’t focus on what your day will look like; instead, focus on being clear on the results you need to deliver. Nobody I know has ever been fired for not following a “typical day.” However, I know several people who were fired for failing to meet expectations. Before accepting a job offer, ensure you’re capable of meeting the employer’s expectations.

  • “How would you describe the company culture?”

Asking this question screams, “I read somewhere to ask this question.” There are much better ways to research a company’s culture, such as speaking to current and former employees, reading online reviews and news articles. Furthermore, since your interviewer works for the company, they’re presumably comfortable with the culture. Do you expect your interviewer to give you the brutal truth? “Be careful of Craig; get on his bad side, and he’ll make your life miserable.” “Bob is close to retirement. I give him lots of slack, which the rest of the team needs to pick up.”

Truism: No matter how much due diligence you do, only when you start working for the employer will you experience and, therefore, know their culture firsthand.

  • “What opportunities are there for professional development?”

When asked this question, I immediately think the candidate cares more about gaining than contributing, a showstopper. Managing your career is your responsibility, not your employer’s.

Cliché questions don’t impress hiring managers, nor will they differentiate you from your competition. To transform your interaction with your interviewer from a Q&A session into a dynamic discussion, ask unique, insightful questions.

Here are my four go-to questions—I have many moreto accomplish this:

  • “Describe your management style. How will you manage me?”

This question gives your interviewer the opportunity to talk about themselves, which we all love doing. As well, being in sync with my boss is extremely important to me. The management style of who’ll be my boss is a determining factor in whether or not I’ll accept the job.

  • “What is the one thing I should never do that’ll piss you off and possibly damage our working relationship beyond repair?”

This question also allows me to determine whether I and my to-be boss would be in sync. Sometimes I ask, “What are your pet peeves?”

  • “When I join the team, what would be the most important contribution you’d want to see from me in the first six months?”

Setting myself up for failure is the last thing I want. As I mentioned, focus on the results you need to produce and timelines. How realistic are the expectations? It’s never about the question; it’s about what you want to know. It’s important to know whether you’ll be able to meet or even exceed your new boss’s expectations.

  • “If I wanted to sell you on an idea or suggestion, what do you need to know?”

Years ago, a candidate asked me this question. I was impressed he wasn’t looking just to put in time; he was looking for how he could be a contributing employee. Every time I ask this question, it leads to an in-depth discussion.

Other questions I’ve asked:

 

  • “What keeps you up at night?”
  • “If you were to leave this company, who would follow?”
  • “How do you handle an employee making a mistake?”
  • “If you were to give a Ted Talk, what topic would you talk about?”
  • “What are three highly valued skills at [company] that I should master to advance?”
  • “What are the informal expectations of the role?”
  • “What is one misconception people have about you [or the company]?”

 

Your questions reveal a great deal about your motivations, drive to make a meaningful impact on the business, and a chance to morph the questioning into a conversation. Cliché questions don’t lead to meaningful discussions, whereas unique, thought-provoking questions do and, in turn, make you memorable.

_____________________________________________________________________

 

Nick Kossovan, a well-seasoned veteran of the corporate landscape, offers “unsweetened” job search advice. You can send Nick your questions to artoffindingwork@gmail.com.

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Canadian Natural Resources reports $2.27-billion third-quarter profit

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CALGARY – Canadian Natural Resources Ltd. reported a third-quarter profit of $2.27 billion, down from $2.34 billion in the same quarter last year.

The company says the profit amounted to $1.06 per diluted share for the quarter that ended Sept. 30 compared with $1.06 per diluted share a year earlier.

Product sales totalled $10.40 billion, down from $11.76 billion in the same quarter last year.

Daily production for the quarter averaged 1,363,086 barrels of oil equivalent per day, down from 1,393,614 a year ago.

On an adjusted basis, Canadian Natural says it earned 97 cents per diluted share for the quarter, down from an adjusted profit of $1.30 per diluted share in the same quarter last year.

The average analyst estimate had been for a profit of 90 cents per share, according to LSEG Data & Analytics.

This report by The Canadian Press was first published Oct. 31, 2024.

Companies in this story: (TSX:CNQ)

The Canadian Press. All rights reserved.

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Cenovus Energy reports $820M Q3 profit, down from $1.86B a year ago

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CALGARY – Cenovus Energy Inc. reported its third-quarter profit fell compared with a year as its revenue edged lower.

The company says it earned $820 million or 42 cents per diluted share for the quarter ended Sept. 30, down from $1.86 billion or 97 cents per diluted share a year earlier.

Revenue for the quarter totalled $14.25 billion, down from $14.58 billion in the same quarter last year.

Total upstream production in the quarter amounted to 771,300 barrels of oil equivalent per day, down from 797,000 a year earlier.

Total downstream throughput was 642,900 barrels per day compared with 664,300 in the same quarter last year.

On an adjusted basis, Cenovus says its funds flow amounted to $1.05 per diluted share in its latest quarter, down from adjusted funds flow of $1.81 per diluted share a year earlier.

This report by The Canadian Press was first published Oct. 31, 2024.

Companies in this story: (TSX:CVE)

The Canadian Press. All rights reserved.

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