The firstvaccine tested in the U.S. revved up people’s immune systems just the way scientists had hoped, researchers reported Tuesday. The shots are poised to begin key final testing.
“No matter how you slice this, this is good news,”, the U.S. government’s top infectious disease expert, told The Associated Press.
The experimental vaccine, developed by Fauci’s colleagues at the National Institutes of Health and, will start its most important step around July 27: A 30,000-person study to prove if the shots really are strong enough to protect against the coronavirus.
But Tuesday, researchers reported anxiously awaited findings from the first 45 volunteers whoback in March. Sure enough, the vaccine provided a hoped-for immune boost.
Those early volunteers developed what are calledin their bloodstream — molecules key to blocking infection — at levels comparable to those found in people who survived COVID-19, the research team reported in the New England Journal of Medicine.
“This is an essential building block that is needed to move forward with the trials that could actually determine whether the vaccine does protect against infection,” said Dr. Lisa Jackson of the Kaiser Permanente Washington Research Institute in Seattle, who led the study.
There’s no guarantee but the government hopes to have results around the end of the year — record-setting speed for developing a vaccine.
“Our goal is to have a vaccine available for broad distribution by year-end or early next year,”president Stephen Hoge in May, after seeing preliminary data on the Phase 1 trial. “If we and others build data that shows that the vaccine has a potential for benefit, that it’s safe and has a potential for efficacy, then, of course, there are circumstances where the vaccine could be deployed to high-risk populations earlier under something called an Emergency Use Authorization. Really though, that’s a decision that regulators, in particular the FDA, have to make.”
The vaccine requires two doses, a month apart.
There were no serious side effects. But more than half the study participants reported flu-like reactions to the shots that aren’t uncommon with other vaccines — fatigue, headache, chills, fever and pain at the injection site. For three participants given the highest dose, those reactions were more severe; that dose isn’t being pursued.
Some of those reactions are similar to coronavirus symptoms but they’re temporary, lasting about a day and occur right after vaccination, researchers noted.
“Small price to pay for protection against COVID,” said Dr. William Schaffner of Vanderbilt University Medical Center, a vaccine expert who wasn’t involved with the study.
He called the early results “a good first step,” and is optimistic that final testing could deliver answers about whether it’s really safe and effective by the beginning of next year.
“It would be wonderful. But that assumes everything’s working right on schedule,” Schaffner cautioned.
And Tuesday’s results only included younger adults. The first-step testing later was expanded to include dozens of older adults, the age group most at risk from COVID-19. Those results aren’t public yet but regulators are evaluating them, and Fauci said final testing will include older adults, as well as people with chronic health conditions that make them more vulnerable to the virus — and Black and Latino populations likewise affected.
Nearly two dozenare in various stages of testing around the world. Candidates from China and Britain’s also are entering final testing stages.
The 30,000-person study will mark the world’s largest study of a potential COVID-19 vaccine so far. And the NIH-developed shot isn’t the only one set for such massive U.S. testing, crucial to spot rare side effects. The government plans similar large studies of the Oxford candidate and another by Johnson & Johnson; separately, Pfizer Inc. is planning its own huge study.
Already, people can start signing up to volunteer for the different studies.
People think “this is a race for one winner. Me, I’m cheering every one of them on,” said Fauci, who directs NIH’s National Institute of Allergy and Infectious Diseases.
“We need multiple vaccines. We need vaccines for the world, not only for our own country.”
Around the world, governments are investing in stockpiles of hundreds of millions of doses of the different candidates, in hopes of speedily starting inoculations if any are proven to work.
Why some say Canada needs to do more to protect essential workers until COVID-19 vaccine arrives – CBC.ca
As Canadians await the rollout of the first round of COVID-19 vaccines, experts say Canada needs to double down on protecting essential workers most at risk of exposure to the coronavirus in the coming months.
Canada will only have a limited supply of vaccines to start, with just 3 million expected to be vaccinated in the first few months of 2021, but the news of COVID-19 vaccines on the horizon could not come at a more critical time.
Over 400,000 Canadians have tested positive for the coronavirus since the pandemic began and the situation in our hardest-hit provinces shows no signs of slowing down.
The percentage of COVID-19 tests across the country that have come back positive during the past week has skyrocketed to 7.4 per cent — up from 1.4 per cent in mid-September and 4.7 per cent in early November. A rising positivity rate can signal that cases are being missed and more people could unwittingly be spreading the virus.
“There’s a light at the end of the tunnel, but we still have to get through the tunnel to get there,” said Dr. Sumon Chakrabarti, an infectious disease specialist at Trillium Health Partners in Mississauga, Ont.
“You also don’t want to be in a situation where you have a raging fire that’s going on and when you’re trying to roll out a vaccine, you’re doing it in a setting where the hospital is overwhelmed and health-care workers are getting sick.”
Alberta positivity rate tops 10 per cent
Of all the COVID hotspots, Alberta has the biggest fire to put out at the moment, and this week asked the federal government and the Red Cross to supply field hospitals to help offset the strain COVID-19 is having on the health-care system.
There, the percentage of COVID-19 tests coming back positive hit an astonishing 10.5 per cent on Friday.
COVID-19 cases in Alberta are growing at such an explosive rate they’ve even outpaced Ontario, a province with 10 million more people, for the first time in the pandemic — with cases in Edmonton alone totalling more than those in Toronto and Peel Region combined.
“If you think this is a hoax, talk to my friend in the ICU, fighting for his life,” Alberta Premier Jason Kenney said during a Facebook livestream Thursday.
“If you’re thinking of going to an anti-mask rally this weekend, how about instead send me an email, call me all the names you want, send me a letter, organize an online rally.”
Yet while much of the focus on public health messaging throughout the pandemic has been focused on individual actions, experts say Canada isn’t doing enough to protect those most in need of support in the coming months.
Ontario, Quebec see surge in workplace outbreaks
While elderly Canadians are most at risk for severe outcomes from COVID-19, totalling close to 90 per cent of all deaths, essential workers on the front lines are facing a worsening situation.
For the first time in the pandemic, active outbreaks in workplaces in Canada’s biggest provinces have outpaced those in long-term care facilities — accounting for 30 per cent of the outbreaks in Ontario and 40 per cent in Quebec, as first reported by The Globe and Mail.
While limited information is available on exactly where the spread of COVID-19 is occurring, Ontario’s ministry of health said in a statement to CBC News the hardest-hit industries include construction, manufacturing, mining, warehousing and transportation.
WATCH | Essential workers talk about being on the front lines of the COVID-19 pandemic
Because of the disproportionate risk of exposure they face, the union for workers in food retail, manufacturing, long-term care, home care and security said Friday that frontline workers should also be among the first recipients of COVID-19 vaccines.
“Workplaces are a big deal,” said Dr. Zain Chagla, an infectious diseases physician at St. Joseph’s Healthcare Hamilton and an associate professor at McMaster University.
“There are people that need to go to work, unfortunately, for us to support society, and again we have to be willing and able to give them at least some measures of safety in their workplace.”
Paid sick leave key to stopping spread of COVID-19
Chakrabarti says one area that could help address rising transmission rates in workplaces is more paid sick leave for those who are unable to miss work due to COVID-19.
Unlike policing people’s contacts in their own homes, it’s a problem policy could tackle, he said.
“Workplaces are things that are really important because you can only do so much to keep things safe.”
If people are going to decide between putting food on their table … or going into isolation … they’re going to show up to work sick.– Dr. Zain Chagla
Chakrabarti says mask wearing and physical distancing aren’t always possible in certain situations in workplaces, especially those that involve workers in close quarters indoors — as evidenced by outbreaks in meatpacking plants, warehouses, and mines.
“Many people are financially unstable and they’re scared because if they do have to go off work, they’ll end up losing income,” he said. Undocumented workers may also be hesitant to speak up about symptoms for fear of being deported.
“So you have a lot of these kinds of factors that I think are barriers for people getting tested.”
Chagla says more targeted education, oversight and internal audits to control COVID-19 transmission are needed in high-risk workplaces, in order to ensure compliance and accountability.
“There’s certainly tons of essential workplaces that will continue to have issues unless people actually intervene and do this type of stuff,” he said.
Last month, the federal government created Canada Recovery Sickness Benefit to give up to $1,000 of support to workers with COVID-19 over two weeks, but Chagla said more could be done.
“You have to incentivize people to get tested,” Chagla said. “If people are going to decide between putting food on their table and paying their rent, going to work or going into isolation … they’re going to show up to work sick.”
Isolating, outreach better than ‘finger wagging’
Chakrabarti says another way to protect essential workers is through the creation of more dedicated isolation facilities for those recovering from COVID-19.
“One big place that amplification is happening is in large families,” he said. “So if you have a place for people to have their meals covered and they can isolate away from their family, that’s going to really help to reduce amplification of the cases that we’re seeing in workplaces.”
Chakrabarti says the “condescension and finger wagging” in public health messaging across the country against individual actions isn’t always effective — especially nine months into the pandemic.
“Community outreach often helps,” said Chakrabati, who is also a member of a recently formed South Asian task force to connect with and inform people in Peel Region.
“I think that a lot of the focus right now is on people. ‘Hey, you stay home, stay home, stop partying,’ that kind of stuff. Whereas we don’t hear a lot of what’s happening in these workplaces.”
“This is going to be a problem throughout the entire pandemic,” said Chagla. “Because they have to stay open.”
Facebook Bans Debunked Claims About COVID-19 Vaccines – Prairie Public Broadcasting
Facebook is banning claims about COVID-19 vaccines that have been debunked by public health experts, as governments prepare to roll out the first vaccinations against the virus.
That includes posts that make false claims about how safe and effective the vaccines are, and about their ingredients and side effects.
“For example, we will remove false claims that COVID-19 vaccines contain microchips, or anything else that isn’t on the official vaccine ingredient list,” Facebook’s head of health, Kang-Xing Jin, said in a blog post. “We will also remove conspiracy theories about COVID-19 vaccines that we know today are false: like specific populations are being used without their consent to test the vaccine’s safety.”
The new ban is an expansion of Facebook’s rules against misinformation about the coronavirus that could lead to imminent physical harm. The company said it removed 12 million such posts from Facebook and Instagram between March and October.
The approach to COVID-19 vaccines is a departure from Facebook’s general approach to vaccine misinformation. The company has made false claims about other vaccines less visible on its platform but stopped short of removing them. In October, it banned anti-vaccination ads.
Facebook said it was extending the policy because COVID-19 vaccines will soon be rolled out around the world. The U.K. became the first country to approve a vaccine this week, with the first doses expected to be available next week. Regulators in the U.S. are expected to approve vaccines before the end of the year.
On Monday, Facebook CEO Mark Zuckerberg said the company would show users “authoritative information” about vaccines. It’s adding a section to its coronavirus information center — a section of its site that promotes credible sources — with details about how vaccines are tested and approved.
YouTube, owned by Google, and TikTok also have said they will remove false claims about COVID-19 vaccines.
Despite efforts by Facebook and other platforms to curb the spread of hoaxes and conspiracy theories, misinformation about the pandemic has spread widely on social media this year.
Editor’s note: Facebook, Google and TikTok are among NPR’s financial supporters.
COVID-19 kills 11 more B.C. residents, as hospitalizations return to record level – North Shore News
While the number of serious cases of COVID-19 in B.C. remains high, with a record 338 people in hospital – 13 more than yesterday – the number of those people in intensive care units fell by four overnight, to 76.
Deaths continue to mount, with 11 more individuals succumbing to the virus overnight, making the death toll 492, since the first COVID-19-related death in the province on March 9.
There were 711 new cases identified, for a total of 36,132 since the first case in B.C. was detected on January 28.
“Currently, 10,957 people are under active public health monitoring as a result of identified exposure to known cases and 25,658 people who tested positive have recovered,” provincial health officer Bonnie Henry and Health Minister Adrian Dix said in a joint statement.
They broke the newly identified cases down by health region, as follows:
• 143 in Vancouver Coastal Health;
• 427 in Fraser Health;
• 10 in Island Health;
• 81 in Interior Health; and
• 50 in Northern Health.
While Fraser Health remains the hot spot in the province for infections, all regions are battling outbreaks. Northern Health’s 50 new infections is a high number for that remote region, and more than double the 23 cases that were identified yesterday.
Two new outbreaks at health care facilities are at Peace Arch Hospital Foundation Lodge in Surrey, and at Richmond Hospital in Richmond.
The outbreak at Youville Residence in Vancouver is over.
Dix yesterday made clear that despite the high number of people in hospital, scheduled surgeries are being done.
Scheduled surgeries are sometimes referred to as “elective” or “non-urgent” surgeries, although no one elects to have surgery if it is not necessary.
Since the B.C. government restarted these surgeries on May 18, there have been:
• 49,100 completed in Fraser Health;
• 32,919 completed in Interior Health;
• 10,458 completed in Northern Health;
• 42,516 completed in Vancouver Coastal Health;
• 37,543 completed in Island Health; and
• 7,266 completed in the Provincial Health Services Authority.
“There have been some questions about acute care capacity in recent days,” Dix. said. “In terms of our base bed capacity, it’s at 87.8%.”
When Dix added what he called “surge beds,” which would be extra beds added to the system, the province’s hospitals are now at 70.6% capacity.
“That’s the level of beds that are occupied overall in hospitals,” he said. “Just to put that in context, last year at this time, [bed occupancy] was at 103.5% of base-bed capacity.”
Dix said ICU base-bed capacity is at 76%, although when new beds that have been added are included, ICU wards across the province are at 54.6% capacity.
Dix has noted that what is needed in addition to beds is staff, and that this is one of the stresses in the system.
There are now nine hospitals in the province with active outbreaks:
• University Hospital of Northern B.C. in Prince George.
• West Coast General Hospital in Port Alberni;
• Saanich Peninsula Hospital in Saanichton;
• Burnaby Hospital in Burnaby;
• Langley Memorial Hospital in Langley;
• Lions Gate Hospital in North Vancouver;
• Richmond Hospital in Richmond;
• Ridge Meadows Hospital in Maple Ridge; and
• Surrey Memorial Hospital in Surrey.
In total, there are 56 seniors’ living facilities that have active outbreaks, and below is a full breakdown by health region.
There are 14 active outbreaks at seniors’ facilities in the Vancouver Coastal Health region, and they include:
• Arbutus Care Centre in Vancouver;
• Banfield Pavilion, in Vancouver;
• Revera Capilano Care Centre in West Vancouver;
• Columbus Residence in Vancouver;
• German Canadian Care Home in Vancouver;
• Lakeview Care Centre in Vancouver;
• Little Mountain Place in Vancouver;
• Renfrew Care Centre in Vancouver;
• Royal Ascot Care Centre in Vancouver;
• Royal Arch Masonic Home long-term care facility in Vancouver;
• St. Judes Anglican Home in Vancouver;
• Three Links Care Centre long-term care facility in Vancouver;
• Villa Cathay Care Home in Vancouver; and
• Windermere Care Centre in Vancouver.
The 35 outbreaks at seniors’ facilities in the Fraser Health region now include:
• Agassiz Seniors Community in Agassiz;
• Agecare Harmony Court Estates in Burnaby;
• Agecare Court Estates in Burnaby;
• Al Hogg Pavilion in White Rock;
• Amenida Seniors Community in Surrey;
• Amica White Rock in White Rock;
• Baillie House long-term care home in Maple Ridge;
• Belvedere Care Centre in Coquitlam;
• CareLife Fleetwood in Surrey;
• Chartwell Langley Gardens in Langley;
• Fellburn Care Centre long-term care facility in Burnaby;
• Finnish Manor in Burnaby;
• Fleetwood Villa Retirement Residence in Surrey;
• Fort Langley Seniors Community in Fort Langley;
• George Derby Centre in Burnaby;
• Good Samaritan Delta View Care Centre 2 long-term care facility in Delta;
• Harrison Pointe retirement home in Langley;
• Harrison at Elim Village in Surrey;
• Hawthorne Seniors Care Community long-term care in Port Coquitlam;
• Hawthorne Seniors Care Community assisted living in Port Coquitlam;
• Hollyrood Manor long-term care home in Maple Ridge;
• Jackman Manor in Langley Township;
• Laurel Place long-term care facility in Surrey;
• Menno Home in Abbotsford;
• Morgan Place Care Society in Surrey;
• Northcrest Care Centre in Delta;
• Peace Arch Hospital Foundation Lodge in Surrey;
• PICS Assisted Living in Surrey;
• Queen’s Park Care Centre in New Westminster;
• Sunset Manor in Chilliwack;
• Tabor Home in Abbotsford;
• The Residence at Clayton Heights in Surrey;
• The Residence in Mission;
• Valley Haven Care Home in Chilliwack; and
• White Rock Senior Village in White Rock.
There are three outbreaks at seniors’ homes in Northern Health:
• North Peace Seniors Housing Society buildings in Fort St. John;
• Rotary Manor Dawson Creek in Dawson Creek; and
• Gateway House long-term care home in Prince George.
Two outbreaks are at seniors’ living facilities in the Island Health region: Tsawaayuss-Rainbow Gardens in Port Alberni and Veterans Memorial Lodge at Broadmead in Victoria.
The Interior Health region has two seniors’ facility outbreaks, at Mountainview Village in Kelowna and Sun Pointe Village in Kelowna.
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